Adult Immunization in Office Practice Naveen Thacker, Niranjan Shendurnikar, Abhay K Shah, Tushar P Shah
INDEX
Page numbers followed by b refer to box, f refer to figure, and t refer to table.
A
Abdala 168
Accidental needle stick injuries 82
Acellular pertussis vaccine 18
Acquired immunodeficiency syndrome 75, 121, 188
Acute flaccid paralysis 41
Acute hypersensitivity reaction 41
Acute respiratory distress syndrome 73
Adaptive system 16
Adenovirus vectored vaccines 172
Adult vaccination 63
center, set-up of 48f
Adverse events following immunization 39, 42t, 48
grades of 40t
surveillance system 39
types of 39t
Advisory Committee on Immunization Practices 23, 39, 62, 69, 85, 89, 113, 127, 139, 142, 144, 160
Aedes aegypti 122
Aedes albopictus 122
Alcoholism 88
Allergy 148
Aluminum hydroxide 19
American Diabetes Association 144
Anaphylactoid reaction 41
Anaphylaxis 41
Antibody 16, 168
Antigen 16
presenting cells 16, 189
Anti-pertussis toxin 67
Anti-rabies
vaccination 121
vaccine 117, 160
Antivaxxers 60
Anxiety 27, 41
Arthritis 176
ASHA workers 62
Asian flu 74
Asplenia 130, 142, 146
congenital 88
Association of Physicians of India 78, 92, 128, 150
Asthma 88, 144
Astrazeneca vaccine 167, 180
Autonomy 61
B
Bacillus Calmette-Guérin 17, 19, 31, 33, 41, 188
B-cells 16
Biomedical Waste Management Rules 28, 28t
Bleeding disorder 142, 148
Blood products, antibody-containing 146
Body mass index 21
Bone marrow transplant 142
Bordetella pertussis 190
Bronchial asthma 78
C
Cancer 78, 188
chemotherapy 145
Cansino vaccine 167, 171173
Cardiomyopathies 88
Cell culture vaccines 118
Centers for Disease Control and Prevention 24, 59, 114, 123, 129, 150, 159, 176
Central Bureau of Health Intelligence 67
Cerebrospinal fluid leak 88
Cervical cancer 12, 105
Chemotherapy 142
Chickenpox 4, 9, 109, 112
infection 109
Chinese hamster ovary cells 168
Cholera 127, 158
public health impact of 130
vaccine 131, 160
Chronic obstructive pulmonary disease 12, 78, 88, 142, 144
Cirrhosis 88
Coadministered vaccine 21
Cold chain 30
components of 31
maintenance 30
Common cold 73
Complement deficiencies 88
Conjugate pneumococcal vaccine 87
Continuous temperature recording devices 37
Corbevax 168170, 173
Coronavac 166, 180
Coronavirus disease 2019 (COVID-19) 9, 47, 151, 158, 165, 172, 174178
infection 180
pandemic 3, 9, 22, 24, 45, 47, 50, 53, 56, 58, 61
spread 22
vaccination 22, 45, 59, 60, 61, 78, 155, 161, 165, 170, 172, 172b, 174178, 184, 185
guideline 161
vaccine 45, 141, 169171, 173179, 181, 182, 184, 186
booster doses of 182, 183
composition 186
contraindications of 176
development of 165
side effects of 170
Covavax 173
Covaxin 166, 169, 170, 173, 174, 180, 181
Covishield 167, 169171, 173, 176, 177, 181
Covovax 168
Cowpox 59
Cuba's abdala 168
Curevac vaccine 167, 171
Cytokines 16
Cytolytic molecules 16
D
Damage-associated molecular patterns 170
Danger signals 16
Death 41
Delta variants 179, 182
Dengue 123
fever 122
infections 122
vaccine 122125, 139, 140
position of 126
Dengvaxia 123, 140
efficacy of 123
Deoxyribonucleic acid 16
vaccines 125, 166
Diabetes mellitus 12, 78, 88
Digital data loggers 37
Digital maximum-minimum thermometers 36, 37f
Diphtheria 9, 67, 68
and tetanus 18, 33, 35
pertussis, and tetanus 9, 33, 35, 60, 67, 138
and tetanus vaccine 67
E
Ebola virus 18, 165
Emergency use authorization 165, 169
Empathy 55
Emphysema 88
Encephalitis 73
Encephalopathy 41
Eosinophils 16
Equine rabies immunoglobulin 119
Escherichia coli 125, 192
F
Fainting 41
Febrile seizures 41
Fever 42, 176
enteric 9, 13
Filamentous hemagglutinin 70
Flu 73
vaccine 73, 78
Food and Drug Administration 76
Fresh frozen plasma 146
G
Gamalaya 167, 171, 173
Gastrointestinal system 194
Gender neutral vaccination 108
Geometric mean titers 17, 181
Geriatric Society of India 92
Gluteal muscle 25
Graft versus host disease 145
Granulomatous disease, chronic 88
Guillain-Barré syndrome 22, 78, 172, 173
H
H1N1 3, 7476
H2N2 74
H3N2 7376
Haemophilus influenzae B 16, 19, 33, 82, 127, 129, 145, 146
Healthcare professional 45, 53, 150
Heart
disease 78, 88
failure, congestive 88
Hemagglutinin 74
Hematopoietic stem cell transplantation 145, 192
Hemoglobinopathies 88
Hepatitis 33
A 4, 9, 13, 24, 101, 137, 140, 143, 145, 151
adult 4
vaccination 102, 103
vaccine 11, 35, 101103, 160
virus infection 101, 102, 144
B 9, 11, 24, 27, 28, 137, 143, 145, 151, 152
chronic 86
immunoglobulin 84, 153
infection 4, 81, 82, 84
surface antigen 153
vaccination, current status of 84
vaccine 35, 81, 84, 140, 151, 153t, 189
virus 15, 19, 81, 83, 84, 144
C 27, 28, 81, 137
vaccine, role of 103
Herpes viruses 188
Herpes zoster 5, 13, 113, 114
vaccine, common adverse effects of 114
Hong Kong flu 74
Human cytomegalovirus disease 192
Human immune system 15
Human immunodeficiency virus 27, 28, 75, 88, 105, 112, 121, 142, 151, 188
infection 88
Human papillomavirus 7, 18, 19, 24, 40, 105, 106, 137, 145, 188
infection 9, 105
vaccination 107
vaccine 105107, 139
bivalent 106
Hypertension 88
Hypotonic hyporesponsive episode 41, 42
I
Immune system 15
pathogenesis of 122
role of 122
Immunity 6
active 15
cell-mediated 16, 110, 143
cellular 16
herd 20, 21f
humoral 16
passive 15
sterile 6
vaccine-induced 178
Immunization 3, 7
adult 46, 57
general aspects of 1
Immunocompetent host 142
Immunoglobulin
A 194
G 67
intravenous 146
M 110
Immunologic memory 18
Immunosuppressive therapy 142
Inactivated influenza vaccine 78
composition of 75
high-dose 75
Inactivated Kolar strain 132
Inactivated polio vaccine 33, 60, 82, 145, 148, 151, 158
Inactivated vaccine 19, 173
platform 166t
Inactivated whole virion vaccines 166
Indian Academy of Pediatrics 4
Indian Association of Occupational Health 93, 150
Indian Council of Medical Research 124, 191
Indian Medical Association 93, 150
Indian Society of Nephrology 93
Infectious diseases 3
Influenza 9, 33, 73, 151
A virus 74, 75
antigenic subtypes of 74t
illness 75
infection 74
prevention of 75
vaccination, benefits of 152
vaccine 73, 7679, 79t, 151
dosage schedule of 76
safety data of 78
virus
A 3, 73
B 73
C 73
importance of 73
Injectable polio vaccine 155
Injection site abscess 41, 42
Innate immune system 16
Innate T-cells 16
Integrated digital thermometer 36
Intensive care unit 178
Intussusception 41
Invasive pneumococcal disease 12, 87, 88b
Isothermic cold boxes 31, 36
J
J&J 167, 173, 180
Janssen 169, 180
coronavirus disease 2019
(COVID-19) vaccine 167
Japanese encephalitis 19, 127, 131, 132
vaccine 3, 132, 155, 158
K
Kidney disease 78
chronic 141, 144
L
Lactation 142
Light-sensitive vaccines 35
Live oral Ty21A typhoid vaccine 96
Live-attenuated vaccine 18, 75, 76, 125, 132, 146
Liver disease 78
chronic 88, 103, 142, 144
Lower respiratory tract infections 12
Lymphadenitis 41
M
Malaria Policy Advisory Committee 190
Malaria vaccine 190
Malignancies 142
Measles 151
mumps, and rubella 19, 24, 33, 40, 61, 107, 127, 140, 142, 145, 151
vaccine 110, 140, 151
rubella 60, 153
vaccine 158
Meningococcal conjugate vaccine 127, 129
Meningococcal disease 9, 129
prevention 154
Meningococcal meningitis 11
Meningococcal polysaccharide vaccine 130
Meningococcal vaccine 130, 152, 154, 159
recommendation of 130
Microarray patches 195
Micronutrient deficiency 21
Middle east respiratory syndrome coronavirus 165
Misconceptions 53
Moderna 167, 169, 171, 172, 180
Monocytes 16
mRNA vaccines 166, 173
Mucosa-associated lymphoid tissues 193
Mucosal vaccination 193
Multisystem inflammatory syndrome 177
Mumps 151
Mycobacterium tuberculosis 188
Myocarditis 73
Myositis 73
N
National Action Plan for Dog Mediated Rabies Elimination 121
National Immunization Program 10, 45, 52, 61, 87, 140
National Institute of Allergy and Infectious Diseases 125, 166
National Vaccine Advisory Committee of Centre for Disease Control 28
National Vector Borne Disease Control Program 132
Natural killer T-cells 16, 191
Needle stick injuries 85
Needle-free injector system 169
Neglected tropical diseases 116
Neisseria meningitidis 11, 129, 152, 188
Neuralgia, postherpetic 114
Neuraminidase 74
Neuritis, brachial 41
Neurotropic human varicella-zoster virus 109
Neutrophils 16
Nonsteroidal anti-inflammatory drugs 177
Northern hemisphere pattern 74, 77f
Novavax 168, 173, 180
O
Omicron variants 179, 182, 185
O-phthaldialdehyde 90
Oral immunization, limitations of 194
Oral polio vaccine 33, 60, 146, 160
bivalent 158
Oral typhoid vaccine 146
Osteitis 41
Osteomyelitis 41
P
Papillomatosis, respiratory 106
Paratyphoid vaccine 191
Passive immunization 119
Pathogen-associated molecular patterns 170
Pertussis 9, 67, 68, 151, 188
Pfizer 167, 169, 171, 172, 180
Phagocytic disorders 88
Plasmodium falciparum 190
Pneumococcal conjugate vaccine 88, 143, 145
Pneumococcal disease 9, 12
Pneumococcal infection 87
Pneumococcal pneumonia 5
Pneumococcal polysaccharide 148
vaccine 88
Pneumococcal vaccination 93
Pneumococcal vaccine 12, 87, 89, 92, 93
Pneumonia, community-acquired 90
Polio 151, 158
vaccine 160
Poliomyelitis, inactivated 107
Polysaccharide 18
conjugated 18
Postexposure prophylaxis 117, 119t
Posthematopoietic stem cell transplantation 145t
Pregnancy 142
Protein 18
subunit vaccines 166, 168, 173
Pseudomonas aeruginosa 96
Public health disease surveillance 8
Q
Quadrivalent vaccine 107
R
Rabies 9, 116, 151
exposure, categories of 117t
immunoglobulin 117
monoclonal antibody 117
passive immunization 119
prophylaxis 117
vaccination 121
vaccine 116, 152, 155, 160, 190, 191
Radiotherapy 142, 145
Randomized controlled trial 90
Recombinant viral vector vaccines 166
Renal disease, chronic 144
Research Society for Study of Diabetes in India 93
Respiratory syncytial virus 22
Reverse transcription polymerase chain reaction 185
Rheumatoid arthritis 175
Rituxan therapy 175
Rituximab 175
Rubella 9, 13, 151
syndrome, congenital 137
S
Saccharomyces cerevisiae 82
Salmonella
enterica serovar typhi 95
paratyphi 191
typhi 95, 154, 191
Seizures 41, 42
Sepsis 41
Severe acute respiratory syndrome coronavirus 2 4, 19, 175
virus 24, 165, 185
Sexually transmitted infection 105
Shigella
flexneri 192
sonnei 192
Shingles 9
Sickle cell disease 88
Sinopharm 166, 171, 174, 184
Sinovac 166, 171, 174
Solid organ transplant 142, 145
Southern hemisphere pattern 74, 77f
Spanish flu 74
Splenectomy 88, 142
Splenic dysfunction 88
Spodoptera frugiperda 76
Sputnik-V 167, 169171, 173, 180
Staphylococcus aureus 192
Stem thermometer 36
Steroids 142
Streptococcus pneumococci 87
Streptococcus pneumoniae 12, 73, 87, 143, 188
Swine flu 74
Sympathy 55
Systemic inflammatory response syndrome 73
T
T-cells 16, 83, 122, 189, 191
activation 15
immunity 185
Temperature monitoring devices 36
Tetanus 9, 67, 68
diphtheria, and pertussis 67, 68, 151
vaccine 138, 151
maternal 10
neonatal 10
prophylaxis 71t
toxoid 24, 31, 35, 35, 138
Tetravalent vaccines 76, 193
Thrombocytopenia 41
heparin-induced 176
T-lymphocyte deficiency 88
Toxic shock syndrome 41
Travel medicine 7
Triplex vaccine 192
Trivalent influenza vaccine 76
Tuberculosis 188
Tumor necrosis factor-alpha 171
Typhoid 96, 151
conjugate vaccine 19, 96, 98, 151
fever 95, 99
polysaccharide vaccine 160
vaccination 96
vaccine 9599, 154
U
Universal Human Pre-Exposure Immunization Against Rabies 12
Universal Immunization Programme 3, 154
V
Vaccination
route 21
schedule 21
Vaccine 35, 45, 157
administration 23
behavior, spectrum of 62, 63f
carrier 31
delivery
reduced pain of 195
system 194, 195
failure 20
general aspect of 1
hesitancy 56
determinants of 62
induced thrombotic thrombocytopenia 172, 173
platforms 166f
preventable diseases 9, 15, 39, 45, 67, 127f, 142, 150, 157
epidemiology of 9
protection, correlate of 20
storage 30
types of 19, 19t, 79
vial monitor 37, 37f
Varicella 4, 13, 109, 151
disease 112
infection 109, 110
vaccine 109, 110, 112, 113, 151
safety profile of 111
virus 6
zoster
immunoglobulin 113
virus 109, 140
Vaxchora 130
Vibrio cholerae 130, 196
Viral vector vaccines 125, 167, 173
pros and cons of 173
W
Whole cell pertussis vaccines 138
Whooping cough 9
World Health Organization 46, 56, 77, 81, 87, 96, 101, 116, 137, 150, 153, 154, 157, 179, 182
categories 117t
World Rabies Day 121
Wound management 71t, 117
Y
Yellow fever 18, 148, 158, 161
vaccination 158, 159
vaccine 159
Z
Zika virus 165
Zoster vaccines 5, 109, 114
types of 114
Zycov-D 168170, 173
×
Chapter Notes

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Adult Immunization in Office Practice
Adult Immunization in Office Practice
Editors Tushar P Shah MD (Pediatrics) (Gold Medalist) LLB Director Department of Clinical Research Kashiben Gordhandas Patel Children Hospital Chief Consultant and Director Navkar Children Hospital Vadodara, Gujarat, India Abhay K Shah MD (Gold Medalist) D Ped (Uni first) FIAP Senior Pediatrician and Infectious Disease Consultant Director Dr Abhay K Shah Children Hospital Ahmedabad, Gujarat, India Academic Editors Niranjan Shendurnikar MD (Pediatrics) FIAP Child Health Consultant Ankur Maternity Hospital Vadodara, Gujarat, India Naveen Thacker MD (Pediatrics) FIAP Consultant Pediatrician and Director Deep Children Hospital and Research Centre Kutch, Gujarat, India Foreword Stanley A Plotkin
Jaypee Brothers Medical Publishers (P) Ltd.
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Adult Immunization in Office Practice
First Edition: 2023
9789354656491
Printed at:
All the selfless and undaunted Corona Warriors
who continue to confront the pandemic
with their resolve, strength and courageous efforts
to value and fight save millions of human lives.
All those who have helped and are continuing
in doing research, preparation, distribution and delivery
of the COVID-19 vaccines in billions of doses globally.
Contributors Foreword
Routine pediatric vaccination practiced throughout the world has changed the face of human life to the point that in most countries a newborn child is very likely to survive to adulthood. Only the elderly among us can remember when surviving childhood was a signal accomplishment. Now children in almost every country in the world receive the benefits of vaccination. However, the situation in adults is quite different, as has been starkly clear during the COVID-19 pandemic. First, vaccines for adults have not been uniformly available in every country, and second, adults have not uniformly known about the need for vaccination. There has been a third factor, too that is the ignorance about vaccination by physicians who do not take care of children.
Vaccination against diseases such as influenza is obviously important at all ages, and catch-up vaccination of adults who have missed vaccines as children is sometimes necessary, but certain vaccines are aimed specifically at the adult age group, including those against human papillomaviruses, meningococcal, group B pneumococci, and zoster.
It must be borne in mind that vaccination is particularly important in older adults, in whom senescence of the immune system is an important phenomenon that increases the danger of infection. That phenomenon has been quite important during the COVID-19 outbreak, but it plays a role with all infectious diseases of the elderly. Moreover, vaccination of children has allowed more of them to survive into adulthood, and so they also need protection from adult diseases.
As one who first visited India in the 1960s, I have witnessed there, the growth of the vaccine industry and an increase in vaccine experts and vaccine expertise. This book will serve to augment vaccination of adults not only in India but also in neighboring countries in which vaccine-preventable diseases continue to occur, and in which increased knowledge of vaccines will help to decrease mortality and disease.
Stanley A Plotkin MD
Emeritus Professor
Department of Pediatrics
University of Pennsylvania
Philadelphia, Pennsylvania, USA
Preface
Vaccines and immunization continue to be of significant importance for public health all over the world. A series of measures such as improvement in routine immunization coverage, disease surveillance and adverse events following immunization (AEFI) reporting systems, capacity building of healthcare workers continually improves the vaccine delivery to children and pregnant women. Yet the needs and potential benefits of vaccines and immunization for adults are much undervalued and even ignored both by the public at large and the healthcare providers.
In spite of scientific advances and improved coverage in children, the knowledge, information, and practices on vaccines and immunization have largely focused on children without any significant and systematic approach to address the needs of vaccines beyond this age group. Even in the many affluent and developed nations with successful and coordinated childhood immunization programs, the vaccine coverage beyond the pediatric age group has remained suboptimal leaving a significant gap in the protection provided by the vaccines to the community at large. Available information has shown that a doctor's recommendation is the single most important factor in improving vaccination rates.
With the COVID-19 pandemic and development of vaccines against it, the concept of prevention got a shot in the arm and a paradigm shift to increase a general awareness and relevance about the role of vaccines in the prevention of morbidity and mortality in adult populations too. At the same time, the changing demography, prevalence of lifestyle diseases, epidemiological shift of vaccine-preventable diseases (VPDs), increasing life expectancy of the people and national health economics are the potential driving forces to reap the immense and expandable but unfulfilled benefits which the science and technology of vaccines has to offer to all those eligible adults. Unlike routine childhood immunizations, the needs and recommendations for adults would vary and be based upon on the age, prior vaccinations, existing health conditions, medication history, lifestyle, occupation, travel, and exposure. It is time now that adult vaccinations and their practice need to be planned and implemented to become an inclusive national health priority.
Healthcare professionals belonging to wide spectra of clinical medicine and its different specialties can be effective partners in generating awareness to the public at large beyond the traditionally targeted age groups to maximize the full benefits of life-saving interventions that vaccines offer. With the ease of availability of online information to lay public, its acceptance or otherwise would need to be scrutinized for practical implications. Beyond the childhood, vaccinations need to become a tool for healthy aging.
The book has been purposefully written in a Question–Answer format and as a ready-reckoner to simplify the available literature, to be easy to read and practice and to include the essential and practical aspects of vaccines and immunization from an adult perspective. This should hopefully be a helpful and an updated guide to further an awareness and skills in the use of vaccines for the adults. Eminent contributors from different medical specialties have come together in this book to collate available evidence and guidelines in the present context as a practice tool for adult vaccinology. The basics of immunization, individual vaccines, the use of vaccines in special situations, and COVID-19 vaccine and its evolving recommendations thus form an integral part of the book. The book should be practically useful to different medical doctors from general practitioners including family physicians, consultants, and super-specialists.
We earnestly anticipate and hope that the book serves its purpose to spread the awareness about vaccines to be a routine component part of health care in adults and elderly, and decrease the burden of infectious diseases in the people. The provider and the patient education along with public health policies can become a promising endeavor and a future road map of healthy life of adulthood. The challenges are ubiquitous, but an active collaboration between government/private sector, different stakeholders and policy makers can facilitate the vaccine access to eligible adults contributing to strengthening adult immunization practices in the years ahead.
Tushar P Shah
Abhay K Shah
Niranjan Shendurnikar
Naveen Thacker
Acknowledgments
At the completion of our prestigious project, we the editors feel overwhelmed when we look back, over the past few weeks which have become our glittering memorable days in a synchrony of an endeavor and a sense of fulfilment.
As such, the idea of a book dealing with a relatively dormant topic on adult immunization could have not been conceived and delivered, unless there were committed contributors who were from different specialties to deal with the subject within the given time frame.
When Dr Stanley A Plotkin, the Father of Modern Vaccinology and Professor Emeritus of Virology, University of Pennsylvania, USA, readily agreed to pen a foreword for the book, we felt truly honored and blessed and felt a push within ourselves to make our efforts as perfect and as flawless as possible. For a tireless advocate, researcher and a crusader that Dr Plotkin is, since 1957 for the protection of human beings against infectious diseases, the words can never be enough to express our honest gratitude to him.
We have been extremely fortunate to have contributions from a wide range of eminent researchers, public health experts, medical specialists, young budding consultants, and other faculties to spare their valuable time and give us an updated and value-based additions to the contents of the book. Even within a shortened time-frame, they have always responded quickly and helped us in a positive manner. Their contributions reflect dedication, commitment, and expertise in vaccines and immunization. We owe them our gratitude.
We sincerely appreciate and acknowledge continued assistance and encouragement from Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Ms Chetna Malhotra (Senior Director—Professional Publishing, Marketing and Business Development), Ms Pooja Bhandari (Production Head), and Dr Rajul Jain (Development Editor) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, throughout for efforts in ensuring the quality and the publication of this book in a timely manner.
The selfless support from our family members for bearing with us and busy schedules is also sincerely acknowledged and that has acted like a “booster shot” to keep us energized, motivated and on the go!