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Controversies in Obstetrics & Gynecology
Usha Manaktala, Latika Sahu, Devender Kumar
SECTION 1: OBSTETRICS
CHAPTER 1:
Controversies in Prenatal Screening for Aneuploidy
OVERVIEW
CONTROVERSIES
Selective versus Universal Screening
First Trimester versus Second Trimester Screening
RISK ASSESSMENT: TWIN GESTATION
Nuchal Translucency in Twins
Nuchal Translucency Combined with Serum Markers
NONINVASIVE PRENATAL TESTING: SCREENING OR DIAGNOSIS?
RECOMMENDATIONS
CHAPTER 2:
Prenatal Care: How Many Antenatal Visits are Required?
INTRODUCTION
OBJECTIVES OF A PRENATAL VISIT5
EVOLVING MODELS OF PRENATAL CARE
Perinatal Outcome
Satisfaction with Care
Cost-effectiveness
RECOMMENDATIONS BY VARIOUS ORGANIZATIONS
CONCLUSION
CHAPTER 3:
Management of Midtrimester Preterm Prelabor Rupture of the Membranes
OVERVIEW
INPATIENT OR OUTPATIENT MANAGEMENT
ANTENATAL SURVEILLANCE: MATERNAL AND FETAL
ROLE OF AMNIOCENTESIS
ROLE OF PROPHYLACTIC ANTIBIOTIC: REGIMEN AND DURATION
Role of Vaginal Cleansing in Labor
ROLE OF TOCOLYSIS
ROLE OF CORTICOSTEROIDS
ROLE OF AMNIOINFUSION FOR PREVENTION OF PULMONARY HYPOPLASIA
ROLE OF FIBRIN GLUE
TIMING OF DELIVERY
MODE OF DELIVERY
RECOMMENDATIONS
CHAPTER 4:
Recurrent Miscarriage: The Role of Supplementation of Progesterone
INTRODUCTION
UNEXPLAINED RECURRENT MISCARRIAGE
Management
ROLE OF PROGESTERONE IN RECURRENT MISCARRIAGE
Progesterone5
Uses
Various Types of Progesterone
Advantages of Oral Micronized Progesterone
Advantages of Vaginal Route of Progesterone
Role of Progesterone Deficiency in the Etiology of Recurrent Miscarriages
Role of Progesterone Therapy in the Management of Recurrent Miscarriage
CONCLUSION
CURRENT TRIALS
CHAPTER 5:
Monochorionic Twins: Is Elective Preterm Delivery Mandatory?
OVERVIEW
SPECIFIC COMPLICATIONS OF MONOCHORIONIC TWIN PREGNANCIES
Diagnosis
Prediction of Adverse Outcome
Management
OPTIMAL TIMING AND MODE OF DELIVERY: CONTROVERSIES
Uncomplicated MCDA Pregnancies (Without Fetal Growth Restriction and TTTS)
Monochorionic Monoamniotic (MCMA) Pregnancies
Conjoined Twins
Severe Twin-to-Twin Transfusion Syndrome
RECOMMENDATIONS
CHAPTER 6:
Pre-eclampsia: Is there a Role of Prophylaxis?
OVERVIEW
ETIOPATHOGENESIS
PROPHYLAXIS IN PRE-ECLAMPSIA
Prevention of Development of Risk Factors
Obesity and Insulin Resistance
Sperm Exposure and Paternal Factors
Detection of Women with High-risk
Clinical Examination of Body Mass Index (BMI)
Mean Arterial Pressure
Biochemical Markers
Radiological
Combined Predictors
CONTROVERSIES IN PROPHYLAXIS FOR PRE-ECLAMPSIA
Prophylaxis against Pre-eclampsia in High-risk Population
Lifestyle Interventions
Rest
Exercise
Salt Restricted Diet
Nutritional Supplements
Calcium
Garlic
Marine Oil
Antioxidants
Magnesium and Selenium
Vitamin D
Folic Acid
Probiotic Yoghurt
Pharmacological Prophylaxis
Antiplatelet Drugs
Diuretics
Progesterone
Nitric Oxide Agents
Low Molecular Weight Heparin
RECOMMENDATIONS
CHAPTER 7:
Management of Gestational Diabetes Mellitus: Insulin or OHA or Insulin with OHA
OVERVIEW
MANAGEMENT—CONTROVERSIES
Medical Nutrition Therapy
Exercise
INSULIN THERAPY
When to Start Insulin?
Types of Insulin
DRAWBACKS OF INSULIN THERAPY: NEED OF ORAL HYPOGLYCEMIC AGENTS
Glyburide
Metformin
OTHER ORAL HYPOGLYCEMIC AGENTS
Drawbacks of Oral Hypoglycemic Agents
CONCLUSION
CHAPTER 8:
Mild Hypertension in Pregnancy: Management Options
PRETERM BIRTH
NEONATAL OUTCOME
ECONOMICS
CONCLUSION
CHAPTER 9:
Intrauterine Death of Fetus: Expectant Management versus Immediate Induction of Labor
OVERVIEW
DIAGNOSING IUFD AND DISCLOSURE TO PARENTS
IDENTIFYING THE CAUSE OF IUFD: MATERNAL ASSESSMENT
History
Examination
Investigations
CONTROVERSIES
Management of IUFD: Expectant versus Immediate Induction of Labor
Immediate Induction of Labor
Expectant Management
Methods for Induction of Labor
Contraindications for Spontaneous Labor/Vaginal Delivery
Managing Labor
LOOKING FOR THE CAUSE OF IUD AFTER EXPULSION OF THE FETUS: FETAL AND PLACENTAL ASSESSMENT
Fetal Autopsy
Fetal Karyotyping and Genetic Evaluation
POSTDELIVERY CARE AND FOLLOW-UP
COUNSELING FOR SUBSEQUENT PREGNANCY
RECOMMENDATIONS
CHAPTER 10:
Management of Adnexal Masses in Pregnancy
INTRODUCTION
DIFFERENTIAL DIAGNOSIS OF ADNEXAL MASSES
Evaluation
Management
CONTROVERSIES IN MANAGEMENT
Observation
Surgery
Timing of Surgery
Laparotomy or Laparoscopy
Role of Fertility Preserving Surgery in Ovarian Malignancy in Pregnancy
Role of Ultrasound Guided Cyst Aspiration
RECOMMENDATIONS
SECTION 2: GYNECOLOGY
CHAPTER 11:
Dysfunctional Uterine Bleeding: When to Intervene Surgically?
OVERVIEW
SURGICAL MANAGEMENT OF DUB
Dilatation (D) and Curettage (C)
Endometrial Ablation
First Generation
Second Generation
Third Generation
CONTROVERSIES
Surgery as First-line Treatment for DUB
Surgery as Second-line or Further Pharmaceutical Treatment
What Surgery Preferable and When?
Recommendations on Endometrial Ablation/Resection
RECOMMENDATIONS
CHAPTER 12:
Syndromic Management: What are the Pros and Cons?
OVERVIEW
DRUGS FOR THE SPECIFIC ORGANISM1–3
INPATIENT THERAPY
TREATMENT FOR PARTNER/S
Rationale for Syndromic Approach
Importance
SYNDROMIC MANAGEMENT: PROS
SYNDROMIC MANAGEMENT: CONS
CONCLUSION
CHAPTER 13:
Pelvic Organ Prolapse: To Mesh or Not to Mesh?
OVERVIEW
CONTROVERSIES ON MESH REPAIR
RECOMMENDATIONS
CHAPTER 14:
Controversies in Polycystic Ovarian Syndrome
OVERVIEW
DEFINITION
ETIOPATHOLOGY
TREATMENT
Metformin in PCOS
Metformin for Correction of Metabolic Syndrome
Metformin for Correction of Ovulation
Metformin for Correction of Hirsutism
Treatment of Infertile PCOS Women
Agonist vs Antagonist for IVF
PCOS IN TEENAGERS/ADOLESCENTS
Lifestyle Modification and Weight Loss
Treatment of Hirsutism
CONCLUSION
CHAPTER 15:
Adenomyosis in Infertile Women: What are the Options?
INTRODUCTION
PATHOGENESIS
Risk Factors in Suspicion of Associated Adenomyosis4–8
Clinical Presentation of Adenomyosis
How Adenomyosis Causes Infertility?
INVESTIGATIONS
Biochemical Markers
Ca 125
VEGF-A
Imaging Techniques
Transvaginal 2D Ultrasound
Doppler Ultrasound
Magnetic Resonance Imaging
Histopathological Diagnosis
Myometrial Needle Biopsy
MANAGEMENT OF ADENOMYOSIS
MANAGEMENT OPTIONS FOR ADENOMYOSIS IN INFERTILE PATIENTS
Medical Treatment
Uterine Artery Embolization
Electromyolysis
TVS Guided Myolysis
Laparoscopic Myolysis
External High Intensity Focused Ultrasound21
Mechanism
Advantages
Disadvantages
Laparoscopic High Intensity Focused Ultrasound
Mechanism
Advantage
Disadvantages
SURGERY
How much Resection is Required?
Localized Excision
Laparoscopy
Laparotomy
Fundectomy (Wedge Resection)
Disadvantages
Triple Flap Method
Zenomectomy
Associated Risks of Adenomyosis25
Effect on Assisted Reproduction Techniques
CONCLUSION
CHAPTER 16:
BRCA Gene Mutation: What to do and When?
OVERVIEW
CONTROVERSIAL ISSUES
Referral for BRCA Testing
MUTATION DETECTION
Risk Reduction: Nonsurgical Preventive Options
Surveillance
Chemoprevention
Risk Reduction: Prophylactic Surgical Options
Prophylactic Bilateral Mastectomy
Prophylactic Bilateral Salpingo-oophorectomy
Surgical Technique
Pathological Examination
Hysterectomy along with Prophylactic Surgery
Surveillance for Primary Peritoneal Cancer After Risk-reducing Salpingo-oophorectomy
RECOMMENDATIONS
CHAPTER 17:
Follow-up of Borderline Ovarian Tumors
OVERVIEW
CONTROVERSIES
Diagnosis by Previous Surgery
Postoperative Treatment
Treatment of Recurrences Following Surgery for Fertility Preservation
Treatment of Recurrent Borderline Epithelial Ovarian Tumor
Treatment of Future Fertility
Treatment of Hormone Deprivation
Follow-up Visits
RECOMMENDATIONS
CHAPTER 18:
Neoadjuvant Chemotherapy versus Upfront Surgery for Advanced Ovarian carcinoma
OVERVIEW
PRINCIPLES OF PRIMARY SURGERY [NATIONAL COMPREHENSIVE CANCER NETWORK (NCCN) GUIDELINES]2
Diagnosis before Neoadjuvant Chemotherapy
When to Perform Interval Debulking Surgery
Optimal Goal of Interval Debulking Surgery
Chemotherapy
NCCN Guidelines: Primary Chemotherapy/Primary Adjuvant Therapy Regimes
CONTROVERSIES
Prospective Nonrandomized Trials
Prospective Randomized Phase III Trials
RECOMMENDATIONS
CHAPTER 19:
Human Papillomavirus Vaccine: Should it be a Part of Universal Immunization program in India?
INTRODUCTION
HUMAN PAPILLOMAVIRUS
Gardasil
Cervarix
Human Papillomavirus as a Part of National Immunization Program
Does HPV Vaccine Satisfy the Criteria to be Included in UIP?
Indian Scenario of Carcinoma Cervix and Human Papilloma Virus (HPV)
Efficacy
Safety Profile
Indian Scenario
Cost
CONCLUSION
CHAPTER 20:
Menopausal and Climacteric Symptoms: Hormone versus Nonhormonal Therapy
OVERVIEW
DRUGS USED IN HORMONE REPLACEMENT THERAPY
Estrogens4
Progestogens
Tibolone
Androgens8
NONHORMONAL/ALTERNATIVE THERAPY FOR CLIMACTERIC SYMPTOMS
Selective Estrogen Receptor Modulators
Bisphosphonates
Phytoestrogens15
Neuroendocrine Agents
Selective Serotonin and Noradrenaline Reuptake Inhibitors (SSRI/SNRI)22
Vaginal Lubricant Creams
Black Cohosh
Evening Primrose Oil
Stellate Ganglion Blockade
Other Complementary Interventions27
LIFESTYLE MODIFICATIONS DIET AND SUPPLEMENTS
Exercise28 (International Menopause Society Recommendations)
PSYCHOLOGICAL HEALTH IMPROVEMENT
Initial Investigations and Screening
CONTROVERSIES
Immediate Effects of Hormone Replacement Therapy
Long-term Effects of Hormone Replacement Therapy
Osteoporosis
Cardiovascular
Cognition
Cancer
Endometrial Cancer
Venous Thromboembolism and Stroke
FOOD AND DRUG ADMINISTRATION CONTRAINDICATIONS TO MENOPAUSAL HORMONE THERAPY3
ALTERNATIVES TO HORMONE REPLACEMENT THERAPY
Pharmacological
Nonpharmacological
RECOMMENDATIONS
INDEX
TOC
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