Complex Surgical Cases of the Limbic System Sepehr Sani, Mustafa K Baskaya, Richard W Byrne
INDEX
Page numbers followed by f refer to figure.
A
Adult limbic system 1
Adult remnant of the hippocampus 2f
Alveus 2
Ambient cistern 18
Ammon's horn 1
Anaplastic astrocytoma 136
Anaplastic mixed oligoastrocytoma 136
Anterior choroidal artery 32, 47, 141
Anterior temporal lobectomy 35
Anterior temporal lobectomy with amygdalohip- pocampectomy 35
neocortical resection 35
positioning and equipment 35
resection of the hippocampus 45
resection of uncus and amygdala 38
Approaches to the mesial temporal lobe for epilepsy 26
surgical anatomy 26
Arachnoid villi 63
Arteriovenous fistulas (AVFs) 140
Arteriovenous malformations (AVMs) 71, 140
B
Bardeen chest 91
Basal ganglia 8
Basal vein of Rosenthal 34, 142
Brain mapping during surgery 107
epilepsy specific techniques in eloquent cortex 115
multiple subpial transections 115
responsive neurostimulation system 116
indications 107
integrating with functional imaging 108
preoperative preparation 108
anesthetic considerations 109
craniotomy considerations 110
equipment 109
preparations and positioning 110
stimulation mapping 110
stimulation pitfalls 114
subcortical stimulation mapping 114
surgical endpoints 114
Broca's area 107
C
Calcarine sulcus 88
Callosal sulcus 2f
Callosomarginal artery 100
Capillary telangiectasias 140
Central nervous system (CNS) 140
Choroidal fissure 31
Choroid plexus 18
Cingulate gliomas 136
Cingulate gyrus 2, 90, 99
surgical approaches 99
Cingulate gyrus tumors 130
anatomical classification and growth patterns 134
clinical features 134
histopathological characteristics 135
overview of anatomy 130
surgery 136
surgical approaches 136
surgical outcomes 136
Collateral sulci 57
Corpus callosum 2
Corticofugal fibers 88
Crura of fornix 4
Crus of the fornix 16
D
Deep venous drainage 143
Diagonal band of Broca 5
Diencephalon 1
E
Entorhinal cortex 48
F
Falx-occipital fissure 88
Fasciolar gyrus 33
Fimbria 1
Fimbriodentate fissure 4
Foramen of Monro 16, 33
Fornix 1
Frontoparietal lobes 6
Frontotemporal curvilinear incision 35
Fusiform gyrus 36
G
Giant limbic tumors 129
Grade I ganglioglioma 126
Grade II astrocytoma 126
Grade IV glioblastoma 126
Gyrus of Ebertaller 22
H
Habenula 8
Hemianopia 130
Heschl's gyrus 9, 72
Hippocampal fissure 1
Hippocampal tail 2
Hippocampus and the choroidal fissure 33
I
Indusium griseum 2, 33
Infralimbic gyrus 13
Insula 21
Internal carotid artery (ICA) 54
Internal cerebral veins 152
Intralimbic gyrus 30
L
Labbe and Sylvian veins 48
Lamina terminalis 142
Left anterosuperior insular low-grade glioma 75
history 75
surgery 76
Left frontal-cingulate grade II mixed olio-astrocytoma 100
history 100
surgery 100
Left insular-subfrontal low-grade glioma; combined transsylvian/subfrontal- transcortical approach 78
history 78
surgery 78
Left posterior insula cavernoma 82
history 82
surgery 84
Left uncus cavernous malformation 53
history 53
surgery 53
Lenticulostriate arteries 71
Level of limen insula 73
Limbic cavernous malformations 154
anatomic distribution 154
clinical features 154
surgery 155
surgical approaches and techniques 155
surgical outcomes 156
Limbic embryologic development 1
Limbic lobe 140
Limbic system 1
structure and development 1
amygdala 5
fornix and mammillary body 3
hippocampus 1
insula 5
parahippocampal gyrus 3
septal area 5
Limen insulae 13
Lingual gyrus 88
Low-grade glioma 32
M
Magnetoencephalography (MEG) 108
Malignant gliomas 136
Mammillary body 8
Mediobasal temporal tumors 123
clinical features 124
growth patterns and anatomical classifications 125
histopathological characteristics 126
overview of microsurgical anatomy 123
surgery 126
surgical approaches 126
surgical outcomes 129
Mesial pia 38
Mesial pia of the temporal horn 18
Metzenbaum scissors 93
Meyer's loop 33, 88, 146
Middle cerebral artery 54, 141
Mixed oligoastrocytoma 136
Motor evoked potential 100
N
Nasal cannula 110
Neocortical limbic structures 8
Neurolon sutures 93
O
Occipital interhemispheric approach 87
anatomy 87
contraindications 89
details of surgical approach 91
history 87
indications 89
risks and pitfalls 95
Occipitoparietal sulci 148
Occipitotectal fibers 17
Occipitotemporal gyrus 3
Ojemann cortical stimulator 111
Olfactory stria 5
Opaque arachnoid bands 152
P
Parahippocampal gyrus 31
Parietal-occipital sulcus 88
Pericallosal artery 100
Planum polare 9
Planum temporale 9
Postcentral gyrus 75
Posterior cerebral artery 141
Posterior communication (PCOA) artery 47
Posterior interhemispheric parafalx 148
Posterior pole of incisura 127
Q
Quadrantanopia 130
Quadrigeminal cistern 65, 95, 152
Quadrigeminal segment 142
R
Responsive neurostimulation system (RNS) 116
Right-sided amygdala and hippocampus low grade glioma 48
history 48
surgery 51
Ringer's solution 109
Root of the zygoma 35
S
Schramm's series 126
Selective amygdalohip- pocampectomy 45
Sensorimotor stimulation 111
Septal nuclei 5, 8
Somatosensory cortex 111
Somatosensory evoked potential 100
Spetzler-Martin (SM) grading system 145
Splenium of the corpus callosum 88
Spontaneous hemorrhage 151
Stein's anatomical classification 148
Subcortical stimulation mapping (SSM) 114
Superior insular sulcus 21
Superior temporal gyrus 36
Supracerebellar transtentorial approach 57
anatomy 57
gross anatomy 57
vascular anatomy 58
contraindications 60
description of the approach 60
closure 69
dural opening and dissection 63
incision and craniotomy 61
preoperative evaluation and positioning 60
history 57
indications 58
risks and pitfalls 69
Supramarginal gyrus 73
Surgery for giant and unusual tumors 120
Surgery for vascular malformations of the limbic system 140
anatomical classifications 144
arteriovenous malformations 143
cavernous malformations 153
clinical features 145
surgical approaches 145
calloso-cingulate arteriovenous malformations 148
mediobasal temporal arteriovenous malformations 145
parasplenial arteriovenous malformations 148
surgical considerations 149
surgical outcomes 153
vascular anatomy of the limbic system 140
calloso-cingular area 142
mediobasal temporal region 141
Surgical anatomy of the insula 71
insular anatomy 72
operative approach 74
Sylvian fissure 21, 111
Sylvian fissure and opercular anatomy 24
T
Telencephalon 1
Temporal lobe 6, 9, 73
anatomy 9
amygdala 13
hippocampus 15
mesial surface 11
superior surface 9
temporal horn and choroidal fissure 17
uncus 11
histology 9
vascular relationships 18
anterior choroidal artery 19
internal carotid artery 18
middle cerebral artery 20
posterior cerebral artery 19
posterior communicating artery 18
Temporal stem 73
Tentorial incisura 58
Transcranial magnetic stimulation (TMS) 108
Transsylvian approach to amygdalohippocam- pectomy 47
Tumor resection in the anterior temporal lobe 47
U
Uncal gyrus 38
Uncal recess 47
Uncinate fasciculus 48
Uncohippocampal artery 142
Uncus and amygdala 32
V
Vagus nerve stimulation (VNS) 116
Vascular clips 63
Vein of Galen 58
Vein of Labbé 36, 65
Velum terminale 30
Venous anatomy 65
Vertex of the gyrus 116
Visual field defects (VFD) 153
W
Wernicke's area 107
Y
Yasargil's series 126
×
Chapter Notes

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FM1Complex Surgical Cases of the LIMBIC SYSTEMFM2
FM3Complex Surgical Cases of the LIMBIC SYSTEM
Editors Sepehr Sani MD Assistant Professor Department of Neurosurgery Rush University Medical Center Chicago, Illinois, USA Mustafa K Baskaya MD Professor Department of Neurological Surgery University of Wisconsin-Madison School of Medicine Madison, Wisconsin, USA Richard W Byrne MD Chairman Department of Neurosurgery Rush University Medical Center Chicago, Illinois, USA Foreword Nicolas Kluger MD PhD
FM4
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Complex Surgical Cases of the Limbic System
First Edition: 2017
9789386261441
FM5Dedicated to
We would like to dedicate this book to our patients and their families.
FM7Contributors FM9Foreword
The past decade has witnessed an unprecedented interest in limbic system diseases and their treatments, as functional imaging and neuromodulation of limbic circuitry have gained sway diagnostically and therapeutically, and improvements in operative technique have made approaches to this region increasingly more feasible. Epilepsy, tumor, vascular, and stereotactic neurosurgeons need to understand thoroughly the complex regional anatomy and relationships of the limbic system with the brainstem, diencephalon, and associated vasculature, in order to navigate safely in this region. Unfortunately, and owing to the inherent complexity of this region, it is difficult to find a single compendium of practical surgical knowledge about the limbic system.
Drs Sani, Baskaya, and Byrne have admirably filled this currently unmet need by delivering a comprehensive and beautifully illustrated text that supplies the reader with practical, surgically based, step-by-step descriptions of complex cases in the limbic and paralimbic systems—including temporal, insular and cingulate regions. They begin this journey with a careful review of the embryological development and anatomy of the limbic system, and then methodically tackle the relevant surgical approaches and indications. Using a combination of cadaveric specimens, imaging, and intraoperative photos, to illustrate their clinical experience, the authors provide an unparalleled guide for the field. The information provided in Surgery of the Limbic System serves as a crucial pre-operative guide to surgeons seeking more in-depth information about these regions, whether for epilepsy, tumor, vascular, or stereotactic neurosurgery.
Aviva Abosch MD PhD
Vice Chair for Research
Department of Neurosurgery
Professor of Neurosurgery and Neurology
Director
Department of Stereotactic and Epilepsy Surgery
University of Colorado School of Medicine
Aurora, Colorado, USA
Past-President
American Society for Stereotactic and Functional Neurosurgery
FM11Preface
The limbic and paralimbic areas of the human brain hold profound fascination for both neuroscientists and neurosurgeons. The essential functions of the connections necessitate maintaining functions of the limbic and paralimbic structures, an important goal of surgery in this region. These critically important neuropsychological functional connections are often compromised by the pathology of the mesial temporal lobe, thus making surgery in this region safe, as the deficit created by the pathology is typically not worsened by surgery. The fact that much of the regional pathology is benign, but the conditions they cause, such as epilepsy are not, makes operating in this area a common challenge for neurosurgeons. The unique, obscure, and buried anatomy, the critical surrounding neurovascular structures of limbic and paralimbic archi- and paleo-cortex and the varied, complex pathology makes surgery of this region challenging in the best of circumstances for the most experienced surgeons. For these many reasons, we have dedicated a large portion of our practices, career and research to the mastery of surgery in this region.
The goal in producing this textbook is to pass on to practitioners—neurosurgeons, neurologists, neuroradiologists and neuroscientists—a comprehensive text to act as a compass when confronting limbic and paralimbic pathology. Because limbic pathology is not on the surface, the textbook describes the complex regional anatomy in a practical way for surgeons who must rely on local landmarks more than image guidance. The essential anatomical fiducials available in the limbic lobe are described in great detail, as they are the key to safe surgery in this region. In addition, because the limbic lobe is not visible on the surface of the brain, the issue of choosing the safest surgical approach is paramount. Much attention to surgical approach is included in this text. Finally, the diversity of pathology that is found in this region is addressed. From mesial temporal sclerosis, to glioma, to vascular lesions, all common pathologies are covered.
Richard W Byrne MD
FM13Acknowledgments
The production of this book owes significant gratitude to the many who have shaped out interest and knowledge in the field of neurosurgery. We would like to thank Dr Andre Olivier who sparked the interest in limbic neurosurgery. Drs Walter Whisler and the late Roy AE Bakay who provided tremendous mentorship and serves as role models for excellence. The physical production of this work would not have been possible without the dedicated efforts of Anthony Serici at Rush University's department of Anatomy and Cell Biology.
Lastly, we would like to thank Mr Jitendar P Vij (Group Chairman), Mr Ankit Vij (Group President), Ms Chetna Malhotra Vohra (Associate Director—Content Strategy), Nikita Chauhan (Development Editor) and the entire team of Jaypee Brothers Medical Publishers, New Delhi, India for their tireless efforts in producing the book in its final form.
FM17Introduction
The limbic and paralimbic areas of the human brain hold profound fascination for both neuroscientists and neurosurgeons. Maintaining the essential neuropsychological functions of the limbic and paralimbic structures is an important goal of surgery in this region. These critically important neuropsychological functional connections are often compromised by the pathology of the mesial temporal lobe, thus making surgery in this region safe, as the deficit created by the pathology is typically not worsened by surgery. The fact that much of the regional pathology is benign, but the conditions they cause, such as epilepsy are not, makes operating in this area a common challenge for neurosurgeons. The unique, obscure, and buried anatomy, the critical surrounding neurovascular structures of limbic and paralimbic archi- and paleo-cortex and the varied, complex pathology makes surgery of this region challenging in the best of circumstances for the most experienced surgeons. For these many reasons, we have dedicated a large portion of our practices, career and research to the mastery of surgery in this region.
The goal in producing this textbook is to pass on to practitioners-neurosurgeons, neurologists, neuroradiologists and neuroscientists a comprehensive text to act as a compass when confronting limbic and paralimbic pathology. Because limbic pathology is not on the surface, the textbook describes the complex regional anatomy in a practical way for surgeons who must rely on local landmarks more than image guidance. The essential anatomical fiducials available in the limbic lobe are described in great detail, as they are the key to safe surgery in this region. In addition, because the limbic lobe is not visible on the surface of the brain, the issue of choosing the safest surgical approach is paramount. Much attention to surgical approach is included in this text. Finally, the diversity of pathology that is found in this region is addressed. From mesial temporal sclerosis, to glioma, to vascular lesions, all common pathologies are covered.