Adult Immunization in Office Practice
Adult Immunization in Office Practice
Editors
Tushar P Shah MD (Pediatrics) (Gold Medalist) LLB
Director Department of Clinical Research Kashiben Gordhandas Patel Children Hospital Chief Consultant and Director Navkar Children Hospital Vadodara, Gujarat, India
Abhay K Shah MD (Gold Medalist) D Ped (Uni first) FIAP
Senior Pediatrician and Infectious Disease Consultant Director Dr Abhay K Shah Children Hospital Ahmedabad, Gujarat, India
Academic Editors
Niranjan Shendurnikar MD (Pediatrics) FIAP
Child Health Consultant Ankur Maternity Hospital Vadodara, Gujarat, India
Naveen Thacker MD (Pediatrics) FIAP
Consultant Pediatrician and Director Deep Children Hospital and Research Centre Kutch, Gujarat, India
Foreword
Stanley A Plotkin

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Adult Immunization in Office Practice
First Edition: 2023
9789354656491
Printed at:
All the selfless and undaunted Corona Warriors
who continue to confront the pandemic
with their resolve, strength and courageous efforts
to value and fight save millions of human lives.
All those who have helped and are continuing
in doing research, preparation, distribution and delivery
of the COVID-19 vaccines in billions of doses globally.
- Aashay A Shah MD (Pediatrics)
- Pediatric Gastroenterologist and Hepatologist
- Narayana Multispecialty Hospital
- Ahmedabad, Gujarat, India
- Abhay K Shah MD (Gold Medalist)
- D Ped (Uni first) FIAP
- Senior Pediatrician and Infectious Disease Consultant
- Director
- Dr Abhay K Shah Children Hospital
- Ahmedabad, Gujarat, India
- Arun Wadhwa MD (Pediatrics)
- Consultant Pediatrician
- Rainbow Children Hospital
- New Delhi, India
- Baijul Desai DNB (Pediatrics)
- Clinical Associate
- Department of Pediatrics
- PD Hinduja Hospital
- Mumbai, Maharashtra, India
- Bhaskar Shenoy MD (Pediatrics)
- Head
- Department of Pediatrics
- Chief, Division of Infectious Disease
- Manipal Hospitals
- Bengaluru, Karnataka, India
- Bhavesh Patel MD (Medicine)
- Consultant Physician
- Dr Bhavesh Patel Hospital
- Vadodara, Gujarat, India
- Brajendra Mishra
- MD (Community Medicine)
- Professor and Head
- Department of Community Medicine
- LN Medical College and JK Hospital
- Bhopal, Madhya Pradesh, India
- Chandrakant Lahariya
- MD (Community Medicine) MBA PGDHHM
- Founder and Executive Director
- Foundation for People-Centric Health Systems
- New Delhi, India
- Chandra Mohan Kumar
- MD (Pediatrics) FIAP MAMS
- Additional Professor
- Department of Pediatrics
- All India Institute of Medical Sciences
- Patna, Bihar, India
- Chitra Pandya
- MD (Community Medicine) Dip in Comm Mental Health
- Founder
- Medicine Beyond Classroom
- Varun Complete Healthcare
- Vadodara, Gujarat, India
- Chittranjan C Chaubal
- MD (Medicine) DM (Gastroenterology)
- Professor and Head
- Department of Medicine
- People's College of Medical Sciences and Research Centre
- Bhopal, Madhya Pradesh, India
- Deepak Saxena
- MD (Community Medicine) PhD (Epidemiology)
- Professor
- Indian Institute of Public Health
- Gandhinagar, Gujarat, India
- Digant D Shastri
- MD (Pediatrics) FIAP
- Chief Pediatrician and CEO
- Killol Clinic and Vaccination Center
- Surat, Gujarat, India
- Divya Dave MD (Pediatrics)
- Associate Professor
- Department of Pediatrics
- Government Medical College
- Vadodara, Gujarat, India
- GK Agrawal MD (Pediatrics) DCH
- Consultant Pediatrician
- Department of Pediatrics
- Carewell Multispeciality Hospital
- Bhopal, Madhya Pradesh, India
- K Dhanalakshmi
- DNB (Pediatrics)
- Consultant Pediatrician
- Department of Pediatrics and Pediatric Infectious Diseases
- Kanchi Kamakoti CHILDS Trust Hospital
- Chennai, Tamil Nadu, India
- Meera Shah MD (Medicine)
- Senior Resident
- Department of Medicine and Division of Rheumatology
- SVP Hospital
- Ahmedabad, Gujarat, India
- M Surendranath
- MD (Pediatrics) DCH FACI FIAP
- Head
- Department of Pediatrics
- Vijay Marie Hospital
- Hyderabad, Talangana, India
- Naveen Thacker
- MD (Pediatrics) FIAP
- Consultant Pediatrician and Director
- Deep Children Hospital and Research Centre
- Kutch, Gujarat, India
- Niranjan Shendurnikar
- MD (Pediatrics) FIAP
- Child Health Consultant
- Ankur Maternity Hospital
- Vadodara, Gujarat, India
- Nitin K Shah MD (Pediatrics) DCH
- Head and Senior Consultant
- Department of Pediatrics
- PD Hinduja Hospital
- Mumbai, Maharashtra, India
- Pankaj D Desai
- MD (Obs & Gyne) FICOG FICMCH
- Consultant Obstetrician and Gynecologist
- Janani Maternity Hospital
- Vadodara, Gujarat, India
- Rama Kaja MD (Pediatrics) DNB
- Faculty
- Vijay Marie Hospital
- Hyderabad, Telangana, India
- Ravi Joshi
- MBBS MD (Pediatrics) FNB
- Associate Consultant
- Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation
- Narayana Health City
- Bengaluru, Karnataka, India
- Rutviz Mistry
- MD DM (Rheumatology)
- Consultant Rheumatologist
- Department of Rheumatology
- KD Hospital
- Ahmedabad, Gujarat, India
- Sagar S Kulkarni
- MD (Pediatrics) DCH DNB
- Director and Consultant Pediatrician
- Bhakti Children Hospital
- Aurangabad, Maharashtra, India
- Sandhya Gupta MD (Physiology)
- Professor
- Department of Physiology
- Institute of Medical Sciences and SUM Hospital
- Siksha ‘O’ Anusandhan
- Bhubaneswar, Odisha, India
- Sandul Yasobant MPH PhD
- Post Doctoral Fellow
- Center for One Health Education, Research and Development (COHERD)
- Indian Institute of Public
- Health Gandhinagar (IIPHG) Gandhinagar, Gujarat, India
- Sapan C Pandya
- MD (Medicine)
- DM (Rheumatology)
- Consultant Rheumatologist
- Department of Rheumatology
- Vedanta Institute of Medical Sciences
- Ahmedabad, Gujarat, India
- Satish V Pandya
- MD (Pediatrics) PGDAP FIAP
- Consultant Pediatrician and Counsellor
- Varun Complete Health Care
- Vadodara, Gujarat, India
- Shalini Pandya MD (Medicine)
- Consultant Physician and Diabetologist
- Department of Endocrinology
- Sterling Hospital
- Ahmedabad, Gujarat, India
- Srinivas G Kasi
- MD (Pediatrics) DCH
- Consultant Pediatrician
- Kasi Clinic
- Bengaluru, Karnataka, India
- Sunil Bhat MBBS MD FPHO
- Director and Head
- Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation
- Narayana Health City
- Bengaluru, Karnataka, India
- T Jacob John
- MBBS DCH FRCP PhD
- Emeritus Professor
- Department of Microbiology and Virology
- Christian Medical College
- Vellore, Tamil Nadu, India
- Tushar P Shah
- MD (Pediatrics) (Gold Medalist) LLB
- Director
- Department of Clinical Research
- Kashiben Gordhandas Patel
- Children Hospital
- Chief Consultant and Director
- Navkar Children Hospital
- Vadodara, Gujarat, India
- Unmesh Upadhyay
- MD (Pediatrics)
- Consultant Pediatrician
- Vismay Childcare Hospital
- Ahmedabad, Gujarat, India
- Urvinder Kaur
- DCH DNB (Pediatrics)
- Pediatric Hemato-oncologist
- KGP Children Hospital
- Vadodara, Gujarat, India
- Venkatarao Epari
- MD (Community Medicine)
- Professor
- Department of Community Medicine
- Institute of Medical Sciences and SUM Hospital
- Siksha ‘O’ Anusandhan
- Bhubaneswar, Odisha, India
- Vipin M Vashishtha
- MD (Pediatrics) FIAP
- Director
- Mangla Hospital and Research Center
- Bijnor, Uttar Pradesh, India
Routine pediatric vaccination practiced throughout the world has changed the face of human life to the point that in most countries a newborn child is very likely to survive to adulthood. Only the elderly among us can remember when surviving childhood was a signal accomplishment. Now children in almost every country in the world receive the benefits of vaccination. However, the situation in adults is quite different, as has been starkly clear during the COVID-19 pandemic. First, vaccines for adults have not been uniformly available in every country, and second, adults have not uniformly known about the need for vaccination. There has been a third factor, too that is the ignorance about vaccination by physicians who do not take care of children.
Vaccination against diseases such as influenza is obviously important at all ages, and catch-up vaccination of adults who have missed vaccines as children is sometimes necessary, but certain vaccines are aimed specifically at the adult age group, including those against human papillomaviruses, meningococcal, group B pneumococci, and zoster.
It must be borne in mind that vaccination is particularly important in older adults, in whom senescence of the immune system is an important phenomenon that increases the danger of infection. That phenomenon has been quite important during the COVID-19 outbreak, but it plays a role with all infectious diseases of the elderly. Moreover, vaccination of children has allowed more of them to survive into adulthood, and so they also need protection from adult diseases.
As one who first visited India in the 1960s, I have witnessed there, the growth of the vaccine industry and an increase in vaccine experts and vaccine expertise. This book will serve to augment vaccination of adults not only in India but also in neighboring countries in which vaccine-preventable diseases continue to occur, and in which increased knowledge of vaccines will help to decrease mortality and disease.
Stanley A Plotkin MD
Emeritus Professor
Department of Pediatrics
University of Pennsylvania
Philadelphia, Pennsylvania, USA
Preface
Vaccines and immunization continue to be of significant importance for public health all over the world. A series of measures such as improvement in routine immunization coverage, disease surveillance and adverse events following immunization (AEFI) reporting systems, capacity building of healthcare workers continually improves the vaccine delivery to children and pregnant women. Yet the needs and potential benefits of vaccines and immunization for adults are much undervalued and even ignored both by the public at large and the healthcare providers.
In spite of scientific advances and improved coverage in children, the knowledge, information, and practices on vaccines and immunization have largely focused on children without any significant and systematic approach to address the needs of vaccines beyond this age group. Even in the many affluent and developed nations with successful and coordinated childhood immunization programs, the vaccine coverage beyond the pediatric age group has remained suboptimal leaving a significant gap in the protection provided by the vaccines to the community at large. Available information has shown that a doctor's recommendation is the single most important factor in improving vaccination rates.
With the COVID-19 pandemic and development of vaccines against it, the concept of prevention got a shot in the arm and a paradigm shift to increase a general awareness and relevance about the role of vaccines in the prevention of morbidity and mortality in adult populations too. At the same time, the changing demography, prevalence of lifestyle diseases, epidemiological shift of vaccine-preventable diseases (VPDs), increasing life expectancy of the people and national health economics are the potential driving forces to reap the immense and expandable but unfulfilled benefits which the science and technology of vaccines has to offer to all those eligible adults. Unlike routine childhood immunizations, the needs and recommendations for adults would vary and be based upon on the age, prior vaccinations, existing health conditions, medication history, lifestyle, occupation, travel, and exposure. It is time now that adult vaccinations and their practice need to be planned and implemented to become an inclusive national health priority.
Healthcare professionals belonging to wide spectra of clinical medicine and its different specialties can be effective partners in generating awareness to the public at large beyond the traditionally targeted age groups to maximize the full benefits of life-saving interventions that vaccines offer. With the ease of availability of online information to lay public, its acceptance or otherwise would need to be scrutinized for practical implications. Beyond the childhood, vaccinations need to become a tool for healthy aging.
The book has been purposefully written in a Question–Answer format and as a ready-reckoner to simplify the available literature, to be easy to read and practice and to include the essential and practical aspects of vaccines and immunization from an adult perspective. This should hopefully be a helpful and an updated guide to further an awareness and skills in the use of vaccines for the adults. Eminent contributors from different medical specialties have come together in this book to collate available evidence and guidelines in the present context as a practice tool for adult vaccinology. The basics of immunization, individual vaccines, the use of vaccines in special situations, and COVID-19 vaccine and its evolving recommendations thus form an integral part of the book. The book should be practically useful to different medical doctors from general practitioners including family physicians, consultants, and super-specialists.
We earnestly anticipate and hope that the book serves its purpose to spread the awareness about vaccines to be a routine component part of health care in adults and elderly, and decrease the burden of infectious diseases in the people. The provider and the patient education along with public health policies can become a promising endeavor and a future road map of healthy life of adulthood. The challenges are ubiquitous, but an active collaboration between government/private sector, different stakeholders and policy makers can facilitate the vaccine access to eligible adults contributing to strengthening adult immunization practices in the years ahead.
Tushar P Shah
Abhay K Shah
Niranjan Shendurnikar
Naveen Thacker
Acknowledgments
At the completion of our prestigious project, we the editors feel overwhelmed when we look back, over the past few weeks which have become our glittering memorable days in a synchrony of an endeavor and a sense of fulfilment.
As such, the idea of a book dealing with a relatively dormant topic on adult immunization could have not been conceived and delivered, unless there were committed contributors who were from different specialties to deal with the subject within the given time frame.
When Dr Stanley A Plotkin, the Father of Modern Vaccinology and Professor Emeritus of Virology, University of Pennsylvania, USA, readily agreed to pen a foreword for the book, we felt truly honored and blessed and felt a push within ourselves to make our efforts as perfect and as flawless as possible. For a tireless advocate, researcher and a crusader that Dr Plotkin is, since 1957 for the protection of human beings against infectious diseases, the words can never be enough to express our honest gratitude to him.
We have been extremely fortunate to have contributions from a wide range of eminent researchers, public health experts, medical specialists, young budding consultants, and other faculties to spare their valuable time and give us an updated and value-based additions to the contents of the book. Even within a shortened time-frame, they have always responded quickly and helped us in a positive manner. Their contributions reflect dedication, commitment, and expertise in vaccines and immunization. We owe them our gratitude.
We sincerely appreciate and acknowledge continued assistance and encouragement from Shri Jitendar P Vij (Group Chairman), Mr Ankit Vij (Managing Director), Ms Chetna Malhotra (Senior Director—Professional Publishing, Marketing and Business Development), Ms Pooja Bhandari (Production Head), and Dr Rajul Jain (Development Editor) of M/s Jaypee Brothers Medical Publishers (P) Ltd, New Delhi, India, throughout for efforts in ensuring the quality and the publication of this book in a timely manner.
The selfless support from our family members for bearing with us and busy schedules is also sincerely acknowledged and that has acted like a “booster shot” to keep us energized, motivated and on the go!