Infection Control and health care prevents the spread of infection within the health care settings. Doctors and allied staff should procure themselves with handling of biomedical waste and instituting infection control procedures. Implementation of such measures prevents cross infection or hospital acquired infections and provides the assurance of quality health care delivery. Great number of pathogens such as bacteria, viruses, fungi and protozoas contributes in spreading infectious diseases such as hepatitis, recurrent herpetic labialis, HIV, multidrug resistant TB. The disease or infection can spread from patient to dental health care personnel (DHCP), DHCP to patient, patient to patient and patient to community. The unique nature of dental procedures, instrumentation and patient care settings demands specific strategies directed in prevention of transmission of diseases. Occupational Safety and Health Administration (OSHA) and Center for Disease Control and Prevention (CDC) have given specific guidelines to safeguard DHCP and patients. Biomedical waste originates from human health care, again a potential hazard to public health and environment. Infectious biomedical waste is a contaminant under environment protection act and is managed as per the guidelines by ministry of health of the particular country. Doctors and the staff should institute preventive procedures starting from hand washing and hand care, use of personal protective equipments for maintenance of standard methods of sterilization and disinfection.