This chapter provides detail description of Tuberculosis of the central nervous system. Chapter has 19 well illustrated diagrams and pictures. Tuberculosis, history and pathogenesis of tuberculosis, central nervous system tuberculosis, intracranial tuberculomas, tuberculoma en plaque, tuberculous abscess, cystic tuberculoma, multiple grape like tuberculoma, tuberculous encephalopathy with an inconsequential tuberculoma, clinical features of tuberculoma, investigations of an intracranial tuberculoma, antitubercular chemotherapy, multi-drug resistant tuberculosis, surgical treatment are given in detail. 222 references are included at the end of the chapter to facilitate further reading.