PG Textbook of Pediatrics Siddarth Ramji, Rakesh Lodha, Piyush Gupta, PSN Menon
INDEX
Page numbers followed by f, t and b refer to figure, table and box, respectively.
A
Aarskog syndrome 823t
Abdominal crisis in sickle cell disease 1862
Abdominal distension 1627
Abdominal migraine 1643, 1656
Abdominal pain 1197, 1626
chronic 16548
chronic functional 16548
Abdominal tuberculosis 1339, 17024
Abetalipoproteinemia 1612, 2534
ABG.See Arterial blood gas
Abnormal uterine bleeding 1188
ABO incompatibility 513
Absence seizure 2442
Academic challenge 1205f
Acanthocyte 1828t
Acellular pertussis vaccine 1273
Achalasia cardia 1645
Achondroplasia 3177
growth hormone for 54
novel treatment for 57t
Acid maltase deficiency 154
Acid peptic disease 165962
Acid poisoning 357
Acid suppression therapy 1650
Acid-base balance
abnormalities of 23642
Acid-base disorders
compensation in 235t
Acid-base equilibrium 2316
Acidified glycerol lysis test 1879
Acidosis
metabolic 238
respiratory 236
ACoRN scoring system 441t
Acoustic stimulation test 502
Acquired immunodeficiency syndrome. See HIV
Acrocyanosis 3054
Acrodermatitis enteropathica 1014, 3096
Acromegaly
heart disease in 2285
Acropustulosis 3109
ACTH stimulation test 2719
Actinomycosis 13256
Activated charcoal 336t
for drug poisoning 340
Activated partial thromboplastin time (aPTT)
reference values for 1726t
Active listening 1201
Active surveillance 1044t
Acute chest syndrome
in sickle cell disease 1863
Acute childhood ataxia 2533
Acute diarrhea. See Diarrhea
Acute disseminated encephalomyelitis (ADEM) 2541
Acute encephalitic syndrome 1447b
Acute flaccid paralysis 1421t, 26037
enteroviral 1416
Acute hematogenous osteomyelitis 3135
Acute hepatitis 17625
etiology of 1762f
Acute inflammatory demyelinating polyneuropathy (AIDP) 2608
Acute intermittent porphyria 150
Acute kidney injury (AKI) 23426
complications of 2345t
drug dosing in 2346
renal replacement therapy for 23478
snakebite induced 367
Acute liver failure 17914
Acute lung injury
ventilation for 321
Acute lymphoblastic leukemia 280410
Acute motor axonal neuropathy (AMAN) 2608
Acute myeloid leukemia 28106
Acute nephritic syndrome. Also See Nephritic syndrome 2321
Acute otitis media 1970
Acute postinfectious measles encephalitis 1374
Acute promyelocytic leukemia 2815
Acute pulmonary histoplasmosis 1552
Acute respiratory distress syndrome 3107
in relapsing fever 1319
management of 315f
ventilation for 322
Acute respiratory infection (ARI) control program 2040
Acute tubular necrosis 2343
Acute watery diarrhea. See Diarrhea
Acylcarnitines 102
Adams forward bending test 3131f
Adapted aerosol delivery 2030t
Adaptive behavior 868t
Adaptive functioning
tests of 870
Addison disease 2718
Adductor angle 593t
Adenoid facies 1989f
Adenoiditis 1988
Adenoma sebaceum 2553f, 3105f
Adenosylcobalamin deficiency 1846
Adenotonsillectomy 1994
ADHD. See Attention deficit hyperactivity disorder
Adie pupil 3015
Adipocyte programming 2792
Adipokines
in obesity 812t
Adiponectin 812t
Admixture lesions 2181, 220713
Adolescence. Also See Adolescent
characteristics of 1143
theories of 1143
Adolescent
cancer in 2797
community counseling programs for 1144
dietary recommendations for 1164
education of 1161
health risk behaviors in 1159
HIV in 1442
homosexuality 1150
injuries in 1176
media literacy of 1161
mental health of 1170
nutrition 1163, 1167f
policies and legislations for 1162
problems of 1144
promoting health of 120711
psychosocial development of 11517
rights of 1143
risk behavior in 1159
risk factors in 1208
substance abuse in 1173
with JIA 2934
Adolescent counseling 1146, 12007
Adolescent education 1211
Adolescent friendly health services 12115
Adolescent growth spurt 751
Adolescent health 3231 Also See RMNCH+A
factors influencing 115863
national health programs for 1213
Adolescent immunization 1146, 1208
Adolescent reproductive and sexual health 1145, 1213
Adoption 320912
ADR. See Adverse drug reaction
Adrenal gland 2720
normal development 270912
physiology 270912
Adrenal crisis 2720
Adrenal insufficiency 271723
in thalassemia 2787
Adrenalitis
autoimmune 2721
Adrenarche 2694t
Adrenocorticotropic hormone (ACTH) 2667
Adrenoleukodystrophy 2721
neonatal 111
Adverse drug reactions 258
Adverse events following immunization (AEFI) 106571
anxiety-related 1066
causality assessment 106970
error-related 1066
management of 1067
prevention of 1068
product related 1066t
quality defect-related 1066t
reporting of 1069t
vaccine-scare related 1067
Advisory Committee for Vaccination 1050
Aedes aegypti 1450
AEFI. See Adverse events following immunization
Aerosol therapy 202933
Antibiotics as 2064
AFP. See Acute flaccid paralysis
AFP surveillance 1422
Agammaglobulinemia 188t
Agenesis
of corpus callosum 2428
of lung 1997
Ages and Stages Screening Questionnaire 845
Agglutination tests 1226
AHA guidelines 2015 281
Aicardi syndrome
ocular manifestations of 3045
AIDS. See HIV
Air displacement plethysmography 811t
Air leaks
in the newborn 6827
ventilator-induced 236
Air pollution 3223
Air transport
of newborn 582
Airway
assessment of 270
management in trauma 381
Airway clearance techniques
for bronchiectasis 2070
in cystic fibrosis 2063
Airway malacia 1998
Airway obstruction
due to adenoids 1989
Airway resistance 1953
AKI. See Acute kidney injury
Alagille syndrome 1733
ocular manifestations of 3046
Albinism 66f, 3076
ocular manifestations of 3041
Albright hereditary osteodystrophy 2781
Albumin
synthesis of 1725
ALCAPA 2161
Aldosterone-related hypertension 2732
Alexander disease 2573
Alkali poisoning 357
DROOL score for 360
Alkaline phosphatase 1724
Alkalosis
chloride depletion 240
metabolic 240
respiratory 237
Alkaptonuria 66f
ocular manifestations of 3041
ALL. See Acute lymphoblastic leukemia
Alleles 24
Allergy
basis of 20914
factors predisposing to 211
food related 963
in ascariasis 1495
Allergen 210
and asthma 2022
testing 187, 220t
Allergen-specific immunoglobulin E 219
Allergen-specific immunotherapy 210
Allergic disorders
and elevated IgE 213t
classification of 215
diagnosis of 21421
evaluation of 216
management of 21421
prevention of 210
Allergic asthma 216
Allergic bronchopulmonary aspergillosis 1538
Allergic conjunctivitis 216
Allergic rhinitis 215, 19668
treatment options for 1967t
Alopecia 3126
Alopecia areata 3126
Alpers syndrome 105
Alpha fetoprotein 1725
Alpha granule deficiency 1898t
Alpha thalassemia 1865
α thalassemia 1868
Alpha-1antitrypsin 1725
Alpha-1 antitrypsin deficiency 20145
Alpha-dystroglycanopathy 2632, 2633f
α-globin chain disorders 1870t
Alport syndrome 1898t, 2330
ocular manifestations of 3046
Alstrom syndrome 2779t
obesity in 2781
ALTE. See Apparent life-threatening episodes
Alveolar bleeds 20558
Ambiguous vaccine-derived poliovirus 1420
Ambulatory blood pressure monitoring 2370
Amebiasis 14848
and chronic diarrhea 1608
Amebic colitis 1485
Amebic liver abscess 1485
Amebic meningoencephalitis 14878
Amegakaryocytic thrombocytopenia with radioulnar synostosis 1913
Amelogenesis imperfecta 797
Amenorrhea 1183
diagnostic evaluation of 1185f
primary 1185
secondary 1186f
Amiel-Tison neurological examination 592
Amino acids
branched chain 75
in CSF 78f
in plasma and urine 1727
metabolism of branched-chain 93f
Amino acid disorders 7485
Aminolevulinate synthase 170
Aminotransferases 1723
AML. See Acute myeloid leukemia
Ammonia 1726
in hepatic encephalopathy 1790f
Ammonia detoxification 91
Ammonia hypothesis 1783
Amniotocele 3033
Amylase rich foods 960, 960t
ANA. See Antinuclear antibodies
Anaerobic infections 132932, 1330f
Analgesia 32732
Anaphylaxis 216
classification of 217t
following vaccines 1067
Anaplastic large cell lymphoma 2835, 2837
ANCA-associated vasculitides 2327, 2962
Ancylostomiasis 14971500
Anderson Fabry disease 138, 150
Androgen biosynthesis, disorders of 2741t
Anemia
acute 1811
age-specific causes of 1812
and heart disease 2284
approach to diagnosis of 181125
chronic 1812
classification of 1825
congenital dyserythropoietic 1833
Diamond-Blackfan 1832
grades of severity 1811t
in CKD 2384
in malaria 1476
in neonates 1813f
in preterm 469
in the neonate 538f
laboratory approach to 1817
macrocytic 1823f
microcytic hypochromic 1821f
neonatal 53345
Anencephaly 741
Anganwadis 1037
Angelman syndrome 51t, 3077t
Angiosteohypertrophy
ocular manifestations of 3043
Angle's classification 794
Animal related injuries 38792
WHO recommendations for 1406t
Anion gap 238, 2354t
Aniridia 2979, 3006
Anisometropia 2981
Ankyloblepharon 3028
Ankyloglossia 796
Anodontia 797
Anogenital warts 3072
Anophthalmia 2977
Anorectal disorders 722, 17138
Anorexia nervosa 9305
Antenatal counseling
for breastfeeding 458
Antenatal diagnosis
of neural tube defect 2417
of skeletal dysplasia 3184
Antenatal risk factors 497t
Antenatal steroids 676
Anterior capsular cataract 2999
Anterior cord syndrome 2577t
Anterior polar cataract 2999
Anthropometry
in newborns 437
in PEM 979
interpretation of 760
Anthropometric measurements
age-dependent 979
Anthropometric parameters 782
Anthroponoses 1220t
Antibiotic
properties of 1261
selection of 1260
classification of 12623t
for acute diarrhea 1580
for bronchiectasis 2070
for neonatal meningitis 514t
for PID 203
for severe acute malnutrition 989
in dysentery 1584
tips for prescribing 1266
Antibiotic associated diarrhea 16159
Antibiotic prophylaxis
for IE 2245t
for UTI 2377
for VUR 2378
Antibiotic resistance 614
mechanisms of 1233
in Salmonella 1285
Antibiotic susceptibility 1260
Antibiotic therapy
deciding the duration of 1261
for meningitis 2473
for staphylococcal infection 1300
in cystic fibrosis 2064
principles of 12607
Antibody 186, 1041t
Antibody deficiencies
treatment of 203
Anticardiolipin antibodies 2971
Anticoagulant therapy 1934
for DIC 1942
for stroke 2518
Anticonvulsants 638t
Anti-D for ITP 1920
Antidiuretic hormone (ADH) 2668
Antidotes 340, 339t
Anti-ds DNA antibody 2919
Antiendomysial antibodies 186
Antiepileptic drugs (AED) 24501, 2452t
for neonatal seizures 637
for neurocysticercosis 2491
Antifibrinolytic agents
for DIC 1942
Antifungal therapy 152832
Antigen 1040t
Antigen recognition 181
Antigenic drift 1392
Antigenic shift 1392
Anti-glomerular basement membrane 2322
Antigravity adaptations 2295
Antihistamines
for allergic disorders 219
for allergic rhinitis 1968
Antihypertensive agents 2372t
Anti-IgE antibody 210
Antileishmanial drugs 1480
Anti-liver-kidney microsomal antibodies 186
Antimalarial combination therapy 1474
Antimicrobial combinations 1264
Antimicrobial prophylaxis 1264
Antimicrobial resistance 12329, 1265
advisory group on 1235
surveillance of 1235
WHO global strategy for 1237t
Antimicrobial stewardship 1238, 1266
Antimicrobial therapy
adverse reactions to 1265
empiric vs. definitive 1261
for brain abscess 2497
for infective endocarditis 2243
for neonatal sepsis 600
for persistent diarrhea 1592
for pneumonia 2038t
for treating cholera 1590t
Antimitochondrial antibodies 186
Antimüllerian hormone (AMH) 2737
Anti-neutrophil cytoplasmic antibodies (ANCA) 185, 2919, 2962
Antinuclear antibodies (ANA) 184, 2919
in SLE 2935t, 2942
Antioxidants 947, 2295
Anti-parietal cell 186
Anti-phospholipid antibodies 2919
in SLE 2942
maternal 421
Antiphospholipid syndrome 29702
Antiplatelet antibodies 1917
Antiprothrombin antibodies 2971
Antipyresis. Also See Fever management 1249
Antipyresis
non-pharmacological 1248
pharmacological 1249
Antipyretic
choice of 1250
in febrile seizure 2438
Antiretroviral (ARV) drugs 1440t
Antiretroviral therapy (ART) 1440t, 1441t
Antisense oligonucleotides 2616
exon skipping 2622
Anti-sera 1041t
Anti-smooth muscle antibodies 186
Anti-snake venom 370
Antithrombin deficiency 1930
Antitubercular therapy 134650
second line 1354t
Antiviral drugs 136973
for herpes simplex infections 14023
Anxiety disorders 9358
Aortic regurgitation 2236
Aortic stenosis 21728
chest x-ray in 2176t
subvalvar 2177
supravalvar 2177
surgery for 2294
valvar 2173
Aortic valve disease 22369
Aortopulmonary collaterals
in TOF 2183
Apert syndrome
ocular manifestations of 3040
Aphallia 733
Aplasia cutis congenital 3061
Aplastic anemia 183444
Aplastic crisis
in sickle cell disease 1864
in parvoviral infections 1411
Apnea 1992
in newborn 65963
management of 661
ventilation for 667
Apnea of prematurity 468, 659, 896
Apnea testing 2507
Apnea-hypopnea index (AHI) 1992
Apparent life-threatening episodes (ALTE) 897
Appendicitis 17012
Appetite test 987b
Applied nutrition program 1036
Apt Downey test 539
Arachidonic acid metabolism pathway 1249f
Archimedes spiral drawing 2525f
ARDS. See Adult respiratory distress syndrome
Arginase deficiency 87, 89t
Argininosuccinate lyase (ASL) deficiency 85, 89t
Argininosuccinate synthetase deficiency (ASS deficiency or citrullinemia type 1) 89t
Argyll-Robertson pupil 3015
Arm span 752f
Arnold Chiari malformation 745, 2429
Array comparative genomic hybridization 53
Arrhythmia
diagnosis of 2265
Arrhythmogenic right ventricular cardiomyopathy 2256
Artemisinin-based combination therapy 1474
Arterial blood gas 233
interpretation of 234
normal values 234t
Arterial ischemic stroke 2510
antiplatelet and anticoagulant drugs in 1937t
Arterial pulse 20901
Arterial thrombosis 1931
treatment of 1937
Arthralgia
in chikungunya 1460
Arthritis 2914
hematological conditions with 2914
in Lyme disease 1322
in parvovirus infections 1411
in SLE 2935t
juvenile idiopathic 2927
Arthrogryposis 318890
Arthrogryposis multiplex congenita 3188
Articulation disorders 901
Ascariasis 14937
Ascites 17049, 1740t
approach to a child with 1706
management of 1749
Ascitic fluid 1706, 1707f
ASD. See Atrial septal defect
Asepsis 1217
Aseptic meningitis
in mumps 1378
Aspartate- glutamate carrier deficiency 89t
Aspartate glutamate transporter defect 87
Asperger disorder 921
Aspergillosis 153841
invasive 1540
Aspiration pneumonia 2010t
Aspiration syndromes 20159
cough in 1975
in cleft palate 1636
Asplenia syndrome 2142
immunization in 1140
Assent 14
Assessment
of sick child 269273
Assist/control ventilation (ACV) 320
Assisted controlled ventilation 667
Association 37
AST: ALT ratio 1725
Asthma 20229
acute severe 2026
allergy tests for 187
control of 2026
control of 2027t
cough in 1976
drug delivery devices in 2026
life-threatening 2027b
long-term outcome of 2028
pathogenesis of 2022
pulmonary severity score for 2027t
severity of 2025
treatment of 2024
vaccination in 2026
ventilation for 321
Asthma predictive index 2021t
Asthma severity score
Becker's 2027t
Astigmatism 2981
Astrocytoma 2847
Asymmetric septal hypertrophy 2257
Asymptomatic bacteriuria 2377
Ataxia 25307
approach to 2535
with selective vitamin E deficiency 2534
Ataxia telangiectasia 193, 2534, 3043, 3105
Ataxia with oculomotor apraxia (AOA) 2535
Atlantoaxial subluxation 2578b
Atopic dermatitis 964t, 30834
ocular manifestations of 3042
Atopic wheeze 2020b
Atrial fibrillation 2268
Atrial flutter 2267
Atrial septal defect 21504
chest X-ray in 2101
closure of 2120
surgery for 2293
Atrial switch operation 2201
Atrioventricular block 2281
Atrioventricular canal 2082
Atrioventricular nodal reentrant tachycardia 2271
Atrioventricular reentrant tachycardia 2268
Atrioventricular septal defects 21547
Attachment
for breastfeeding 456
Attention-deficit hyperactivity disorder (ADHD) 90916
drugs for 915t
Atypical absence 2442
Atypical Burkitt lymphoma 2836
Atypical pneumonia 2036
Atypical teratoid/rhabdoid tumor 2851
Aural medications 264
Autism spectrum disorder 92127
assessment tools for 925
drugs for 926
Autoantibodies 2919
Autohemolysis test 1879
Autoimmune adrenalitis 2721
Autoimmune disorders
and elevated IgE 213t
maternal 421
Autoimmune hemolytic anemia (AIHA) 1884
cold reactive 1885
drug induced 1885
mixed type 1885
warm 1884
Autoimmune hepatitis 1770
treatment of 1780
treatment regimes for 1781f
Autoimmune liver disease 1763
Autoimmune lymphoproliferative syndrome (ALPS) 194, 195t
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) 2768
Autoimmune polyglandular syndrome 2721
Autoinflammatory disorders 198
Automatic atrial tachycardia 2273
Autonomic disorders 2657
Autonomic dysfunction 2653
Autonomic function tests 2653
Autonomic nervous system 2653
Autonomic neuropathies 265361
Autonomy 13
Autosomal dominant hypophosphatemic rickets 2774
Autosomal dominant inheritance 28
Autosomal recessive hypophosphatemic rickets 2774
Autosomal recessive inheritance 30
Avascular necrosis of the capital femoral epiphysis 3161
Avian influenza 1394
Axenfeld-Rieger anomaly 3006
Axillary freckling (Crowe's sign) 3103f
Azoles 1530
B
B cell development 1809
Bacteremia
anaerobic 1330
in dysentery 1584
pneumococcal 1289
salmonella 1283
staphylococcal 1297
Bacterial index
in leprosy 1363
Bacterial infection
natural history of 12579
Bacterial pericarditis 2260
Bacterial virulence 1257
Balanced diet 954, 955t
Balanitis
candidal 1534
Balanoposthitis
candidal 1534
Ballard score 438b
Ballon atrial septostomy 2120, 2201
Balloon mitral valvotomy 2235
Balloon valvuloplasty 2120, 2165
Balloon tamponade 1752
Balloon-occluded retrograde transvenous obliteration 1746
Balwadi nutrition program 1036
Bangle test 980
Barbiturate coma 2506
Bardet-Biedl syndrome 2779t
obesity in 2780
Barker hypothesis 1169, 2791
Barlow test 440
Bartter syndrome 2357
Basal metabolic rate 944b
Base excess 234b
Basic life support 27781
sequence for 278t
Basilar impression 3143
Basilar invagination 2578b
Basophil
mediators of 212t
Basophilic stippling 1828t
Batten disease
ocular manifestations of 3045
B-cell 183
B-cell defect 201
B-cell mediated immunity 1041t
BCG vaccines 10715
AEFI 1067b
in HIV-positive cases 1073
newer 1073
revaccination with 1072
second dose of 1073
Becker muscular dystrophy 2620
Beckwith-Wiedemann syndrome 164, 487, 827
Behavior
in LBW 480
patterns of 923
Behavioral problems 8837
in adolescents 1162
in Down syndrome 46t
Behavior therapy
for enuresis 891
for intellectual disability 871
Behavioral risk factor surveillance system 1044t
Behcet disease
eye involvement in 2996, 3046
Bell staging 565b
Beneficence 13
Benign childhood epilepsy with centrotemporal spikes 2447
Benign childhood occipital epilepsy (Gastaut type) 2447
Benign hereditary chorea 2523
Benign myoclonus of infancy 2460
Benign neonatal sleep myclonus 636
Benign paroxysmal vertigo 2462
Benzodiazepines poisoning 345
Benzonsky identity style model 1156
Beriberi 998
Bernard-Soulier syndrome 1898t, 1913
Beta-blockers
poisoning with 346
β-globin chain disorders 1870t
β-hemolytic invasive Group A streptococcal infections, 1293
β-oxidation cycle 100f
β-thalassemia 1868
classification of 1869t
pathophysiology 1869
Bethlem myopathy 2631
Beverages 953, 1032
Bicarbonate 234b
fractional excretion of 2354t
reabsorption of 2303f
Bile acid tests 1726
Bile metabolism 1721
Bile salt diarrhea 1612
Biliary atresia 1729, 1771
investigations for 1731t
Bilirubin 1722
metabolism 511
neurotoxicity of 514
Bilirubin-induced neurologic dysfunction 515t
Bioelectrical impedance analysis 811t
Biological agents
for rheumatic disorders 2926
Biotin 1001
Biotin deficiency
skin changes in 3096
Birth asphyxia
seizures in 634
Birth injuries 50511
in LGA babies 489
Bitot spots 994
Bladder exstrophy 2313
Bladder training exercises
for enuresis 891
Bladder-bowel dysfunction
and VUR 2377
Blastomycosis 154951
Blau syndrome 199, 199t
Bleeding disorders 18949, 1896t
in children 1911f
in neonate 54550
Bleeding time 1926
Blepharitis 3029
Blepharophimosis 3028
Blepharoptosis 3028
Blindness 2973
schooling and 3052
Blistering dactylitis 3067
Bloch-Sulzberger syndrome
ocular manifestations of 3042
Blood component therapy 19436, 2902
for DIC 1941
Blood culture
in neonatal sepsis 599
Blood gas 306t
classification and interpretation 306
Blood pressure 2091
in newborn 440
normal 271t
Blood products
administering 266
Blood transfusion
in newborn 541
Bloom syndrome 3125
BLS. See Basic life support
Blueberry muffin baby 3059
Blunt injuries 389
Body dissatisfaction 1171
Body fat
assessment of 811t
Body fluids 2226
composition of 225t
Body mass index 786, 810
Body proportion 752
Body surface area
in burns 394
Bone age 8009
Bone
development of 800, 2775
disease in preterm 469
disorders in CKD 2384
fragility disorders 27748
strength assessment 2775
Bone marrow
examination 181920
congenital failure of 182934
transplantation 190, 2905
Bone marrow stem cell transplantation (BMT) for lysosomal disorders 118
Bone mineral density
in rickets 1008
Bone mineral physiology 27657
Bone tumors 28827
Borjeson-Forssman-Lehmann syndrome 2779t, 2782
Bornholm disease 1416
Boron 1020
Borrelia infections 1318
Boston criteria 1252t
Botulism 1331, 2605t
Boutonneuse fever 1564
Bowel bladder dysfunction 2380
BPD. See bronchopulmonary dysplasia
Brachial plexus injury 509
at birth 509
Bradyarrhythmias 283, 22812
Brain abscess 24938
Brain death 25068
Brain malformations 242632
Brain stem glioma 2851
Brain tumor 284156
Brainstem auditory evoked potentials 2400
Breakthrough varicella 1396, 1399
Breast
development 2697t
engorgement 445, 457
Breastfeeding 4539
and allergy 210
and HIV 1443
benefits of 453
contraindications 459t
drugs and 258
in special situations 458
jaundice 513t
ten steps to successful 455b
Breastmilk
and jaundice 512
expressed 458, 475
Breastmilk jaundice 513t
Breath hydrogen test 1676
Breath-holding spells 8979, 2460
Breathing
assessment of 270
mechanics of 1953
difficulty in 1956
Brief resolved unexplained events (BRUE) 897
Bronchial provocation tests 2024
Bronchiectasis 2067
Bronchiolitis 200915
differential diagnosis of 2010t
drug treatment for 2012t
Bronchitis 1977
Bronchogenic cyst 1998
Bronchopulmonary dysplasia 7005
in preterm 468
Bronchoscopy 1959
Browns superior oblique tendon sheath syndrome 3023
Brown-Sequard syndrome 2577t
Brown-Vialetto-van-Laere syndrome 2613t
Brucellosis 13148
treatment of 1317b
Bruckner red reflex 2982f
Bubonic plague 1312
Budd-Chiari syndrome 1747
Buffer base 234b
Buffer systems 232
Bulimia nervosa 932
Bullous pemphigoid 3107
Bullying 1171
Buphthalmos 3005
Burkitt lymphoma 2833, 2836
Burns 392401
chemical 398
electric 399
emergency management of 391
surgical management of 399
Burn wound
Infection of 397
treatment of 399
Busan pledge 3227b
C
Cabot's ring bodies 1828t
Cafe-au-lait macules 2555, 3102
Caffey's disease 3182
Calcipenic rickets 2366, 2771
Calcium 946, 2765
disorders of 276771
excretion of 2306t
for adolescents 1166
requirement for LBW 473
Calcium channel blockers
for PAH 2221
poisoning with 346
Calcium deficiency rickets 2368t
Calcium-sensing receptor 2765
Calorie 944
of common foods 956
Calpainopathy 2587f
Campylobacter dysentery 1585
Canavan disease 2573
Cancer
effects of chemotherapy 278891
epidemiology of 27948
immunization in 1140
principles of treatment 27982803
Candidiasis 15337
congenital 3060
congenital cutaneous 605
in HIV 1434
Candida meningitis
in newborns 616
Cap disease 2641t
Capillary leak syndrome
in pancreatitis 1665
Capillary malformation 3074
Capillary refill time
in newborn 440
Caput succedaneum 506
Carbamate poisoning 350
Carbamoyl phosphate synthetase (CPS1) deficiency 85, 89t
Carbohydrates 944
digestion of 1597
for parenteral nutrition 1030
metabolism of 1721
requirements for LBW 473
Carbohydrate metabolism defects 14350
Carbon dioxide transport 232
Carbonyl iron 1843
Cardiac arrest 273, 287
pathophysiology of 274f
treatment of 275
Cardiac catheterization 211924
Cardiac computed tomography 2123
Cardiac emergencies 2287t
Cardiac loop 2082
Cardiac magnetic resonance imaging 2123
Cardiac malposition 213444
Cardiac resynchronization therapy 2133
Cardiac tamponade 2290
Cardiomyopathy 2248
anthracycline induced 2258
genetic mutations causing 2255
in Duchenne muscular dystrophy 2257
Cardiopulmonary assessment 281
Cardiopulmonary resuscitation 2737
Cardiovascular examination 20905
Cardioversion 287
Carditis 2224
Career guidance 1206
Caries 162932
Carnitine 102, 1790
therapy for FAOD 103
Carnitine acylcarnitine translocase deficiency 101t
Carnitine cycle 100f
Carnitine palmitoyltransferase-I deficiency 101t
Carotenoids 947
Carpenter syndrome 2779t
obesity in 2782
Carrier 1217
in diphtheria 1269
in hemophilia 1906t
screening for 62f
Casal necklace 999
Case 1217
Case definition
cholera 1589
measles 1376
mumps 1379
rickettsial fevers 1560b
tuberculosis 1348b
Cat eye syndrome 49
heart disease in 2098t
Cat scratch disease
ocular manifestations of 3038
Cataract 29983005
Catch-up growth
in severe acute malnutrition 990
Catch-up immunization 1141
Catecholaminergic polymorphic ventricular tachycardia 2280
Catheter ablation 2276, 2277t
Cattle-related injuries 389, 391
Cavitary pulmonary histoplasmosis 1552
CblB disease 1846
CblF disease 1847
Celiac disease 1611, 16828
in Down syndrome 46t
Cell-based assays 189
Cell-mediated immunity 183
Cellular immunity 1041t
Cellulitis 3066
Central cord syndrome 2577t
Central core disease 2641t
Central cyanosis 2178
Central hypoventilation 20768
Central hypoventilation syndrome 2660
Central nervous system
anaerobic infections of 1330
in PEM 976
Central precocious puberty 2702
Centronuclear myopathies 2641t, 2643
Cephalhematoma 507
Cereals 948
nutritive value of 956t
Cerebellar astrocytoma 2847, 2850f
Cerebellar function 2530
Cerebellar signs 2394
Cerebral edema
in DKA 2762t
Cerebral gigantism 487
Cerebral malaria 1475
Cerebral palsy 84658
chart of a child with 851t
classification of 847t
differential diagnoses of 853t
manifestations of 854
Cerebral perfusion pressure 2504
Cerebral salt wasting 2679
Cerebral venous sinus thrombosis 1931, 2519
Cerebrospinal fluid 23957
in meningitis 1547t
in newborns 512t
Ceruloplasmin 1725
Cervical spine infections 3146
Cervical vertebral synostosis 3145
CFTR modulators 2066
Chalazion 3029
Chancroid
in adolescents 1195
Chaotic atrial rhythm 2268
Chaperon therapy
for lysosomal disorders 119
Charcot-Marie-Tooth disease 1 2650t, 2651
Charcot-Marie-Tooth neuropathy 1A 51t
CHARGE syndrome 706, 2743t
Chediak-Higashi syndrome 195t, 196, 1896b, 3041, 3077t
Chelation therapy
in thalassemia 1873
Chemical pollution 3227
Chemoprophylaxis 1217
for Hib 1288
for TB 1340
Chemotherapy
principles of 2799
Cherry red spot 72f, 120
Chest circumference
in PEM 979t
Chest compressions
technique 279f
in newborns 435
Chest pain 1956
Chest physiotherapy
for bronchiolitis 2013
in cystic fibrosis 2064
Chest tube drainage
for empyema 2043
Chickenpox. See Varicella
Chikungunya fever 145962
diagnostic criteria of 1461t
Chikungunya vaccine 1461
Chilblain 402
Child abuse
and neglect 32019
ocular manifestations of 3040
sexual 3206
Child behavior checklist 882
Child health
and environment 3223
concerns in 58
in affluent nations 5
in developing countries 6
in India 4
indicators of 321623
integrated approach to 3230
programs for 32307
Child labor 31963200
Child line 3214
Child nutrition programs 3233
Child protection
constitutional provisions for 3213t
Child rights 3212
in India 3213
Childhood blindness 3047b
Childhood disintegrative disorder 921
Childhood interstitial lung disease (chILD). See Interstitial lung disease
Child mortality
and vitamin A supplementation 995
Child-rearing practices 880
Chimeric vaccine 1103
Chlamydial infections 15734
in adolescents 1195
Chlamydophila pneumonia infection 1573, 2036
Chloride depletion alkalosis 240
Chloride excretion 2306t
Choanal atresia 1960
Choking 280
Cholera 158791
antimicrobial treatment for 1589
Cholera toxin 1588
Cholera vaccines 11145, 1590
in epidemic situation 1114
Choleragen (CT) 1588
Cholestatic hepatitis 1426
Chorea 2523
Chorionicity 492
Choroid plexus tumor 2855
Choroid gyrate atrophy 83
Christ-Siemens-Touraine syndrome 3122
Chromium 1018
Chromosome
abnormalities of 42
nomenclature of 42
Chromosomal disorders 4254
congenital heart diseases in 20868t
Chronic abdominal pain. See Functional abdominal pain
Chronic arthritis 2915
conditions mimicking 2915
Chronic bullous disease of childhood 3108
Chronic cough
evaluation of 1977
Chronic daily headache (CDH) 2466
Chronic diarrhea 15971615
approach to a child with 1599
causes of 1600t
classification of 1597t
in HIV 1436t
pathophysiology of 1598
without failure to thrive 1613
Chronic granulomatous disease 194
diagnosis of 189t
Chronic hepatitis-B
treatment of 1780
Chronic kidney disease (CKD) 23835
and rickets 2368t
Chronic liver disease 176583
approach to a child with 1776f
management of 1778
stigmata of 1742t, 1769
Chronic lung disease
in newborn 700
in preterm 468
Chronic mucocutaneous candidiasis 1534
Chronic myelogenous leukaemia 281722
Chronic pancreatitis 1667
Chronic pulmonary disease 2010t
Chronic refractory heart failure 2133
Chronic secretory diarrhea 1603
Chronic suppurative otitis media 1971
Chronic undernutrition
and short stature 819
Churg-Strauss syndrome 2963
Chylous ascites 1704
Cilia 2058
Ciliary beat frequency 2060
Ciliary studies 2059
Circulating vaccine-derived poliovirus (cVDPV) 1420
Circulation
assessment of 271
in PEM 976
management in trauma 381
Circulatory support 279
Cirrhosis 1740
classification of 1772
Cirrhotic ascites 1705
Citrin deficiency 87
Citrullinemia Type 1 85
CKD. See Chronic kidney disease
Cleansing agents
for newborns 3063
Cleft lip 16327
Cleft palate 16327
breastfeeding in 458
Cleidocranial dysplasia 3179, 3186t
Clinically isolated syndrome 2541t, 2546
Cloacal exstrophy 731, 732
Clonic seizures 636
Clostridium difficile-associated diarrhea 1616
Clotting factor activity assays 1907
Clotting factor deficiencies 190610
Clouston syndrome 3123
CMD. Also See Congenital muscular dystrophy
with epidermolysis bullosa 2629t
with familial junctional epidermolysis bullosa 2635
with laminin-α2 deficiency 2628, 2630f
with mitochondrial structuralabnormalities 2629t, 2635
Coagglutination 1226
Coagulase negative Staphylococcus 1299
Coagulation
assays 1895t
cascade 1892f
physiology of 545
Coagulation disorders 18949
in acute liver failure 1793
in newborn 546
Coagulation inhibitors
for DIC 1942
Coarctation of aorta 216872
emergency management of 2288
surgery for 2294
Cobalamin 1000
absorption of 1847t
deficiency of 1849
Cobblestone malformation 2430
Coccidioidomycosis 15439
Cochlear implants 877
Cockayne syndrome 3125
Coenzyme Q (10) (CoQ)/ubiquinonedeficiency 2534
Cofactor-dependent epilepsy 2563t
Cohen syndrome 2779t
obesity in 2782
Cold agglutinin syndrome 1885
Cold box 1063
Cold chain 105965
equipment for 1059, 1062
Cold injuries 4017
Cold panniculitis 3059
Cole vicious cycle model 2067
Collagen dressing 399
Collagen vascular disorders
and heart disease 2284
hypopigmentation in 3082
Collagen VI deficient CMD 2629t
Collodion baby 3121
Colloidal iron 1843
Coloboma 2978
Colonoscopy 1756
for chronic diarrhea 1609f
Colostrum
types of 453
Coma 24982502
approach to a child with 2499
Combination vaccines 113639
Combined immunodeficiency 202t
with associated or syndromic features 192, 193t
Combined/T-cell defect 201
Common cold 1978
Communication
deficits in 922
nonverbal 1203t
verbal 1204t
Communication disorders 900
classification of 903t
Communication skills 1203
Community acquired pneumonia 2035t
Community screening
for sickle cell disease 1866
Compartment syndrome
in snakebite 367
Complement deficiencies 199, 202t
Complement regulatory defects 200t
Complementary feeding 957
and allergy 210
Complementary foods 959
Complete heart block 2281
Compliance 665
Computed tomography
of brain 2402
Condom use 1198
Conduct disorder 916
Condylomata acuminate 3072
Conflict of interest 12
Congenital adrenal hyperplasia 27137
and bone age 802
newborn screening of 175
Congenital adrenal hypoplasia 2722
Congenital afibrinogenemia 1899
Congenital aganglioniosis 1672
Congenital amegakaryocyticthrombocytopenia 1913
Congenital cataract 3003t
Congenital central hypoventilationsyndrome 896, 2076
Congenital cricopharyngeal achalasia 1645
Congenital cutaneous candidiasis 1534
Congenital cystic adenomatoid malformation (CCAM) 1996
Congenital defects of phagocyte 196t
Congenital disorders of glycosylation 71f
Congenital disorders of N-linkedglycosylation 148
Congenital dyserythropoietic anemia 1833
Congenital erythyropoietic porphyria 151t
Congenital fiber type disproportion 2641t, 2644
Congenital glaucoma 3009
Congenital heart defects
chromosomal syndromes with 20868t
in Down syndrome 46t
surgical considerations in 22914
Congenital hepatic fibrosis 1747
Congenital HIV syndrome 1216
Congenital hyperinsulinism 531
Congenital hypothyroidism 2682
newborn screening of 175
Congenital ichthyosis 3120t
Congenital immunodeficiency
and chronic diarrhea 1610
immunization in 1139
Congenital insensitivity to pain 2659
Congenital kyphosis 3155
Congenital lactase deficiency 1680
Congenital lens abnormalities 2999t
Congenital malformations
in IUGR 470
of the upper respiratory tract 19603
Congenital melanocytic nevus 3074
Congenital muscular dystrophy (CMD)2601t, 2623, 2628, 2635
with rigid spine 2631
Congenital muscular torticollis 3142
Congenital myasthenic syndrome 2646
Congenital myopathies 26405
Congenital myotonic dystrophy 2601t
Congenital nephrotic syndromeSee Nephrotic syndrome
Congenital ovarian cyst 734
Congenital portosystemic shunts 1790
Congenital pulmonary airway malformation (CPAM) 1996
Congenital rubella syndrome 626, 1381
prevalence of 1096
Congenital scoliosis 3152
Congenital structural myopathy 2601t
Congenital subglottic stenosis 1962
Congenital syphilis
ocular manifestations of 3038
Congenital talipes equinovarus 316770
Congenital telangiectatic erythema 3125
Congenital zika virus infection 2422
Congential myotonic dystrophy 2624
Congestive heart failure 212535
treatment of 2290t
Conjugate vaccines 1043t
for typhoid 1101
meningococcal 1120
Conjunctiva
congestion of 2975f
injuries of 3034
intraepithelial neoplasia of 2989
tumor of 2989
Conjunctivitis
in newborn 606
pneumococcal 1289
Conotruncal relationship 2142
Consensus 13
Consent 14
Constipation 1627, 166872
chronic 1671
drugs used in the treatment of 1671t
functional 1668
refractory 1672
Constitutional delay in growth andpuberty 2698
Constitutional obesity 810
Constraint-induced movement therapy 855
Constrictive pericarditis 2261
Contact carriers 1229
Contact dermatitis 30856
Contact lens 2985
Contagious 1217
Containment 1040t
Contamination
of food 1034
Continuous glucose monitoring systems 2757
Continuous positive airway pressure(CPAP) 320, 674f
and BPD 702
Contraception
lack of 1193
Contraction stress test 502
Conus medullaris syndrome 2577t
Convalescent carriers 1219
Convention on the rights of the child(CRC) 3212
Conversion disorder 939t
Cooling
for fever 1249
Coombs test 1886f
Coping 1209
by street children 3194b
Copper 1018
Copper deficiency
skin changes in 3097
Cord blood transplants 2911
Cord care 444
Core myopathies 2642
Core-Rod myopathy 2641t, 2643
Cornea
infections of 29878
injuries of 3034
keloid of 2981
Cornelia de Lange syndrome 41f
Coronary artery
Anomalies in TOF 2183
fistula 2162
Coronary sinus ASD 2150
Corrected transposition of the greatarteries 2206
Corrigan sign 2236
Corrosive poisoning 35762
management of 361f
Cortical cataract 2999
Corticosteroids
and immunization 1140
for croup 2003
for DMD 2621
for ITP 1919
in CNS TB 2478
intranasal 1968
Corticotropin-releasing factor (CRF) 2667
Cortisol 2711
in PEM 976
Costello syndrome 487
Cough 1956
approach to a child with 19748
chronic 1975
post infectious 1975
Counseling 1201t
adolescent 12001207
for intellectual disability 871
for twins 494
premarital 1147
principles of 1201
process and steps of 1202
Cover test 3017b
Cover-uncover test 3017b
Cow milk protein allergy 1610, 964f
Coxsakievirus
intrauterine infection 632t
Cracked nipple 457
CRAFFT questionnaire 1174b
Cranial dysraphism 2415
Cranial nerve examination 2391
Craniocervical junction abnormalities 2578
Craniopharyngioma 2853
Craniosynostosis 746, 3180
C-reactive protein (CRP) 918
Creatine metabolism 2564
Creatine phosphokinase 2589
Creative thinking 1209
Crescentic glomerulonephritis 2323
Cri du chat syndrome 48
ocular manifestations of 3039
Critical thinking 1209
Crohn disease 1660, 168895, 1691t
ocular manifestations of 3046
Cross syndrome 3077t
Croup 20014
Croup score 2002
Crouzon syndrome
ocular manifestations of 3040
Crowe sign 2555f
Crude birth rate 3222t
Crude death rate 3222t
Cryptococcal meningitis 1541, 1543
Cryptococcal pneumonia 1541, 1543
Cryptococcosis 15413
in HIV/AIDS 1435t, 1543
Cryptophthalmos 2978
Cryptorchidism 2746
Cryptosporidiosis 14913
and chronic diarrhea 1608
CTEV. See Congenital talipes equinovarus
Cuff leak test 323
Culture methods 1224
Cushing syndrome 822, 27239
Cutaneous blastomycosis 1550
Cutaneous diphtheria 1268
Cutaneous herpes 1401
Cutaneous histoplasmosis 1552
Cutaneous leishmaniasis 1481, 1483t
Cutaneous mastocytosis 3090
Cutis marmorata 3054
Cyanosis
in the newborn 55563
Cyanotic congenital heart disease
clinical approach 217882
Cyanotic spell. Also See Hypercyanotic spells
emergency management of 2288
treatment of 2188
Cyclic neutropenia 196t
Cyclical vomiting syndrome 1642, 1643, 2462
Cystic fibrosis 20627
and chronic diarrhea 1612
ivacaftor for 56
Cystic kidney diseases 23158
acquired 2317
congenital 730
Cysticercosis. Also See neurocysticercosis
uveitis in 2995
Cystinosis 2356
ocular manifestations of 3043
Cystinuria 84, 2363
Cystitis 2375t
Cystography 2375t
Cytogenetic testing 52
Cytogenomic microarray 40
Cytokines 180
in hematopoiesis 1810
in obesity 812t
Cytokine storm 598
Cytomegalovirus
in HIV 1435t
infections 625
D
Dacryocystocele 3033
Dandy Walker malformation 746, 2429
Datura poisoning 353
Day-care infections 12434
1000-day window of opportunity 1038
De ritis ratio 1723
Deafness
newborn screening of 176
Death rate for 5–15 years 3222t
DEBONEL 1561
Deciduous dentition 790
Decision making 1209
Decontamination 336, 1217
in corrsive poisoning 359
Deep brain stimulation 2526
Deep freezers 1062
Deep vein thrombosis 1930
Defibrillation 280, 288
Deficiency of the debrancher enzyme 150
Deficit fluid therapy 230
for diarrhea 1579
Deformations 37
Deformity
assessment of 3131
Dehydration
assessment of 1578t
classification of 1578
in cholera 1589
in severe acute malnutrition 986
Dejerine Sottas disease 2651
Delayed puberty 26982701
22q11.2 deletion syndrome
cervical spine in 3147
Delinquency
juvenile 1175
Delta F 508 mutation 2063
Demand feeding 456
Demyelinating disorders
acquired 2541t
Dengue 144959
case classification 1450
in utero transmission of 1452
treatment of 1455t
warning signs in 1450f
WHO guidelines for management 1456f
Dengue hemorrhage fever 1449
Dengue shock syndrome 1449
Dengue vaccines 11314, 1459
currently licensed 1131t
Dense granule deficiency 1898t
Dent disease 2356
Dental caries 162932
Dental fluorosis 1022
Dentition
development of 790800
Denver Developmental Screening Test 845
Deoxyribonucleic acid. See DNA
Depression
diagnostic criteria for 1172b
in adolescents 1172
Dermal melanocytoses 3061
Dermal sinus 2415
Dermatitis herpetiformis 3108
Dermatomyositis 294451
Dermatomyositis sine myositis 2946
Dermatophyte infections 3068
Desferrioxamine toxicity 2786
Development
effects of hearing impairment on 874
factors affecting 831
history of 841
in mid and late childhood 838
in the first year 833
in the preschool child 835
in the second year 835
laws of 831
normal 8339
of the high-risk infant 842
process of 830
psychosocial in adolescents 1151
theories of 830, 1152
Developmental assessment 840, 860, 882
importance of 830
Developmental Assessment Scale for Indian Infants (DASII) 845
Developmental defects
seizures in 635
Developmental delay
algorithm for detecting 840
red flag signs for 861t
Developmental dysplasia of hip (DDH)315761
examination for 440
Developmental maneuvers 850t
Developmental origins of health anddiseases 421, 482f
Developmental screening 594, 711
for intellectual disability 868
tests for 594t, 844
Developmental surveillance 868
algorithm for 840f
Dexamethasone suppression test 27256
Diabetes insipidus 2677
nephrogenic 2359
Diabetes mellitus
and enterovirus 1417
classification of 274952
complications of 27605
immune mediated 2751
in thalassemia 2787
maternal and effect on fetus 419
neonates born to mother with 525t
ocular manifestations of 3044
staging of 2752t
type 1 27529
type 2 2750
Diabetic ketoacidosis 2761
Dialysis
chronic 2385
Diamond-Blackfan syndrome 1818f
Diaper dermatitis 605
Diaphragmatic hernia 7105
Diarrhea 15751620
acute watery 157583
antibiotic associated 16159
chronic nonspecific 1426
chronic osmotic 1604
chronic. See Chronic diarrhea
Cryptosporidium 1492
factitious 1614
fatty 1604
functional 1613
in HIV-infected 1581
in severely malnourished children 1581
nutritional management of 1581
osmotic 1576
osmotic vs secretory 1599t
pathogens for 1575t
persistent 15917. See Persistent diarrhea
prevention of 1582
risk factors for 1580
secretory 1576
small and large bowel 1600t
Diarrheal dehydration
pathophysiology of 1577
Diastematomyelia 744
DIC. See Disseminated intravascularcoagulation
2,4-dienoyl-CoA reductase deficiency 102t