World Clinics Dermatology Fungal Infections Topical Treatments
World Clinics Dermatology Fungal Infections Topical Treatments
Editor-in-Chief
Rashmi Sarkar MD MNAMS
Guest Editor
Surabhi Sinha MD DNB MNAMS
2019 Volume 5 Number 1

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Cover images: (Left) Atypical tinea—Tinea faciei involving unilateral ear lobe. Courtesy: Surabhi Sinha, Sidharth Tandon, Rashmi Sarkar. (Middle) Onychomycosis of all fingernails. Courtesy: Somodyuti Chandra, Indrashis Podder. (Right) Tinea recidivans: New lesions of dermatophytosis occurring at the periphery of the healing lesions. Courtesy: Sheetanshu Kumar, Vinay Keshavamurthy.
WORLD CLINICS DERMATOLOGY: Fungal Infections Topical Treatments
2019, Volume 5, Number 1
ISSN: 2347-7156
9789352709984
Printed in India
Editor-in-Chief
- Rashmi Sarkar MD MNAMS
- Professor
- Department of Dermatology, STD and Leprosy
- Maulana Azad Medical College and Lok Nayak Hospital
- New Delhi, India
Guest Editor
- Surabhi Sinha MD DNB MNAMS
- Consultant Dermatologist
- Department of Dermatology and STD
- Dr Ram Manohar Lohia Hospital and Post Graduate Institute of
- Medical Education Research
- New Delhi, India
Contributing Authors
- Akansha Bhargava MD
- Senior Resident
- Department of Dermatology, Venereology and Leprosy
- Bundelkhand Medical College
- Sagar, Madhya Pradesh, India
- Indrashis Podder MD DNB
- RMO cum Clinical Tutor
- Department of Dermatology
- College of Medicine and Sagore Dutta Hospital
- Kolkata, West Bengal, India
- Isha Narang MD MRCP (SCE)
- Specialist Registrar (Dermatology)
- University Hospitals of Derby and Burton
- United Kingdom
- Mala Bhalla MD
- Professor
- Department of Dermatology, Venereology and Leprosy
- Government Medical College and Hospital
- Chandigarh, Punjab, India
- Monika MD
- Senior Resident
- Department of Dermatology, Venereology and Leprosy
- Government Medical College and Hospital
- Chandigarh, Punjab, India
- Neha Dubey MD
- Consultant Dermatologist
- Medanta The Medicity Hospital and Meraki Skin Clinic
- Gurugram, Haryana, India
- Nisha V Parmar MD
- Specialist Dermatologist
- Department of Dermatology
- Rashid Hospital, Dubai Health Authority
- Dubai, United Arab Emirates
- Priyanka Sharma MD
- Senior Resident
- Department of Dermatology, Venereology and Leprosy
- Government Medical College and Hospital
- Chandigarh, Punjab, India
- Sheetanshu Kumar MD
- Senior Resident
- Department of Dermatology, Venereology and Leprology
- Postgraduate Institute of Medical Education and Research
- Chandigarh, Punjab, India
- Sidharth Tandon MD
- Consultant Dermatologist
- Yashoda Hospital
- Ghaziabad, Uttar Pradesh, India
- Sneha Ghunawat MD DNB
- Consultant Dermatologist and Cosmetologist
- Meraki Skin Clinic
- Gurugram, Haryana, India
- Fellowship ISD, Phillipines
- Clinical Observership, NUH, Singapore, Fellowship IADVL (Trichology)
- Somodyuti Chandra MD DNB SCE (UK)
- Fellow, Venkat Center for Skin and Plastic Surgery
- Bengaluru, Karnataka, India
- Vinay Keshavamurthy MD DNB MRCP MNAMS
- Assistant Professor
- Department of Dermatology, Venereology and Leprology
- Postgraduate Institute of Medical Education and Research
- Chandigarh, Punjab, India
Rashmi Sarkar MD MNAMS
Editor-in-Chief
Fungal diseases are common dermatologic complaints in medical practice and definitely one of the commonest skin infections seen worldwide. Antifungal agents can be used both topically and systemically; however, systemic agents are reserved for more widespread or severe fungal infections. Dermatophytoses are usually amenable to topical agents if localized, but may need oral antifungals if multisite infection is present or the dermatophytosis is at certain areas like soles, nails, or scalp, etc.
Topical antifungals have limited but important indications. Although, the older azoles have been there for long, newer ones like luliconazole, eberconazole and sertaconazole work well in the current scenario, with systemic antifungals according to each individual case.
The current issue of World Clinics in Dermatology 2019 gives a wide insight into older and newer exciting broad-spectrum topical antifungals.
I hope this edition would be equally helpful to practitioners, dermatology departments and students of dermatology, all over the world.
Rashmi Sarkar MD MNAMS
Professor, Department of Dermatology
Maulana Azad Medical College and Lok Nayak Hospital
New Delhi, India
Email: rashmisarkar@gmail.com
© 2019 Jaypee Brothers Medical Publishers. All rights reserved.
Abbreviations
5FC
5-flucytosine
AARS
Aminoacyl tRNA synthetase
AFST
Antifungal susceptibility testings
AmB
Amphotericin B
BMD
Broth microdilution
CC
Clinical cure
CLSI
Clinical and Laboratory Standards Institute
CoC
Complete cure
DC
Dendritic cell
DLSO
Distal subungual onychomycosis
DNA
Deoxyribonucleic acid
EPS
Extracellular polymeric substances
EUCAST
European Committee on Antimicrobial Susceptibility Testing
FDA
Food and Drug Administration
HIV
Human immunodeficiency virus
IFN-γ
interferon-gamma
IgE
Immunoglobulin E
IH
Immediate hypersensitivity
IL-17
Interleukin-17
IL-2
Interleukin-2
ITS
Internal transcribed spacer
KOH
Potassium hydroxide
LFTs
Liver function tests
MALDI-TOF MS
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
MC
Mycological cure
MIC
Minimum inhibitory concentration
NCR
Natural coniferous resin
Nd:YAG
Neodymium: yttrium-aluminium-garnet
NLCs
Nanostructured lipid carriers
OTC
Over-the-counter
PAMP
Pathogen-associated molecular pattern
PCR
Polymerase chain reaction
PD
Pharmacodynamics
PDT
Photodynamic therapy
PK
Pharmacokinetics
POCT
Point-of-care testing
PRR
Pattern recognition receptor
PV
Pityriasis versicolor
RCTs
Randomized controlled trials
RFLP
Restriction fragment length polymorphism
SDD
Susceptible-dose-dependent
SLNs
Solid lipid nanoparticles
SQLE
Squalene epoxidase
STI
Sexually transmitted infection
TCSs
Topical cough suppressants
Th17
T helper 17
Th1
T helper 1
TLR-4
Toll-like receptor 4
TNF-α
Tumor necrosis factor-alpha
TRB
Terbinafine
tRNA
Transfer ribonucleic acid
TTO
Tea tree oil
USFDA
United States Food and Drug Administration
UVA
Ultraviolet A
VVC
Vulvovaginal candidiasis