Handbook of Drugs in Infertility
Handbook of Drugs in Infertility
Series Editors
Nandita Palshetkar MD FCPS FICOG FRCOG (UK)
President FOGSI 2019 Scientific Director, Bloom IVF Professor Department of Obstetrics and Gynecology Dr DY Patil Medical College Hospital and Research Center Navi Mumbai, Maharashtra, India
Rohan Palshetkar MS (Obs/Gyne) FRM
ART Consultant and Endoscopic Surgeon Associate Professor Unit Head Dr DY Patil Medical College Hospital and Research Center Navi Mumbai, Maharashtra, India
Editors
Seema Pandey MD FICOG FRM
President, Azamgarh Obs Gyn Society Managing Committee Member, ISAR (2018–20) Secretary, UP ISPAT (2018)
Pratik Tambe MD FICOG
Chairperson, FOGSI Endocrinology Committee (2017–19) Managing Council Member, MOGS Managing Council Member, IAGE, MSR, AMC (2015–18)
Foreword
Nandita Palshetkar
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Handbook of Drugs in Infertility
First Edition: 2020
9789389776447
Printed at
President | Dr Nandita Palshetkar |
Secretary General | Dr Jaydeep Tank |
Vice President (West Zone) | Dr Rajendrasingh Pardeshi |
Vice President (West Zone) | Dr Haresh Doshi |
Vice President (North Zone) | Dr Sudha Prasad |
Vice President (East Zone) | Dr Rajat Mohanty |
Vice President (South Zone) | Dr Aswath Kumar |
Deputy Secretary General | Dr Madhuri Patel |
Treasurer | Dr Suvarna Khadilkar |
Joint Treasurer | Dr Parikshit Tank |
Joint Secretary | Dr Ameya Purandare |
Immediate Past President | Dr Jaideep Malhotra |
President Elect | Dr Alpesh Gandhi |
Adolescent Health | Dr Girish Mane |
Clinical Research | Dr Meena Samant |
Endocrinology | Dr Pratik Tambe |
Endometriosis | Dr Kuldeep Jain |
Endoscopic Surgery | Dr B Ramesh |
Ethics and Medicolegal | Dr Geetendra Sharma |
Family Welfare | Dr Shobha Gudi |
Food Drugs MedicoSx Equipment | Dr Vidya Thobbi |
Genetics and Fetal Medicine | Dr Mandakini Pradhan |
HIV/AIDS | Dr Mrutyunjay Mohapatra |
Imaging Science | Dr Meenu Agarwal |
Infertility | Dr Asha Baxi |
International Academic Exchange | Dr Varsha Baste |
MTP | Dr Bharti Maheshwari |
Medical Education | Dr Abha Singh |
Medical Disorders in Pregnancy | Dr Komal Chavan |
Midlife Management | Dr Rajendra Nagarkatti |
Oncology | Dr Bhagyalaxmi Nayak |
Perinatology | Dr Vaishali Chavan |
Practical Obstetrics | Dr Sanjay Das |
Public Awareness | Dr Kalyan Barmade |
Quiz | Dr Sebanti Goswami |
Safe Motherhood | Dr N Palaniappan |
Breast | Dr Sneha Bhuyar |
Sexual Medicine | Dr Sudha Tandon |
Urogynecology | Dr Nita Thakre |
Young Talent Promotion | Dr Vinita Singh |
Anagha Karkhanis
Anil Gudi
Anupama Futela
Anuradha Chaudhary
Anuradha Khar
Apoorva Pallam Reddy
Archana Reddy
Arshi Iqbal
Ashish Ramchandra Kale
Ashok Kumar
Ashwini Ashish Kale
Chaitanya Ganapule
Dhawal Baxi
Ekika Singh
Fessy Louis T
Jyothi Budi
Kalyani Shrimali
Kavita Darade
Kavitha Gautham
Kedar Ganla
Kundan Ingale
Lavanya Kiran
Laxmi Chirumamila
Lipika Mohrana
Mahavar P
Manju Sharma
Manjushri Kothekar
Megha Gupta
Namrata Ohri
Neelam Ohri
Neharika Malhotra Bora
Nikita Banerjee
Nisha Thakre
Pallavi Aggarwal
Parasuram Gopinath
Parvathy T
Pratik Tambe
Priya Bhave
Priyanka H Vora
Rajalaxmi Walavalkar
Rajeev Agarwal
Rajesh Koradia
Rakhi Singh
Rana Khan Chaudhary
Reema Sirkar
Revathi K
Ridhi Desai
Ritu Hinduja
Rohan Palshetkar
Rohit Gutgutia
Rupal Shah
Sachin Kulkarni
Sapna Ahuja
Satpathi G
Seema Pandey
Selvapriya Saravanan
Sheetal Sawankar
Shivani Sachdev
Shruti Gadekar
Shrutika Kamath Thakkar
Sini Venu Gopal
Smriti Agrawal
Sowparnika SN
Srilatha Gorthi
Tarini Taneja
Veronica Irene
Vimee Bindra
Foreword
It gives me great pleasure to know that the Handbook of Drugs in Infertility is ready for release. The aim of this book is to highlight the utility of the available drug treatment options available to us in the practical management of fertility issues.
As busy practitioners, we rarely have time to read and update ourselves with current recommendations and evidence. We hope this volume will help you to keep abreast of the latest developments in this field and give you some valuable tips and pointers which you can implement in day-to-day practice.
If we are to have progress, we must again be dominated by hope rather than fear
—Bertrand Russell
My Presidential theme for my FOGSI year 2019 is “We for Stree—Safer, Stronger, Smarter”. During the year, we have attempted to focus on academic, social and community health initiatives aimed at improving the profile of women in our country. I am pleased to acknowledge the efforts of ordinary FOGSIans who have united and stood with us to contribute to a series of initiatives which have refocused our contributions not only toward the health of Indian women, but their social, financial and educational upliftment as well.
I am committed to FOGSIans, delivering continuing medical education programs and to help our members to perform to the best of their ability in the areas in which they practice. We have also executed a raft of initiatives to help women from poor socioeconomic areas receive appropriate care through our social and community healthcare initiatives, e.g. The FOGSI Saving Mothers initiative. The FOGSI Manyata project also aims to bring a certain minimum standard of care to the women of India via accreditation and training of private nursing homes and healthcare personnel and I would urge all of you to participate in this project.
I hope this updated evidence-based volume on drugs and management alternatives in infertility will be of help to FOGSIans and practicing gynecologists throughout the country. My congratulations to the editors Dr Seema Pandey and Dr Pratik Tambe, the authors, contributors and the publishers for their hard work and efforts towards the release of this book!
Nandita Palshetkar
President FOGSI 2019
Preface
Respected colleagues and dear friends,
It is with immense pride that we bring to you this Handbook of Drugs in Infertility.
Treating patients presenting with infertility is an important component of contemporary practice. Often as practicing gynecologists, we are confused with the plethora of options available to us and are unaware regarding the specifics with respect to the pharmacological minutiae and application of such knowledge in day-to-day practice as per the current recommendations and evidence.
Too much action with too little intent makes for wasteful exertion of energy and the confusion between movement and progress
– Steve Maraboli
This handbook is a humble attempt to bring together a diverse range of authors ranging from general gynecologists to basic infertility practitioners and fertility physicians practicing assisted reproductive technology (ART) to contribute their knowledge, experience and expertise on all the available drugs and formulations being used in fertility practice today. We hope this book will serve as a ready reckoner and a single go-to reference for the dosages, duration and practical applications for therapeutic alternatives in various clinical scenarios.
We have attempted to include the most updated recommendations and guidelines in a single volume which will be easily accessible to practitioners from various backgrounds including postgraduate students, general gynecologists, infertility specialists and ART consultants. If the material presented is helpful to you in treating your patients, our hard work and efforts in putting together this volume will have been well served.
We wish to thank our FOGSI President Dr Nandita Palshetkar and the Office Bearers, without whose blessings and encouragement, this book would not have materialized. We also wish to place on record our gratitude to our publishers M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, who will help bring this handbook to FOGSIans across the length and breadth of India.
Yours sincerely,
Seema Pandey
Pratik Tambe
(Editors)
Acknowledgments
We wish to place on record our gratitude to our FOGSI President Dr Nandita Palshetkar and the Office Bearers, contributors, Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Ms Chetna Malhotra Vohra (Associate Director–Content Strategy), Sabarish Menon (Commissioning Editor, Mumbai Branch) and Kritika Dua (Senior Development Editor) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, academic partners for their hard work, cooperation and dynamic participation towards the timely release of this book.