A
Acetazolamide 67
Acetylsalicylic acid 89
Adenosine triphosphate 11
Adrenaline 41
Akinesia 109
Alcuronium chloride 87
Allantoxanamide inhibits enzyme uricase 80
Allantoxanamide treatment in rats, hypouricemic activity after 80
Aminophylline 88
Anesthesia, endpoint of 114
Anesthetized dog, method using 30
Angiotensin antagonism 45
Antacids 119
Antianxiety agents 98
Antiasthmatic drugs 83
Antidiarrheic agent 128
Antiepileptic drugs 105
Antiparkinsonian drugs 108
Antitoxin 25
Antitussive agents 92
Antiuricosuric drugs 67
Anxiety 98
Anxiolytic drugs 98
Arrhythmia 9
Aspartate transaminase and alanine transaminase 14
Astemizole 9
Atropine sulfate 88
B
Beta blocking effects in anesthetized dogs, screening for 51
Bioassay 25
applications of 25
demerits of matching 27
of acetylcholine principle 31
of ach using rat ileum preparation 28f
of adrenaline 30
principle 30
standard preparation 30
of digitalis 32
of D-tubocurarine 32
procedure 32
rabbit head-drop method 32
of estrogen 35
of insulin 33
of noradrenaline 31
principle 31
procedure 31
of oxytocin 34
of oxytocin using rat uterus 34
evaluation 34
procedure 34
of thyroxine 38
principles of 26
procedure of
four point 29
three point 28
types of 26
Blind pharmacological screening 25
Blood pressure
in conscious hypertensive rats 48
in pithed rats 47
evaluation 48
procedure 47
measurement 49
Blood urea nitrogen 22
Body plethysmography and respiratory parameters 89
Bradykinin potentiation 45
Bradykinin triacetate 88
Breathing air, normal 92
Bronchodilating drug, effect of 89
Bronchospasmolytic activity in anesthetized guinea pigs 87
β-sympatholytic activity in isolated rat spleen 41
Bupivacaine 115
C
Calcium chloride 34
Cannula, implantation of 49
Carbachol 85
Carbamazepine 105
Carbonic anhydrase inhibitors 67
Cardiac arrest in guinea pigs, digitalis induced 26
Cardiac puncture technique 59
Cardiac toxicity, reports of severe 9
Cardiovascular drugs 41
Cardiovascular system 25
Carotid body denervation 91
Cecocolic junction 126
Charcoal Norit A 35
Cheng-Prusoff equation 104
Chinchilla rabbits 45
Chronic renal failure
after subtotal nephrectomy in rats 76
in rats 75
evaluation 76
procedure 75
test 67
Clonazepam 102
Congestive heart failure 41
Corneal reflex present 118
Coronary artery, left circumflex 53
Cortical collecting duct 69
Cromakalim 45
Cyclic flow reductions 61
Cytosol preparation 35
Cytosolic fraction binding 35
D
Dazoxiben HCl 89
Deep vein thrombosis 56
Diarrhea-free period 128
Diarrheal excretion, early 128
Disodium hydrogen orthophosphate 34
Dopamine, prodrug of 111
Dose response curve 27
Drug 25
acting on lower urinary tract, evaluation of 80
acting on urinary tract 67
acting, screening of 25
affecting motility, evaluation of 94
classification of 24
development, stages 1
in process of 1
discovery 1
high throughput screening 2
latency, duration of 118
test 99
using isolated rat stomach, evaluation of 120
D-tubocurarine, test solution of 32
Duloxetine 67
E
Electric shock 107
Endralazine 49
Enflurane 112
Enteric nervous system 125
in clinical practice 13
in diagnosis of diseases, application of 10
increased in serum in
cholestasis 23
liver damage 23
leak from cell 11
levels in serum and plasma, regulation of 11
production, alteration in 12
tests, selection of 12
Enzymology, clinical 10
Equivalent short circuit current 71
Estrogen responsive element gene 37
Ethosuximide 105
Etomidate 112
Ex vivo-assays 61
Eyelid closure 109
F
Fanconi's syndrome 20
Fecal pellet output 128
Fixed dose test 6
Flexed posture 109
Fluoroquinolone 9
Food effect 8
Functional plasma enzymes 10
G
GABA-mimetic agents 107
Gabapentin 105
Gama-amino butyric acid 100
Gamma-glutamyl transferase 23
Gastric acidity, measurement of 21
Gastric fluid, functional tests of 20
Gastric function tests 20
Gastric oxyntic glands 11
Gastrointestinal system, complex 125
Gastrointestinal tract 125
Gatifloxacin 9
Glomerular filtration rate 72
Glomerular function tests 22
Gould pressure transducer 91
H
Halothane 112
Helicobacter pylori 20
Hemodynamic measurements, preparation for 53
Homogenates 35
Hormones 25
Human pharmacology 8
Hydroxy dopamine 110
Hypercholesterolemia 56
Hypertension 41
I
Imipramine-HCl 88
In vivo methods 72
In vivo models 61
In vivo tests 87
Inhalation toxicity, acute 7
Inhalational anesthetics 112
Inhibition of acid secretion 120
International Conference on Harmonization 4
Intracellular electrical measurements 71
Intracellular enzymes 12
Intravenous bolus injection 53
Intravenous injections of histamine 90
Intrinsic agonistic activity 51
Isocitrate dehydrogenase of heart muscles 13
Isoflurane 112
Isoguvacine 99
Isolated blood vessels, contractile and relaxing activity on 45
Isonicotinic acid hydrazide 106
Isozymes 11
L
Late diarrheal excretion 128
Laxative and antidiarrheal agents 125
Levothyroxine 40
Lewy bodies 108
Lichtfield-Wilcoxon procedure 107
Lidocaine 116
Lipophilic character of drugs 5
Lipschitz test 72
L-triiodothyronine 40
Lysosomes 20
M
Magnesium chloride 34
Medullary collecting duct 69
Meissner's plexus 125
Membrane preparation 100
Methacholine 88
Microperfusion experiments 76
Mouse uterus cytosol, determination of specific binding in 36
Muscarinic agonists tremorine 108
Muscimol 99
Muscle diseases 18
N
Nephrectomy, two-thirds 76
Nephritis, experimental 77
Nephrotoxic serum, preparation of 78
Nerves, extrinsic 42
New drug application 8
New drug development process 1
Nicorandil 45
Nifedipine 49
Nuclear extract preparation 36
Nuclear uptake 36
P
Paget's disease 20
Pancreas 11
Papillary collecting duct 69
Paracetamol 4
Pentylenetetrazole test 105
Perineal nerve 42
Peripheral venous catheter 125
Pharmacodynamics 4
Photinus pyralis 37
Photocells 95
Picrotoxin 106
Pinacidil 45
Pirbright guinea-pigs 87
Pirbright white guinea pigs 90
Platelet rich plasma, deaggregation in 59
Pneumotachography in anesthetized guinea pigs 90
Post-marketing surveillance 9
Postural tremor 109
Potassium channel openers, effects of 45
Potassium chloride 34
Preclinical studies 3
Procaine 116
Product characterization 3
Propofol 112
Prostaglandin synthesis inhibition 85
Prostaglandin treated animals 126
Prostate specific antigen 12
Proton pump inhibitors 119
Psoas muscle 49
Pulmonary artery pressure 53
Pulmonary capillary pressure, mean 53
Pulmonary mechanics 91
Pulmonary resistance, calculation of 90
R
Rabbit's duodenum, method using 31
Rabeprazole 119
Rat brain by telemetry, EEG analysis from 96
Respiratory function in vivo 88
Rigidity 109
S
Salivary glands 11
Secreted enzymes 11
Sevoflurane 112
Simple pharmacological screening 25
Sodium chloride 34
Sodium cyanide 91
Sodium dihydrogen orthophosphate 34
Sodium hydrogen carbonates 34
Sprague-Dawley or Wistar rats, female 34
Subaqueous tail bleeding time in rodents 65
Subcritical stenosis 61
Succinylcholine 89
Sucrose 99
Synthetic function, tests for 23
Systolic blood pressure 48
T
Tail cuff method 48
Tensile strength of connective tissue in rats 40
Test tube to new drug application, steps from 2f
Thiazides 67
Thrombin time 56
Thromboelastography 57
alpha angle 58
clot
formation time 58
strength 58
evaluation 58
procedure 57
reaction time 58
Thromboxane synthetase, inhibitor of 89
Tiagabine 105
Tissue preparation 99
Tolpropamine-HCl 88
Toxic class method, acute 6
Toxicological studies 6
Toxins 25
Transepithelial electrical measurements 71
Transpulmonary pressure 90
Tremorine 108
Tris-sucrose buffer 35
Tubular function tests 22
Tumor lysis syndrome, acute 67
Tumors 19
Tyrode's solution 44
U
Urapidil 49
Uricosuric and hypouricemic activity 79
Urinary bladder and internal urethral sphincter 82
Urinary incontinence, management of 67