Essentials of Clinical Pathology Shirish M Kawthalkar
INDEX
Page numbers followed by b refer to box, f refer to figure, and t refer to table.
A
Abetalipoproteinemia 158
ABO antisera 394, 394b
ABO grouping 176, 386t, 394, 396, 398, 399, 399t
methods of 396
ABO incompatibility 417
ABO mismatched blood 425
ABO system 385
antibodies of 389
antigens of 387, 388f
ABO tube test, grading of 395f
Abortion 170
Abscess 194
intra-abdominal 196
Absolute reticulocyte count 240
Acanthocytes 250
Acetest tablet test 29
Achlorhydria 148
Acid
base balance, kidney regulation of 43f
citrate dextrose 213, 214
elution test 310f, 433
fast bacilli 124f
load test 54
phosphatase 192, 203
urine 40
Acidified glycerol lysis time 433
Acidified serum test 433
Acidity, total 148
Acquired venous thrombotic disorders 362t
Acridine orange flow cytometry 187
Actinomyces 122
Activated partial thromboplastin time 354, 354f, 355, 356, 433
features of 355t
Acute blood loss 293
anemia 313
Acute coronary syndrome 92, 93
characteristics of 92t
Acute diarrhea
causes of 127f
evaluation of 128f
Acute disseminated intravascular coagulation 349f
Acute kidney injury 55
biomarkers of 53, 53t
Acute leukemias 325, 329f, 382t
classification of 325
laboratory diagnosis of 326
Acute myeloid leukemia 325, 327t, 329t, 378
classification of 326t
Acute phase reactants 264, 264t
Addison's disease 59
Adenoma 166
Adenosine
deaminase 106, 112
diphosphate 340
Adenovirus 143
Adrenaline 356
Adrenocorticotropic hormone 7
Adult Still's disease 197
Aedes aegypti 289
Aeromonas 137
Afibrinogenemia 350
Agarose gel electrophoresis 89f
Agenesis 163
Agglutination inhibition test 170f
Air-liquid interface 174
Alanine aminotransferase 76
Albumin 213
cobalt binding 97
creatinine ratio 25, 25t
gradient 114
measurement of 108
Albuminocytologic dissociation 105
Albuminuria 52
evaluation of 52f
grading of 25t
Alcohol abuse 89
Alcoholism 7, 80, 240
Alkali denaturation test 433
Alkaline
phosphatase 76, 380
picrate reaction 51
urine 41
Allergic diseases 255
Allergic purpura 344
Allergic reactions 425, 427
Alloantibodies 413
Allogeneic blood donation 406t
Alpha angle 361
Alpha thalassemia, genotypes in 303f
Altitude 7
Alzheimer disease 171
Amebic dysentery 132t
Amino acids 44
Aminoaciduria 44
generalized 53
Aminotransferases, causes of raised 82t
Ammonium
chloride loading test 54
magnesium phosphate 41
urate crystals 42
Amniotic fluid 175, 435
bilirubin 175
measurement of 175
fixed volume of 174
Amoebae 106
Amoeboma 130
Amorphous phosphates 19
Amorphous urates 19, 41
Amphotericin B 100
Amplification 342
Amylase 115, 157, 158
Amyloid 84
Amyloidosis 268
Analgesics 255
Anaphylactic reaction 427
Anaphylactoid purpura 344
Ancylostoma duodenale 134
Anemia 196, 238, 240, 277, 293, 298, 299t, 314
aplastic 238, 240, 251, 300, 300f
cause of 314, 314t
classical 301, 301t
classification of 240, 293
clinical features of 314t
detection of 216
determine severity of 312
diagnosis of 238b, 313, 314f
dilutional 175
etiological classification of 293t
hemolytic 240, 251f, 252, 272, 315
hypochromic 268
immune hemolytic 308, 317
macrocytic 252, 268, 315
megaloblastic 238, 251f, 260, 295, 297f, 298
macrocytic 298
microcytic 252
hypochromic 260, 296f, 315, 316f
moderate degree of 303
morphological classification of 259
nonmegaloblastic macrocytic 298
normocytic normochromic 315
nutritional 240, 251
pathogenesis of 277f
pernicious 145
severity of 227, 301, 313
sideroblastic 252f, 299, 299f
Anaerobic empyema 110
Angina
pectoris 93
unstable 93
Angiotensin-converting enzyme 43
Animal inoculation studies 288
Anionic dye 247
Antecubital fossa, venepuncture in 211f
Anthropological studies 399
Antiacetylcholine receptor antibodies 433
Antibasement membrane antibodies 433
Antibody
dependent enhancement 290
detection of 291f, 413
identification 414, 414b
panel, interpretation of 414
immune 413
screening 413, 414, 414b, 414f
Anticardiolipin antibodies 433
Anticentromere antibodies 433
Anticoagulant 117, 212, 246
preservative solution 403
use of incorrect 214
Anticyclic citrullinated peptide antibody 433
Anti-D reagents 398, 398t
Antidesmoglein antibodies 433
Antiendomysial antibodies 433, 434
Antifibrinolytic therapy 360
Antigen
coexpression of 377
detection of 133
expression 206
reaction 411
retrieval 380
Antigliadin antibodies 433
Antiglobulin 317
crossmatch 418
test 321
applications of 323
Antiglomerular basement membrane antibodies 433
Antiglutamic acid decarboxylase 433
Antihemidesmosome antibodies 433
Antihistone antibodies 433
Anti-insulin antibodies 433
Anti-islet cell antibodies 433
Anti-Leishmania antibodies 288
tests for detection of 287
Antileukocyte antibodies, detection of 379
Antimicrosomal antibodies 433
Antimitochondrial antibodies 433
Antimyeloperoxidase antibodies 433
Antineutrophil cytoplasmic antibody 196, 433
Antinuclear antibody 433
test 195
Antiparietal cell antibodies 433
Antiphospholipid antibody 177, 367
syndrome 365, 367
Antiphospholipid syndrome 177
diagnosis of 177, 365b
Antiplatelet agents 360
Antiplatelet antibodies 379, 433
Antiplatelet drugs 345
Antiproteinase antibodies 433
Antiribonucleic acid polymerase antibodies 433
Antiribonucleoprotein antibodies 433, 434
Anti-signal recognition protein 433
Anti-Smith antibodies 433
Antismooth muscle antibodies 433
Anti-sperm antibodies 190
Antithrombin 367
Antithyroglobulin antibodies 166, 433
Antithyroid antibodies 166
Antithyroid drugs 255
Antithyroid peroxidase 166
antibodies 166, 433
Antithyroid-stimulating hormone receptor antibodies 434
Antitopoisomerase antibodies 434
Antitransglutaminase 434
Antral follicle count 184
Antral G cell, hyperplasia of 145, 148
Anuria 18
Apheresis 420
B 421
platelets 423
Aplastic anemia 238, 240, 251, 300, 300f
causes of 300t
severity of 300
Aplastic crisis 251, 272
Apo A-I lipoprotein system 88
Apo B-100 lipoprotein system 88
Apolipoprotein 86f, 88
A 88
B-100 88
C-II 88
E 88
Apt test 141, 434
Arterial blood
collection 214
gas 214
analysis 368
Arteritis, temporal 194, 196
Arthralgia 195
Arthritis
crystal-induced 119
tuberculous 119
Arthrocentesis 118
Artificial insemination 185
Ascaris lumbricoides 133, 134f
fertilized eggs of 134f
Ascheim-Zondek test 170
Ascites
causes of 113, 113t
classification of 114f
Ascitic fluid 114b, 115t
examination of 114
Aseptic meningitis 106
Asexual cycle 275
Asherman's syndrome 182
Aspartate aminotransferase 76, 213
Aspergillus niger infection 110
Aspermia 187
Assisted reproductive technologies 185
Asthenozoospermia 187
Atrial myxoma 194, 197
Auer rods 434
Auramine rhodamine 123
Autoagglutination 250f, 251, 308f, 396, 434
Autoantibody 413, 418
Autocontrol test 396
Autocontrol tube 395
Autohemolysis test 321, 322f, 434
Autoimmune destruction, cell mediated 59
Autoimmune diseases 193, 195
Autoimmune disorders 81, 116, 194, 362
Autoimmune hemolytic anemia 293, 308, 308f
diagnosis of 309f
Autoimmune lymphoproliferative syndrome, diagnosis of 379
Autoimmune thyroid disease 177
Autoimmunity 59
Autologous donation 400, 406, 406t
advantages of 406
disadvantages of 406
Automated complete blood cell count 216
Automated digital cell morphology instrument 242
Automated hematology analysers 257f
clinical usefulness of 216
Automated platelet count 242
method 244
Automated platelet parameters 223
Automated red cell
indices 260t
parameters 223
Automated reticulocyte parameters 223
Autosomal dominant disorders 350
Autosomal recessive diseases 350
Azoospermia 187
evaluation of 180f
Azotemia, prekidney 51, 53t
Azure B-eosin complexes 247
Azurophil 247
granules 327
B
B cell
function, genetic defects of 60
immature 207
neoplasms, mature 334, 336t, 378
progenitor 207
Bacillary dysentery 132t
Bacillus cereus 128, 138, 426
Backpacker's diarrhea 128
BACTEC-TB460 125
Bacteria 37, 411, 434
Bacterial culture
collection for 17
samples for 122f
Bacterial infections 137, 254, 288
Bacteriological culture 122, 429
Bacteriuria 33
asymptomatic 37t
Barr body 434
Bartonella henselae 196
Bartter syndrome 44
Basal acid output 147
determination of 148b
Basal body temperature 182
Basedow-Graves’ disease 162
Basket cells 434
Basophilia 195, 255
Basophilic leukemia 148
Basophils 206, 252
Behcet's disease 195
Bence Jones proteins 25, 434
Benedict's test 26, 27, 27t, 434
grading of 27f
Bentiromide test 157, 434
Benzidine 140
test 32, 434
Berger's disease 31
Bernard-Soulier syndrome 345, 357f
Beta human chorionic gonadotropin, measurement of 168b
Beta thalassemia 302, 303f
clinical features of 303t
hematological features of 303t
homozygous 302
intermedia 302
major 302f, 320f
minor 320f
mutations, population distribution of 302t
trait 278
Bicarbonate secretion 157
Bile acids, formation of 72f
Bile pigment 29
Bile salts 30
deficiencies of 141, 152
formation of 72f
Biliary cirrhosis, primary 75, 80
Biliary tract disease 158
Bilirubin 29, 98, 115
albumin complex 71
crystals 42
in urine, tests for detection of 29
metabolism, normal 71, 72f
unconjugated 75, 76
Bilirubinuria 30b
Bimodal histogram 222
Biochemical cardiac marker 92
studies 94
Biochemical tests 337
Biological hazards 14
Biopsy 271
endometrial 182
laparoscopic 56
open 56
pleural 112
surgical 56
transvenous 56
Bite cell 250, 434
Biuret method 77
Biuret test 434
Blast cells 253
Bleeding disorders 340, 344, 344t, 349f, 350t
diagnosis of 349
evaluation of 356f
inherited 346t
Bleeding time 351, 434
selective prolongation of 355
Blind liver biopsy, percutaneous 83
Blister cell 250, 434
Blood 246
ammonia 78
bag 403, 404
types of 403b
bank 400
biochemistry 50
borne pathogens 14b
cells 202
count 236b
examination of 248f
morphology 212f
production 267
clots, prevention of 402
collection 210, 213, 214, 218, 353b, 403
errors in 236
tubes 213
component 420, 421, 421f, 422t
preparation of 421f
culture 214
derivatives 420
dilution of 236, 243
donation 400, 406
donor
counseling 411
notification 411
paid 400
permanent deferral of 401b
processing of 405
professional 400
replacement 400
selection of 401
types of 400
voluntary 400
emergency issue of 418
gas 6
glucose
estimation of 64
fasting 64
postprandial 64
random 64
self-monitoring of 67
specimens 64
group 386t, 394
A 386
A2 397
AB 387
B 387
incompatibility 428
microplate method for 396f
O 386
substances, determination of 192
systems 385, 385t, 393t
test tube method of 396
uses of 399
in urine, tests for detection of 32
loss
acute 293
chronic 134
products 420
issue of 419
sample, collection of 214
advantages of 282
examination of 248
fixation of 246
in anemias, role of 252b
in leukemias, role of 254b
in thrombocytopenia, role of 257b
normal 257
platelet counting from 242
preparation of 245, 245f
staining of 246
thick 284
types of 246
uses 245
specimen, types of 4
transfusion 399, 402
practice 408t
type 385
urea nitrogen 50
vessel
disorders of 344
wall 340
Blue diaper syndrome 19
Blue-colored ferric ferrocyanide 273
B-lymphocyte 207t
Body systems, changes in 8
Boiling test 23
Bombay blood group 388, 389
inheritance of 389f
Bombay phenotype 388b
Bone
diseases of 80
disorder of 269
Bone marrow 201, 272, 326, 339
aspiration 269, 272t, 271
indications for 268
sites of 269f
smear 271, 272, 273f
biopsy 269, 272t, 274b, 300
indications for 269
sample 270
sections 273
cellularity of 274f
examination 196, 267, 317
indications for 268
infiltration 240
iron stain 294
morphological examination of 295
normal 267b
sampling 268
smear 270, 337f
stem cells in 207
stromal cells of 267
transplantation 238
trephine biopsy 270, 271, 273
volume 267
Bordetella pertussis infection 256
Bovine 402
Bradycardia 194
Brain
herniation of 101
involvement of 136
lymphoma, primary 197
natriuretic peptide 113
Breakbone fever 289
Breath
CO2 tests 154
hydrogen test 154
tests 157
Broad casts 38
Broad-spectrum antibiotics 128
Bromsulfthalein excretion test 81
Bronchoalveolar lavage fluid 125f, 126
Brown-black granular pigment 276
Brucellosis 234, 408
Brugia
malayi 283, 284, 285
timori 283
Buccal smear test 434
Buffy coat
method 434
smear from 232f
Bulb pipettes 235
Burkitt lymphoma 291
Burr cell 250, 434
Butterfat test 153
C
Cabot's ring 249f, 251, 434
Calcium 342
carbonate crystals 41
oxalate crystals 41
phosphate 120
pyrophosphate dihydrate 119, 120
Camelback fever 194
Campylobacter
blood agar 137
jejuni 138
Capillary blood 218
collection tubes 210
Capillary fragility test 289, 434
Capillary hematocrit tubes 232
Capillary tube 233
method 285
Carbohydrate 28, 157
absorption 150f
digestion of 150, 150f
Carcinogenic chemicals 14
Cardia 144
Cardiac defects 60
Cardiac disease 116
Cardiac failure, congestive 97
Cardiac injury markers 97
Cardiac marker 95t, 97
kinetics of 95f
Cardiac muscle cell 95f
Cardiac reperfusion 93
Cardiac troponins 96
Cardioesophageal junction 147
Cardiovascular system, biomarkers of 97
Casts 38
bacterial 39
genesis of 38f
Cat-scratch disease 196
C-D-xylose breath test 434
Celiac disease 152
Cell 35, 104f
abnormal 272
components staining orange 247
counts 103, 112, 115
debris, removal of 375
grouping 394, 295f, 397
interpretation of 395t
malignant 126f
mushroom-shaped 436
populations, characterization of 377
surface antigens 327
Cellophane tape technique 137
Cellular casts 39
Cellular components 422
Cellular elements 34
Central nervous system
disorders of 96
neoplasms of 100
Cephalhematomas 350
Cerebral irradiation 182
Cerebrospinal fluid 98, 103, 105t, 108t
chemical examination of 103
circulation of 98
collection of 98
composition of 98
direct wet mount of 106
examination of 98
functions of 98
Gram's stained smears of 107f
gross appearance of 101
Cerebrovascular accident 96
Cervical mucosa, ferning of 183f
Cervical mucus
penetration test 191
study 183
Chemical
analysis 119
examination 21, 111, 114, 128, 140
hazards 14
method 227
preservatives 18
tests 32, 32f, 33
Chest
pain, sudden onset of 95
radiograph 196
Chikungunya
fever 234
viruses 289
Child-Turcotte-Pugh grading system 83t
Chlorhexidine 99, 211
Chloride 98
Chloroacetate esterase 435
Cholecystokinin 156
test 434
Cholestasis 80, 81
intra-abdominal 74
sites of 75f
Cholesterol 7, 86
crystals 42, 120
esters 151
total 89
Christmas disease 347
Chromatin 247
Chromopertubation 184
Chromosomal abnormalities 177
Chromosomal analysis 179
Chronic diarrhea
causes of 127t
classification of 127t
evaluation of 127, 142f
Chronic kidney disease 50
increased risk of 45, 45b
staging of 47t
Chronic lymphocytic leukemia 334, 334f, 336
diagnosis of 334t
Churg-Strauss syndrome 433
Chylomicron 86, 87f, 88
Chylomicronemia, familial 89
Chylothorax 110, 113
Chylous fluid 114
Chymotrypsin, pancreatic 157
Cirrhosis
alcoholic 197
assess severity of 83t
Cisterna magna 100
Citrate
excess, causes of 353
toxicity 425
Citrate tube 213
Citrated platelet poor plasma 354
Clean-catch specimen 17
Clinitest tablet method 27
Clomiphene citrate challenge test 184, 434
Clonidine suppression test 434
Clopidrogrel 402
Clostridium
botulinum 128
difficile 127, 128
colitis 197
perfringens infection 288
Clot
formation time 102, 361
retraction time 434
Coagulation 350t
acquired inhibitors of 349
disorders of 31, 344
factors 341t
hereditary disorders of 354
inherited disorders of 346
inhibitors of 343
proteins 359
system 341
tests 353, 367
Coccidia 132
Codocytes 250
Cold
agglutinins 223
alloantibodies 397
antibodies 413
reactive antibodies 417
Colloid droplets, endocytosis of 160
Colon cancer, fecal genetic testing for 143
Colonic adenocarcinoma 194
Column agglutination technology 396, 413
Comet assay 187
Commercial automated culture systems 125
Commercial test kits 282
Compatibility test 416
completion of 419
steps in 416
Complete blood count 218, 350
interpretation of 225
Compression venous duplex ultrasound 368
Computed tomographic pulmonary angiography 368
Computer-assisted semen analysis 191
Concentration techniques 135, 284
Congo red
stain 274
test 149
Conjugated bilirubin 75, 76
Contamination, bacterial 425, 426
Continuous glucose monitoring systems 67
Contraceptive pill 165
Convulsions 404
Cooley's anemia 302
Coombs’ test 321, 323
direct 434
indirect 434
principle of 323f
Copper reduction tablet test 27
Coproporphyria, hereditary 370
Cord blood 215
Coronary artery disease 68, 89
risk factors for 93b
Coronary syndrome, acute 92, 93
Corrosive 14
Cortisol 7, 59
binding globulin 175
Coulter principle 216
Cowper bulbourethral glands 178, 186
C-peptide 58f
Cranial computerized tomography 101
Cranial meninges 98f
Craniopharyngioma 182
C-reactive protein 264, 434
high-sensitivity 97, 435
uses of 264
Creatine kinase 96
Creatinine clearance 7, 48, 49
estimation of 48
Cretinism 167
Creutzfeldt-Jakob disease 408
Crigler-Najjar syndrome 74, 75
Crow-Fukase syndrome 336
Cryoglobulins 223
Cryoprecipitate 421, 423, 424
Cryptococcal antigens 107
Cryptococcal meningitis 106, 197
Cryptococcus neoformans 106, 106f, 291
Cryptosporidium parvum 132, 133
Crystals 39, 40f, 119
abnormal 42
Curschmann spirals 434
Cushing's syndrome 60
Cutaneous porphyria 373t
evaluation of 372f
Cyanmethemoglobin method 229
Cyclic neutropenia 255
Cyclospora cayetanensis 132, 133
Cystatin C clearance 48
Cysteine crystals 42
Cystic fibrosis 152
Cysticercosis 136
diagnosis of 136
Cysticercus
cellulosae 136
scolex of 136
Cysts 131f, 132, 132f
Cytapheresis 405
Cytoadherence 276
Cytoadhesion 277
Cytochemical reactions 329f, 330t
Cytochemistry 218, 326
Cytogenetic analysis 268, 329
Cytogenetic defects 171
Cytological examination 112, 116, 121, 126
Cytomegalovirus 128, 195, 196
Cytopenia, prevalence of 291
Cytoplasm 327
Cytoplasmic organelles 206
Cytoplasmic vacuoles 253
D
D antigen, testing for weak 399b
Dacryocyte 434
Davidsohn differential absorption test 434
D-dimer test 368, 434
De Quervain's thyroiditis 163
Dead sperms 188f
Decoy cell 37
Deep venous thrombosis, diagnosis of 367
Delayed hemolytic transfusion reaction 426
Dengue
diagnosis of 291b
fever 234, 289
classical 289
hemorrhagic fever 233, 289
infection 291f
shock syndrome 290
virus 290
Deoxyuridine suppression test 434
Dexamethasone suppression test 434
Diabetes insipidus 54b
Diabetes mellitus 58, 62, 62f, 63b, 67f, 69t, 89, 161
acute metabolic complications of 69
classification of 58
complications of 62
gestational 60, 65
interpretation of 61t
laboratory diagnosis of 66t
monitoring of 66b
pathogenesis of type 1 59f
role of laboratory in 63, 63b
type 1 59
type 2 59, 60b
Diabetic ketoacidosis 62, 69, 69t
monitoring of 70
Diabetic nephropathy, evolution of 68f
Diacetyl monoxime
test 434
urea method 51
Diamond-Blackfan anemia 300
Diarrhea 139t
acute 127f
bloody 137
chronic 127t
fatty 127
infectious 139b
inflammatory 127
types of 137
watery 127, 137
Diathesis, hemorrhagic 55
Diazo method 76, 76f
Dietary creatinine 51
Dietary lipids, digestion of 150
Dietary proteins, digestion of 151
Dietary triglycerides, digestion of 150
Differential absorption test 434
Diffuse kidney disease 45
Digital hemoglobinometer 230
Dihydroepiandrosterone 183
Dihydrorhodamine reduction test 434
Dilute Russell viper venom
test 365
time 434
Dilute thromboplastin inhibition test 434
Dipotassium salt 232
Direct antiglobulin test 321, 323f
principle of 323f
Direct bilirubin 76
Direct fluorescent antibody assay 132, 133
Direct spectroscopic estimation 77
Direct urease test 146
Disaccharidase 150, 150f
deficiency 152
Disaccharides 150, 396
Disseminated intravascular coagulation 348, 356, 427
Distal convoluted tubule 44
Distal tubular function 53
Döhle inclusion body 253, 253f
Dolichos biflorus 386
Doll's eye reflex 101
Donath-Landsteiner test 434
Donor blood
collection of 400, 400f, 403, 405f
repeat testing of 417
Donor plasma 390
Donor platelets
random 422
single 423
Donor red cells 390
Donor sperm 185
Double oxalate 213
Double quotidian fever 194
Down's syndrome 171173, 435
screening for 176
Downey cell 434
Drepanocyte 250, 434
Dromedary fever 194
Dubin-Johnson syndrome 74, 75
Duffy antigen 278
Duodenal aspirates 132
Duodenal fluid 135
Duodenal ulcer 146, 148
Duodenum 147
Dutasteride 402
D-xylose absorption test 154, 434
Dye excretion tests 434
Dye hydrotubation test 184
Dysbetalipoproteinemia, familial 89
Dysentery
acute 128
evaluation of 127
Dysfibrinogenemia 365
Dyshoromonogenesis 163
Dyskeratosis congenita 300
Dyslipidemia 89
causes of 91
Dysmorphic red cells 36f
Dyspareunia 182
Dyspnea, transfusion 425
E
Ecarin clotting time 360
Echinocytes 250, 434
Echis carinatus 360
Ectopic pregnancy 158, 169
early diagnosis of 168
Edward syndrome 171173
Effusion lymphoma, primary 291
Eggs
donation 185
identification of 136
Ehrlich's aldehyde test 31, 31f, 372, 434
Ehrlich's reagent 372
Electrical impedance 216
principle of 217f
Electrocardiography 368
Electron microscopy 56, 327
Elevated pleural fluid amylase 112
Elevated proteins, differential diagnosis of 105
Elliptocytes 250
Elliptocytosis, hereditary 306, 307
Embryo transfer 185
Emergency lumbar puncture, indications for 100
Empyema 110
Encephalitozoon hellem 133
Encephalitozoon intestinalis 133
Endocarditis, subacute bacterial 196
Endocrine
component 156
disorders 60, 177
function 43, 175
Endogenous lipid pathway 88f
Endogenous pathway 88
Endogenous pyrogens 193
Endolimax nana 131
Endometriosis 182, 185
Endometritis, tuberculous 182
Endothelial-bound lipoprotein lipase hydrolyzes triglycerides 88
Endotoxin, limulus lysate assay for 107
Entamoeba
dispar 131
hartmanni 131
histolytica 130, 131
cysts of 131f
trophozoite of 131f
Enteric adenovirus 139
Enterobius vermicularis 135, 137
egg of 38
Enterocytozoon bieneusi 133
Entero-test 135
Enterotoxigenic escherichia coli 139
Enzymatic methods 51, 64
Enzyme 88, 150
antibody conjugate methods 380
immunoassay 131, 139, 171
linked immunosorbent assay 286, 292, 409
test, principle of 411f
locations of 79f
pancreatic 158
Eosin-5-maleimide binding test 434
Eosin-Nigrosin stain 188f
Eosinophilia 195
Eosinophils 206, 220, 248, 252, 434
maturation of 206
Epididymis 186
Epilepsy, common cause of 136
Epinephrine 356
Epithelial cast 39f
Epithelial cells, transitional 36, 36f
Epstein-Barr virus 195, 196, 256
Erythroblasts, different stages of 203
Erythrocyte
analysis 379
protoporphyrin test 435
sedimentation rate 4, 261, 262, 262t, 265t
factors affecting 261, 261b
methods for 262
reference ranges for 263, 264
significance of 261
stages of 261
zinc protoporphyrin 294
Erythrocytic schizogony 276
Erythroid 206, 274
cell markers 378
hyperplasia 272
lineage 327
maturation of 272
Erythroleukemia, acute 329
Erythropoiesis 203
ineffective 435
stages of 203f
Erythropoietin 43
therapy 238
Escherichia coli 19, 22, 106, 304, 345
intestinal pathogenic 139t
Esophageal diseases 140
Esophagogastroduodenoscopy 149
Esterase reaction, nonspecific 330f
Ethambutol 125
Ethanol 211
concentration of 174
gelation test 435
Ethylenediaminetetra-acetic acid 4, 5, 210, 212, 246
Etretinate 402
Euglobulin lysis test 435
Euthyroid sick syndrome 164
Euthyroidism, screening for 165
Excretory function 43, 73
Exflagellation 277
Exocrine pancreas
diseases of 60
major components of 155f
Exocrine pancreatic insufficiency 142, 157
Exoerythrocytic schizogony 276
Exogenous lipid pathway 88f
Exogenous pathway 87
Extrahepatic biliary obstruction 84
Extravascular hemolysis 318f
Extrinsic pathway 342
Exudates 110
F
Fab classification 325t, 327t, 331t
Factor V Leiden 363
Faget's sign 194
Faggot cell 435
Falciparum
infection 281f
malaria 304
Fallopian tubes 182
False thrombocytopenia, causes of 257
False-negative test, causes of 141, 417
False-positive test, causes of 140, 282
Fanconi's anemia 300
Fanconi's syndrome 44
Fasting lipid profile 90
Fasting serum gastrin level 145
Fat
absorption of 151f
cells 267
digestion of 151f
insufficient emulsification of 141
malabsorption of 152, 153f
test for malabsorption of 141
Fatty cast 38, 39f
Febrile illness 197
Febrile non-hemolytic transfusion reaction 426
Fecal alpha-1 antitrypsin clearance 142
Fecal calprotectin 142, 143b
Fecal elastase-1 142
Fecal enzymes, estimation of 157
Fecal fat
estimation of 153, 158
globules 151
quantitative estimation of 141
Fecal leukocyte
examination 137
presence of 137
Fecal molecular testing 143
Fecal osmotic gap 142
Fecal pH 142
Fecal sample 140f
microscopic examinations 128f
Fecal specimen, concentration of 129
Feces 141, 372
consistency of 129f
examination of 127
Felty's syndrome 194, 195
Female infertility 180
causes of 181, 182t
evaluation of 183f
Fern test 176, 183, 435
Ferric chloride test 29, 435
Fetal acetylcholinesterase 171
Fetal anemia, degree of 175
Fetal chromosomal aneuploidy 173
Fetal lung
immaturity 174
maturity
determination of 174
evaluation of 174
testing 174
Fetal red cells, detection of 310
Fetal single gene diseases, detection of 173
Fetoprotein, low alpha 435
Fever 194
filarial 284
high grade 426
low-grade 130
pathogenesis of 193, 194f
pattern of 194
relapsing 194
Fibrin degradation products 355, 359, 360f, 435
Fibrinogen
degradation products 435
detection of 359
disorders of 355
estimation of 360
latex agglutination test for 360f
Fibrinolysis 340, 343
Fibrinolytic system 343
Fibroblasts 267
Fibroid 182
Fibrous pericardium 116
Field's stain 279
FIGLU excretion test 435f
Filarial antigen, detection of 285
Filarial deoxyribonucleic acid, detection of 286
Filarial worms 283
Filariasis, lymphatic 283
Finasteride 402
Fisher-race system 391f
Flagella
axial filaments of 132
hypo-osmotic swelling of 191
Flammable chemicals 14
Floatation techniques 129
Florence test 192
Flow cytometric analysis 112, 313t, 317, 324
Flow cytometry 283, 374, 374f 382t
advantage of 379
applications of 377
components of 374
general steps in 375
limitation of 379
Fluid, hemorrhagic 114
Fluidics 374
Fluorescence
dye, polarization of 175
in situ hybridization 332f, 335f
labeled inactive toxin aerolysin 312
microscopy 123, 124
polarization 175
staining, advantages of 124
treponemal antibody absorption test 435
Fluoride bulb 213
Fluorochrome-labelled monoclonal antibodies 374
Foam
significance of 18
stability index 174
test 30
Folate deficiency 240, 297, 298t
Follicle stimulating hormone 168, 178, 180, 183
Follicular cell 160
Follicular lymphoma 336
Forensic medicine, crime investigation in 399
Formol-ethyl acetate concentration technique 130f
Formol-gel test 288f, 435
Fouchet's test 30, 30f, 435
Fractional test meal 148
Fragmented red cells 224
Free thyroxine 165
Fresh frozen plasma 361, 403, 421424
indications for 423t
Friedman test 170
Froin's syndrome 102
Frozen red cells 422
Fructose, test for 191
Functional activated protein C resistance assay 363
Fungal meningitis 100, 106
Fungi, stains for 274
G
Gamete intrafallopian transfer 185
Gametogony 276
Gammaglobulinemias, monoclonal 338t
Gammaglobulins 435
Gasometric method 227
Gastric
acid secretion 144
stimulation of 145f
acidity 147
analysis 144
contraindications to 146
indications for 145
method of 147
tests for 148
anatomy, normal 144
biopsy 146
diseases 140
juice 144, 147
normal 145
outlet, obstruction of 146
physiology, normal 144
ulcer 146
Gastrin 156
Gastrointestinal infections 138t
Gastrointestinal molecular panel 143
Gaucher's disease 268
Gaussian distribution 8
G-banding technique 435
Gel technology 323f
Gel-based card test 312
Genetic
defects 60
factors, role of 278
tests 187
Genomic tests 187
Gerhardt test 435
Germ cell aplasia 180
Gestational carrier surrogacy 185
Gestational diabetes mellitus 60, 65
screening for 176
GHRH-arginine stimulation test 435
Giant cell arteritis 194
Giant metamyelocyte 298f
Giardia intestinalis 132
Giardia lamblia, trophozoite of 132f
Giemsa stain 274, 279
Gilbert's syndrome 74, 75
Gittleman syndrome 44
Glanzmann's thrombasthenia 345, 351, 357, 358f
Glitter cells 435
Global hemostatic tests 361
Glomerular diseases 31
Glomerular filtration
barrier 44f
rate 46, 47, 68, 175
estimation of 49t
evaluation of 50f
Glomerular function 46
Glomerular proteinuria 22, 23f
Glomerulonephritis
acute 34
membranoproliferative 56
Glomerulus 43
Glucagonoma 60
Glucose 28f
6 phosphate dehydrogenase
6-phosphate dehydrogenase deficiency 278, 307, 307f, 307t, 321, 321f
enzyme 205f
challenge test 65
concentration 64
estimation of 64, 105
in urine, tests for detection of 26
tolerance test 435
Glutathione
oxidized 205
reduced 205
stability test 435
Glycemic control
assessment of 63
targets 68
Glycoprotein, Rh associated 391
Glycosuria 26, 53, 62, 68
causes of 25
evaluation of 28f
Glycosylated hemoglobin test 435
Gmelin's test 30, 435
Goiter 161
Goitrogens, exogenous 163
Goodpasture's syndrome 56
Graft-versus-host disease 428
Gram's smear 106, 112, 125
Gram's stain 118, 119, 122, 137
Gram-negative diplococci 122
Gram-positive diplococci 122
Granular cast 38, 39f
Granularity index 225
Granulocytes 274, 313f
function, loss of 405
immature 225
Granulocytic cells 206t
Granulomatous disease, chronic 379
Granulopoiesis, stages of 206f
Graves’ disease 59, 162, 166
Gravid segments 136
Ground itch 134
Growth
hormone 59, 402
plate, epiphyseal cartilage of 117
Guaiac test 435
Guillain-Barré syndrome 100
Gunther's disease 370
Gut endocrine cells 150
H
Haemophilus influenzae 106, 107f, 121, 304
Ham's acidified serum lysis test 317, 324, 324f, 335
Hamster egg penetration assay 191
Hashimoto's thyroiditis 59, 163, 166
Headache, postpuncture 101
Heart
defects, congenital 171
disorders of 96
failure, congestive 425
Heat
and acetic acid test 23
instability test 435
Heinz bodies 240, 251, 321, 435
Hektoen enteric 137
Helicobacter pylori 137
infection 146
diagnosis of 146t
tests for 146
Helmet cell 436
Helper-inducer T cell marker 378
Hemagglutination tests 283
Hemarthrosis 350
Hematocrit 219
level 313
Hematologic disorders 255, 362
Hematological tests 212
Hematology analyzers 216, 217f, 218, 218t, 224t
advantages of 225
limitations of 225
Hematolymphoid neoplasms 382t
Hematoma 101, 350
Hematopathology 374, 377
Hematopoiesis 71, 201, 267
hierarchy of 202f
stages of 201b
Hematopoietic cells 267
Hematopoietic growth factors 203t
synthesis of 267
Hematopoietic stem cell 205
markers 378
Hematopoietic tissue 267
Hematoxylin and eosin 56
Hematuria 32, 33t
causes of 31
Heme biosynthesis 369f
pathway 369
Hemighost cell 434
Hemiglobincyanide method 229
Hemochromatosis 81, 82, 84
Hemocytometer 234
Hemodilution, acute normovolemic 406
Hemoglobin 7, 32f, 33, 203, 218, 220, 227b, 290, 313
activity of 140
carries oxygen 227
casts 38
catabolism of 317f, 318f
color scale 229f
D Punjab disorders 305
derivatives 227
disorders 316, 319t
E disorders 306
electrophoresis 304, 316, 318, 320f
estimation 227, 230, 313, 321, 403
indications for 227
fecal immunochemical test for 141
fetal 379
glycated 66, 67, 67b, 67f
hereditary disorders of 301, 301t
reference ranges for 204t
S, solubility test for 318
synthesis 370
type of 204, 204t
variants 227
Hemoglobinemia 428
Hemoglobinopathies 240
Hemoglobinuria 33t, 426, 428
causes of 32
detection of 33
Hemolysates 319
Hemolysis 31, 315, 390
causes of 316
evidence of 428
intravascular 32
Hemolytic anemia 240, 251f, 252, 272, 315
acquired 317
detection of 216
differential diagnosis of 252f
evaluation of 318f
macroangiopathic 312
microangiopathic 312, 313f
Hemolytic disease 175, 308
management of 309f
Hemolytic transfusion reaction 293, 425, 425f, 427t
Hemolytic uremic syndrome 313, 345
Hemopericardium, traumatic 116
Hemophagocytic syndrome 268
Hemophilia 347
acquired 347
B 347
classification of 347t
Hemorrhage 31, 55
fetal-maternal 312
intraperitoneal 84
retroperitoneal 350
subarachnoid 102, 102t
Hemorrhagic manifestations 289
Hemosiderin 33
Hemostasis
disorders of 350
physiology of 340
primary 340
screening tests for 350
secondary 340
specific tests for 356
Henle loop 44
Henoch-Schonlein purpura 56, 344
Heparin 213, 246
tests affected by 367
therapy 355
monitor 354
unfractionated 360
tube 117, 213
Hepatic fibrosis, markers of 73
Hepatic injury 73, 79
Hepatic lesions, focal 84
Hepatic lipase 88
Hepatitis
A virus 427
acute 80
B
antigen 176
immune globulin 402
virus 409, 409f, 427
C virus 410, 427
genome 410f
D virus 428
panel 195
viral 82, 402
viruses 408, 428
Hepatobiliary disease 80
Hepatocellular disease 74, 81
Hepatocellular injury 81, 82f
Hepatocytes 71
Hereditary spherocytosis 306, 306f
diagnosis of 379
Herpes simplex virus 126
Herpes zoster 290
Hess’ test 434, 435
Heterophie antibodies 435
Heterozygous state 413
Hexagonal phase phospholipid test 365
Hexokinase 205
Hh blood group system 387
High low packed cell volume, causes of 233
High packed cell volume 233
High protein diet 7
High-density lipoprotein 87, 88
cholesterol 69
High-frequency alloantibodies 417
High-molecular weight kininogen 342
High-performance liquid chromatography 319
High-sensitive cardiac troponin assays 96
Hirschsprung disease 171
Hirudin therapy 360
Histidine loading test 435
Histogram 221
bimodal 222
Histoplasma capsulatum 197, 257, 268, 272, 287, 291
Histoplasmosis 125
Hodgkin's lymphoma 194, 195, 291
Hollander's test 145, 148
Homocysteine 364
Homovanillic acid 437
Hookworm 134
eggs 134f
emonstration of 134
Hormonal studies 179
interpretation of 181t
Horned cells 250
Horseradish peroxidase 380
Housekeeping procedures 14
Howell-Jolly bodies 241, 249f, 251, 291, 435
Human albumin solutions 424
Human chorionic gonadotropin 168170
free serum 171
level of 169f
Human immunodeficiency virus 193, 195, 197, 402, 408, 410, 428
viral load 292
Human leukocyte antigens 207
Human pituitary gland 402
Humans, intestinal parasites of 130, 130f
Hyaline cast 38, 39f, 40
Hydrocele 284
Hydrochloric acid 144, 145
Hydrogen
breath test 435
peroxide 205
Hydrosalpinx 185
Hydroxyapatite 120
Hyperbilirubinemia
congenital 75t
conjugated 74
unconjugated 74
Hypercalcemia, familial 19
Hypercholesterolemia
causes of 90t
familial 89
polygenic 89
Hyperglycemia 26, 62, 64
fasting 58
hyperosmolar 64
Hypergranular variant 376
Hyperhomocysteinemia 364, 366, 367
Hyperinsulinemia 60
Hyperlipidemia, primary 89t
Hyperosmolar hyperglycemic state 62, 69, 69t
Hyperprolactinemia 182
Hyperreactive malarial splenomegaly syndrome 277
Hypersplenism 176, 255, 313
Hyperthyroidism 60, 161, 162b, 165
early diagnosis of 165
evaluation of 163f
primary 162t, 165, 167t
secondary 162t, 165
Hypertriglyceridemia 89, 229
causes of 90t
familial 89
Hyperventilation 404
Hypoaldosteronism, hyporeninemic 55
Hypocalcemia 60
Hypochromic red blood cells 224
Hypoglycemia 60, 69, 106
Hypo-osmotic swelling test 435
Hypoplasia, congenital 182
Hypothalamic failure 184
Hypothalamic-pituitary
dysfunction 182
testis axis 178f
Hypothalamus secretes gonadotropin releasing hormone 178
Hypothermia 425
Hypothyroidism 89, 96, 116, 162, 164b, 184
causes of 163t
congenital 163
evaluation of 164f
neonatal screening for 167
primary 163, 163t, 167t
secondary 163, 163t
tertiary 163
Hysterosalpingography 184, 185f
Hysteroscopy 184
I
Idiopathic thrombocytopenic purpura 268
Immature red cells 249f, 251
Immature reticulocyte fraction 216, 223
Immune hemolysis 71
Immune hemolytic anemias 308, 317
classification of 308t
Immune thrombocytopenic purpura 344
Immunity 208
Immunofixation 339f
electrophoresis 337
Immunofluorescence 56, 380
Immunoglobulin 424
G 108
nonspecific 287, 424
specific 424
Immunohistochemical markers 382t
Immunohistochemistry 374, 380
advantages of 381
applications of 381
disadvantages of 382
technique of 380
Immunological assays 170, 190
Immunological platelet counting 242
Immunophenotypic profile, typical 335f
Immunophenotyping 327, 337, 377
In vitro fertilization 185
Inadequate skin disinfection 214
Inadvertent brachial arterial puncture 404
Indicanuria 19
Indirect antiglobulin test 323, 414, 418, 418f
principle of 323f
Indirect immunofluorescence 283
Infections 60, 63, 194, 234, 256
bacterial 137, 288
detection of 264
parasitic 255
procalcitonin 265
suspected 268
transmission of 427
viral 137, 195
Infectious diseases 184, 194, 195
hematology of 275
Infertility 178
diagnosis of 181
female 180
initial investigation of 187b
investigation of 18, 187
male 178, 181t
Inflammation
chronic 234
markers of 265t
Inflammatory bowel disease 195
Inflammatory diseases 100, 195
Inflammatory disorders 194
Injury, cholestatic 83f
Insulin 58f
action 60
hypoglycemia test 148
major actions of 58b
metabolic actions of 58
pump 63
resistance syndrome 61
secretion, absolute deficiency of 59
tolerance test 435
Intermediate density lipoprotein 87
Interstitial fibrosis 180
Intestinal bacterial flora, reduction of 31
Intestinal diseases 140, 158
Intestinal infection 136
Intestinal mucosal cells 150f
Intestinal parasites, diagnosis of 137t
Intra-abdominal venous thrombosis 366
Intracerebral bleeding 350
Intracranial pressure, raised 101
Intracytoplasmic myeloperoxidase, detection of 379
Intracytoplasmic sperm injection 185
Intraluminal filling defect 367
Intramuscular hematoma 350
Intrauterine insemination 185
Intravascular hemolysis 32
evidence of 312
Intrinsic pathway 342
Inulin clearance test 435
Iodameba butschlii 131
Iodide
diffusion of 160
oxidation of 160
Iodine 159
deficiency 163
wet mount 135f
Iohexol clearance test 48
Ionized calcium analysis 6
Ionizing radiation 255
Iron
deficiency 238
anemia 134, 240, 252f, 259, 293, 293t, 294, 294f
stages of 294
overload 301, 427
stain 273f
studies 317
Irradiated red cells 422
Ischemia, symptoms of 96
Islet autoantibodies 66
Islet cell transplant function 63
Isocoproporphyrinogen 373
Isomorphic red blood cells 36f
Isoniazid 125
Isopropanol precipitation test 435
Isospora 128
belli 132, 133
Ito cells 71
Ivy's method 351
J
Jaffe's reaction 48, 51
Jamshidi bone marrow biopsy needle 270f
Jaundice 73, 82t
causes of 73
cholestatic 81
classification of 74t
differential diagnosis of 29f
hepatic 74
investigation of 76f
obstructive 31
physiologic 74
posthepatic 74
prehepatic 74
types of 76t
Jejunal contents, culture of 154
Jod-Basedow phenomenon 162
Joint
disorders 118t
classification of 117
lubrication of 117
K
Kala-azar 268, 286
Kallmann's syndrome 182
Kaposi's sarcoma 197, 291
Katex test 288
Kell antigen system 398
Keratocytes 250
Ketoacidosis 19, 64
alcoholic 28
Ketone 27
bodies 29f
testing for 69
in urine, tests for detection of 28
Ketonuria, causes of 27
Ketosis 62
Kidney
azotemia 51
biomarkers 52
biopsy 54, 55, 56
percutaneous 56t
disease 45, 50
function 43, 45
tests 43, 45, 46, 46t
impairment of 45, 51
injury, acute 55
neoplasm 55
structure of 43
tubules, physiology of 45f
Kikuchi's disease 194
Kleihauer-Betke acid elution technique 310
Kleihauer-Betke test 310f
use of 311f
Klima and Salah bone marrow aspiration needles 270f
Klinefelter's syndrome 181f
Kostman's syndrome 255
L
Lactase
deficiency, causes of 152
dehydrogenase 6, 115
Lactose
intolerance, diagnosis of 154f
tolerance test 151, 152, 153
Lactulose breath hydrogen test 151
Lamblia 132
Lamellar body count 174
Langerhans
cell markers 378
islets 156
Laparoscopy 184
Larvae
detection of 135
excretion of 135
Latex agglutination tests 106, 107
Laxative abuse, tests for 155
Lecithin cholesterol acyltransferase 88
Leder stain 435
Leede-Rumpel test 434
Leiomyoma 182, 185
Leishman stain powder 247
Leishmania donovani 257, 268, 272, 286, 287
bodies 287f
complex 286
life cycle of 286, 287f
Leptocyte 251, 435
Leucapheresis 405
Leucine crystals 42
Leukemia 240
acute 325, 329f, 382t
lymphoblastic 325, 377
aleukemic 268, 326
chronic
lymphocytic 334, 334f, 336
myeloid 255t, 331, 332f
cute myeloid 325, 327t, 329t, 378
lymphoblastic 329t
subleukemic 326
Leukemoid reaction 254, 255f, 255t
Leukocyte 379
adhesion deficiency 379
alkaline phosphatase
reaction 333f
score 435
analysis 378
count, raised 288
esterase test 34
morphology 251, 253
numerical abnormalities of 254
poor red cells 422
Leukocytosis 234, 268
causes of 234
Leukocytospermia 187
Leukoerythroblastic reaction 254
Leukopenia 195, 234, 254
Levey-Jennings chart 12f
Leydig cells 178
Licensure 13
Liddle syndrome 44
Light-emitting diode 124
Liley's graph 435
Limb of Henle 44
Lipase 435
Lipemic blood 229
Lipid disorder 86
evaluation of 90f
identification of 89
Lipid profile 68, 90t
Lipoprotein 86
classification of 89f
disorders 89
classification of 88
lipase 88
major 87t
metabolism 87
disorders of 86
molecule 86f
very low-density 86
Liquid
chromatography 305f, 320f
culture 125
media 124
Litmus paper test 21
Livedo reticularis 366
Liver
biliary cirrhosis of 89
biopsy 82, 84, 196
adequacy of 84
handling of 84
laparoscopic 85
percutaneous guided 85
processing of 84
types of 83
cell 79f
carcinoma 197
disease 80f, 158, 251f, 349, 427
alcoholic 84
etiologic diagnosis of 81
nature of 81
enzyme studies 73, 79
excretory function of 73
function 71, 73, 354
tests 71, 73, 73b, 73t, 81, 195
infiltrative diseases of 80
metabolic functions of 73, 77
metastases 197
necrosis, massive 79
stiffness 73
transplantation 84
Loeffler's syndrome 133, 134, 135, 255
Low hemoglobin
density 224
production 294
Low packed cell volume, causes of 233
Low semen volume 179
evaluation of 180f
Low-density lipoprotein 87
cholesterol 69
Lowenstein-Jensen medium 112, 124, 125
Lugol iodine test 30
Lumbar puncture 101, 105
complications of 101
indications for 100
needles 99f
site of 99f
Lumbar vertebrae, spinous processes of 269
Lundh meal 157
Lundh test 435
Lung
diseases 255
injury
acute 425
transfusion 426
Lupus anticoagulant 365, 435
confirmatory tests for 365
Lupus anticoagulant, diagnosis of 365b, 366f
Lupus erythematosus cell 232f
Lupus pleuritis 113
Luteal defect 177
Luteinized unruptured follicle 182
Luteinizing hormone 178, 180, 183
Lymph index 225
Lymph node
aspirate 287
biopsy 196
macrophages of 289
Lymphadenopathy, persistent 428
Lymphangitis 284
Lymphoblasts 256
Lymphocyte 207, 212, 220, 252, 258
atypical 253, 290, 290f, 434
culture, mixed 208, 436
reaction, mixed 208
subsets, enumeration of 378
Lymphocytopenia 256
Lymphocytosis 195, 256, 289
acute infectious 256
differential diagnosis of 256
mature 256
Lymphocytotoxicity test 435
Lymphohistiocytosis, hemophagocytic 268
Lymphoid
cells 377f
leukemias, suspected chronic 268
leukemoid reaction 256
progenitor 202
tissue
disorders of 291
mucosa-associated 207
Lymphoma 195, 240
lymphoplasmacytic 336
Lymphoproliferative disorders, chronic 253
Lysed capillary blood method 285
Lysed venous blood method 285
Lytic agent 225
M
Macroamylasemia 158
Macroangiopathy 63
Macrocytes 249
Macrocytic anemia 252, 268, 315
diagnosis of 251f
evaluation of 316f
Macrosomia, fetal 60
Macrovascular disease 63
Mad cow disease 402
Malabsorption
causes of 152, 152t
syndrome 150, 152
tests for 150, 151, 155
Malaria 194, 196, 277, 277f, 278, 402
diagnosis of 283t
differential diagnosis of 278
parasite 275, 279, 428
detection of 216, 282
life cycle of 275, 276f
morphology of 281f
nucleic acid sequences of 283
rapid diagnostic test for 282f
self-diagnosis of 282
severe 279t
transmission, unstable 275
Male infertility 178, 181t
causes of 179, 179t
investigations of 179
Malignancy 113, 116, 193, 234, 366
hematological 325
Malignant diseases 194, 195, 197
Mantle cell lymphoma 336
Mantoux test 435
Marrow
fibroblasts 267
particles, cellularity of 272
specimens
examination of 271
processing of 271
types of 267
Massive transfusion 428
Masson trichrome 84
Mast cell markers 378
Mastectomy 5
Mastocytosis, systemic 148
Maternal serum 435
alpha-fetoprotein 172
Maturation arrest 180
McConkey's agar 107
Mean cell
hemoglobin 259, 260
concentration 259, 260
volume 176, 219, 259, 260
Mean corpuscular volume 7
Mean platelet volume 221
Meckel's diverticulum 293
Megakaryocytes 208, 274
markers 378
series 272
Megakaryocytic lineage 327
Megaloblastic anemia 238, 251f, 260, 295, 297f, 298
causes of 296t
evaluation of 299f
Membrane
filtration 284
premature rupture of 176
Meningitis
tuberculous 106
types of 108t
Menstrual cycle, normal 182f, 183f
Mental retardation, severe 171
Mentzer index 435
Mesothelioma 110
Metabisulfite test 436
Metabolic disorders 254
Metabolic syndrome 61
Metabolic waste products, excretion of 43
Metarubricyte 203
Metastatic malignancy 240
Metastatic mucinous adenocarcinomas 110
Methemalbuminemia 316
Methemoglobin
elution method 436
reduction test 436
Methylene blue 247
Mexican hat cells 250
Microaggregates, formation of 406
Microalbuminuria 25, 52
Microcytes 249
Microcytic anemia 252
differential diagnosis of 217t, 252f
Microcytic hypochromic anemia 260, 296f, 315, 316f
differential diagnosis of 295t
Microfilaria 38
morphology of 285
Microhematocrit capillary tubes 233f
Microhematocrit tube 285
concentration technique 285f
Microorganisms
inactivation of 145
killing of 145
Microsporidia 133
Microvascular disease 63
Miliary tuberculosis 194, 197, 268
Milky fluid 114
Milwaukee shoulder 119
Minimal residual disease
detection of 331, 378
monitoring of 331
Molecular genetic analysis 358
Monoblast 206
Monoclonal antibody 131, 171, 312, 375
Monoclonal immunoglobulin deposition diseases 336
Monocytes 206, 212, 220, 252
formation of 207f
Monocytic lineage 327
Monocytosis 195, 255, 289
Mononucleosis, infectious 256
Monosodium urate 119, 120
Monospot test 436
Moraxella catarrhalis 122
Morphological sperm forms, abnormal 190f
Morula-like appearance 133
Mosquito cycle 277
Mosquito vector 289
Motile trypanosomes 106
Motulsky dye reduction test 436
Mouth cells 250
Mucin clot test 118
Mucosa, disorders of 152
Mucosal biopsy 152
Mucus
copious amounts of 129
secreting epithelium 144
Muddy-brown casts 436
Multiple myeloma 194
Multiple sclerosis 108, 108f
Multipotent stem cells 202
Mutagenic chemicals 14
Myalgia 195
Myasthenia gravis 208
Mycobacteria 123, 124f
growth indicator tube 124, 125
Mycobacterium avium-intracellulare 128, 197, 291
Mycobacterium tuberculosis 106, 112, 123, 291
complex 123
Mycoplasma pneumonia infection 288
Myelodysplastic neoplasms, classification of 331t
Myelodysplastic syndrome 194, 197, 221, 251f, 331
classification of 331t
Myelofibrosis 240, 333
Myeloid 272
cell 377f
markers 378
lineage 327
progenitor 202
Myeloma 337f
asymptomatic 336
nonsecretory 336
osteosclerotic 336
Myeloperoxidase 326, 327, 436
stain 330f
Myeloproliferative disorders 254, 268
Myeloproliferative neoplasms 194, 195, 331
classification of 332t
Myelosuppressive therapy 238
Myocardial cells 94
Myocardial infarction 93f, 96, 116, 265
acute 93, 94, 94b
diagnosis of 95t
types of 93, 94, 94f
Myocardial injury 94
biochemical markers of 95t
diagnosis of 94b
Myocardial ischemia, changes of 93
Myocarditis 96
Myoglobin 33, 96
casts 38
Myoglobinuria 33t
Myxedema 162, 240
N
Naïve B cell, mature 207
Nasogastric tube 147
Natural anticoagulants, deficiencies of 367
Nausea 404
NBT-PABA test 157
Necator americanus 134
Necrozoospermia 187
Needle-stick injury 215
Neisseria meningitides 107f, 304
Neonatal alloimmune thrombocytopenia 345
Neonatal isoimmune neutropenia 255
Neonatal respiratory distress syndrome 174
Neoplasm, hematological 289, 377, 378t
Neoplastic disease 195
Neoplastic disorders 197, 256
Neoplastic plasma cells, quantification of 339
Nephritic syndrome 39b
Nephrocalcinosis 19
Nephropathy, membranous 56
Nephrotic syndrome 23b, 34, 89
diagnosis of 24
Neubauer chamber, platelets in 243f
Neural tube defect 171, 173
diagnosis of 173f
Neurocysticercosis 136
Neutropenia 255
Neutrophil 205, 220, 248, 258, 291
function, evaluation of 379
granulation, degree of 225
hypersegmented 253, 435
hypogranulation of 253
polymorphonuclear 252
stages in maturation of 206t
Neutrophilia 254
congenital 234
Newton's rings 235
Nigrosin 188
Nitrazine test 176
Nitrite test 33
Nitroblue tetrazolium dye reduction test 436
Nitroprusside reaction, classic 28
Noncellular casts 38
Non-fasting lipid profile 90
Non-Hodgkin lymphoma 163, 197, 274
Non-megaloblastic macrocytosis 260
Non-ST segment elevation myocardial infarction 92
Non-thyroidal illness syndrome 164
Normal mature plasma cells, detection of 339
Normocytic normochromic anemia 315
evaluation of 317f
Normozoospermia 187
Norovirus 143
Northern blot 436
Nuchal translucency 172
Nuclear chromatin 131f
Nucleated red cells 223, 236, 251
Nucleic acid testing 411
Nutritional deficiencies 293
O
O’Sullivan's test 65
Obstruction, lymphatic 158
Oligoasthenoteratozoospermia 187
Oligoclonal bands 107, 108f
Oligozoospermia 187
Oliguria 18
Oocysts 132
Oral anticoagulants, tests affected by 367
Oral cavity 291
Oral contraceptive therapy 365
Oral glucose tolerance
curve 65f
test 64, 65t
Oral iron therapy, response to 295
Organ transplantation 208, 399
Orthotoluidine test 32
Osler's nodes 196
Osmolality 20, 54
Osmotic fragility 321
curve 322f
test 321, 436
Oval cells 71
Oval fat bodies 37, 436
Ovalocytes 250
Ovarian disorders 185
Ovarian dysfunction 182
Ovarian hyperstimulation syndrome 184
Ovum, fertilization of 179f, 180
Oxygen binding low molecular weight protein 96
Oxyhemoglobin method 230
P
Packed cell volume 231, 260
estimation of 233t, 314
uses of 231
Packed red cell 421
transfusion 390, 422t
Pain, abdominal 135
Pancreas
anatomy of 155, 155f
diseases of 152
physiology of 155
Pancreatic acini 155f
Pancreatic arylesterase, test for 157
Pancreatic disease 113, 158
Pancreatic function tests 150, 155, 156, 156t
Pancreatic insufficiency 152
Pancreatic juice, composition of 156b
Pancreatic lipase, deficiency of 141
Pancreolauryl test 152, 157, 436
Pancreozymin 156
Pancytopenia 195
Pandy's test 105f
Pap smear 175
Pappenheimer bodies 240, 249f, 251, 436
Para-Bombay blood group 388
Paracentesis 114, 114f
abdominal 113, 114t
therapeutic 114
Paracoagulation test 436
Paragonimus 126
Parasite 143, 248, 408, 411
aldolase 282
culture 288
density 280
detection of 127, 279
in blood smear 283
lactate dehydrogenase 282
Parotitis 158
Paroxysmal nocturnal hemoglobinuria 293, 312, 317, 324f, 379
tests for 324
Partial thromboplastin time 342
Parvovirus B19 291
Patau syndrome 171
Paternity testing 399
Paul-Bunnell-Davidsohn test 436
Peak acid output 147
Pediatric diarrhea 128
Pel-Ebstein fever 194, 195
Pelger-Huet cells 253
Pelvic abscess 196
Pentagastrin stimulation 146
Pentagastrin test 436
Pepsin 145
secretion 145
Peptic ulcer
disease 145
surgery for 145
dyspepsia 146
Pericardial effusion 116
causes of 116t
Pericardial fluid 116
Pericardiocentesis, indications for 116
Periodic acid Schiff 56, 327, 436
reaction 330f
stains 203
Periodic non-stress test 311
Peripheral blood 289, 375
changes in 291
smear 290f, 314
Peritoneal adhesions 185
Peritoneal fluid 113
Peritonitis
biliary 84
secondary bacterial 115f, 115t
Perl's Prussian blue stain 84, 203
Perl's stain 272
Persistent polyclonal B-cell lymphocytosis 256
Phenothiazines 255
Pheochromocytoma 60
Philadelphia chromosome 436
Phlebotomy, therapeutic 407
Phosphate 41
crystals 42
Phosphatidylglycerol 174
Photoelectric methods 227
Photomultiplier tubes 376
Pincer cell 436
Pinocytosis 160
Pinworm eggs 135
Pituitary failure 184
Plasma 64, 219
cell 207, 253, 256, 337f
dyscrasia, suspected 268
establishing clonality of 339
gate 376
leukemia 336
markers 378
myeloma, immunophenotyping of 339
neoplasms 334, 336b, 337
quantitation of 337
components 422, 423
containing bag 421
derivative 420, 424, 424t
frozen 423
potassium 6
proteins 341
transfusion of 390
transport proteins 175
Plasmablastic lymphoma 291
Plasmacytoma 336
Plasmapheresis 405
Plasmodia 280t
Plasmodium
knowlesi 275
species 411
vivax 275
Platelet 256, 340, 350t, 356, 422
activation 379
adhesion 341f
aggregation 356, 357f, 358f
analysis 379
concentrate 422
count 220, 242, 351
automated 221
calculation 243
manual 242, 243b
methods of 242b
disorders 344
inherited 358
distribution width 221
evaluation of 357b
formation, stages of 208f
fraction, immune 221
function 357
analyzer 352
disorders of 345, 346f, 358t
glycoprotein
analysis of 357
antigens 329
histogram 222
abnormal 222f
normal 220f
large cell ratio 221, 223
lumiaggregometry 358
neutralization test 365
parameters 218, 220
interpretation of 226
poor citrated plasma 353
receptors, deficiency of 379
reticulated 221, 223, 379
rich plasma 421, 423
size 257t
transfusion 423, 423t
transmission electron microscopy 357
Plateletpheresis 405, 423
Plesiomonas 137
Pleural cavity 109f
Pleural effusion 109
causes of 13, 109, 109t, 113t
evaluation of 111f
Pleural fluid 109, 110
appearance of 110
chemical examination of 112
collection of 110
examination of 110
glucose level 111
pH 112
triglyceride 112
Pleural tuberculosis, diagnosis of 112b
Pneumocystis jiroveci
cysts 125, 125f
pneumonia 197
Pneumonic plague 125
Point of care testing 13, 95
Polyagglutination 397
Polyarteritis nodosa 194, 197
Polychromatic cells 248, 251
Polyclonal gammaglobulinemias 338t
Polycystic ovarian
disease 182
syndrome 177, 185
Polycythemia 227, 227b
vera 233, 333
Polycythemic blood 246
Polydipsia, psychogenic 54t
Polymerase chain reaction 106, 107, 139, 286, 288
role of 119
Polymyalgia rheumatica 194
Polysaccharides 150
Polyurias 18, 369, 370t
acute neurovisceral 371f
classification 369
clinical characteristics of 371t
clinical features 370
congenital erythropoietic 370
cutanea tarda 370, 373
cutaneous 373t
erythropoietic 370
fluorescence 372
Porphyrins, tests for 372
Positive chemical test, evaluation of 33f
Positive tau protein 108f
Postanalytical errors 8
Postcoital test 191, 436
interpretation of 191b
Post-kala-azar dermal leishmaniasis 286
Post-kidney azotemia 51
Postrenal proteinuria 22, 23
Post-transfusion purpura 345, 427
Potassium oxalate 214
Potential antibody-directed therapy 378
Poultry products 128
Povidone iodine 403
Prediabetes 61
Predictive value
negative 11
positive 10
Pre-erythrocytic schizogony 275
Pregnancy 80
and lactation 402
early diagnosis of 168
ectopic 158, 169
loss, recurrent 177
morbidity 177
normal 169
termination of 170
tests 168
types of 169
Prekidney biopsy evaluation 55, 55f
Preterm labor 173
Primitive stem cell markers 327
Proerythroblast 203
Proficiency testing program 12
Progesterone, estimation of 183
Proglottids 136
Proinsulin 58f
Prolonged bleeding time, evaluation of 352f
Promonocyte 206
Pronormoblast 203
Prorubricyte 203
Prostaglandins 43, 193
Prostate 186
enlargement of 402
Protein 22, 77, 114
binding disorders 161
C 364
deficiency of 364
resistance, activated 363
deficiency of 363
electrophoresis 107
estimation of 24
heat test for 23f
losing enteropathy 142
quantitative estimation of 24
reagent strip test for 24f
S deficiencies 364
Proteinuria 24t
causes of 22, 22t
evaluation of 26f
grading of 24f
mechanisms of 22b
overflow 22
prerenal 22
tests for detection of 23
tubular type of 23
Proteolysis 160
Proteolytic enzyme pepsinogen 144
Prothrombin complex concentrate 424
Prothrombin time 78, 352, 436
principle of 352f
uses of 353
Prothymocyte 207
Protoporphyria, erythropoietic 370, 373
Protozoa 130
cysts 129, 137
Prussian blue stain 33f
Pseudoappendicitis 128
Pseudocasts 38
Pseudochylous pleural effusion 111, 111t
Pseudogout 119
Pseudomonas 18, 22, 34, 408
fluorescens 426
Psoriasis, severe 402
Pulmonary angiography 368
Pulmonary artery Doppler study 175
Pulmonary embolism, diagnosis of 368
Pure red cell aplasia 240, 251
Purple urine bag syndrome 18
Purpura fulminans 366
Pus cells 35, 36f
Pyelonephritis, acute 34
Pyloric part 144
Pyloric stenosis 146
Pyrazinamide 125
Pyrexia of unknown origin 84, 193
Pyrogenic cytokines 193
Pyrogens, exogenous 193
Q
Quadruple test 172
Qualitative tests 169
Quantitative tests 169
Queckenstedt's test 100, 101
R
Rabies vaccine 402
Radioactive iodine uptake test 166, 436
Radioisotope test 141
Radiolabelled agents, clearance of 47
Radiolabelled isotopes, clearance of 49
Raised serum alkaline phosphatase
causes of 82
evaluation of 83f
Rapid immunochromatographic test 282, 285
Rapid plasma reagin test 411, 436
Rapid rat test 170
Reactive cells 377
Reagent strip
method 20, 27, 31
test 21, 21f, 23, 24f, 28f, 29, 29f, 32
use of 21t
Reaven's syndrome 61
Rebuck skin window test 436
Recipient blood sample 416
pretransfusion testing of 417
Red blood cell 35, 38, 203, 257
count 216, 219
parameters 218, 226
production of 293
stages in maturation of 203t
Red cell 219, 248250, 405, 422
abnormalities 350
agglutination of 395
apheresis 405
arrangement, abnormal 250f, 251
autoagglutination of 434
basophilic stippling of 434
cast 39, 39f
components 421
distribution 219, 301
enzyme 204
defects 316
inclusions 249f, 251
indices 259
large clusters of 308f
lysis of 375
membrane 204, 386f
disorders of 306, 316
size and shape of 249f
storage lesion 406b
suspension 422
Red diaper syndrome 19
Refractometer method 20, 77
Reheated rice syndrome 128
Reiter's cells 119
Renal cell carcinoma 194, 197
Renal disease 40t, 240
urinary findings in 34t
Renal failure 89
acute 429
chronic 240
Renal function 175
Renal glycosuria 28f
Renal proteinuria 22
Renal tubular
acidosis 55b
epithelial cell 36
casts 39
Rendu-Osler-Weber syndrome 344
Renin 43
angiotensin aldosterone system 43, 44f
Reproductive system, male 178
Reptilase time 436
Reticular cells 267
Reticular dysgenesis 255
Reticulin fibers 267
Reticulocyte
count 223, 238, 239f, 240, 379
method 239
uses 238
utility of 238b
hemoglobin content 223, 295
maturation of 239
percentage 239
stained 239f
Reticulocytopenia 240
Reticulocytosis 240
Reverse passive hemagglutination assay 409, 410f
Reye's syndrome 78
Rh antibodies 392
Rh antigen
immunogenicity of 393f
variations of 392f
Rh hemolytic disease 310f
Rh system 390
antigens of 390
inheritance 391f
Rh typing 176, 398
Rheumatoid arthritis, juvenile 194, 197
Rheumatoid factor 112, 436
Ribbon-like stool 129
Ribonucleic acid 238
Ribosome 238
rich lymphocyte cytoplasm 247
Richter's syndrome 334
Riedel thyroiditis 163
Rifampin 102, 125
Robertsonian chromosomal translocation 171
Romanowsky stain 120, 247, 247b
Romanowsky-Giemsa effect 247
Romanowsky-stained blood smears 272, 285
Rotavirus 128, 143
Roth spots 196
Rothera's test 28, 20f, 436
Rotor syndrome 74, 75
Rouleaux formation 250f, 397, 417, 436
Round cells 190
Roundworm 133
Routine stool culture, culture media for 139t
Rubella 176, 402
infection 176
Rubriblast 203
Rubricyte 203
Rumpel-Leede capillary fragility test 434
Russell viper venom 365, 436
Ryle's tube nasogastric 147
S
Sahli's acid hematin method 228
Sahli's hemoglobinometer 228, 228f
Sahli's method, disadvantages of 228
Sahli's pipette 228
Saline lock 5
Salmonella 34, 127, 137, 143, 408
typhi 138
Sarcoidosis 194, 195
Schilling's test 146, 436
Schistocyte 250, 426, 436
Schistosoma haematobium, egg of 37f, 38
Schizocyte 436
Schizogony 275
Schumm's test 436
Schwachman-diamond syndrome 300
Sclerosed veins 5
Sclerosing cholangitis, primary 75, 80
Secretin 156
cholecystokinin test 436
Sedimentation techniques 129
Semen
analysis 179, 186, 187b
indications for 186
terminologies in 187b
variables of 187t
biochemical analysis of 191
collection of 187
examination of 192
liquefaction of 178
presence of 192
reactive oxygen species 187
volume 186
Seminal fluid 187b
examination of 187
Seminal vesicles 186
Serous body fluids, examination of 109
Serous pericardium, visceral layer of 116
Serratia 408
liquefaciens 426
Serum alanine transferase 80f
Serum albumin 77
estimation of 77
Serum alkaline phosphatase 7, 80
Serum alpha-fetoprotein 176
Serum aminotransferases 79
Serum amylase, evaluation of raised 158f
Serum anti-Müllerian hormone 184
Serum bilirubin 7, 75, 76
Serum ceruloplasmin, low 435
Serum C-peptide 66
Serum creatinine 48, 51
level 51
Serum creatinine ratio 52
Serum free light chain assay 337
Serum gamma-glutamyl transferase 80
Serum grouping 394, 396
Serum immunoglobulin quantitation 337, 339
Serum iron 294
Serum lipase 158
Serum myoglobin 95
Serum protein electrophoresis 77, 78f, 196, 337, 339
components of 338t
principle of 338f
Serum protein, total 77
Serum triglycerides 90
Serum troponin 95
Serum tube 213
Sexual act, dysfunction of 182
Sexual cycle 277
Sheehan's syndrome 182
Sheep blood agar 137
Shigella 127, 137, 138, 143
Shock, development of 277
Sickle cell 225, 250
anemia 305f, 320f
disease 31, 252, 318
disorders 304, 304t
slide test 317, 319f
trait 278, 305f
Sickle hemoglobin, ssolubility test for 319f
Sickling disorders 304
Sickling test 316
Sideroblasts 273
Siderocytes 273
Silver methenamine stain 125f
Simmond's disease 182
Sims-Huhner test 436
Sjogren's syndrome 194, 208
Skeletal anomalies 171
Skeletal muscle
disorders of 96
mass 51
Skin
diseases 255
necrosis, warfarin-induced 366
piercing 402
puncture 210
test 288
Slide
cleaning of 246
test 394
Small bowel mucosal disease 158
Small intestine 154
diseases of 141
Small lymphocytic lymphoma 336
Smudged cells 436
Sodium
artefactual elevation of 213
citrate 212, 246
fluoride 214
fractional excretion of 53
lauryl sulfate method 230
loading test 436
urinary concentration of 53
Solid media
conventional
agar-based 124
egg-based 124
Solubility test 436
Southeast Asian ovalocytosis 278
Specimen 232, 353, 375
collection 4
tubes 4t
mixing of 6
testing process of 3
Spectrophotometry 102
Sperm
concentration
method 188
principle 188
function tests 187, 191
microscopic examination for 192
morphology 189
normal 189b
motility 188
method 188
principle 188
viability 188
method 188
principle 188
vitality 188
Spermatozoa 37
morphology of 189f
Spermatozoon 189
Spermmar test 190
Spherocytes 250
Spherocytosis, hereditary 306, 306f
Spin crossmatch 418
Spinal cord 297f
tumor 105
Spinal needle 101
Spinnbarkeit test 183
Splenic aspirate, examination of 287
Splenic lymphoma 336
Splenic marginal zone lymphoma 336
Spondyloarthropathy 119
Sporadic pregnancy loss 177
Sporogony 277
Sporozoites 132
Sputum 434
collection methods 123t
cytological examination of 126
examination of 121, 123, 126f
Gram's stained smear of 122f
induction of 121
sample, unacceptable 122f
smear 123
examination of 123
Squamous epithelial cell 36, 36f
Stable malaria transmission 275
Stain, removal of 247
Staphylococcus aureus 138
Steatorrhea, evaluation of 153f
Stein-Leventhal syndrome 182
Stem cell collection 405
Sterile tube 117
Sternal tenderness 195
Sternum 269
Steroid hormones, catabolism of 71
Still's disease 194
Stomach
functions of 145
parts of 144f
Stomatocytes 250
Stool
antigen detection 146
culture 137
Straw-colored transudative fluid 110
Streptococcus pneumoniae 107f, 122f, 304
Stress 8
hormones 58
String test 135
Stroma 267
Strongyloides stercoralis 134
Subarachnoid
epidermal cyst 101
subdural 101
Subepithelial electron-dense deposits 56
Submucosa 130
Sucrose hemolysis test 317, 324, 436
Sulfonamide 255
crystals 42
Sulfosalicylic acid test 24, 24f, 24t, 436
Suprapubic aspiration 17
Supravital stain 239f
Swollen red cells 36f
Syncope 404
Syndrome X 61
Synovial fluid 116, 119, 436
analysis 117, 118t, 120
collection of 117
composition of normal 117
examination of 109, 117
functions of 117
laboratory examination of 118
proteins 119
types of crystals in 120t
Synovial membrane 117
Syphilis 408, 412f
serologic tests for 106, 107
test for 176
trasfusion-transmission of 428
Systemic lupus erythematosus 194, 195, 208
T
T cell neoplasms, mature 334, 378
T lymphocyte 207t
Tachycardia 194
Taenia saginata 137
egg of 136f
Taenia solium, egg of 136f
Takayasu's arteritis 194
Tallquist hemoglobin chart 228
Target cell 250, 436
Tartrate-resistant acid phosphatase 437
Tear drop cell 250, 434
Telangiectasia, hereditary hemorrhagic 344
Telescoped urinary sediment 436
Tense ascites 84
Teratogenic chemicals 14
Teratozoospermia 187
Terminal deoxynucleotidyl transferase 329, 437
Testes 186
Testicular biopsy 179, 180
Testicular microlithiasis 180
Tetra-iodothyronine 159
Tetrazolium linked cytochemical method 437
Thalassemia 302
asymptomatic 303
classification 302
diagnosis of 304b
major 252f
minor 252f
trait 259, 303
Thiosulphate citrate bile-salt sucrose 138
Thoracentesis 110
therapeutic 110
Thoracoscopy 113
Thrombin receptor blocker 360
Thrombin time 437
principle of 355f
Thrombocythemia, essential 333
Thrombocytopenia 344, 352
detection of 216
evaluation of 351f
heparin-induced 345, 366
inherited 221b
isolated 268
Thrombocytosis 244, 268
Thrombophilia 177, 362, 366
acquired 365
diagnosis of 367
inherited 177, 363, 363t
testing
general principles of 367b
indications for 367
limitations of 367
tests for 366
Thrombophlebitis
migratory superficial 366
superficial 404
Thromboplastin generation test 437
Thrombopoiesis 208
Thrombotic disorders, inherited 362t
Thrombotic thrombocytopenic purpura 312, 345
Thyroid
adenomas 162
antibody testing, indications for 166b
autoantibodies 166
diseases 161
disorders 96, 161
terminologies in 161b
dysgenesis 163
failure of 163
follicle 159
histology of 159f
peroxidise 160
stimulating hormone 160, 163, 164, 168, 183
Thyroid function 161
assessment of 165
tests 159, 162b, 164, 164b, 176
interpretation of 166t
Thyroid gland 159, 160, 165
anatomy of 159f
enlargement of 161
Thyroid hormone 159
binding proteins, disorders of 161b
biosynthesis of 159
functions of 159
metabolism of 160
production, regulation of 160f
synthesis of 159, 160f
Thyroiditis 162
granulomatous 163
subacute 163
Thyrotoxicosis 162
causes of 162t
Thyrotropin-releasing hormone 160, 163, 164
stimulation test 165
Thyroxine 59, 159
binding globulin 160, 161, 165, 175
total 165
Tibia 269
Ticlopidine 402
Tissue
factor pathway inhibitor 342
necrosis 254
thromboplastin inhibition test 365, 437
Toluidine blue stain 327
Total iron binding capacity 294
Total leukocyte count 103, 118, 234, 327
Total porphyrins, test for 372
Tourniquet 5, 211
test 290, 434
Toxic
adenoma 162
chemicals 14
granules 253, 253f
multinodular goiter 162, 166
peroxide, detoxification of 205f
Toxoplasmosis 196
Transfusion
adverse effects of 425, 425t
hemosiderosis 427
medicine 208
types of antibodies in 413b
reaction 428
records 416
Transvaginal ultrasound 174
Transvenous liver biopsy 85
Traumatic lumbar puncture 102t
Traumatic tap 105
Traveller's diarrhea 128
Treponema pallidum 176, 408, 411, 428
Trichomonas vaginalis 38
Trichrome stain 131f
modified 133
Trichuris trichiura 134
egg of 135f
Triglycerides 7, 86
Triiodothyronine 165
Trisodium citrate 213
Trisomy 171, 173
Tropheryma whipplei 152
Trophoblastic disease, gestational 170
Trophozoite 130, 131f, 132, 137
nucleus 131
Tropical eosinophilia 255
Troponins 96
regulate 96
True chylous effusion 110, 111, 111t
Trypanosomes 257
Tubal block 185
Tubeless gastric analysis 148
Tuberculin test 435
Tuberculosis 185, 196
extrapulmonary isolated organ 194
mycobacterium 106, 112, 123, 291
Tuberculous pleural effusion 113
Tubular fibrosis 180
Tubular function 53
Tubular necrosis acute 53t
Tubular proteinuria 22, 23, 23f, 53
Tumor
cells 382
necrosis factor 208
Turbid fluid 114
Turk cell 437
Turner's syndrome 182
Typhoid fever 194, 196, 234
Tyrosine
crystals 42
iodination of 160
U
Ulcer
benign 146
endoscopic biopsy of 132
malignant 146
Ulex europaeus plant 386, 388
Ultrasonography 182
Umbilical stump bleeding 350
Uninucleate cyst 131f
Unlyzed red cells 223
Upshaw-Schulman syndrome 345
Urea
blood level of 50
breath test 146, 437
clearance 48
clot solubility test 359, 437
formation of 50f
Urease-Berthelot reaction 51
Uric acid crystals 40
Urinalysis 16, 175, 195
indications for 16
types of microscopy for 35t
Urinary albumin excretion 45, 68
Urinary casts 39f, 40t
Urinary indicant, test for 154
Urinary pH, measurement of 22
Urinary sediment
eosinophils in 434
microscopic examination of 32
types of 34f
Urinary tract
infection 16, 19, 33, 37t
liquid biopsy of 34
lower 22
obstruction of 51
Urine 28f, 29f, 372, 437
abnormal 41t
bilirubin 77
chemical examination of 21
collection of 16, 17, 17b
crystals 41t
culture 175, 195
examination of 16
glucose 26
ketones 28
myoglobin in 32f
organisms in 37f
osmolality 54
physical examination of 18b
preservatives 17
protein electrophoresis 25f, 337, 339
red blood cell 31, 436
sample
collection of 16
random 24
sediment 35f
examination 35
staining of 33f
specific gravity of 20b, 53
turbid 19t
urobilinogen, usefulness of 29f
Urinometer method 19, 20f
Urinothorax 110
Urobilinogen 30, 31f, 77
in urine, tests for detection of 31
test for 141
Uropathy, obstructive 110
Uterine
abnormalities 177
anomalies 185
malformations 182
status 184
Uterus 182
V
Vagina 192
Vaginal cytology 183
Vagotomy 145
Vanillylmandelic acid 437
Varicella 402
Vas deferens 186
Vascular disorders 350t
Vascular endothelial growth factor 337
Vascular thrombosis 177
Vasectomy, check effectiveness of 192
Vasovagal attack 404
Venepuncture site 211
Venepuncture, complications of 212
Venereal disease research laboratory slide test 176, 411
principle of 412f
Venous blood 218
collection 210
Venous thromboembolism, diagnosis of 368b
Vibrio cholerae 128, 138, 143
Vicia graminea 386
Villous adenoma 129
Villous lymphocytes 336
Vim-Silverman liver biopsy needle 83f
Virchow's triad 362, 362f
Virus 143, 409
infects immature dendritic cells 289
Visceral leishmaniasis 196, 286, 288f
Viscosity 118, 187
Visual appearance 187
Visual methods 227
Vitamin
assays 298
B12 317
deficiency 297f, 298t
metabolism, normal 295
fat-soluble 152
K
antagonist 360
deficiency 348
Vivax infection 281f
Voluminous rice water diarrhea 128
Vomiting 404
von Willebrand disease 346, 347, 357f
classification of 348t
tests for 359t
von Willebrand factor 312, 340, 359
Vorapaxar 360
W
Wafer cell 435
Waldenstrom macroglobulinemia 336
Warfarin 360, 402
therapy 360
Warm antibodies 413
Waste products 127
Water
deprivation test 54, 437
loading test 437
Watson-Schwartz test 32f, 437
Waxy cast 38, 39f, 437
Wegener's granulomatosis 56, 433
Weibel-Palade bodies 340
Westergren method 262
Western blot test 292, 437
Westgard multirules 13t
Wharton's jelly 215
Whipple's disease 152
White blood cell 35, 36f, 205, 208f, 257
casts 437
count 216
histogram 220f, 222
parameters 220
White cell 248, 251
abnormalities 351
cast 39, 39f
fragments of 223
Whole blood 420
activated clotting time 360
donation, single 420
donors, types of 400
transfusion 422t
Widal test 437
Wiener and Fisher-race systems 392t
Wiener theory 391f
Willis-Ekbom disease 294
Wilson's disease 81, 82, 84
Wintrobe hematocrit tubes, anticoagulated blood-filled 232f
Wintrobe
method 231, 263
mixture 213
tube 231, 233
Wiskott-Aldrich syndrome 351, 357
Wolff-Chaikoff effect 163
Wound healing, defective 350
Wuchereria bancrofti 283, 284, 285
life cycle of 284f
X
Xanthochromia 102, 437
X-linked disorders 173
X-linked erythropoietic protoporphyria 369, 370
Xylose lysine deoxycholate 137
Y
Yeast cells 37
Yellow fever 234, 289
Yersinia 127, 137
enterocolitica 138, 408, 426
pestis 125
Yolk sac 169
Z
Ziehl-Neelsen smear 106
Ziehl-Neelsen stain 106, 112, 123, 124f, 124, 125, 274
modified 133
sputum smear 123
Ziehl-Neelsen technique 123
Zika 289
Zollinger-Ellison syndrome 145, 148
diagnosis of 157
Zona pellucida 178
Zygote 132
intrafallopian transfer 185
travels 169
Zymogen granules 155
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