The treatment of periodontal disease is based on the fact that it is caused by bacterial plaque. Hence, the removal of plaque and all factors that favor its accumulation is therefore of primary consideration in local therapy. Systemic therapy may be used as an adjunct to local measures, especially if it is indicated in localized juvenile periodontitis and rapidly progressing periodontitis cases. Here, the systemic antibiotics are used to completely eliminate the bacteria that invade gingival tissues. This chapter covers the factors that affect healing and healing after periodontal therapy. Healing is affected by local and systemic factors. Under local factors, those factors that can delay the healing are excessive tissue manipulation, unnecessary trauma to the tissue, presence of foreign bodies, etc. Healing is improved mainly by good debridement and proper immobilization of the wound.