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Pearls in Clinical Pediatrics
Pushpendra Magon
SECTION 1: CLINICAL PEDIATRICS
CHAPTER 1:
Children are Unique
UNIQUE DEVELOPMENT AND GROWTH RIGHT FROM THE WOMB
DISEASE PRESENTATION, DIAGNOSIS AND MANAGEMENT ARE UNIQUE
AGEWISE THEY ARE UNIQUE
Infants
Toddler (1-3 years)
Preschooler (3-6 years)
School Goer (6-12 years)
Adolescent
UNIQUE PARENTING AND PSYCHOPATHOLOGY
CHAPTER 2:
Know What is Normal and What is Not?
WHY TO IDENTIFY WHAT IS NORMAL?
POINTS TO REMEMBER
CHAPTER 3:
Essentials of History-taking and Examination in a Neonate
STRUCTURE OF THE HISTORY
STRUCTURE OF EXAMINATION
CHAPTER 4:
Outline of Pediatric History and Examination
STRUCTURE OF PEDIATRIC HISTORY
STRUCTURE OF EXAMINATION
Vital Signs
Anthropometry
General Physical Examination
Head-to-Toe Examination
Head (Fig. 4.1)
Eyes
Ears/Nose
Oral Cavity
Neck
Chest
Abdomen
Musculoskeletal
External Genitalia
Systemic Examination
POINTS TO REMEMBER
CHAPTER 5:
Nutrition
NUTRIENTS
WHAT IS RAINBOW DIET = VIBGYOR
VITAMINS
MINERALS
STRUCTURE OF NUTRITIONAL HISTORY
EXAMINATION (HEAD-TO-TOE)
Hair Examination
Examination of Eyes
Examination of Neck
Examination of Mouth
Examination of Skin
Examination of Nails
Examination of Joints and Bones
Examination of Abdomen
PROTEIN ENERGY MALNUTRITION
ANTHROPOMETRY
WEIGHT
HEIGHT
HEAD CIRCUMFERENCE*
MID UPPER ARM CIRCUMFERENCE (MUAC)
Interpretation
LABORATORY TESTS
To Identify the Presence of Nutritional Deficiencies
To Monitor Recovery
TREATMENT
Energy Rich Foods
Sprouting-Amylase Rich foods (ARFs)
Infant and Young Child Feeding
Age Specific Diet
PREVENTION OF MALNUTRITION ON NATIONAL SCALE
CHAPTER 6:
Developmental Assessment
DEVELOPMENTAL DELAY—FIVE GROUPS
1. Global Developmental Delay
2. Dysmorphisms
3. Motor Delay
DIAGNOSIS OF CEREBRAL PALSY
POSTER Criteria by Levene
4. Language Delay
Steps to Assess
5. Neuroregression
HISTORY PROCESS
PHYSICAL EXAMINATION
Inspect
Helpful Clues
Take Measurements
INVESTIGATION
TOOLS FOR DEVELOPMENTAL ASSESSMENT
POINTS TO REMEMBER
CHAPTER 7:
Central Nervous System
EMBRYOLOGY
Gastrulation (Fig. 7.1)
Neurulation (Fig. 7.2)
Nerve Cell Migration
ANATOMICAL AND PHYSIOLOGICAL ASPECTS
UPPER MOTOR NEURONS
LOWER MOTOR NEURONS
AUTONOMIC NERVOUS SYSTEM AND THE BLADDER
Sympathetic Chain (T1-L2)
Parasympathetic Craniosacral Outflow (CN III, VII, IX, X and S2-4)
Pathologies of Autonomic Nervous System
THE BLADDER
Neurogenic Bladder
Upper Motor Neuron (UMN) Lesions
Lower Motor Neuron (LMN) Lesions
HISTORY
EXAMINATION
Summary of CNS Examination
General Physical Examination
Higher Functions/Mental Status Exam
Assess States of Consciousness
Cranial Nerves
Also look for “Horizontal Eye Movements”
Sensory Evaluation
Motor System Evaluation
Motor System—Grading of Strength
Feel
Move
Elicit Reflexes
Enhancement of Reflexes
Reflex Grading
Babinski's Reflex
Superficial Reflexes
Primitive Reflexes
Signs of Meningeal Irritation
Cerebellar Function Assessment
For Testing Intactness of Brainstem Function
Assessment of Autonomic Nervous System
Developmental Assessment
NEUROLOGICAL EXAMINATION OF THE INFANT
CHAPTER 8:
Cardiovascular System
AN OVERVIEW OF CARDIOVASCULAR SYSTEM HEART EMBRYOLOGY
Cardiogenic Region (Fig. 8.1)
Formation of Heart Tube (Fig. 8.2)
Looping of Heart Tube
Septation
Atrial Septation
Ventricular Septation
ANATOMY
Heart Borders and Relations
PHYSIOLOGY
Fetal Circulation
Transitional Circulation
Timing of Shunt Closure
Neonatal Circulation
PATHOLOGY
Congenital Heart Diseases (CHD)
Acquired Heart Diseases
SYMPTOMATOLOGY
Central Cyanosis
Chest Pain
Dyspnea
Syncope
Wheeze
Hemoptysis
Failure to Thrive
PATHOPHYSIOLOGY
Pulse
Inequality of Pulses
Heart Sounds
Auscultate Clockwise
The First Sound
The Second Sound
Abnormal Sounds
Murmurs or Bruits
The Point of Maximum Intensity and Timing
Character of Murmurs
Points to Remember
APEX BEAT
Blood Pressure
POINTS TO REMEMBER
STRUCTURE OF HISTORY
STRUCTURE OF EXAMINATION
General Physical Examination
SYSTEMIC EXAMINATION
Inspection and Palpation
Check Blood Pressure
Jugular Venous Pressure
Chest Wall Shape
Palpation
Percussion
Auscultation of the Heart
Abdomen
Cenral Nervous System (CNS)
Respiratory System (RS)
APPROACH TO CARDIOVASCULAR PROBLEMS OF A NEWBORN INFANT
Check Mother
Check Baby/Infant
Check Lab Investigations
Bedside Tests
TREATMENT
Medical
Surgical
CHAPTER 9:
Respiratory System
INTRODUCTION
DEVELOPMENTAL PECULIARITIES
ANATOMICAL PECULIARITIES OF CHILDREN
UNIQUE RESPIRATORY PHYSIOLOGY AND PATHOLOGY
Risk factors for development of sinusitis:
Peculiarities of Infection in Children
Peculiarities of Respiratory Rate, Depth and Patterns
Normal Respiration
Tachypnea (Fast Regular Breathing)
Bradypnea (Slow Regular Breathing)
Hyperventilation (Fast Regular Deep Breathing)
Hypoventilation
OVERVIEW OF HISTORY AND EXAMINATION
History
Review of Previous Diagnosis, Drug Treatment and Family History
EXAMINATION
Inspection
Body Habitus, Nutritional State and Look give a Clue
Look at the Chest
Palpation
Assessment of Tactile Fremitus
Percussion
Diaphragmatic Excursion
Auscultation
Normal Breath Sounds (Inspiratory Phase > Expiratory Phase)
Bronchial Breathing (Inspiratory Phase = Expiratory phase) with Gap in Between
Bronchovesicular Breath Sounds (Expiration is Prolonged)
Absent Breath Sounds
Adventitious Sounds
SUPPURATIVE COMPLICATIONS OF PNEUMONIAS
BEDSIDE TESTS
SPO2(Saturation of Oxygen) and Blood Pressure (BP) Monitoring
Hyperoxy Test
Cold Agglutinin Test
CHAPTER 10:
An Approach to Abdomen
ADOPT AN ASK, LOOK, FEEL AND HEAR APPROACH ASK (HISTORY TAKING)
Important Points to Note in Child with Abdominal Symptoms
LOOK
Look at the Child
Look at the Hands
Look at the Abdomen
FEEL (PALPATION)
Palpation of the Spleen
Palpation of the Liver
Ballottment for Enlarged Kidneys
For Masses Arising from the Pelvis
Hernial Orifices
Perrectal Examination
FEEL AND HEAR (PERCUSSION)
HEAR (AUSCULTATION)
POINTS TO REMEMBER
CHAPTER 11:
An Overview on Importance of Dermatology in Diagnosis
SKIN—A DIAGNOSTIC MARKER
Neurocutaneous Disorders (Phakomatosis)
Neurofibromatosis
Ataxia-Telangiectasia
Tuberous Sclerosis
Sturge-Weber Syndrome
Malignancies Like Leukemias
Vascular Anomalies
Nutritional Deficiencies
Immunodeficiency Disorders
Primary Immunodeficiency
Acquired Immunodeficiencies (AIDS in Particular)
Poisonings
Skin Changes and the Corresponding Suspected Disease
Infectious Rashes
Maculopapular Eruptions
Vesicular Eruptions
Exanthems with Arthritis
HAIR
NAILS
CHAPTER 12:
Vaccination
IMMUNIZATION
Active Immunization
Passive Immunization
INFECTIOUS VACCINES
NONINFECTIOUS VACCINES
COMBINATION VACCINES
VACCINES FOR SPECIAL SITUATIONS
INDIAN ACADEMY OF PEDIATRICS—SCHEDULE FOR VACCINATION (2011)
BCG (BACILLUS CALMETTE-GUÉRIN)
POLIO VACCINE
HEPATITIS B VIRUS (HBV) VACCINE
NEW HEPATITIS B VACCINE
DPT VACCINE (DTWP AND DTAP)
MEASLES AND MMR VACCINE
HIB VACCINE
OPTIONAL VACCINES
Rotavirus
ROTAVIRUS VACCINE
Efficacy
Interactions
Rotavirus Vaccine (Rota) in Special Situations
Precautions
Pneumococcus
PNEUMOCOCCAL VACCINES
Dosing
Based on Age of Starting the Vaccination the Number of Doses Vary
Side Effects
Varicella
VARICELLA VACCINE
A KILLED HEPATITIS A VACCINE
LIVE ATTENUATED HEPATITIS A VACCINE
Vaccine Efficacy
Contraindications
ADOLESCENT VACCINATION
Recommended Vaccines for Adolescents
Dosage Schedule
Side Effects
PROPER STORAGE OF VACCINES
Storage Units
To Freeze or not to Freeze
Where to Store?
Stability of Vaccines before Reconstitution at Room Temperature
SECTION 2: AN OVERVIEW OF BEDSIDE TESTING
CHAPTER 13:
Blood— Peripheral Smear
INDICATIONS
To Establish a Diagnosis
To Give Warning Signals
COMMON STAINS
RED BLOOD CELLS (RBCS)
RETICULOCYTES
WHITE BLOOD CELLS (WBCS)
PLATELETS
POINTS TO REMEMBER
CHAPTER 14:
Staining Microbiological Specimens (Part-I)
GRAM STAINING
Fixing
Staining (Mnemonic-CGAS)
POTASSIUM HYDROXIDE PREPARATION
The Potassium hydroxide (KOH) Preparation
Procedure
Microscopic Examination
CHAPTER 15:
Staining Microbiological Specimens (Part-II)
ZN STAINING (MNEMONIC-CSAM)
CHAPTER 16:
Culturing Microbiological Specimen
CULTURE MEDIA
CLASSICAL MEDIA
Types
Solid (agar) Media
Semisolid Media
Liquid (broth) Media
Enriched Culture Media
Selective Culture Media
Differential Media
BLOOD CULTURE
URINE CULTURE
STOOL CULTURE
CHAPTER 17:
Cerebrospinal Fluid Examination
TECHNIQUE
INDICATIONS
DIAGNOSTIC INDICATIONS
To Identify the CNS Infections
Staining Characteristics
To Differentiate the Infections
To Diagnose Inflammatory Diseases
Look for
Pedia Pearls:
In Subarachnoid Hemorrhage
Myelography
THERAPEUTIC INDICATIONS
To Relieve Increased Intracranial Pressure
To Inject Medications Intrathecally
ANESTHETIC INDICATIONS
For Spinal Anesthesia and Epidural Anesthesia
Precautions
CSF INTERPRETATION
Careful Interpretation in Newborns
Reactionary Findings
Dilution or Leakage
EARLY CLUES
Opening Pressure
Color of CSF
COMPLICATIONS
CHAPTER 18:
Urine Examination
URINE
AIM OF URINE EXAMINATION
COLLECTION OF URINE SAMPLE
In Older Children
In Infants and Small Children
Suprapubic Puncture
NAKED EYE CHARACTERISTICS
Urine Volume
Color
MICROBIOLOGICAL TESTS
Urine Microscopy
Microscopic Urine Sediment Tests
Cells
Casts and Their Associated Conditions
Urine Culture
CHEMICAL TESTS
pH
Specific Gravity (Density)
Urine Protein
Urine Glucose
Urine Ketone Bodies
Blood in the Urine
Bile Salts in Urine
Bile Pigments in Urine
Bile Pigments in Urine
TESTS OF GLOMERULAR FUNCTION
TESTS OF RENAL TUBULAR FUNCTION
SECTION 3: PROCEDURES
CHAPTER 19:
Liver Biopsy
INDICATIONS
To Assess Liver Damage Based on
To Diagnose
To Evaluate Response to Therapy
EQUIPMENT AND PROCEDURE
CONTRAINDICATIONS
COMPLICATIONS OF PERCUTANEOUS LIVER BIOPSY
CHAPTER 20:
Bone Marrow Tests(Aspiration, Biopsy, Hematopoietic Stem Cell Transplantation)
INDICATIONS
To Diagnose and Stage the Hematologic Disease
To Assess the Overall Bone Marrow Cellularity
To Diagnose Various Storage/Infiltrative Disorders
For Therapeutic Follow-up
For Stem Cell Transplantation
EQUIPMENT AND PROCEDURE
Bone Marrow Aspiration Needle
Bone Marrow Trephine Biopsy Needle
Procedure
Types of Samples
Bone Marrow Aspirate
Bone Marrow Biopsy
Biopsy Imprints (Touch smear)
COMPLICATIONS
TYPES OF STEM CELLS
SOURCE OF STEM CELLS
Bone Marrow
Peripheral Blood
Cord Blood
Prerequisite
How the Stem Cells Act
Engraftment
Apoptosis
Graft Versus Tumor (GVT) Effect
USES OF STEM CELLS
TYPES OF TRANSPLANT
Autologous Transplants
Syngeneic Transplants
Allogeneic Transplants
COMPLICATIONS
CHAPTER 21:
Reading an Electrocardiogram
INTRODUCTION
HOW IMPULSE TRAVELS
HEART RATES (2 METHODS)
WAVES
P Waves
QRS Complex
QRS Axis (Fig. 21.1)
Calculation of QRS Axis
R and S Waves
ST Segment
Helpful Normal Values
T Wave
INTERVALS
ASSESSMENT OF HYPERTROPHY
RHYTHMS
Fast Rhythms
Tachycardia
Sinus Tachycardia
Supraventricular Tachycardia (SVT)
Ventricular Tachycardia (VT) (Fig. 21.3)
Ventricular Flutter
Ventricular Fibrillation (Fig. 21.4)
Wolff-Parkinson White Syndrome (WPW)
Atrial Flutter
Atrial Fibrillation
Slow Rhythms
Bradycardia
Sinus Bradycardia
Sinus Arrhythmia
Sick Sinus Syndrome
Heart Blocks
Junctional Escape Rhythm
Idioventricular Rhythm
Asystole (Ventricular Standstill)
SECTION 4: PEDIATRIC IMAGING
CHAPTER 22:
CT Scans
CT FUNDAMENTALS
Types of CT
Attenuation
Grey/White Matter Differentiation
SKULL FRACTURES
Linear Skull Fractures
Growing Skull Fractures
CT Findings
HERPES SIMPLEX VIRUS ENCEPHALITIS
Herpes Simplex Virus
HSV Encephalitis (Fig. 22.1)
CT Findings (Fig. 22.1)
TUBERCULAR MENINGITIS
BRAIN EDEMA
ACUTE EPIDURAL HEMATOMA
SUBDURAL HEMORRHAGE (FIG. 22.4A)
SUBARACHNOID HEMORRHAGE (FIG. 22.4B)
INTRACEREBRAL HEMATOMAS
SUMMARY
HYDROCEPHALUS
CHAPTER 23:
Chest X-ray(Classical Chest X-rays and Newborn Chest X-rays)
FIRST OBSERVE THE FOLLOWING POINTS
View
Exposure
Verify Right and Left
Rotation
Phase of Inspiration
READ THE X-RAY IN THIS ORDER
A = Airway
B = Bones
C = Chest Tissues (Lung Parenchyma)
C = Cardiac Outline
Margins of the Heart Seen on X-ray
D = Diaphragm
E = Evaluate
CARDIOMEGALY ON CHEST X-RAY (FIG. 23.2)
Causes
Check the Following Points
1. The Cardiothoracic Ratio
2. The Hilar Vessels
3. Global or Local Dilatation
4. Aorta
5. Pulmonary Artery
TENSION PNEUMOTHORAX (INFANT) (FIG. 23.3)
Clinical Features
Chest X-ray Findings
EMPHYSEMA
Chest X-ray Findings
FOREIGN BODY ASPIRATION (FIG. 23.4)
Clinical Features
Chest X-ray Findings
CROUP
Clinical Features
Chest X-ray Findings
NORMAL CHEST FILM OF A NEWBORN
NEONATAL PNEUMONIA
Chest X-ray Findings
MECONIUM ASPIRATION SYNDROME
Chest X-ray Findings
HYALINE MEMBRANE DISEASE (FIG. 23.6)
Chest X-ray Findings
TRANSIENT TACHYPNEA OF THE NEWBORN (TTN)
Chest X-ray Findings
DIAPHRAGMATIC HERNIA (FIG. 23.7)
Chest X-ray Findings
PNEUMOTHORAX (NEWBORN) ( FIG. 23.8)
Chest X-ray Findings
CONGENITAL LOBAR EMPHYSEMA
Chest X-ray Findings
SUMMARY
CHAPTER 24:
Abdominal X-rays
INTRODUCTION
CALCIFICATIONS
SITES OF CALCIFICATION
Pancreatic Calcification
Biliary Calcification
Renal Calcification
Ureteric Calcification
TYPES OF CALCULI
Renal Stones
Appendicular Stones
Bladder Stones
BONE AND SOFT TISSUES
Bone
Soft Tissues
GAS
Intraluminal Gas
Within the Bowel Wall (Intramural Gas)
Extraluminal Gas
AIR FLUID LEVELS
Intussusception
Worms in the GIT
Subphrenic Abscess
ANORECTAL MALFORMATIONS
CHAPTER 25:
Bone X-rays
INTRODUCTION
BONE AGE: USES (MNEMONIC ABCD)
OTHER USES OF X-RAY OF BONES
BONE AGE ASSESSMENT
RADIOGRAPHIC EXAMINATION FOR BONE AGE ESTIMATION
WRIST X-RAY
Introduction
Rickets (Fig. 25.2)
Where and When to Focus Our Attention
ELBOW X-RAY
X-RAY LONG BONES
CHAPTER 26:
Skull X-rays/Spine X-rays
INDICATIONS
Following Trauma
To Aid in Diagnosis
VIEWS (FIG. 26.2)
NOTE THE FOLLOWING POINTS ON SKULL X-RAYS (TEN POINTS)
1. Clarity
2. Size
Small Head
Large Head
3. Shape
4. Fontanelles
5. Skull Sutures
Primary Craniosynostosis
6. Intrasutural Bones
7. Fractures
8. Skull Density
9. Intracranial Calcification
10. Sella Turcica
NOTE THE FOLLOWING POINTS ON SPINE X-RAYS
Effect of Age
Birth Trauma Causing Spinal Injury
Dysmorphisms
Infections
Developmental Defects
Types of Sacral Agenesis
SECTION 5: EQUIPMENT
CHAPTER 27:
Equipment (For Airway Obstruction/For Circulation/For Poisoning/For Supportive Care of Newborns)
OROPHARYNGEAL AIRWAY (FIG. 27.1)
Indications for Oral Airway
THE SUCTION TRAP (DEE-LEE SUCTION) (FIG. 27.2)
Indications for Use
SUCTION BULB
SUCTION CATHETER
SUCTION APPARATUS
RESUSCITATION BAG (FIG. 27.3)
Do's of Ventilation
Airway Management is an Art
Bag and Mask Ventilation
Procedure
Indication of Bag and Mask Ventilation
Contraindications
Bag and Tube Intubation/Ventilation
Equipment and Procedure
Types of Endotracheal Intubation
Indications
Relative Contraindications
Complications of Intubation
NG (NASOGASTRIC) TUBES
INDICATIONS OR USES OF NG TUBES
Complications of NG Feeding
INCUBATORS (FIG. 27.6)
RADIANT WARMERS (FIG. 27.7)
CONVENTIONAL PHOTOTHERAPY (FIG. 27.8)
OXYGEN SUPPLY DEVICES
Low Flow Devices
Side Effects
Oxygen Hood
SECTION 6: MEDICATIONS
CHAPTER 28:
Emergency Drugs
NEONATAL RESUSCITATION
Naloxone
Prostaglandin E1
SUPRAVENTRICULAR TACHYCARDIA
Adenosine
DOCUMENTED METABOLIC ACIDOSIS
Sodium Bicarbonate (8.4% Solution W/V)
NEONATAL SEIZURES
Calcium
Glucose
Phenobarbital
CARDIAC ARREST
Epinephrine
ANAPHYLAXIS
Epinephrine
SHOCK DESPITE VOLUME RESUSCITATION
Epinephrine
VOLUME OVERLOAD
Furosemide
DIABETIC KETOACIDOSIS
Insulin, Regular
TET SPELLS
Morphine Sulfate
HYPERTENSIVE CRISIS
Diazoxide
Nitroprusside Sodium
RAISED INTRACRANIAL TENSION
Dexamethasone
Mannitol
CONVULSIONS
Diazepam
Phenytoin
POISONINGS
Charcoal (Activated as a Slurry)
Atropine Sulfate
Indications
CHAPTER 29:
Calcium Gluconate
CALCIUM
CALCIUM GLUCONATE (FIG. 29.1)
INDICATIONS
CONTRAINDICATIONS
CHAPTER 30:
Sodium Bicarbonate
SODIUM BICARBONATE
INDICATIONS
Documented Metabolic Acidosis (pH < 7.15)
For Alkalinization of Urine
For Treatment of Hyperkalemia with or without Cardiac Arrest
INJ. SODIUM BICARBONATE (FIG. 30.1)
Dose of Sodium Bicarbonate (in mEq)
Adverse Reactions
Drug Interactions: Mnemonic ABCD
CHAPTER 31:
Phenytoin
PHENYTOIN (FIG. 31.1)
INDICATIONS AND DOSAGE
For Cardiac Arrhythmias Associated with Digitalis Intoxication
For Treatment of Seizures/Trigeminal Neuralgia and Head Injury
ADVERSE EFFECTS
CHAPTER 32:
Aminophylline
INTRODUCTION
INDICATIONS AND DOSAGE
As a Bronchodilator
As a Respiratory Center Stimulant
As a Cardiotonic in Left Ventricular Failure (LVF)
Dosage
MECHANISM OF ACTION
Side Effects (Mnemonic ABCD)
CHAPTER 33:
Adrenaline
ADRENALINE
INDICATIONS AND DOSAGE
Resuscitation in Pulselessness, Hypotension and/or Bradycardia
Dosage
Post-resuscitation (Infusion)
Anaphylaxis
Dosage
Status Asthmaticus
Dosage
Croup/Bronchiolitis
Dosage
Adverse Effects/precautions
CHAPTER 34:
Furosemide
FUROSEMIDE—A LOOP DIURETIC
INDICATIONS AND DOSAGE
Pulmonary Edema
Congestive Heart Failure
Hypertension and Edema
During Poisoning
In Premature Infants
Dosage
Adverse Effects
SPIRONOLACTONE—A POTASSIUM SPARING DIURETIC
CHAPTER 35:
Dopamine
INTRODUCTION
ACTIONS
DRUG EFFECTS
DOSAGE (INTRAVENOUS DOSAGES HAVE A WIDE RANGE)
CHAPTER 36:
Oral Rehydration Solution
ORAL REHYDRATION SOLUTION (ORS) THERAPY (FIG. 36.1)
HISTORY
Advantages of ORS
PRINCIPLE OF ORS
Bad News
Good News
STANDARD WHO ORS
REDUCED OSMOLARITY ORS
KILLER ORS
GUIDELINES
FAILURE OF ORAL REPLACEMENT THERAPY
CHAPTER 37:
Digoxin
INDICATIONS AND DOSAGE
Congestive Cardiac Failure
Tachyarrhythmias
Digoxin Dosage (Therapeutic Levels are 1-2 ng/ml)
Drug Interactions
DIGOXIN TOXICITY
Adverse Effects
Management of Toxicity
Acute Toxicity
Chronic Toxicity
Contraindications of Digoxin
CHAPTER 38:
Steroids
INDICATIONS
A . Autoimmune Disorders
B. Bronchial Asthma
C. Cortisol Supplementation
D. Dermatologic Diseases
E. Emergencies
Acute Adrenal Insufficiency with Shock
Anaphylaxis/Allergy
Refractory Shock
Refractory Hypoglycemia
Acute Attack of Ulcerative Colitis
F. Fevers
Typhoid in Toxic State
G. Granulomatous Inflammations
H. Hypotensive Low Birth Weight Babies
I. Inflammation
J. Joint Inflammation
K. Keeping Muscular Dystrophy Under Control
L. Lung Maturation
TYPES
Hydrocortisone
Indications and dosage
Oral Prednisolone
Contraindication
Interactions
Adverse Effects
CHAPTER 39:
Antibiotics
COMMON ANTIBIOTICS AND ANTIBIOTIC GROUPS
Penicillin and Ampicillin
Cephalosporins
Aminoglycosides
Metronidazole
Quinolones
Caution in Children
Vancomycin
Sulfonamides
Carbapenems
Macrolides
Tetracycline
Chloramphenicol
CHAPTER 40:
Vitamins and Minerals
AGEWISE INDICATIONS
Preterm Infants
All Newborn Infants
Side Effects
Older Infants
For Toddlers—Vitamins A and Vitamin D Prophylaxis
For Mothers—Folic Acid Prophylaxis
CHAPTER 41:
Asthma Therapy
STEPS TO ASSESS THE DISEASE
Assess Severity
Assess Progression
Assess Chronicity
DRUGS FOR PREVENTION AND MANAGEMENT
Preventors
Corticosteroids
Cromolyn Sodium (Mast Cell Stabilizer)
Leukotriene Modifiers/Receptor Antagonists
Preventor Plus Controller’ Drugs
Methylxanthines (Aminophylline, Theophylline)
Relievers
Short-acting Beta 2-agonists (Salbutamol)
Anticholinergics
Systemic Steroids
Magnesium Sulfate and Heliox
Preferable Mode of Drug Delivery
Inhalers/nebulizers
Recommendations
Summary of Treatment
Definitions
CHAPTER 42:
Drugs in Seizure Therapy
TYPES OF SEIZURES
Mechanisms of Seizure
Aim of Treatment
DRUG TREATMENT OF EPILEPSY
Principles
Commonly Used Drugs and Dosages
Newer Drugs
Modes of Action and Side Effects
Febrile Seizures: Preventive Drugs
Toxicity
CHAPTER 43:
Drug Treatment of Malaria
STEPS OF TREATMENT
DRUG TREATMENT
NATIONAL VECTOR BORNE DISEASE CONTROL PROGRAM: SUGGESTIONS
First Line of Treatment
In Routine Cases (Presumptive treatment)
In Confirmed Cases (Radical Treatment)
In Positive P. vivax Cases
In Uncomplicated Falciparum +ve Cases
SECOND LINE OF TREATMENT
THIRD LINE OF TREATMENT
In Severe and Complicated Cases
1. Quinine
2. If Non-availability of Quinine, Use Chloroquine
RESISTANCE
CHEMOPROPHYLAXIS (PREVENTION BY SUPPRESSION)
RESERVE DRUGS IN TREATMENT
Artesunate
Artemether
Artemisinin
CHAPTER 44:
Drug Treatment of Tuberculosis
CONSENSUS STATEMENT OF IAP WORKING GROUP (INDIAN PEDIATRICS 1997;34:1093-1096)
Group 1 (Preventive Therapy)
Group II (Mnemonic SIMPLE)
Group III
Group IV
Group V
Indications for Prednisolone
The Indications for prednisolone are those where there is involvement of serous layers, so as to avoid fibrosis
Management of Pediatric Tuberculosis Under the Revised National Tuberculosis Control Program.
Category I
Category II
Category III
Action for Major Antituberculous Drugs
CHAPTER 45:
Oxygen
INTRODUCTION
Hypoxia
Hypoxemia
Response to Hypoxia
States of Hypoxia
SOURCES OF OXYGEN
OXYGEN ADMINISTRATION
USES OF OXYGEN
SECTION 7: PROBLEM-BASED LEARNING
CHAPTER 46:
Anemia
CASE PRESENTATION
History
Investigations
DISCUSSION
IRON DEFICIENCY ANEMIA (IDA)
Etiology
Iron Metabolism
Clinical Features
Good Sources
Stages of Iron Deficiency
Investigations
Peripheral Smear
Treatment
Oral Therapy
Parenteral Iron
APPROACH TO A CASE OF MICROCYTIC HYPOCHROMIC ANEMIA
Differential Diagnosis
History
Clinical History
Etiological History
Dietary History
Family History
Treatment History
Examination
Look for Signs of Anemia
Now Look, Palpate and Percuss for the Cause
Palpate and Percuss
Investigations to Evaluate the Cause
Basic Tests
Also Check the Following
Treatment
CHAPTER 47:
Lymphadenopathy
CASE PRESENTATION
History
Examination
Investigation
APPROACH TO A CASE OF LYMPHADENOPATHY
Differential Diagnosis
Acute Cervical Lymphadenitis
Prolonged Cervical Lymphadenopathy
Lymphangitis
History
Examination
Investigations
Screening
Cultures and Counts
Needle Aspiration/ Lymph Node Biopsy
Serologic Studies
Treatment
CHAPTER 48:
Muscle Disorders
CASE PRESENTATION
History/Examination
Investigation
Diagnosis
DISCUSSION
Muscular Dystrophy (Figs 48.1A and B)
Pedia Pearls:
Inheritance
Types
Pedia Pearls:
Differential Diagnosis
Clinical Features
Wide Based Waddling
Pseudohypertrophied Calves
Gower's Sign
Winging of the Scapulae
Complications
Diagnosis
Prenatal Diagnosis
Investigations
Treatment
HIGHLIGHT
CHAPTER 49:
Bleeding Disorders
CASE PRESENTATION
Investigations
DISCUSSION
Immune Thrombocytopenic Purpura
Management
PATHOPHYSIOLOGY
Bleeding Disorders Involve Primary Hemostasis
Clotting Disorders Involve Secondary Hemostasis
Mixed Disorders (Bleeding + Clotting Abnormalities) DIC (Disseminated Intravascular Coagulation)
DIFFERENTIATE BETWEEN BLEEDING OR CLOTTING DISORDERS
History
Enquire Whether Spontaneous or Post-traumatic
Enquire for Site of Bleeding
Enquire about Age of Onset, Frequency and Severity of each Bleeding Complaint
Enquire About Inheritance
Enquire about Prophylaxis
Examination
Laboratory Investigations
CHAPTER 50:
Acute Rheumatic Fever
CASE PRESENTATION
History
Examination
Investigations
DISCUSSION
Rheumatic Heart Disease (RHD)
Clinical Diagnosis
Major Criteria
Minor Criteria
Clinical Features
Arthritis (Pain and Swelling of Joints)
Pancarditis (Rub, tachycardia and Changing Murmurs)
Sydenham's Chorea
Subcutaneous Nodules
Erythema Marginatum
Differential Diagnosis
Treatment
Prophylaxis
Rheumatic Prophylaxis
Endocarditis Prophylaxis
CHAPTER 51:
NEPHROLOGY CASES
CASE PRESENTATION
Investigations
DISCUSSION
Acute Poststreptococcal Glomerulonephritis (APSGN) (Fig. 51.1)
Pathophysiology
Components (Four)
Types of Glomerulonephritis (GN)
Clinical Features
Complications (Four)
Investigations
Serum:
Urine:
Treatment (Four)
CASE PRESENTATION
History
Investigations
Urinalysis:
Blood chemistry
DISCUSSION
Nephrotic Syndrome (Fig. 51.2)
Pathophysiology
Types
Primary Nephrotic Syndrome
Types
Complications
Differential Diagnosis
Organ wise the various causes of edema are:
ISKDC Terminology
Principles of Investigation
Renal Biopsy
Treatment
Treat Complications
Drug Therapy
In Recurrence/Relapse
In Frequent Relapser/Steroid Dependence
In Continuing Relapses or Steroid Toxicity
SECTION 8: SPOTTERS
CHAPTER 52:
Turner's Syndrome
SPOTTER
Clinical Features
Antenatal Diagnosis
Diagnosis and Treatment
Treatment
SUMMARY
CHAPTER 53:
Achondroplasia
CARDINAL FEATURES
Genetics
Prenatal Testing
Investigations
Differential Diagnosis
Treatment
Multidisciplinary Approach
CHAPTER 54:
Mucopolysaccharidosis
CLINICAL FEATURES
TYPES
TREATMENT
CHAPTER 55:
Neural Tube Defects
INTRODUCTION
Usual Scenario
Etiology
TYPES OF SPINAL DEFECTS
Investigations
Prognosis
Prevention
Treatment
Supportive Therapy
SUMMARY
CHAPTER 56:
Dental Caries
CASE PRESENTATION
DISCUSSION
Dentition
Structure of the Tooth (Fig. 56.2)
Dental Disorders
Complications of Dental Caries
Treatment
Numerical Dental Disorders
Delayed Eruption vs Premature Eruption
Large or Small Teeth
Discoloration of Primary Teeth
SECTION 9: MISCELLANEOUS
CHAPTER 57:
Fever
APPROACH TO A CASE OF FEVER
First Confirm Fever
Documentation of Fever
Next Grade the Fever
Now Establish the Type of Fever
History
Examination
PYREXIA OF UNKNOWN ORIGIN—A DIAGNOSTIC DILEMMA
Remember
Suspicion
Investigations
Management
INDEX
TOC
Index
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