Vertigo and Dizziness: A Case-based Study Ambar Chakravarty
INDEX
Page numbers followed by, f refer to figure, fc refer to flowchart, and t refer to table.
A
Abscess 161
Adenoviruses 78
Alexender's law 76
American Academy of Ophthalmology and Otolaryngology 97
American Academy of Otolaryngology-Head and Neck Surgery 85, 86, 97
Aminoglycoside antibiotics 142
Aminopyridines 233
Amiodarone 40
Anemia 39, 87
Anticardiolipin syndrome 102
Anticholinergics 227
Anticonvulsant toxicity 164
Antiemetics 228
Antiepileptic drugs 164
Antihistamines 227
Antiphospholipid syndrome 102
Antisaccades 14
Aphonia 195
Apparent body motion 46
Apraxia 116
Arnold-Chiari malformation 87
Arteries 83f
Astasia-abasia 115
Asymmetric pursuit gain 53
Ataxia 154
episodic 153, 233
ipsilateral 180
Atlantoaxial joint, computed tomography scan of 160
Atrophy, multiple system 62, 142, 145
Audiometric tests, multiple 88
Audiometry 88
Audiovestibular loss, acute 83
Audiovestibular testing 149, 156
Auditory reflexive saccades 13
Autoimmune diseases 102
Autoimmune inner ear disease 87
Axial stiffness 10
B
Balance
apraxia of 115
cerebellar control of 7
cortical control of 8
disorders 113, 114, 176
Balo's concentric sclerosis 203
Barany Society's Classification of Vestibular Symptoms 125
Barré-Liéou syndrome 109, 110
Basal ganglia 9
Basilar artery 84
hypoplasia of 183f, 184, 186f
Behçet's disease 102, 202
Behcet's syndrome 55
Benign paroxysmal positional vertigo 39, 46, 55, 62, 66, 67, 70, 71, 81, 87, 107, 120, 121, 126, 148, 155, 157, 166, 171, 171f, 204, 210, 211, 219, 220, 226, 232
Benzodiazepines 227
Betahistine 92, 228, 230
mechanism of action of 229f
Bezold-Harisch reflex 61
Bickerstaff's encephalitis 202
Bilateral positive head impulse test 131
Bilateral vestibulopathy 49f, 81, 141, 142
diagnostic criteria for 145
differential diagnosis of 145
natural history of 146
Bithermal caloric testing 89, 103, 144
Bithermal calorigram 167f
Bizarre foot placement 114
Blood pressure 196, 198
low 59
Blurred vision 59
Body ipsipulsion 180
Bow-Hunter syndrome 109
Bow-tie nystagmus 55
Bradycardia 59, 61
Brain
base of 83f
computed tomography scan of 75, 177, 118, 127, 148, 137, 208
magnetic resonance
angiography 84
imaging of 75, 82f, 96, 98, 118, 120, 127f, 128f, 133, 148, 151, 154, 177f, 182, 182f, 185f, 190f, 194f, 196f, 198, 198f, 201f, 203f, 205f, 207f, 209f
plain computed tomography scans of 208f
post-gamma knife radiosurgery magnetic resonance imaging of 209f
postoperative contrast magnetic resonance imaging of 207f
Brainstem 19f, 76, 81, 209f
arterial supply of 215
attack, paroxysmal 106
auditory evoked response 100, 127, 149
infarction 45, 80, 216
involvement 202
stroke 39, 40
transient ischemic attacks 39
C
Calcium channel blockers 228
Caloric inversion 57
Caloric test 22, 56, 89, 100f, 132f, 149
normal ranges for 57
Canal dehiscence syndrome, superior 39, 40, 106, 148
Canal hypoactivity, severe degree of 136f
Canal paresis 157
Canal switch 67, 70
Canalith repositioning techniques 220
Canalithiasis 66
Canal-otolith interaction 150
Canvas syndrome 140
Carbamazepine 40
Caudal fastigial nuclei 13f
Caudal vermis 13f
Cell groups 11
Central nervous system 1, 60, 78, 155, 161
Central tegmental tract 29
Cerebellar
artery
anterior inferior 40, 46, 82f, 83, 120, 215, 216
posterior inferior 46, 40, 190, 190f, 215
superior 45, 179, 215
ataxia 145, 233
degeneration 27, 40, 55
dentate-dentatorubral-rubro-thalamic-thalamocortical circuits 8
diseases 20
functional organization 7
hemispheres 182f
hemorrhage 80
infarct 182f, 192f, 216
peduncle
inferior 14f, 29
superior 29, 55, 177f, 178, 202, 202f
stroke 39, 45, 46, 50, 76
anterior 45
posterior 45
rule out 40
system 38
tumors 87
vertigo syndromes 233
visuomotor function 13f
Cerebellitis 142
Cerebellopontine angle region 208, 209f
Cerebellum 5, 6, 19f, 20, 204, 207f, 215
arterial supply of 215
subserving visuomotor function, structures of 13f
Cerebral
artery, right posterior 186f
cortex 8
Cerebrospinal fluid 127, 201, 206
Cervical
spine
magnetic resonance imaging of 110
therapy, manual 113
X-ray of 110
vertigo, proprioceptive 108
vestibular-evoked myogenic potentials 58f, 131, 135f, 171f
Cervico-ocular reflex exercises 110
Chemotherapeutic agents 143
Chiari malformation 43
Clumsy 159
Cogan's syndrome 87, 102
Colliculus, superior 15
Commissure, posterior 17
Computed tomography angiography 107, 190, 191f
Computerized dynamic platform posturography 158
Conductive deafness, gross 170f
Consciousness, loss of 151
Contralateral hemiparesis 196
Corneal reflex, ipsilateral loss of 80
Coronary artery
bypass grafting 189
disease 187
Corrective exercises 112
Corticocerebellar interconnection 8
Corticopontine pathways 8
Cough 40
Cranial nerve 19f
deficits 79
Craniocervical junction anomalies 27, 40
Craniocorpography 73f, 138f
Craniovertebral anomalies 161
C-reactive protein 168
Crescendo course 39
Creutzfelt-Jakob disease 161
Crista ampullaris 2
Cryptococcosis 161
Cupulolithiasis 66, 225
Cytomegalovirus 78
D
Dentate nucleus 29
ipsilateral 179
Diabetes mellitus 193
Dimenhydrinate 226
Diplopia 180
Diuretics 92
Dix-Hallpike maneuver 67-69, 171
Dix-Hallpike test 41, 65f, 67, 69, 71, 72, 103, 109, 129, 148, 213, 219, 225
Dizziness 33, 34, 35, 38, 40, 59, 109, 120, 152, 168
chronic 149, 157fc
subjective 130, 156, 157
diagnosis of 45
functional 106, 145
head motion-induced 125
history of 102
persistent postural-perceptual 81, 145, 173, 175
phobic postural 145
post-traumatic complaints of 157fc
postural-perceptual 129
psychogenic 172
visually-induced 145
Dorsal oculomotor vermis 11
Dorsal pontomesencephalic junction 201f
Dorsolateral pontine nucleus 19
Duct obstruction 86
Dynamic visual acuity 40, 42
test 143
Dysphagia 80
Dysrhythmia, caloric 57
E
Ear pressure 39
Electrocardiogram 186
Electrocardiography 233
Electrocochleogram, normal 103f
Electroencephalogram 151
Electronystagmography 210
Encephalitis 142
Encephalomyelitis
acute disseminated 202
paraneoplastic 161
Endolymph
absorption of 86
production of 86
Endolymphatic flow, receptive zones of 4f
Endolymphatic hydrops 86, 90, 90f, 91f, 98
demonstration of 90
Endolymphatic sac 86
Epileptic skew deviation 161
Epileptic vestibular aura 106
Episodes, acute 157fc
Episodic vestibular symptoms 152
Epley's maneuver 71, 72, 73, 148, 221, 222, 223f
Epstein-Barr virus 78
Erythrocyte sedimentation rate 168
European Academy of Otology and Neurotology 85
Eustachian tube 43
Extrapyramidal syndromes 113
Eye movements
abnormal 80
torsional vestibular 21
vestibular control of 11
F
Facial hypoesthesia, contralateral 180
Faint 35
Falling, fear of 10
Fasciculus
bilateral medial longitudinal 184
medial longitudinal 12
Fastigial oculomotor region 11
Fearfulness 154
Fever, high 79
Fistula, perilymphatic 39, 40, 79, 87
Fixation suppression 56
Flocculus 12, 13f
Fluid-attenuated inversion recovery 177, 190f, 196f, 198
images 192f
sequence 177f, 182f, 203
Fracture, skull base 40
Frenzel's glasses 76
Functional magnetic resonance imaging studies 8
G
Gait 7
akinesia 10
disorders 114, 233
central 145
higher level 114
Gamma-aminobutyric acid-enhancing agents 80
Ganglia, vestibular 78
Gasperini syndrome 84
Gaze-evoked nystagmus 12, 15, 31, 40, 56, 75, 80
Gentamicin 93, 142, 143
intratympanic 93
injections of 231
Glasgow coma scale score 181
Glottic valsalva test 56
Glucocorticoids, intratympanic 93
Glycerol dehydration test 89
Goodpasture syndrome 102
Gorkha earthquake 174
Graviceptive vestibular pathways 162
Gross hypoactive canals, bilateral 132f, 134f
Gufoni's maneuver 224, 225
Guillain-Mollaret triangle 29, 29f
Gynecologic tumors 40
H
Hair cells, types of 3f
Hashimoto's thyroiditis 102
Head impulse test 41, 75, 76, 131, 164, 187, 193, 204, 210, 216, 220
normal 121
Head trauma 40
Headache 47, 123, 124, 127, 128, 168, 205
Head-up tilt table test 61
Hearing loss 79, 82, 87, 96, 99, 143, 157
acute 40
audiogram of severe mixed 97f
bilateral 85
fluctuating 40, 85, 88
intermittent 96
isolated 98
Heart rate 60-62
Hemicrania continua 168
Hemihypesthesia, contralateral 195
Hemisphere control 19
Hemorrhage 84, 215
subarachnoid 208f, 209f
Hemorrhagic shock models 60
Hennebert's sign 43
Hepatic coma 161
Herpes simplex virus 78
Hiccups 40, 80
Histamine receptors 230
Hoarseness 80
Holter monitoring 191
Horizontal head impulse test 218
Horizontal pursuit, control of 19f
Horizontal saccades, control of 16f
Horizontal semicircular canals 78
Horizontal vestibulo-ocular movement, control of 21f
Horner's syndrome 31, 180, 216
ipsilateral 80
Human balance 1, 38
neurology of 1
Human labyrinth 2f
Hydrops, secondary 87
Hyperintense lesion 196f
Hypermetric ipsilateral saccades 12
Hypermetric saccades, bilateral 12
Hypertension 193
Hypertrophy, left ventricular 191
Hyperventilation syndrome 43
Hyperventilation test 55
Hypoglycemia 39, 153
Hypometric saccades, bilateral 12
Hypoplasia 183f, 186f
vestibular aqueduct 86
Hypoplastic left vertebral artery 185
Hypotension, postural 39, 40
Hypothesis, infectious 78
I
Infarction 80
Influenza virus
A 78
B 78
Intensity
moderate 124
severe 124
International Classification of Headache Disorders 33, 124, 128, 154
International Headache Society Classification 106
International League Against Epilepsy 152
Interstitial nucleus of Cajal 16, 28, 31, 161
Intracranial pressure 161
Ischemic lesions, multifocal 116
J
Japan Society for Equilibrium Research 85
K
Korean Balance Society 85
L
Labyrinth, vascular supply of 84f
Labyrinthectomy 94
Labyrinthine infarction 79, 217
Labyrinthitis 79
Legs, crossing of 114
Lempert's roll over maneuver 148, 224, 224f
Lermoyez’ syndrome 88, 119
Lesion, effect of 12
Leukoaraiosis 120
Lightheadedness 39
constellation of symptoms of 59
Limb ataxia, ipsilateral 80
Lithium 40
Locomotor 116
Lorazepam 227
Loud noise 39, 40
Lower motor neuron, ipsilateral 195
Lymphomas 202
M
Macula 2
Magnetic resonance
angiogram 186f
angiography 183f
Mastoid tenderness 79
Medulla, lesion of 55
Medullary syndrome, lateral 31
Memory loss 180
Menière's disease 33, 39, 40, 50, 79, 85, 86f, 101, 107, 119, 126, 140, 152, 157, 166, 172, 210, 220, 227, 231
diagnosis of 103
differential diagnosis of 87t
types of 88
Meningitis 142
Methylenetetrahydrofolate reductase 188
M-glass 76
Micropressure therapy 93
Midbrain, lesion of 53, 55
Migraine 39, 109, 158
attack 128
vestibular 34, 39, 46, 81, 106, 123-125, 152, 155
Mondini dysplasia 156
Movement disorders 145
Multiple lacunes 120
Muscle tone regulation 10
Myoclonus 28
Myokymia, superior oblique 106
N
National Institutes of Health Stroke Scale 187, 191
Nausea 47, 63, 125
Neomycin 143
Neoplasms 142
Neurectomy, vestibular 94
Neuritis, acute vestibular 230
Neurologic symptoms, transient unprovoked 121fc
Neuroma, acoustic 87, 208, 209f
Neurons, inhibitory burst 18
Neuropathy, peripheral 145
Neurovascular cross compression 106
Nonvertiginous disequilibrium 156
Nuchal rigidity 79
Nuclei, perihypoglossal 27
Nucleus reticularis tegmenti pontis 11
Nystagmus 11, 21, 22, 24, 30, 32, 51, 53, 67, 69, 76, 131, 154, 195, 217
acquired 26, 26t, 28
afferent 25
Bruns 31
caloric 24
central 41
positional 70, 106, 233
vestibular 55
clinical types of 23
congenital 25, 26, 26t
convergence retraction 28
convergent divergent 29
downbeat 12, 27, 40, 145, 233
drug-induced 24
efferent 25
end point 23
epileptic 31
first phase of 66
head shaking 41, 217
horizontal gaze-evoked 43
jerk 22, 66
latent 26
mixed horizontal torsional 55
nonfatigable 79
optokinetic 24, 53
pendular 22
periodic alternating 12, 27, 28, 216
peripheral vestibular 55, 76
perverted head-shaking 12
positional 12, 30, 70, 106
postrotatory 12
pure torsional 27
rebound 12, 31
recovery 31
see-saw 28
torsional 52
types of 26
upbeat 27, 41, 55
divergent 55
vestibular 24, 30, 32, 40, 76
voluntary 25
waveforms of 23f
O
Occipital acute infarct, right 191f
Ocular contrapulsion 12
Ocular ipsipulsion 12
Ocular lateropulsion 18
Ocular motor
abnormalities 20
functions, localization of 12
system 11, 12
testing 42
vermis 13f, 14f
Ocular oscillations 31
Ocular tilt 40
reaction 161
Ocular Todd's paralysis 32
Ocular vestibular-evoked myogenic potential 133, 135f, 170f, 210
Oculocephalic maneuver 21
Oculopalatal tremor 29, 29f
Olivary nucleus, inferior 11, 14f
Omnipause neurons 11
Ophthalmoplegia, internuclear 25, 43, 184, 187
Optokinetic inversion 26
Optokinetic test 53
Organ of Corti 1
Oscillopsia 21
Otoconia 63
Otolithic hypofunction 48
Otosclerosis 87
Ototoxic 142
P
Pain
loss of 80
neck 109
Palatal tremor, essential 29
Pallor 154
Panic attacks 106, 153
Paraflocculus 12, 13f
Parainfluenza virus 78
Paramedian pontine reticular formation 195
Paraneoplastic syndrome 40
Paresis 146
Parkinson's disease 51, 52, 114, 145
Parkinson's syndromes 145
Paroxysmal positional vertigo 45, 63
anterior canal benign 56, 225
posterior canal benign 65f, 223f
right posterior canal benign 223f
Patent foramen ovale 188
Peptide, calcitonin gene-related 129
Perilymphatic fistula, traumatic 148
Petrosal bone 90f, 91f
Phonophobia 124
Photophobia 124
Polychondritis, relapsing 102
Pontine infarction 84, 194f
Pontine paramedian reticular formation 11, 21f
Pontine syndromes, lateral 195
Ponto-cerebellar pathways 8
Posterior commissure, nucleus of 12
Presbiotonia 87
Presyncope 35
Promethazine 92
Pure tone audiometry 166f
Pursuit 51
adaptation 12
gain 12
initiation, smooth 12
pathway, smooth 52fc
subsystem 18
Pusher syndrome
lateral 114
posterior 115
Q
Quadriplegia 195
R
Raymond-Cestan syndrome 195
Reflex
neurocardiogenic 61
tachycardia 61
vestibular epilepsy, diagnosis of 153
Rheumatoid arthritis 102, 127
Roll test, supine 41, 69f, 109, 129
Romberg's test 73, 140, 143, 172
Rotational vertebral artery occlusion syndrome 106, 109, 110
Rotatory chair tests 144
Rubella virus 78
Rupture theory 86, 87
S
Saccade 51
adaptation 12
Saccadic contrapulsion 12
Saccadic deviation 32
Saccadic ipsipulsion 12
Saccadic lateropulsion 14f
Saccadic pathway 52fc
Saccadic pursuit 12
contraversive 12
Saccadic subsystem 13
Sarcoidosis 102
Scarpa's ganglion 4
Scheibe aplasia 156
Schilder's disease 203
Sclerosis, multiple 43, 79, 83, 87, 102, 161, 203
Scopolamine 92
Seizure 151, 164
Semicircular canal 1, 5, 84f
lateral 232
superior 133f
stimulation, ocular motor effects of 54f
superior 4f, 63, 64f, 74f, 131, 193, 210, 220
Semicircular ducts 4
Semont's maneuver 171f, 222, 223f
Sensorineural hearing loss 156, 157, 166f
fluctuating 85
high-frequency 139f
mid-frequency 89f, 97f
mild degree of 132f
Serotonin reuptake inhibitors, selective 60
Sjögren syndrome 102
Skew
deviation, types of 162
test of 217
Snellen's chart 143
Somatic afferent, special 3
Somatosensory integration 10
Spasmus nutans 26
Speech slurring 180
Spinal artery, anterior 198f
Spinning, severe 62
Spinocerebellar ataxia 142
Stair-step saccades 51
Steroids 92
Strain 40
Streptomycin 143
Stress 176
disorder, post-traumatic 175
Stroke 39, 45, 46, 75, 189, 215, 232
ischemic 215
medullary 196
posterior circulation 39, 181, 184, 185, 187, 190
risk of 215
Sudden noise 13
Sweating 59
Syncope 35, 39
Systemic lupus erythematosus 102
T
Tachy-brady-arrhythmia 153
Tendon reflexes 181
Thalamus 12, 55
Thyroid disease 87
Tilt table test 61
Tinnitus 40, 88, 143
intermittent 96
TiTrATE 36
protocol 36fc
Tobramycin 142
Tonic-clonic
grand mal seizure activity 60
seizure, generalized 100
Transient ischemic attack 87, 152, 215, 233
Trauma 161
Trochlear palsy 40
Truncal ataxia 79
Tuberomammillary nucleus 1
Tullio phenomenon 39, 40
Tumarkin's crisis 88
pathophysiology of 88
Tumarkin's drop attack 88
Tumor 43, 161
Tympanic membrane, inflamed 79
U
Uncinate fasciculus 179
Unterberger test 140
Urticular pathway 40
Usher syndrome 156
V
Valacyclovir 80
Valsalva test, nose and mouth closed 56
Vanucchi's maneuvers 225
Vascular loop compression syndrome 87
Vascular theory 79
Vasculitis, disseminated 102
Ventral pontine syndromes 195
Ventral uvula 13f
Vertebral artery 183f, 186f
dissection 148
stenosis of 84
Vertebrobasilar insufficiency 232
Vertical divergence, dissociated 163
Vertical saccades generation, control of 17f
Vertical vestibulo-ocular pathways 21f
Vertiginous spells, severe 208
Vertigo 33-35, 38, 46, 59, 63, 69, 104, 109, 120, 121, 123, 126-129, 151, 180, 205, 217
acute 40, 75, 217
onset 46, 82, 99, 133, 190
severe spinning 75
attacks of 154
cervical 108, 109, 111
cervicogenic 108, 109, 149
diagnosis of 45
disappearance of 203f
epileptic 152, 153
episodes of 123
fluctuating 101
head motion-induced 125
history of 102
intermittent 103
lateral canal benign paroxysmal positional 69, 224f
medical management of 226
migrainous 130
pediatric 157fc
phobic postural 40, 130
positional 125
recurrent 40, 141, 154
reflex epileptic 153
rotational vertebral artery 109
rotatory 40, 98, 102, 120, 169, 185, 200
somatoform phobic postural 106
spinning 62, 63
spontaneous 39, 125
vascular 215
vestibular 39
visual 142
Vestibular aqueduct syndrome 156
Vestibular deficit, unilateral 145
Vestibular disorders 33
classification of 33
common 46
peripheral 230
specific 230
Vestibular dysfunction 156, 164
unilateral 100
Vestibular evoked myogenic potential 77, 149, 170
Vestibular exercises, specific 81
Vestibular function
interpretation of 136
tests 48, 48f, 123
Vestibular implants 235
Vestibular loss, peripheral 53
Vestibular nerve 5
superior 54f
Vestibular neuritis 39, 46, 75, 78, 81, 155
inferior 55
superior 11, 55
Vestibular nuclear
complex 5
connections 6f
infarct 217
tonicity 229f
Vestibular nuclei 11, 12, 226, 229f
Vestibular ocular reflex 42, 218
Vestibular organ
dysfunction of 82
physiological role of 9
Vestibular paroxysmia 39, 47, 104, 107, 152, 232
diagnostic criteria for 105
Vestibular rehabilitation 234
therapy 234
principles 234
Vestibular schwannoma 210
Vestibular suppressant medications 145
Vestibular symptoms, classification of 34
Vestibular syndrome
acute 215, 216
chronic 145
Vestibular system 1, 2, 38
interaction of 6
Vestibulocochlear nerve 3, 127f, 128f
Vestibulolithiasis 74, 74f
Vestibulo-ocular reflex 5, 8, 20, 50, 65, 76, 127, 161, 166, 169, 194, 210, 234
bilateral reduced 133f
dysfunction, bilateral posterior canal 167f
intact 99
low 134f
Vestibulopathy, types of bilateral 141
Vestibulo-spinal reflexes 42
Vestibulo-visual symptoms 33, 34
Video head impulse test 48, 50, 133, 133f, 134f, 138f, 143, 166, 167f, 169, 172, 193f
Videonystagmography 51, 158, 169
tests 137
Vision, double 205
Visual acuity test, head-shaking 22
Visual attraction 50
Visual aura 124
Visual disorders 145
Visual fixation 76
Visual system 38
Vogt-Koyanagi-Harada syndrome 102
Vomiting 40, 47, 99, 154
W
Wallenberg's syndrome 27, 80, 216
Weber tuning fork test 88
Wegener granulomatosis 102
Wernicke's encephalopathy 27, 41, 55
Whipple's disease, cerebral 29
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Vertigo and Dizziness A Case-based Study
Vertigo and Dizziness A Case-based Study
Author Ambar ChakravartyMD FRCP Honorary Professor and Emeritus Consultant in Neurology Vivekananda Institute of Medical Sciences Kolkata, West Bengal, India Foreword UK Misra
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Vertigo and Dizziness: A Case-based Study Ambar Chakravarty
First Edition: 2020
9789389188332
Printed at
My beloved
Srilekha and Subhadeep
CONTRIBUTORS
Author
Co-Authors
Invited Contributors
FOREWORD
Learning, teaching and sharing knowledge is the most evolved human activity and is regarded as the source of ultimate pleasure. One of the most efficient means of learning and teaching is through storytelling and this had been extensively used in ancient Indian teachings. Case discussion is also a form of storytelling. The importance of case reports, however, has gone down in modern medical journals. Vertigo is a common neurological problem but does not get adequate attention in undergraduate and postgraduate training programs. The patients with vertigo, often shuffle between neurologist, ENT surgeon, neurosurgeon, psychiatrist and physician; as happens with many other disorders with overlapping symptoms.
Professor Ambar Chakravarty is an astute clinician, has wide interests not only in medicine but also in art and philosophy. I am very happy to see his book entitled “Vertigo and Dizziness: A Case-based Study “. Section 1 of this book deals with the anatomical and physiological basis of vertigo, and the relevant investigations. Section 2 has 46 well-illustrated cases presenting the clinical problems, relevant investigations followed by a discussion section in which the answers of some key questions are embedded. Section 3 of the book deals with the pharmacological and non-pharmacological treatment of vertigo. I am sure, this is a very innovative and interesting book addressing the unmet needs of the readers and help them diagnose and treat their patients with vertigo better. I also wish this book would make some neurologists and trainees interested in the field of vertigo, which will improve teaching and research in the area of vestibular disorders, central and peripheral.
UK Misra MD DM FRCP FNA FNASc FAMS
Professor
Department of Neurology
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India
PREFACE
This book is primarily meant for practicing neurologists and neurology trainees. Vertigo and dizziness are extremely common symptoms. More than 10% of all patients attending neurological outpatients department of any major teaching hospital in the country, present with vertigo and dizziness. Approximately half of these subjects have vestibular disorders, about a quarter are of psychogenic in origin and the rest is constituted by neurological and mixed disorders. Truly speaking, the assessment and management of most of these patients are often far from adequate and appropriate. The fault in reality lies in our training program wherein very little attention is given to the aforementioned two issues. There are probably a child's handful of neurologists in the country who take active interest in the management of such patients. The referral perspectives of physicians at large is also perhaps far from ideal. The fact that the principal end organ responsible for disordered balance and the genesis of vertiginous symptoms lies in the inner ear, make both general physicians and lay public think that patients with vertigo and dizziness should ideally be seen by ENT specialists at least initially. This view is shared by many neurologists as well-resulting in many such patients attending a neurological OPD being referred to the ENT specialists. This may be viewed as a point of debate. Physiologically speaking, vertigo results from either a sensory mismatch between various balance concerned afferents (including those coming from the labyrinth) or from a CNS misinterpretation of the information gathered. Both of these occur in the brain. The first in the vestibular nuclear level situated in the brainstem and the second at various levels of the CNS right up to the cortex. So, the problem is essentially a neurological one. Most cases of vertigo, if proper diagnosis can be made, can be treated medically and through physical means. A small minority needs surgical interventions. Hence it is essential for neurologists to be well conversant with these disorders, their diagnosis and management. Testing vestibular functions have been revolutionized in recent times and some ENT specialists have acquired special skills to perform and interpret these. Neurologists need to be acquainted with the principles of such tests, which nowadays are generally computer based. However, for correct diagnosis and management of patients with vertigo, the test results need to be properly correlated with clinical history and physical findings. It is only neurologists who are properly trained to acquire that skill. The sole purpose of this book is to get more and more neurologists interested in the discipline of neuro-otology for proper management of patients with vertigo and balance disorders.
The book is divided into three sections. Section 1 deals with The Basics which include anatomical and physiological basis of maintenance of human balance, vestibular and cerebellar control of eye movements, classification of vestibular disorders, elicitation of proper history in patients presenting with vertigo and finally a step-wise physical examination and lastly a commentary on currently practiced vestibular function tests.
Section 2 is the Case Study section. Forty-six cases are discussed in a very interactive way with the case history and findings detailed first followed by the investigations performed and the results of therapy, when applicable. This clinical note is followed by a series of questions which are likely to crop up in the minds of the readers after going through the case. The final section is the discussion, embedded in which would lie the answers to all the questions raised, along with other relevant and up to date information on the subject discussed.
This section includes around 10 cases of posterior circulation strokes presenting with vertigo which have been discussed in way of clinico-anatomical and clinico-radiological correlation – an essential part of training to be a neurologist. No very detailed referencing had been done considering the time constraint for busy medical practitioners and trainees, and only few major ones are listed at the end of each case/chapter for those interested in more detailed discourses. In relation to the cases, many of the vestibular function tests performed on them, are discussed in a lucid manner to make correlation of clinical history and function tests easily understandable.
Section 3 mostly discusses Management Issues. Apart from the medical management of vertiginous disorders (including some detailing of drug pharmacology), detailed descriptions of canalith repositioning techniques for BPPV are provided. This section also includes a commentary on Vertigo in Posterior Circulation Strokes which would be of great interest to neurologists and trainees.
I am grateful to my co-authors (my colleagues in the Department), Drs Angshuman Mukherjee, Debasish Roy, Barun Kumar Sen and Kausik Pan for filling in the gaps in my writing and for critically reviewing the manuscript, especially the Case Studies section. I also thank the Invited Contributors, Drs Sandip Chatterjee and Jayanta Roy for providing me with three cases each for discussion and to Dr Srinivas DR (Neuro-otologist, Bengaluru) for contributing the commentary on Vestibular Function Tests. Thanks also to Dr Anirban Biswas for performing most of the audiovestibular functions tests for the patients included in the Case Study section, in his laboratory in Kolkata.
I must express my deep gratitude to ALTIMA Division of Intas Pharmaceuticals and in particular to Mr Somikant Bhardwaj, Senior Vice President, for providing an educational grant needed for publication of the book and taking the responsibility of its distribution to neurologists and trainees across the country.
I am deeply indebted to Professor UK Misra for kindly agreeing to write the Foreword of the book highlighting the need for publication of such a volume.
Lastly I, would express my deep appreciation to my publishers Jaypee Brothers Medical Publishers (P) Ltd. for taking all the trouble for printing and publishing the book in time.
Ambar Chakravarty