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Spinal Infections and Trauma
S Rajasekaran, Anil K Jain, Ajoy P Shetty, Rishi M Kanna
SECTION ONE: SPINAL INFECTIONS
CHAPTER 1:
Bacteriology of Spinal Infections
INTRODUCTION
PATHOGENESIS
MICROBIAL AGENTS
Importance of Staph. aureus in Spinal Infections?
TYPES OF SPINAL INFECTIONS
Classification of Spinal Infections
Pyogenic Infection
Vertebral Osteomyelitis
Discitis
Spondylodiscitis
Spinal Epidural Abscess
Facet Joint Arthritis
Granulomatous Infections
Tuberculous Infections
Fungal Infections
Parasitic Infections
Postoperative Spinal Wound Infection
Prevention of Postoperative Wound Infections
Spinal Infections in the Immunocompromised
DIAGNOSIS OF INFECTION
Specimen Collection and Transport
Microscopy—Gram Stain/Acid-Fast Stain
Cultures
Molecular Diagnostics
HISTOLOGY
ACKNOWLEDGMENTS
CHAPTER 2:
Biomechanical Aspects of Spinal Infections
INTRODUCTION
ANATOMICAL CONCEPTS
EFFECTS OF INFECTIOUS DISEASES ON THE ANATOMICAL STRUCTURES
BIOMECHANICAL FEATURES IN INFECTIOUS DISEASES OF THE SPINE
EFFECT OF BIOMECHANICAL FORCES ON VERTEBRAL ENDPLATES (VEP)
SUMMARY
CHAPTER 3:
Imaging in Spinal Infections
INTRODUCTION
VARIOUS MODALITIES OF IMAGING
Radiographs
Ultrasonography
Computed Tomography
Magnetic Resonance Imaging
Limitation of MRI
Contraindications of MRI
Functional Imaging
Molecular Imaging
SPINAL OSTEOMYELITIS
SPONDYLODISCITIS
Pyogenic Spondylodiscitis
Plain Radiography
Computed Tomography
Magnetic Resonance Imaging
Healing Pyogenic Spondylodiscitis (see Figs 7A and B)
Functional Imaging
Gallium-67 Scans
Leukocyte-Labeled Scintigraphy
Radiolabeled Antibiotic 99mTc-Ciprofloxacin
Streptavidin / 111 In-Biotin Complex
Positron Emission Tomography
Differential Diagnosis on Imaging
Granulomatous Spondylodiscitis
Tubercular Spondylodiscitis
Plain Radiographs
Computed Tomography Scan
Magnetic Resonance Imaging
Brucella Spondylodiscitis16
Fungal Spondylodiscitis
Aspergillus Spondylodiscitis6
Atypical Appearance in MRI
Conditions Mimicking Infective Spondylodiscitis
Degenerative Spinal Disease33
Acute Schmorl's Nodes
Ankylosing Spondylitis
Neuropathic Spine
Childhood Discitis
Radiological Findings in Childhood Discitis34,35
INTRASPINAL INFECTIONS
Epidural Infection22,36
Subdural Infection
Intradural Infection (see Fig. 9)
Meningitis
Myelitis39
Cord Abscess40
Complications of Intraspinal Infection
Arachnoiditis
Postoperative Spinal Infection
CONCLUSION
ACKNOWLEDGMENT
CHAPTER 4:
Management Principles of Spinal Infections
INTRODUCTION
BACTERIOLOGY
MANAGEMENT PLAN
Clinical Evaluation and Establishing Diagnosis
Nonsurgical Treatment
Antibiotic Therapy
Monitoring Response to Treatment
Surgical Treatment
Debridement
Instrumentation
Anterior versus Posterior versus Combined Approach for Debridement and/or Stabilization
Single-Stage versus Two-Stage Combined Anterior and Posterior Procedures
Reconstruction of Anterior Column– Strut Graft versus Mesh Graft
Pediatric Pyogenic Vertebral Osteomyelitis and Spondylodiscitis
SUMMARY
SECTION TWO: TUBERCULOSIS OF SPINE
CHAPTER 5:
Tuberculosis of the Spine: A Historical Perspective and Evolution of Treatment
HISTORICAL PERSPECTIVE
EVOLUTION OF TREATMENT OF SPINAL TUBERCULOSIS
The Pre-antitubercular Era
Pre-chemotherapy Operative Treatment and its Results
Post-antitubercular Era
The Post-antitubercular Era (Middle-Path Regimen)
EVOLUTION OF SURGICAL TREATMENT OF SPINAL TUBERCULOSIS
Impact of Anterior Radical Debridement (Hong Kong Procedure)
Impact of MRC Trials
Understanding Adherence Properties of Tubercle Bacilli
DRUG RESISTANCE, RELAPSE, OR RECURRENCE
NEW IMAGING MODALITIES
IMMUNODEFICIENCY AND TUBERCULOSIS
THE CHALLENGES FOR FUTURE
CHAPTER 6:
Spinal Tuberculosis—Microbiology and Pathology
INTRODUCTION
TYPES OF MYCOBACTERIUM ORGANISMS
MTB—Morphology
Ziehl-Neelsen (ZN) Acid-Fast Staining Procedure
Auramine/Rhodamine (AR) Staining
MICROBIOLOGICAL DIAGNOSTIC METHODS FOR MTB
Detection from Samples
Molecular Identification of Mycobacterial Species from Culture
Molecular Methods for Detection of Drug Resistance
Solid-Phase Hybridization Techniques
Real-Time PCR Techniques
MTB Genome5,6
PATHOLOGY OF SPINAL TUBERCULOSIS
Modes of Infection13
Abscesses (Granulomas)
Spondylodiscitis—“The Classic Lesion”
Central Body Lesions
Paradiscal Lesions
ATYPICAL TUBERCULOSIS
HISTOPATHOLOGY20
Method of Sample Collection
Macroscopic Aspects
Microscopic Aspects
The Epitheliod Giant Cell Follicle
The Necrotizing Granuloma
CONCLUSION
ACKNOWLEDGMENT
CHAPTER 7:
Clinical Features and Physical Assessment of Tuberculosis of Spine
INTRODUCTION
CLINICAL PRESENTATION
TUBERCULOUS COLD ABSCESS
TUBERCULAR SPINAL DEFORMITY
NEUROLOGICAL DEFICITS
TUBERCULOSIS OF SPECIFIC REGIONS
Posterior Element Tuberculosis
Cervical Spine Tuberculosis
Thoracic Tuberculosis
Lumbar Tuberculosis
Spinal Tuberculomas
Immune Deficiency and Spinal Tuberculosis
Secondary Tuberculosis of Spine
DIFFERENTIAL DIAGNOSIS
CHAPTER 8:
Investigations for Spinal Tuberculosis
INTRODUCTION
BLOOD INVESTIGATIONS
Erythrocyte Sedimentation Rate (ESR)
C-reactive Protein
Total and Differential Leukocyte Counts
TUBERCULIN SKIN TEST
SEROLOGICAL TESTS
TISSUE DIAGNOSIS
Smear Examination
Culture
Histopathological Examination
Molecular Diagnostics
OTHER INVESTIGATIONS
CONCLUSION
CHAPTER 9:
Neurological Deficit
INTRODUCTION
PATHOLOGY OF NEUROLOGICAL DEFICITS
STAGING OF NEURAL DEFICIT
March of Neural Deficit
CLINICAL PRESENTATIONS
Intraspinal Tuberculous Granuloma
TREATMENT
Paraplegia of Active Disease
INDICATIONS OF SURGERY
Clinical Factors
Treatment Factors
Imaging Factors
Patient Factors
SURGICAL DECOMPRESSION (ANTERIOR OR POSTERIOR)
Radical Surgery versus Debridement Surgery
SURGICAL APPROACHES TO TUBERCULAR SPINE
Limitations of Extrapleural (Anterolateral) Approach
Posterior Transpedicular Approach
INSTRUMENTED STABILIZATION
Surgical Risk
Prognosis in Tuberculous Para/Quadriplegia
NEUROLOGICAL COMPLICATIONS IN HEALED DISEASE
Pathogenesis of Neurological Complications in Healed Disease
Management
Correction of Severe Kyphosis for Prevention of Late Onset Paraplegia
CHAPTER 10:
Deformity in Spinal Tuberculosis
INTRODUCTION
NATURAL HISTORY OF PROGRESS OF DEFORMITY
Phase I—Progression in Active Phase
Phase II—Progression in Healed Phase
OTHER FACTORS INFLUENCING DEFORMITY
Severity of Involvement
Presence of Instability
“Spine at Risk” Radiological Signs
Level of Lesion
PATTERNS OF HEALING
Type A Healing
Type B Healing
Type C Healing
BUCKLING COLLAPSE
SURGERY FOR PREVENTION OF DEFORMITY
SURGERY FOR ESTABLISHED DEFORMITY
Closing-opening Wedge Osteotomy
SUMMARY
CHAPTER 11:
Spinal Intradural and Meningeal Tuberculosis
INTRODUCTION
DEFINITION
INCIDENCE
ETIOLOGY AND PATHOGENESIS
CLINICAL PRESENTATION
IMAGING STUDIES
MANAGEMENT
OUTCOME
ACKNOWLEDGMENTS
CHAPTER 12:
B. Management: Management Principles—An Overview
HISTORICAL REVIEW1
CHEMOTHERAPY
Monitoring the Patient on Chemotherapy
SURGERY
Indications for Surgery
Surgical Approach24
Reconstruction of Anterior Column
Factors Influencing the Progression of Kyphosis
Surgery for the Prevention of Deformity
Functional Disability due to Kyphosis35
Anterior Radical Surgery24
Complications
Complications of Isolated Anterior Arthrodesis
Graft-related Complications
Debridement, Reconstruction and Instrumentation by Posterior Approach
Debridement Followed by Anterior Instrumentation52–54
Surgery for Healed Kyphosis
Posterior Vertebral Column Resection34
TUBERCULOSIS OF CERVICAL SPINE
TUBERCULOSIS OF THE LUMBAR SPINE70,71
Pott's Paraplegia73,74
Decompression and Arthrodesis of Spine24
Late Onset Paraplegia78,79
CHAPTER 13:
Drug Therapy for Spinal Tuberculosis
RATIONALE OF CHEMOTHERAPY
ESSENTIAL DRUGS/FIRST-LINE DRUGS
INH
Rifampicin
Pyrazinamide
Ethambutol
Streptomycin
Thiacetazone
RESERVE DRUGS/SECOND-LINE DRUGS
Kanamycin and Amikacin
Cycloserine
Capreomycin
Quinolones
Ethionamide and Prothionamide
Para-aminosalicylic Acid
DIFFERENTIAL ACTION OF ANTITUBERCULAR DRUGS IN BACTERIAL POPULATION
SCIENTIFIC BASIS FOR INTERMITTENT THERAPY: THE “LAG PERIOD” FACTOR
CASE DEFINITIONS
New
Relapse
Treatment after Failure
MULTIDRUG REGIMENS FOR CHEMOTHERAPY
Duration of Chemotherapy
Short-course Chemotherapy
Directly Observed Treatment Strategy (DOTS)
Drug-resistant Tuberculosis
Principles of Treating Drug-resistant Tuberculosis
MANAGEMENT OF COMMON ADVERSE EFFECTS OF CHEMOTHERAPY20
Coloring of Body Secretions
Drug-induced Hepatitis
Pre-existing Liver Disease
Nausea and Vomiting
Skin Reactions
CONCLUSION
CHAPTER 14:
Multidrug-resistant Tuberculosis of the Spine
INTRODUCTION
DEFINITIONS
CAUSES OF DRUG RESISTANCE
LABORATORY DIAGNOSIS OF RESISTANCE
MANAGEMENT PRINCIPLES
CONCLUSION
CHAPTER 15:
Upper Cervical Tuberculosis
INTRODUCTION
PATHOLOGY
PRESENTATION
IMAGING
TREATMENT
CONCLUSION
CHAPTER 16:
Tuberculosis of the Lower Cervical Spine
CERVICAL SPINE INFECTIONS
PECULIARITIES OF CERVICAL SPINE TUBERCULOSIS
CLASSIFICATION
Cervical Spine Tuberculosis in Skeletally Immatured Patients
Cervical Spine Tuberculosis in Skeletally Matured Patients
CLINICAL FEATURES
Examination Findings
Imaging of Cervical Spine Tuberculosis
Differential Diagnosis
MANAGEMENT
Bracing
THE ROLE OF SURGERY
Surgery in Patients with no Neurological Involvement
Neurological Involvement in Patients with Cervical Spine Tuberculosis
Choice of Approaches to the Surgical Treatment of Cervical Spine Tuberculosis: Anterior Surgery for Cervical Spine Tuberculosis
Anterior Debridement with Bone Grafting
Procedure
Posterior Surgery
The Hartshill Rectangle
The Lateral Mass Fixation Systems
Results of Instrumented Fusion
Anterior and Posterior Surgery for Cervical Spine Tuberculosis
Post-tuberculous Cervical Kyphosis
SUMMARY
CHAPTER 17:
Thoracic and Thoracolumbar Tuberculosis
INTRODUCTION
ANATOMICAL PECULIARITIES
CLINICAL PRESENTATION
DIAGNOSIS
Hematological Investigations
Skin Tests
X-rays
Computed Tomography
Magnetic Resonance Imaging
Bone Scan
Smear and Culture
Histological and Microbiological Confirmation of Diagnosis
What does recent literature say for biopsy?
DIFFERENTIAL DIAGNOSIS
TREATMENT
Role of Instrumentation
Conservative Treatment
Controversy in Spine: Duration of Antitubercular Treatment
Surgical Treatment
Approaches
Assessment of Healing
Follow-up
COMPLICATIONS
Conservative Management
Operative Management
SPECIAL SITUATIONS
Late Onset Paraplegia
Noncompressive Deficits
Unstable Spine
Deformity
Growing Spine
AUTHORS' RECOMMENDATIONS
CHAPTER 18:
Lumbosacral Tuberculosis
INTRODUCTION
Development and Biomechanics of Lumbosacral Spine
Anatomical Peculiaritiesof Lumbosacral Spine
Natural History of Lumbosacral Tuberculosis
CLINICAL PRESENTATION
Symptoms and Signs
Local
INVESTIGATIONS
Blood Investigations
Aspiration Cytology
X-ray
CT Scan
PET/CT Scan
Magnetic Resonance Imaging
MANAGEMENT
Medical Management
Surgical Treatment
Indications
Surgical Options
SPECIAL CONSIDERATIONS IN LUMBOSACRAL TUBERCULOSIS
Isolated Sacral Tuberculosis
Pelvic Incidence
Lumbopelvic Instrumentation
Approaches to Lumbopelvic Junction
Posterior Approaches
Anterior Approaches
Augmented Fixation
CONCLUSION
CHAPTER 19:
C. Surgical Techniques: Tuberculosis of Spine: Biopsy Techniques
INTRODUCTION
TECHNIQUES
Open Biopsy
Percutaneous Biopsy
APPROACH AND TECHNIQUE
TYPES OF NEEDLES USED
DIFFICULT AREAS
COMPLICATIONS
EXAMINATION OF SPECIMEN
AUTHORS’ PREFERRED TECHNIQUE (FOR THORACIC AND LUMBAR SPINE)
CONCLUSION
CHAPTER 20:
Cold Abscess in Spinal Tuberculosis
INTRODUCTION
PATHOGENESIS
CRANIOVERTEBRAL JUNCTION
Radiological Features
Management
MIDCERVICAL SPINE (C3-C6)
CERVICO-DORSAL JUNCTION AND UPPER DORSAL SPINE (C7-D4)
THORACIC SPINE
LUMBAR AND LUMBOSACRAL SPINE
Psoas Abscess
Drainage of Psoas Abscess
Coccygectomy for Drainage of a Pelvic Abscess
PROGNOSTIC SIGNS IN PLAIN RADIOGRAPH1
Ultrasonography
Computed Tomography
Magnetic Resonance Imaging
Radionuclide Scanning
PRINCIPLES OF MANAGEMENT
TYPES OF TREATMENT
Aspiration
Aspiration with Injection of Antibiotics
Incision with Drainage
Excision
Fate of the Abscess
CHAPTER 21:
Minimally Invasive Spine Surgery in Spinal Infections
INTRODUCTION
HISTORY OF MINIMALLY INVASIVE SPINE SURGERY (MISS)
ADVANTAGES OF MISS
THORACIC-LUMBAR SPINE
Anterior MISS Approaches
Video-assisted Thoracoscopic Surgery (VATS)
Laparoscopic Lumbar Spine Surgery
Posterior Approaches
Percutaneous Thoracic and Lumbar Fixation
Minimally Invasive Posterior Decompression in Thoracic Spine
Newer Minimally Invasive Lumbar Spine Techniques
MISS-TLIF
X-LIF (Extreme Lateral Interbody Fusion)
AxiaLIF (Axial Lumbar Interbody Fusion)
Percutaneous Debridement of Pyogenic Spondylodiscitis
CERVICAL SPINE
Minimally Invasive Anterior Procedures
Use of Microendoscopic System for Laminectomy, Decompression and Stabilization
CHAPTER 22:
Anterior Approaches in Spinal Tuberculosis
EVOLUTION OF THE ANTERIOR APPROACH OF THE SPINE
SUBAXIAL CERVICAL SPINE TB
Anterior Approach to the Subaxial Cervical Spine
CERVICODORSAL TB
THORACIC TB
Anterior (Transthoracic) Approach to the Thoracic Spine
Approach to Upper Thoracic Spine T1-T4
Thoracoscopic Approach to the Thoracic Spine
THORACOLUMBAR JUNCTION
Anterior Approach to Thoracolumbar Junction
LUMBAR SPINE
Anterior Retroperitoneal Approach to L2-L5
Anterior Transperitoneal Approach to Lumbosacral Junction, L5-S1
CHAPTER 23:
Anterior Procedures in the Management of Tuberculosis of Thoracic, Thoracolumbar and Lumbar Spine
INTRODUCTION
EVOLUTION OF ANTERIOR SURGERIES IN TB SPINE
INDICATIONS FOR SURGERY IN SPINAL TB
ANTERIOR SURGICAL OPTIONS
Stand Alone Anterior Surgical Procedures
Combined Anterior and Posterior Surgeries
Anterior Decompression/Debridement without Fusion
Anterior Decompression/Debridement with Fusion without Instrumentation
Surgical Approach
Operative Procedure
Materials Used for Anterior Column Reconstruction
Anterior Debridement and Fusion with Instrumentation
Combined Anterior and Posterior Surgeries
CONCLUSION
CHAPTER 24:
Posterior Approaches for Management of Spinal Tuberculosis
INTRODUCTION
POSTERIOR APPROACHES TO THE THORACIC SPINE
Transpedicular Approach
Costotransversectomy
Lateral Extracavitary Approach
Results
POSTERIOR APPROACH TO THE LUMBAR SPINE
Author's Preferred Treatment
Results
POSTERIOR APPROACH TO THE CERVICAL SPINE
Complications of Posterior/Posterolateral Approaches to the Spine
SUMMARY
CHAPTER 25:
Surgeries in Healed Tuberculosis of Spine
INTRODUCTION
NATURAL HEALING IN SPINAL TUBERCULOSIS
Problems in Healed Tuberculosis
Back Pain
Late Onset Neurological Deficit
Spinal Canal Stenosis
Pulmonary Complications
Cosmetic Deformity
Surgery in Healed TB
Management Principles
Special Considerations in Post-tubercular Kyphosis
Surgical Approach
Surgical Techniques
Technique of Combined Approaches
Anterior Approach
Posterior Approach
POSTERIOR APPROACHES
Vertebral Column Resection (VCR) Techniques
Closing-opening Wedge Osteotomy (COWO)
Multilevel Modified VCR Technique
En bloc Spondylectomy for Kyphosis Correction
CONCLUSION
SECTION THREE: PYOGENIC INFECTIONS OF SPINE
CHAPTER 26:
Pyogenic Vertebral Osteomyelitis
INTRODUCTION
EPIDEMIOLOGY
PATHOGENESIS
Hematogenous Route
Postoperative or Iatrogenic
Direct Spread
BACTERIOLOGY
CLINICAL PRESENTATION
DIAGNOSIS
Laboratory Studies
Radiographic Studies
Radionuclide Studies
Magnetic Resonance Imaging
Biopsy
MANAGEMENT
Nonoperative Management
Surgical Management
The Goals of Surgical Intervention
The Role of Spinal Implants
FACET JOINT SEPTIC ARTHRITIS
CONCLUSION
ACKNOWLEDGMENT
CHAPTER 27:
Spinal Epidural Abscess
INTRODUCTION
PATHOANATOMY
INCIDENCE
PATHOPHYSIOLOGY AND PATHOGENESIS
Infecting Organisms in SEA3,4,12
Spinal Epidural Abscesses in Special Situations
Postoperative Wound Infections and SEA
Predisposing Risk Factors
CLINICAL FEATURES
DIAGNOSIS4,5
Laboratory Studies
Imaging Studies
Differential Diagnosis
MANAGEMENT OF SEA
General Supportive Treatment
Conservative Management
Conservative Therapy with Antibiotics Alone
CT-guided Needle Aspiration with Antimicrobial Therapy5,9
Surgical Management
Indications for Surgery
Types of Surgery
Antimicrobial Therapy18
OUTCOME
TUBERCULAR SPINAL EPIDURAL ABSCESS
EPIDURAL GRANULOMA
Incidence
Pathogenesis
Classification
Clinical Presentation
Differential Diagnosis
Treatment
CONCLUSION
SECTION FOUR: MISCELLANEOUS SPINAL INFECTIONS
CHAPTER 28:
Fungal Infections
PATHOANATOMY
CLINICAL FEATURES
RADIOLOGICAL FEATURES
DIAGNOSTIC TESTS
TREATMENT
PREVENTION OF INVASIVE ASPERGILLOSIS IN THE IMMUNOCOMPROMISED PATIENT
EPIDEMIOLOGY
DIAGNOSTIC TESTS
SURGICAL TREATMENT
MEDICAL TREATMENT
CHAPTER 29:
Unusual Bacterial Infections
INTRODUCTION
EPIDEMIOLOGY
ETIOLOGY
CLINICAL FEATURES
IMAGING
DIAGNOSTIC STUDIES
TREATMENT
Surgical
Medical
PREVENTATIVE MEASURES
INTRODUCTION
EPIDEMIOLOGY
ETIOLOGY
CLINICAL MANIFESTATIONS
IMAGING STUDIES
DIAGNOSTIC STUDIES
TREATMENT
PROGNOSIS
CHAPTER 30:
Parasitic Infestations
INTRODUCTION
EPIDEMIOLOGY
PARASITOLOGY
PATHOLOGY
CLINICAL FEATURES
LABORATORY FINDINGS
IMAGING FEATURES
Plain Radiographs
Ultrasonography
CT Scan
Magnetic Resonance Imaging (MRI)
DIFFERENTIAL DIAGNOSIS
NATURAL HISTORY
TREATMENT
Surgical
Medical
INTRODUCTION
LIFE CYCLE
PRESENTATION
INVESTIGATIONS
TREATMENT
CONCLUSION
CHAPTER 31:
Spinal Infections in the Immunocompromised Patients
INTRODUCTION
Global Prevalence
HIV AND HOST INTERACTIONS
HIV Transmission
Viral Kinetics, Host Immune Response and Disease Progression
Host Genetic Factors and Disease Progression
HIV and Tuberculosis Coinfection and the Immune Response
Effects of Depleted Immune Response in Surgical Settings
World Health Organization (WHO) HIV Clinical Staging and Approach to Patient Care
Protection of Health Care Workers
OPPORTUNISTIC SPINAL INFECTIONS
Tuberculosis Spondylitis
Other Coinfections
ANTIRETROVIRAL THERAPY
MALIGNANCY AND HIV/AIDS
Non-Hodgkin's Lymphoma (NHL)
Multiple Myeloma
CONCLUSION
CHAPTER 32:
Postoperative Spondylodiscitis
INTRODUCTION
INCIDENCE
ETIOPATHOLOGY
Host Factors
Intraoperative/Surgical Factors
THE SOURCE
Pathogenesis
Anterior Spinal Surgery
Posterior Spinal Infections
CLINICAL PRESENTATION AND DIAGNOSIS
Acute Stage
Chronic Stage
INVESTIGATIONS
Laboratory Investigations
RADIOLOGY
X-Rays and CT scan
Bone Scans
MRI
Biopsy
MANAGEMENT
PREVENTION
Patient, Surgeon and Environment Factors
Prophylactic Antibiotics
TREATMENT
Acute Stage
Duration of Antibiotics
SURGERY
Indications for Surgical Intervention
Surgical Approach
INSTRUMENTATION
Epidural Abscess
PROGNOSIS
SUMMARY
CHAPTER 33:
Peri-implant Spinal Infections
INTRODUCTION
RISK FACTORS FOR WOUND INFECTION
ANTERIOR VERSUS POSTERIOR INSTRUMENTATION
CLINICAL PRESENTATION
INVESTIGATIONS
Laboratory Investigation
Imaging
MICROBIOLOGY OF INFECTION
Implant Removal or Retention
Role of Antibiotic Prophylaxis
CONCLUSION
SECTION FIVE: SPINAL TRAUMA
CHAPTER 34:
Epidemiology of Traumatic Spinal Cord Injuries
INCIDENCE RATE
PREVALENCE OF SCI
SURVIVAL TIME
AGE
GENDER
MARITAL STATUS
EDUCATIONAL LEVEL
PRIMARY OCCUPATIONAL STATUS AT THE TIME OF INJURY
MODE OF INJURY
NEUROLOGICAL LEVEL AND CATEGORY OF INJURY
TIME and PLACE OF INJURY
ASSOCIATED INJURIES
SUMMARY
CHAPTER 35:
Prehospital Care in Spinal Injury Patients
INTRODUCTION
PRINCIPLES OF PREHOSPITAL CARE
Goals of Prehospital Management
PREHOSPITAL CARE SYSTEM
Who Should Deliver Prehospital Care?
INITIAL EVALUATION
Important Considerations in Spinal Injury Patients
PROTECTION OF SPINE
Manual In-line Stabilization
Spinal Immobilization
CERVICAL COLLARS
Precautions during Neck Immobilization22,32
Lateral Stabilizers
Spine Boards
TRANSFER TO TERTIARY UNITS
CONSIDERATION IN SPECIAL CIRCUMSTANCES
Pediatric Spine
Helmet Removal
Penetrating Injuries
Sports Injuries
PITFALLS OF SPINAL IMMOBILIZATION
FUTURE TRENDS
CONCLUSION
CHAPTER 36:
Initial Evaluation of Patients with Spinal Injuries
INTRODUCTION
GENERAL EVALUATION
LOCAL EXAMINATION
NEUROLOGICAL EXAMINATION
Sensory Examination
Sensory Level
Sensory Index Scoring
Motor Examination
Motor Level
Rectal Examination
Motor Index Scoring
Neurologic Level of Injury (NLI)
Skeletal Level
CLASSIFICATION AND SCORING OF THE SPINAL INJURIES
Frankel Scale
ASIA Impairment Scale
Tetraplegia
Paraplegia
Complete Injury
Incomplete Injury
Clinical Syndromes of Incomplete Spinal Cord Injury
Central Cord Syndrome
Cruciate Paralysis
Brown-Séquard Syndrome
Anterior Cord Syndrome
Posterior Cord Syndrome
Initial Management
Prehospital (In Field) Care
CHAPTER 37:
Radiology of Spinal Trauma
INTRODUCTION
PLAIN RADIOGRAPH
CERVICAL SPINE RADIOGRAPH
Cervical Spine Lateral View
Anteroposterior View
Open-mouth Odontoid View
Supine Oblique or “Trauma” Oblique View
Swimmer's Lateral View (Figs 17A and B)
Pillar View
Dynamic Radiographs
THORACOLUMBAR SPINE RADIOGRAPH
PLAIN RADIOGRAPHS FOR SACRUM
SPINAL CORD INJURIES WITHOUT RADIOGRAPHIC ABNORMALITIES (SCIWORA)
Multiple Spinal Fractures
Missed Injuries
COMPUTED TOMOGRAPHY IN SPINAL TRAUMA
Computed Tomography Myelography
Three-dimensional Computed Tomography (CT)
Computed Tomography in Cervical Spine
Computed Tomography Angiography (CTA) (Fig. 36)
Computed Tomography in Thoracolumbar Spine
Computed Tomography of the Sacrum
MAGNETIC RESONANCE IMAGING IN SPINAL TRAUMA
Indications of MRI in Trauma
Magnetic Resonance Angiography for Spinal Trauma
CONVENTIONAL ANGIOGRAPHY FOR SPINAL TRAUMA
RADIONUCLIDE BONE IMAGING FOR SPINAL TRAUMA
CHAPTER 38:
Surgical Decision Making in Spinal Cord Injuries
SURGICAL OR CONSERVATIVE MANAGEMENT
Neurological Recovery
Canal Clearance
Stabilization
Systemic Complications Associated with Acute SCI
Hospital Stay and Cost of Treatment
Progression of Kyphosis and Late Complications of Pain and Neurological Deterioration
Return to Work
THE CONTEXT OF DEVELOPING COUNTRIES
SCI—WHEN TO OPERATE
CONCLUSIONS
Conservative or Surgical treatment
When to Operate
SECTION SIX: SPINAL CORD INJURY
CHAPTER 39:
Pathophysiology of Spinal Cord Injury
INTRODUCTION
EPIDEMIOLOGY
PATHOPHYSIOLOGY OF SPINAL CORD INJURY
Primary Phase
Secondary Phase
Immediate Phase
Early Acute Phase
Subacute Phase
Intermediate Phase
Chronic Phase
SUMMARY
CHAPTER 40:
Current Status of Pharmacological Agents in Acute Spinal Cord Injury
INTRODUCTION
PATHOPHYSIOLOGY OF SCI
Primary Damage
Secondary Damage
Mechanism of Secondary Damage (Fig. 1)
MECHANISM OF ACTION OF PHARMACOLOGICAL AGENTS
Methylprednisolone Sodium Succinate (MPSS)
North American Spinal Cord Injury Study (NASCIS) Trials
The Controversy about NASCIS Trial
Naloxone
Lazaroids
Ganglioside GM-1
Thyrotropin-releasing Hormone
Nimodipine
Gacyclidine (GK-11)
Minocycline
Vitamins
Erythropoietin
Atorvastatin
Cethrin BA-210
Riluzole
ATI-355
CONCLUSION
CHAPTER 41:
Regenerative Strategies in Spinal Cord Injury
INTRODUCTION
PATHOPHYSIOLOGY OF THE SCI AND OBSTACLES TO REGENERATION IN THE INJURED SPINAL CORD
Cavity Formation
Glial Scar Formation
Myelin-Based Inhibitors
APPROACHES TO TREATMENT
Molecular Therapies for Axonal Regeneration
Cell-based Regenerative Strategies
CHALLENGES IN DEVELOPING CELLULAR THERAPIES TO TREAT SPINAL CORD INJURY
WHAT ARE STEM CELLS?
OLFACTORY ENSHEATHING CELLS (OECS)
SCHWANN CELLS
MACROPHAGES
BONE MARROW STROMAL STEM CELLS
NEURAL STEM CELLS AND GLIAL PROGENITORS
EMBRYONIC STEM CELL-DERIVED NSCS, NPCS AND OPCS
ADULT-DERIVED NSCS
DELIVERY METHODS
Delivery of Cells by Injection
Delivery of Cells Using Implantable Scaffolds
CONCLUSION
SECTION SEVEN: CERVICAL SPINE TRAUMA
CHAPTER 42:
Upper Cervical Spine Injuries
ANATOMICAL CONSIDERATIONS
ATLANTO-OCCIPITAL INJURIES
Occipital Condyle Fractures
Atlanto-occipital Dislocations
ATLAS FRACTURES
ATLANTOAXIAL DISLOCATIONS
Transverse Ligament Rupture
C1-C2 Rotary Subluxation
AXIS FRACTURES
Odontoid Fractures
Hangman Fractures
CHAPTER 43:
Missed Spinal Injuries
INTRODUCTION
EPIDEMIOLOGY
CONSEQUENCES OF MISSED SPINAL INJURIES
Case 1
Case 2
Case 3
ETIOLOGY OF MISSED INJURIES
PREVENTION
Clearing the C-Spine
Awake, Alert, Asymptomatic Patient
Awake, Alert and Symptomatic Patient
Temporarily Nonassessable Patient
Obtunded Polytrauma/Unconscious, Intubated Patient
THORACOLUMBAR TRAUMA
Clearing the Pediatric Spine
Post-traumatic Spinal Deformity
SUMMARY
SECTION EIGHT: THORACOLUMBAR SPINE TRAUMA
CHAPTER 44:
Biomechanics and Classification of Thoracolumbar Spinal Injuries
INTRODUCTION
THORACOLUMBAR SPINE
Historical Aspects
Biomechanical Studies Validating the Three-Column Concept of Load Bearing and Stability
Morphology versus Mechanism of Injury
Mechanistic Classification—Ferguson and Allen
AO—Magerl Classification
CONCEPT OF INSTABILITY AND SURGICAL INDICATION
Definition of Instability
Stable versus Unstable Burst Fractures
McCormack and Gaines Load-sharing Classification
The Thoracolumbar Injury Severity Score (TLISS) and Thoracolumbar Injury Classification and Severity System (TLICS)
SUMMARY
CHAPTER 45:
Vertebral Compression Fractures
INTRODUCTION
ETIOLOGY
EPIDEMIOLOGY
CLASSIFICATION
Nicoll's Classification
Holdsworth's Classification
Denis’ Classification
McAfee's Classification
Magerl's Classification
Thoracolumbar Injury Classification
BIOMECHANICS
CLINICAL FEATURES
DIFFERENTIAL DIAGNOSIS
INVESTIGATIONS
X-Rays
CT Scan
Magnetic Resonance Imaging (MRI)
TREATMENT
CHAPTER 46:
Burst Fractures of the Thoracolumbar Spine
INTRODUCTION
DEFINITION
EPIDEMIOLOGY
CLASSIFICATION
PATHOLOGICAL ANATOMY
Imaging
MANAGEMENT
Emergency Management
Early Definitive Management
Late Definitive Management
Indications for Surgery
MANAGEMENT ALGORITHM ACCORDING TO THE AO CLASSIFICATION
CONCLUSION
CHAPTER 47:
Flexion-distraction Injuries and Fracture Dislocations of the Thoracic and Lumbar Spine
INCIDENCE
ANATOMY AND BIOMECHANICAL CONSIDERATIONS
ASSESSMENT
MECHANISM OF INJURY: FLEXION-DISTRACTION INJURY OF THE THORACIC AND LUMBAR SPINE
Imaging
Imaging—Flexion-distraction Injury of the Thoracic and Lumbar Spine
Classification of Flexion-distraction Injury of the Thoracic and Lumbar Spine
MECHANISM OF INJURY: FRACTURE DISLOCATIONS OF THE THORACIC AND LUMBAR SPINE
Imaging—Fracture Dislocations of the Thoracic and Lumbar Spine
MANAGEMENT OF FLEXION-DISTRACTION INJURIES AND FRACTURE DISLOCATIONS OF THE THORACIC AND LUMBAR SPINE
Long versus Short Posterior Fusion Constructs
Minimally Invasive Surgery (MIS)
CONCLUSION
ACKNOWLEDGMENT
CHAPTER 48:
Fractures of the Sacrum
INTRODUCTION
SACRAL ANATOMY
ETIOLOGY AND INCIDENCE
EVALUATION OF SACRAL FRACTURES
Clinical Examination
Radiological Evaluation
Electrophysiological Assessment
CLASSIFICATION
Descriptive Classification Systems
According to the Direction of the Fracture Line (Figs 4A to C)
According to Fracture Line Propagation (Fig. 5)
Denis Three-zone Classification System
Classification of Lumbosacral Junction
Classification of Fracture Stability
Classification of Sacral Neurological Injuries
TREATMENT
Initial Management
Nonoperative Management
Operative Management
Early versus Delayed Surgical Intervention
Sacral Decompression Techniques
Sacral Stabilization Procedures
Principles of Surgical Stabilization Techniques
Sacroiliac Screw Fixation
Sacral Plate Fixation Techniques
Spinopelvic Instrumentation: (Sacral Bypass Fixations) (Figs 13A and B)
Complications of Sacral Fixation
CONCLUSION
CHAPTER 49:
Pediatric Spinal Injuries
INTRODUCTION
EPIDEMIOLOGY
RELATED ANATOMY
BIOMECHANICS
SCIWORA
CLINICAL PRESENTATION
IMAGING STUDIES
X-rays
Role of CT Scans and MRI
MANAGEMENT STRATEGIES
Conservative Treatment
Surgical Treatment
LATE COMPLICATIONS of PEDIATRIC SPINAL INJURIES
Spinal Deformity
Syringomyelia
CHAPTER 50:
Gunshot Injuries to the Spine
INTRODUCTION
BALLISTICS OF GUNSHOT INJURIES
ASSESSMENT
ROLE OF STEROIDS
INVESTIGATIONS
ANTIBIOTIC TREATMENT
INDICATONS FOR SURGERY
LEAD TOXICITY
MIGRATING BULLETS
CASE REVIEW
RESULTS OF TREATMENT
CONCLUSION
CHAPTER 51:
Nonoperative Management of Spinal Injuries
INTRODUCTION
MEDICAL MANAGEMENT OF ACUTE SPINAL CORD INJURY
CONSERVATIVE MANAGEMENT OF UPPER CERVICAL SPINE INJURIES
Indications for Nonoperative Treatment in Upper Cervical Spine Injuries
Cervical Bracing
SOMI Brace
Two- and Four-Poster Collars
Minerva CTO
Biomechanical Studies on Cervical Collars
Halo Orthosis
Technique of Halo Vest Application
Recumbent Skeletal Traction
Application of Gardner-Wells Tongs
CONSERVATIVE MANAGEMENT OF LOWER CERVICAL SPINE INJURIES
Indications for Conservative Management in Lower Cervical Spine Injury
Cervical Orthoses
Cervicothoracic Orthosis
Skeletal Traction
CONSERVATIVE MANAGEMENT OF THORACIC SPINE INJURIES
CONSERVATIVE MANAGEMENT OF THORACOLUMBAR FRACTURES
Decision Making in Conservative Management
Compression Fractures
Burst Fractures
Chance Fracture (Distraction Injury)
Flexion Distraction Injuries and Fracture Dislocations
Extension Injuries
Transverse Process Fractures
Controversies in the Conservative Management of Thoracolumbar Burst Injuries
Providing Stability: Are all Burst Fractures Unstable?
Neurological Deterioration
The Myth of “Canal Clearance”
Prevention of Kyphotic Deformity
Relief of Pain and Return to Work (Functional Status)
NONOPERATIVE MANAGEMENT OF THORACOLUMBAR FRACTURES WITH NORMAL NEUROLOGY
Lumbar and Lumbosacral Orthosis
Clamshell Brace
Knight-Taylor Brace
Corset
Rigid Brace
CHAPTER 52:
Iatrogenic Spinal Cord Injury—Incidence, Prevention and Management
IATROGENIC SPINAL CORD INJURY
Abstract
INTRODUCTION
INCIDENCE OF IATROGENIC SPINAL CORD INJURY
ETIOPATHOGENESIS OF ISCI
Direct Mechanical Injury
Vascular Injury
Preventive Measures
Preoperative Radiological and MRI Assessment of the Spinal Column and Spinal Cord
Preoperative Assessment of Cervical Spine Motion and Positioning
Hemodynamic Precautions
Surgical Technique
Surgical Implants
Intraoperative Navigation
Intraoperative Spinal Neuromonitoring
MANAGEMENT OF IATROGENIC SPINAL CORD INJURY
Neurological Deficit in the Absence of Intraoperative Neuromonitoring
Delayed Onset Postoperative Neurological Dysfunction (Flow chart 2)
Role of Steroids
SUMMARY
CHAPTER 53:
SCI Rehabilitation
ACUTE PHASE REHABILITATION
POST-ACUTE MANAGEMENT OF CONSERVATIVELY AND SURGICALLY MANAGED PATIENTS
MOBILITY
Tetraplegia
Complete Tetraplegia C4
Complete C5/C6 Levels
Complete C7/C8/T1 Levels
Mobility in Paraplegia
Complete Paraplegia T2 to T9
Complete Paraplegia T10 to L2
NEUROGENIC BLADDER MANAGEMENT AFTER SCI
Functional Classification
Incontinence
Retention
Neurological Classification
Management
Neurological Level and Bladder Management
Tetraplegia (C6 and above)
Paraplegia with Good Hand Functions
Medical Management Depending on the Type of the Bladder (Table 2)
NEUROGENIC BOWEL
Goals for the Management of Neurogenic Bowel
Type of Bowel Dysfunction
SEXUAL REHABILITATION
Management
Vibrator Stimulation
Stuffing
Vacuum Tumescence Constriction Method
Vasodilators
Invasive Management
Associated Problems
Fertility
Vocational Rehabilitation
Prevocational Evaluation
Follow-up of Rehabilitated SCI Patients
Objectives of the annual follow-up event (Rehab Mela)
Recent Advances
FUNCTIONAL OUTCOMES IN SCI REHABILITATION
ACKNOWLEDGMENTS
CHAPTER 54:
Complications of Spinal Cord Injury
INTRODUCTION
Early Complications
Late Complications
RESPIRATORY COMPLICATIONS IN SPINAL CORD INJURY
Respiratory Dysfunction after SCI and Pathophysiology
Incidence of Complications
Pneumonia and Atelectasis
Pneumothorax and Chest Injury
Pulmonary Embolism
Pleural Effusion
Sleep Disorders
Aspiration
ARDS
Management
Investigations
Treatment
Positioning
Chest Physiotherapy22
Suctioning
Assisted Cough
Intermittent Positive Pressure Breathing or Ventilation (IPPB) and Bi-level Positive Airway Pressure (BiPAP) or Continuous Positive Airway Pressure (CPAP)
Incentive Spirometry and Resistive Devices
Glossopharyngeal Breathing
Bronchoscopy
Medications
Mechanical Ventilation and Respiratory Failure
CARDIOVASCULAR COMPLICATIONS AFTER SCI
Low Baseline Blood Pressure
Orthostatic hypotension (OH)
Pathophysiology
Clinical Features
Management
Bradycardia and Cardiac Arrest
Autonomic Dysreflexia (AD)
Pathophysiology of AD
Signs and Symptoms
Potential Causes or Precipitating Factors
Urinary System
Gastrointestinal System
Integumentary System
Reproductive
Male
Female
Other Systemic Causes
Treatment
Coronary Heart Disease (CHD)
Risk Factors and Prevention Strategies
Symptoms and Signs
Diagnostic Testing
Management
Peripheral Arterial Disease
Clinical Evaluation
Diagnostic Testing
Management
DEEP VEIN THROMBOSIS IN SPINAL CORD INJURY
Signs and Symptoms
Investigation
Thromboprophylaxis
Failure of Prophylaxis
Treatment
GASTROINTESTINAL (GI) COMPLICATIONS IN SPINAL CORD INJURY PATIENTS
Gastroesophageal Reflux Disease
Factors Promoting Gastroesophageal Reflux in Persons with SCI
Impaired Gastric Emptying
Gastric Dilatation and Ileus
Small Bowel Obstruction
Superior Mesenteric Artery Syndrome
Abdominal Pain and the Acute Abdomen
Ulcer Disease and Bleeding
Fecal Impaction
HEMORRHOIDS
PRESSURE ULCER (PrU)
Introduction
Definition
Pathophysiology227,228
External Factors
Internal Factors
Pressure Ulcer Staging (US National Pressure Ulcer Advisory Board)232
Principles of Pressure Ulcer Management (Fig. 1)
Assessment and Prevention Strategies243–5
External
Behavioral
Internal
Twenty-Four Hour Nutritional Requirements for Persons with SCI246–48
Caloric Intake (Table 1)
Treatment (Fig. 2)
Debridements
Moist Dressings (Table 2)
Adjunctive Therapy
Different Surgical Options for PrU Healing
HETEROTOPIC OSSIFICATION (HO)
Introduction
Pathogenesis
Clinical Presentation
Brooker's Classification of HO (Ayers, et al.)
Investigations
Prevention and Treatment
NSAIDs
Bisphosphonates/Diphosphonates
Radiation Therapy
SPASTICITY
Definition
Assessment of Spasticity
Pathophysiology of Spasticity302
Management
Physical Modalities
Pharmacologic Treatments
GENITOURINARY TRACT COMPLICATIONS
UTI
Treatment
Vesicoureteral Reflux (VUR)
Causes
Investigations
Treatment
Hydronephrosis/Hydroureter
Causes
Symptoms
Diagnosis
Treatment
Urolithiasis
Symptoms
Diagnosis
Treatment
Chronic Pyelonephritis
Renal Failure
Acute Renal Failure (ARF)
Treatment
Chronic Renal Failure (CRF)
Treatment
Epididymitis
Treatment
Bladder Neoplasm
Urethral Stricture
OSTEOPOROSIS IN SPINAL CORD INJURED PATIENT
Pathogenesis
Pattern of Involvement
Clinical Feature: How an Osteoporotic Fracture in SCI is Different?
Management
Treatment for Osteoporosis
Treatment of Fracture
POST-TRAUMATIC PAIN SYNDROMES
Classification
Bryce/Ragnarsson Classification of Pain after SCI392
Pathophysiology of Neuropathic Pain in SCI
Treatment
Oral Pharmacologic Interventions
Psychological Interventions
Surgical Interventions
SYRINGOMYELIA
Symptoms424
Natural History
Treatment
Conservative Treatment429
Surgical Treatment
Prognosis
MORTALITY IN SPINAL CORD INJURY
Mortality in Acute Phase
SECTION NINE: SPECIAL SITUATIONS
CHAPTER 55:
Management of Subaxial Cervical Spine Injuries
INTRODUCTION
EMERGENCY IN-HOSPITAL CARE
Stabilize Vital Parameters
Look For Head/Chest/Long Bone Injuries
Identify a Cervical Spine Injury
Look for Other Spinal Injuries
Assess the Neurological Status
Administration of Steroids
Imaging
Reduction of Fractures/Dislocation
DEFINITIVE TREATMENT
INDICATIONS FOR SURGERY
Neurological
Instability
Spinal Deformity
Special Situations
SELECTION OF SURGICAL APPROACH
Vertical Compression (VC) Injuries
Compressive Flexion (CF) Injuries
Distractive-Flexion (DF) Injuries
Compressive-Extension (CE) Injuries
Distractive-Extension (DE) Injuries
Lateral Flexion (LF) Injuries
COMPLICATIONS
CHAPTER 56:
Osteoporosis and Spinal Trauma
INTRODUCTION
INCIDENCE
CLINICAL FEATURES
CLASSIFICATION
PATHOLOGY
RISK FACTORS
Nonmodifiable Risk Factors
Modifiable Risk Factors
DIAGNOSIS
Laboratory Investigations
Radiology
Conventional Radiographs
Dual Energy X-Ray Absorptiometry
Indications
Ultrasonography
Magnetic Resonance Imaging
Quantitative Computed Tomography (QCT)
Bone Markers
Biopsy
FRACTURES IN OSTEOPOROTIC SPINE
MANAGEMENT
PREVENTION AND MEDICAL MANAGEMENT
Calcium and Vitamin D
Hormone Replacement Therapy
Selective Estrogen Receptor Modulators
Bisphosphonates
Calcitonin
Strontium Ranelate
Fluoride
Teriparatide
MANAGEMENT OF VERTEBRAL COMPRESSION FRACTURES
NONOPERATIVE MANAGEMENT
SURGICAL MANAGEMENT
MINIMALLY INVASIVE TECHNIQUES
OPEN SURGICAL PROCEDURES
Osteoporotic Compression Fracture with Spinal Stenosis
Osteoporotic Compression Fracture with Kyphotic Deformity, Instability and Neurological Deficit
METHODS OF FIXATION33
Cervical Spine
Thoracic and Lumbar Spine
Augmentation with Vertebroplasty
Improving Fixation in Osteoporotic Spine
CONCLUSION
CHAPTER 57:
Special Considerations for Geriatric Spinal Injuries
INTRODUCTION
PREDISPOSING FACTOR
Canal Stenosis
Rigidity
Osteoporosis
Neurological Deficit
ETIOLOGY
LEVEL OF INJURY
TYPE OF INJURY
Cervical Distractive Extension Injuries8
Odontoid Fractures
SYMPTOMS
DIAGNOSIS
COMPLICATIONS
MORTALITY
Management
General Principles of Conservative Management in Geriatric Spinal Injuries
General Principles of Surgical Management in Geriatric Spinal Injuries
Cervical Distractive Extension Injuries
Odontoid Fractures
Predictors of Nonunions49
OUTCOMES
CONCLUSION
CHAPTER 58:
Vertebroplasty for Osteoporotic Vertebral Fractures
INTRODUCTION
CONSEQUENCE OF VERTEBRAL COMPRESSION FRACTURES
INDICATIONS FOR VERTEBROPLASTY
CONTRAINDICATIONS
TIMING OF VERTEBROPLASTY
PREOPERATIVE EVALUATION
Symptoms
Examination
Laboratory Investigations
X-rays
Computed Tomography (CT) Scan
MRI
MATERIALS USED FOR AUGMENTATION
Polymethyl Methacrylate
Calcium Phosphate Cement (CPC)
Recent Developments
VERTEBROPLASTY—HOW DOES IT WORK?
Mechanical Theory
Thermal Theory
Decompression Theory
DEVICES FOR PERFORMING VERTEBROPLASTY
SURGICAL TECHNIQUE
Approach
Transpedicular Vertebroplasty
Extrapedicular Vertebroplasty
POSTOPERATIVE MANAGEMENT
COMPLICATIONS
Techniques to Reduce Cement Leak and Improve Results
CURRENT OPINION ON VERTEBROPLASTY
FUTURE OF VERTEBROPLASTY
CHAPTER 59:
Kyphoplasty of Symptomatic Vertebral Body Compression Fractures
INTRODUCTION
SURGICAL MANAGEMENT
INDICATIONS
DIAGNOSIS AND IMAGING
KYPHOPLASTY
Balloon Kyphoplasty
Mechanical Kyphoplasty
Outcome and Complications
Choice of Bone Cements
Mechanism of Pain Relief
Handling Characteristics
Bone Cement Extravasation
Biomechanical Changes of the Spine and Subsequent Vertebral Body Fractures
Tissue Injury
Future
CHAPTER 60:
Spinal Injuries in Ankylosing Spinal Disorders
INTRODUCTION
CLINICAL PRESENTATION
INVESTIGATIONS
GENERAL PRINCIPLES
SPINAL FRACTURES IN ANKYLOSING SPONDYLITIS
Cervical Spine Fractures
Thoracolumbar Spine Fractures
DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS
Fractures in DISH
COMPLICATIONS
CONCLUSION
INDEX
TOC
Index
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