Jaypee Brothers
In Current Chapter
In All Chapters
X
Clear
X
GO
Normal
Sepia
Dark
Default Style
Font Style 1
Font Style 2
Font Style 3
Less
Normal
More
Manual of Medical Emergencies
PG Raman, LC Gupta
SECTION I: EMERGENCY CONDITIONS
CHAPTER 1:
Acute Myocardial Infarction
INTRODUCTION
PATHOPHYSIOLOGY
Non-atherogenic Causes of AMI
CLINICAL PRESENTATION (TABLE 1.1)
MANAGEMENT
Initial Management
Criteria for Thrombolysis in Acute Myocardial Infarction
Indications
Absolute Contraindications
Relative Contraindications
Indications of Successful Thrombolytic Therapy
Indications
Subsequent Management of MI
Risk Stratification and Revascularization
COMPLICATIONS OF MI (Tables 1.6 to 1.9)
CHAPTER 2:
Unstable Angina
CHAPTER 3:
Cardiac Arrhythmia
SINUS ARRHYTHMIA
SINUS TACHYCARDIA
PREMATURE ATRIAL COMPLEXES
Paroxysmal Supraventricular Tachycardia (PSVT)
MANAGEMENT
DRUG OF CHOICE
DC CARDIOVERSION
ATRIAL FLUTTER
ATRIAL FIBRILLATION
VENTRICULAR PREMATURE COMPLEXES (VPCS)
VENTRICULAR TACHYCARDIA (VT)
ACCELERATED IDIOVENTRICULAR RHYTHM ALSO CALLED AS SLOW VT
TORSADES DE POINTES
VENTRICULAR FLUTTER AND FIBRILLATION
DISORDERS OF IMPULSE CONDUCTION
SICK SINUS SYNDROME
WPW SYNDROME
CHAPTER 4:
Cardiac Arrest and Sudden Cardiac Death
CARDIAC ARREST
SUDDEN CARDIAC DEATH
Epidemiology
Causes
Structural Abnormalities
Functional Abnormalities
Management of Cardiac Arrest
Initial Response
Basic Life Support (Cardiopulmonary Resuscitation)
Advanced Life Support
Term Management of Survivors
SUDDEN COLLAPSE/SUSPECTED CARDIAC ARREST
Advanced Life Support
CHAPTER 5:
Acute LVF/Cardiogenic Pulmonary Edema
CHAPTER 6:
Hypersensitive Emergencies
HYPERTENSIVE CRISES
Accelerated Malignant Hypertension
Mechanism
Clinical Features
Atypical presentation
Laboratory Findings
Biochemistry
Secondary HTN
Prognosis
Causes of Death
Pathophysiology
Clinical Features
Therapy for Hypertensive Emergencies
General Guidelines
Management of Specific Situations
HYPERTENSIVE URGENCIES
General Guidelines for Management
Captopril (Angiopril)
Nifedipine (Cardules/Depin)
Clonidine (Arkamin)
Labetalol (L-Beta)
Nitroprusside (Pruside/Sonide)
Glycerile Trinitrate (Nitroject/Nitrocure)
Diazoxide (Not Available in India)
Hydralazine (Not Available in India)
CHAPTER 7:
Congestive Cardiac Failure
REFRACTORY HEART FAILURE
Definition
Management
CHAPTER 8:
Infective Endocarditis
CHAPTER 9:
Acute Pulmonary Oedema (APO)
CHAPTER 10:
Pulmonary Embolism
PHYSIOLOGY
Clinical Syndrome
DIAGNOSTIC MODALITIES
a. Non-imaging
b. Non-invasive Imaging
c. Invasive Imaging
Diagnostic Strategy
Treatment
Anticoagulation
Thrombolysis
Inferior Vena Cava (IVC) Interruption
Pulmonary Embolectomy
Prevention of Pulmonary Embolism
Combined Modalities
CHAPTER 11:
Fulminant Liver Failure
INTRODUCTION
Nomenclature
Diagnostic Criteria of Liver Failure
Maximum Interval between Jaundice and Liver Failure
Sub Classification
CAUSES OF ACUTE LIVER FAILURE
Infective
Drug Reactions and Toxins
Ischaemic
Metabolic
Miscellaneous
SALIENT FEATURES ABOUT ETIOLOGY
THE INDIAN PERSPECTIVE
CLINICAL FEATURES
INVESTIGATIONS
Haematology
Biochemistry
Virologic Markers
EEG
Scanning and Biopsy
Treatment
General
Specific
Pathophysiology
Measures
Coagulopathy
Pathophysiology
Measures
Respiratory Complications
Pathophysiology
Monitoring
Measures
Septic Complications
Pathophysiology
FEVER AND LEUCOCYTOSIS ARE OFTEN ABSENT
Renal Failure
Pathophysiology
Measures
Cardiovascular Abnormalities
Pathophysiology
Measures
Acute Pancreatitis
Pathophysiology
Measures
Cerebral Oedema
Pathophysiology
Clinical Features
Diagnosis, Monitoring and Measures
Measures
Encephalopathy
Pathophysiology
Clinical Features
Measures
Artificial Liver Support Systems
Liver transplantation
Types of Transplant
CHAPTER 12:
Hypoglycemia
CHAPTER 13:
Acid Base Disorders
MANAGEMENT
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis
CHAPTER 14:
Fluids and Electrolytes
HAEMORRHAGE AND HYPOVOLEMIA
MONITORING OF BLOOD VOLUME
MISCONCEPTIONS
ELECTROLYTE IMBALANCE
CALCIUM
CHAPTER 15:
Blood Transfusion Reaction
CHAPTER 16:
Upper GI Bleeding
THERAPY FOR SPECIFIC LESIONS
ACUTE LOWER GI BLEEDING
Etiology of lower GI Bleeding (Table 16.3)
DIAGNOSIS
THERAPY FOR SPECIFIC LESIONS
CHAPTER 17:
Acute Pancreatitis
DIAGNOSIS
Differential Diagnosis
Grading Disease Severity
COMPLICATIONS
MANAGEMENT
CHAPTER 18:
Hepatic Encephalopathy
INVESTIGATION
Differential Diagnosis
Prognosis
Treatment
CHAPTER 19:
Hepatorenal Syndrome
CHAPTER 20:
Approach to a Case of Coma
CAUSES OF COMA
Evaluation of Unconscious Patient
GRADES OF COMA
RESUSCITATION
INVESTIGATIONS
MANAGEMENT
CHAPTER 21:
Raised Intracranial Pressure
TYPES OF HYDROCEPHALUS
CLINICAL FEATURES OF RAISED INTRACRANIAL PRESSURE
INVESTIGATIONS
MANAGEMENT
BENIGN INTRACRANIAL HYPERTENSION OR PSEUDOTUMOUR CEREBRI OR IDIOPATHIC RAISED INTRACRANIAL HYPERTENSION
Treatment
CHAPTER 22:
Acute Intractable Headache
CHAPTER 23:
Status Epilepticus
MANAGEMENT OF STATUS EPILEPTICUS
Principles of Management of Status Epilepticus
Diagnostic Tests to be Carried Out
Experimental Drugs
CHAPTER 24:
Neuroleptic Malignant Syndrome
HIGH RISK GROUPS
Prevention
CHAPTER 25:
Diabetic Ketoacidosis
CHAPTER 26:
Acute Endocranial Emergencies (Non Diabetic)
GENERAL MEASURES
Complications
Prevention
MYXOEDEMA COMA
Specific Measures
Other General Measures
Causes
Pituitary Crisis
Hypothermia
CHAPTER 27:
Acute Adrenal Insufficiency
CHAPTER 28:
Lactic Acidosis
CHAPTER 29:
Acute Renal Failure
CAUSES OF ACUTE RENAL FAILURE
Prerenal Azotemia
Intrinsic Renal Azotemia
Postrenal Azotemia (Obstruction)
CLINICAL FEATURES
DIAGNOSIS OF ACUTE RENAL FAILURE
RENAL FAILURE INDICES
RADIOLOGICAL FINDINGS
Complications of Acute Renal Failure
MANAGEMENT OF ACUTE RENAL FAILURE
Medical Management
PROGNOSIS
CHAPTER 30:
Chronic Renal Failure
MANAGEMENT
Conservative Management
Management
RENAL REPLACEMENT THERAPIES
Biochemical Indicators
Principle for Renal Replacement
Hemodialysis
Hemofilteration
Peritoneal Dialysis
COMPLICATIONS
Renal Transplantation
Pretransplant Evaluation
Contraindications to Transplant
Immunosuppression After Transplantation
Allografts Rejection
Chronic Rejection
CHAPTER 31:
Typhoid Fever
CHAPTER 32:
Tetanus
CHAPTER 33:
Cerebral Malaria
CHAPTER 34:
Acute Alcohol Intoxication
INTRODUCTION
Mechanism of Action
Clinical Features
Alcohol Paranoid State and Alcoholic Blackout
Investigations
Complications
Management
Methanol Alcohol Poisoning
Clinical Features
Mechanism of Toxicity
Complications
Prognosis
Treatment
CHAPTER 35:
Organophosphates
INTRODUCTION
Mechanism of Action
Pharmacokinetics
Clinical Toxicity
Muscarinic Effects
Nicotinic Effects
COMPLICATIONS
DIAGNOSIS
PREVENTION
MANAGEMENT
General Measures
Supportive Measures
Specific Measures
Mechanism of Action of Oximes
CHAPTER 36:
Celphos Poisoning
INTRODUCTION
Mechanism of Action
Clinical Features
Major Effects
DIAGNOSIS
Other Tests Include
FIRST AID MEASURES OF MANAGEMENT PRINCIPLES
CHAPTER 37:
Snake Bite and Scorpion Bites
CLINICAL FACTORS
INVESTIGATIONS
MANAGEMENT
COMPLICATIONS
SCORPION BITES
Clinical Features
Treatment
CHAPTER 38:
Anaphylaxis
ETIOPATHOGENESIS
CLINICAL FEATURES
ETIOLOGY AND CLASSIFICATION OF ANAPHYLAXIS
Factors Which Affect Anaphylaxis Reaction
Differential Diagnosis
MANAGEMENT
CHAPTER 39:
Gastroesophageal Reflux
CHAPTER 40:
Pituitary Tumors
CHAPTER 41:
Control of Diabetes
INTRODUCTION
RECENT ADVANCEMENTS
Definition of the term ‘Fasting Hyperglycemia’ and ‘Post-prandial Hyperglycemia’
Fasting Hyperglycemia
Post-Prandial Hyperglycemia
2. Newer Classification
3. Newer Insight into the Etiopathogenesis of Diabetes Mellitus
GLUT FAMILY OF PROTEINS: THEIR SIGNIFICANCE IN INSULIN ACTION AND RESISTANCE
ETIOPATHOGENESIS OF LONG-TERM COMPLICATIONS
Cardiovascular
Nephropathy
Neurological Involvement
Evoked Potential Studies: Sub-clinical Detection of Retinopathy/Auditory Nerve Dysfunction
RECENT ADVANCES IN THERAPEUTICS
Insulin Therapy
INSULIN ANALOGUE
RAPID ACTING INSULIN ANALOGUES
Advantages
Cautions
LONG ACTING INSULIN ANALOGUES
ROLE OF CHROMIUM IN DIABETES MELLITUS
INHALATIONAL INSULIN
ORAL INSULIN PILLS: FUTURE PERSPECTIVE
RECTAL INSULIN
ORAL HYPOGLYCEMIC AGENTS
A. SULFONYLUREAS
B. NON-SULFONYLUREAS (RIPAGLINIDE) (PHASE III TRIALS)
Mechanism of Action
Effects
C. INSULIN RECEPTOR SENSITIZING AGENT (THIOZOLIDINEDIONE)
Mechanism of Action
D. α GLUCOSIDASE INHIBITOR (ACARBOSE, MIGLITOL, ETC.)
Mechanism of Action
Pharmacokinetics
E. ALDOSE REDUCTASE INHIBITOR (TOLRESTAT, EPALRESTAT, ETC.)
NON-ROUTINE TREATMENT OPTION
1. Pancreatic Transplantation
2. Islet Cell Transplantation
3. Genetic Modification of Non-pancreatic Cell Lines
THERAPIES UNDER TRIAL
COALITION THERAPY
NEWER INSULIN DELIVERY SYSTEMS
PREVENTION
PREVENTION OF COMPLICATIONS
CHAPTER 42:
Personality Disorders
MANAGEMENT
General Measures of Treatment
Psychotherapy for Personality Disorder General Issue
1. Hysterical Personality Disorder
2. Obsessional
3. Schizoid
4. Borderline
5. Antisocial Personality Disorder
6. Paranoid
7. Schizotypal
8. Narcissistic
9. Avoidant
10. Dependent
11. Compulsive
12. Passive Aggressive
Psychopharmacological Intervention
CHAPTER 43:
Depression
SEROTONIN SPECIFIC RE-UPTAKE INHIBITOR
1. Fluoxetine
Adverse Effects
Interactions
2. Peroxetine
3. Sertraline
SYMPATHOMIMETICS
BENZODIAZOPENES
Alprazolam
MISCELLANEOUS
Trazodone and Nefazodone
Indications
Side Effects
VENLAFAXINE
BUSPIRONE
PINDOLOL
BUPROPION
TREATMENT FAILURE
SWITCHING STRATEGIES
AUGMENTATION THERAPY
AUGMENTATION STRATEGIES
DEPRESSION WITH SOMATIC DISEASES
ELECTRO CONVULSIVE THERAPY (ECT)
TREATMENT COURSE
LIGHT THERAPY
Mechanism of Action
Psychosurgery
Indications
Techniques
CHAPTER 44:
Oxygen Therapy
NORMAL OXYGEN PHYSIOLOGY
EFFECTS OF OXYGEN LACK (HYPOXIA)
INDICATIONS OF OXYGEN THERAPY
Indications of Hyperbaric O2 Therapy
SIDE EFFECTS OF O2 THERAPY
SIDE EFFECTS OF HYPERBARIC O2 THERAPY
METHODS OF O2 DELIVERY
MECHANICAL VENTILATORS (COMMONLY USED ARE)
Indications
I Inadequate Ventilation
II Inadequate Gas Exchange
MODES OF VENTILATION
NEWER MODES OF VENTILATION
SETTING VENTILATORY PARAMETERS
COMPLICATIONS OF VENTILATION
NEWER STRATEGY OF VENTILATION
CHAPTER 45:
Haemodialysis
PRINCIPLE
AIMS OF DIALYSIS
INDICATIONS OF DIALYSIS
Relative Contraindications
COMPONENTS OF HAEMODIALYSIS
VASCULAR ACCESS
Access to the Circulation
Percutaneous Cannulation
a. Subclavian Vein Cannulation
Advantage
Disadvantage
b. Femoral Vein Catheterisation
Advantage
Disadvantage
Complications
SHUNT
Types of Shunts
Complications
ARTERIOVENOUS FISTULA
Types of Internal Fistula
Problems and Complications of AV Fistula
Advantages
Variations of Internal Fistula
ARTIFICIAL KIDNEY (THE DIALYZER)
Hollow Fibre Artificial Kidney (Capillary Dialyzer)
Problems
Dialysis Fluid
HAEMODIALYSIS MACHINE
ACCESSORY EQUIPMENT
DIALYZER SETUP
HAEMODIALYSIS PROCEDURE
INITIATION OF DIALYSIS
Monitoring
Termination of Dialysis
Dialyzer Cleanup
COMPLICATIONS
Complication due to Ultrafiltration
Preventive Measures
Corrective Measures
B. CRAMPS
II. Complication of the Diffusive Process
A. Dialysis Disequilibrium Syndrome (DDS)
B. Arrhythmias
Causes
III. Complications Related to Anticoagulation
IV Iatrogenic Complications
CHAPTER 46:
Antiretroviral Therapy
POINTS OF TARGET IN LIFE CYCLE
ANTIRETROVIRAL DRUGS
1. Classification
1. Zidovudine (AZT)
Resistance
2. Didanosine (ddI)
Indication
3. Zalcitabine (ddC)
Indication
4. Stavudine (D4T)
5. Lamivudine
Nucleotide RTI
Non-Nucleoside RTI
Protease Inhibitors
Baseline Test—Before Art
When to Start
Combination Therapy
Advantages
Combination Tried
Problems with Combination
Choice of Antiretroviral Therapy in Combination
Role of HIV RNA Monitoring
CD4 + Count Monitoring
How Long to Continue
Interruption of ART
Criteria for Changing ART
Prevention of Maternal Fetal Transmission
Newer Anti Retroviral Agents
HIV Vaccine
47:
Antibiotics
CHAPTER 48:
Noninvasive Imaging of CVS
MAGNETIC RESONANCE IMAGING OF THE HEART
Technical Aspects
Localization of Magnetic Resonance Signal
Effects of Moving Blood
TECHNIQUES FOR MRI OF THE HEART
Gating with MRI
Multislice Techniques
Cine MRI
Fast Gradient-Echo MRI
Ischemic Heart Disease
Morphology
Regional Contraction Abnormalities
Visualization of Coronary Arteries
Coronary Artery Bypass Grafts
CARDIOMYOPATHIES
Hypertrophic Cardiomyopathies
Dilated Cardiomyopathy
Restrictive Cardiomyopathy
Right Ventricular Dysplasia
Pericardial Disease
Neoplastic Disease
Congenital Heart Disease
Diseases of the Thoracic Aorta
EVALUATION OF CARDIOVASCULAR FUNCTION
Regional Left Ventricular Function
Myocardial Tagging
QUANTIFICATION OF VALVULAR REGURGITATION
The Signal Void in Regurgitation
Possible Pitfalls
Stroke Volume Ratio and Regurgitant Volume
Velocity Encoded Cine MRI
MEASUREMENT OF BLOOD FLOW
Velocity Encoded Cine MRI
Pitfalls
Estimation of Pressure Gradients and Shunts
Coronary Flow Velocity
CHARACTERIZATION OF MYOCARDIAL TISSUE
MRI Contrast Media for Myocardial Enhancement
Paramagnetic Agents
Magnetic Susceptibility Agents
COMPUTED TOMOGRAPHY
Technical Aspects
Spiral CT Scanner
Ultrafast (Cine, Electron Beam) CT Scanner
EVALUATION OF CARDIAC DIMENSIONS AND FUNCTION
EVALUATION OF SPECIFIC CARDIAC DISEASES
Ischemic Heart Disease
Regional Wall Motion
Myocardial Perfusion
Myocardial Infarction
Coronary Artery Bypass Grafts
Coronary Arterial Calcification
Coronary Angiography
PERICARDIAL DISEASE
Congenital Abnormalities and Cysts of the Pericardium
Pericardial Fluid
Constructive Pericarditis
Effusive Constrictive Pericarditis
PARACARDIAC, PERICARDIAL, AND CARDIAC MASSES
Intracardiac Thrombus
CONGENITAL HEART DISEASE
Standard CT
Ultrafast CT
Evaluation of Cardiac Function in Congenital Heart Disease
DISEASE OF THE THORACIC AORTA
Aortic Dissection
Aortic Aneurysm
Pulmonary Embolism
POSITRON EMISSION TOMOGRAPHY (PET)
Assessment of Regional Myocardial Blood Flow
Myocardial Metabolism
Assessment of Cardiac Performance
Performance
Advantages of Gated Blood Pool
Disadvantages
INFARCT IMAGING
Technetium-99m-sn-Pyrophosphate
Indium-111 Leukocytes
Indium-111-Antimyosin
Myocardial Perfusion Imaging
Thallium-201 Scanning
Myocardial Kinetics of Thallium-201
Pharmacological Vasodilation
Dipyridamole Infusion Protocol
Adenosine Infusion
Dobutamine Stress
Dobutamine Infusion Protocol
Error in Interpretation During Myocardial Perfusion Scintigraphy
Clinical Utility
Diagnosis of Coronary Artery Narrowing by PET
CHAPTER 49:
Disseminated Intravascular Coagulation (DIC)
CAUSES OF DIC
1. Obstetrics
2. Infections
3. Malignancy
4. Shock
5. Immunological
6. Liver Disease
7. Miscellaneous
CLINICAL FEATURES
LABORATORY INVESTIGATION
Differential Diagnosis
TREATMENT
CHAPTER 50:
Sickle Cell Crisis
PATHOPHYSIOLOGY
ACUTE CRISIS AND COMPLICATIONS OF SICKLE CELL ANEMIA
CHAPTER 51:
Ventilatory Support in Critically Ill Patient
NONINVASIVE POSITIVE PRESSURE VENTILATION (NPPV)
Advantages
Aims of Noninvasive Ventilation (NPPV)
Indication
Type I Support
Type II Support
Indications
Application of NPPV
Complications
GASTROINTESTINAL PROPHYLAXIS IN CRITICALLY ILL PATIENT
Microbial Density of the Alimentary Tract
Protective Mechanism
Predisposing Factors
Predisposing Conditions
Stress Ulcers
a. Pathogenesis
b. Clinical Features
Head injury
c. Preventive Strategies
INTERPRETATION OF ARTERIAL BLOOD GASES (ABG'S)
Physiology Principles
Evaluation of Metabolic Acid-base Abnormalities
pH-PCO2 Relationship (Table 51.1)
PCO2 - HCO3 Relationship
Evaluation of Respiratory Acid-base Abnormalities
Assessment of Arterial Oxygenation
Assessment of Deadspace Ventilation
How to Interpret ABG?
EMERGENCIES IN HIV POSITIVE PATIENTS—INDIAN PERSPECTIVE
Some Interesting Facts
SEDATION AND ANALGESIA IN THE INTENSIVE CARE UNIT
Introduction
Non-drug Related Factors
Drugs
Narcotics
Morphine
Benzodiazepines
a. Diazepam
b. Midazolam
Hypnotics
a. Barbiturates
Propofol
Volatile Agents
Nitrous Oxide
Disadvantages
Isoflurane
Relaxants
Indications
Regional Blocks
HAEMORRHAGE AND HYPOVOLEMIA
PARENTERAL FEEDING
Traditional Concepts of Nutritional Status
Body Composition
Serum Proteins
Immune Competence
Clinical Assessment of Nutritional Status
Subjective Global Assessment (SGA)
REFEEDING THE MALNOURISHED PATIENT
ENTERAL VS PARENTERAL
HOW IS PARENTERAL NUTRITION GIVEN?
Steps to Limit Thrombophlebitis
CREATING A TPN REGIMEN
CONSTITUENTS OF TOTAL PARENTERAL NUTRITION (TPN)
Complications of CPN
Mechanical
Metabolic
Infections
Gastrointestinal
HOME PARENTERAL NUTRITION
HYPOTHERMIA
Introduction
Temperature Regulation
Normal Body Temperature
Classification and Recording of Hypothermia
Causes
Urban Hypothermia
PHYSIOLOGY OF HYPOTHERMIA
Thermal Gradients
Metabolism
Nervous System Effects (Table 51.9)
Central Effects
Peripheral Effects
Respiratory Effects
Cardiovascular Effects
Catecholamine Response
Venous Pressure
Coronary Blood Flow
ECG Changes of Hypothermia
EFFECTS ON BLOOD FACTORS
Therapeutic Hypothermia
Indications
Clinical Application
Factors Responsible for Production of Ventricular Fibrillation
Renal Effects
Liver Effects
Pancreatic Effects
Acute Vascular Collapse
Neurosurgery
Cardiac Arrest
Eclampsia
Hyperpyrexia
Techniques of Hypothermia
Disadvantages and Complication
Management
PORTAL HYPERTENSIVE GASTROPATHY (PHG)
Scheme of Discussion
A. Review of Portal Hypertension
B. Definition
C. Clinical Significance
D. Endoscopic Appearance
E. Genesis of Portal Gastropathy (Fig. 51.1)
F. Treatment
Acute Management
G. Complication of PHG
H. Newer Fronts/Points of Discussion
I. Summary
DRUG THERAPY IN PREGNANCY WITH COMMON MEDICAL DISORDERS
Introduction
Drug Handling in Pregnancy
Hepatic Metabolism
Renal Metabolism
Therapeutic Range
Teratogenicity
Mechanisms of Teratogenicity
COMMON INFECTION DURING PREGNANCY
DRUG DURING PREGNANCY
Antibiotics
I. Safe
II. Unsafe in Early Pregnancy
III. Unsafe in Late Pregnancy
IV. Unsafe throughout Pregnancy
Antimalarials
1. Safe
II. Unsafe
Antihelminthic
I. Safe
2. Unsafe
Antiamoebic
1. Safe
GUIDELINES FOR TREATMENT OF TB IN PREGNANCY
Drugs/Safety
Anemia During Pregnancy
Iron Deficiency Anemia (Table 51.15)
Megaloblastic Anemia
Diseases of Gastrointestinal Tract
Treatment
Treatment
Treatment
HYPERTENSION (HTN) (Tables 51.17 to 51.20)
DIABETES IN PREGNANCY
MANAGEMENT OF DM DURING PREGNANCY
SEIZURE DISORDERS DURING PREGNANCY
Epilepsy
ECLAMPSIA
BRONCHIAL ASTHMA
CARDIOVASCULAR DISORDERS
SECONDARY PREVENTION OF RHEUMATIC FEVER
PREVENTION OF INFECTIVE ENDOCARDITIS
ARRHYTHMIAS DURING PREGNANCY
MANAGEMENT OF ARF/CRF
BLEEDING DIATHESIS
ANTICOAGULANTS
THYROID DISORDERS
Hyperthyroidism
Hypothyroidism
HIV During Pregnancy
Analgesics During Pregnancy
CHAPTER 52:
Cerebral Venous Thrombosis (CVT)
INTRODUCTION
RELEVANT ANATOMY
CLINICAL PROFILE
Common Clinical Settings
Special Features of Specific Sinus Thrombosis
a. Transverse (lateral) Sinus Thrombosis
b. Cavernous Sinus Thrombosis
c. Superior Sagittal (longitudinal) Sinus Thrombosis
Differential Diagnosis
Investigations
Treatment
Prognosis and Outcome
Acute Abdomen in Medical Wards
Causes of Acute Abdomen in Medical Wards
1. Intra-abdominal Causes
2. Extra-abdominal Causes
DIAGNOSIS AND MANAGEMENT OF MEDICAL ABDOMINAL EMERGENCIES
Porphyria
Diagnosis
Management
SICKLE CELL CRISIS
Management
HAEMOPHILIA
Causative Factors
Associated Symptoms
Diagnosis
Management
Precipitating Factors
Causative Factors
Diagnosis
Management
ACUTE PANCREATITIS
O/E
Diagnosis
Management
AMOEBIC LIVER ABSCESSES
Causative Factors
O/E
Diagnosis
Management
SUBDIAPHRAGMATIC/SUBPHRENIC ABSCESS
TYPHOID FEVER AND ITS COMPLICATION AS ACUTE ABDOMEN
Causative Factors
O/E
Treatment
Steroids are Contraindicated
CHAPTER 53:
Drug Induced Extra Pyramidal Reaction
WERNICKE'S ENCEPHALOPATHY
DIGITALIS INTOXICATION
Investigations
Treatment
Ventricular Arrhythmia: Extrasystole
CARDIAC TEMPONADE
Clinical Features
Investigations
Treatment
Procedure
SEVERE ANAEMIA
Treatment
Complications
ACUTE HAEMOLYTIC ANAEMIA
Treatment
PROGRESSIVE SEVERE ANAEMIA
Diagnosis
Treatment
BARBITURATE POISONING
Management
DATURA POISONING
OPIATE OVERDOSE
Clinical Features
Management
CHAPTER 54:
Mechanical Ventilation
INDICATION FOR MECHANICAL VENTILATION
PATTERN OF ASSISTED VENTILATION
Assist Control Ventilation
Synchronized Intermittent Mandatory Ventilation (SIMV)
IMV Versus ACV
Pressure-controlled Ventilation
Pressure-support Ventilation
Positive End-expiratory Pressure
Continuous Positive Airways Pressure (CPAP)
Complications
Weaning from Mechanical Ventilation
Bedside Weaning Parameters
Methods of Weaning
T-piece Weaning
Protocols
Minimum Pressure Support
IMV Weaning
False Security of IMV
Which Method ?
CHAPTER 55:
Miscellaneous Emergency Problems
HYPERPYREXIA
Clinical Features
Late sequelae:
Laboratory diagnosis
MANAGEMENT
DROWNING
Pathophysiology
MANAGEMENT
BLEEDING DISORDERS
Causes of Bleeding Diasthesis
Coagulation Disorders
Platelet Abnormalities
Platelet Function Defects
Vascular Defects
Evaluation of Bleeding Diathesis
Investigations
Management
Haemarthrosis
Management of DIC
SECTION II: LABORATORY FINDINGS
CHAPTER 56:
Blood Count
■ RBC COUNT
Men
Women
■ LEUCOCYTOSIS
Neutrophilia
Physiological
Pathological
■ LEUCOPENIA
Infections
Bacterial
Viral
Protozoal
Defective Bone Marrow Function
Bone Marrow Involvement
Sensitivity to Drugs (Agranulocytosis)
Shock
Irradiation
■ LYMPHOCYTOSIS
■ LYMPHOPENIA
■ MONOCYTOSIS
Bacterial Infections
Protozoal
■ EOSINOPHILIA
Allergic Disorders
Parasitic Infestations
Drug Administration
Skin Diseases (Allergy type)
Pulmonary Eosinophilia
Blood Dyscrasias
■ EOSINOPENIA
■ BASOPHILIA
■ PLASMA CELLS
■ PLATELETS
■ THROMBOCYTOPENIA (Below 150,000/cu mm)
■ THROMBOCYTOSIS (count above 450,000/cu mm)
■ PANCYTOPENIA
■ HYPOCHROMIA (Increase in central pallor)
■ MACROCYTES (Larger than small lymphocytes)
■ TARGET CELLS
■ SPHEROCYTES
■ LEUCOERYTHROBLASTIC PICTURE (Immature myeloid and erythroid cells appearing in peripheral blood)
■ RETICULOCYTE COUNT
■ INCREASED PLASMA HAEMOGLOBIN (Normal -0.4 mg/100 ml)
■ LEUCOCYTE ALAKALINE PHOSPHATASE SCORE
■ COOMB'S TEST
■ LUPUS ERYTHEMATOSUS (LE) CELLS
Positive LE Cells in Blood
■ ERYTHROCYTE SEDIMENTATION RATE (ESR)
Westergren Method
Wintrobe Method
ESR Not Raised
ESR Raised
ESR Decreased
ESR Very Rapid Increase
ESR in Diagnosis
ESR in Prognosis and Treatment
Fragility of Erythrocytes
Increased
Decreased
■ BLEEDING TIME
Bleeding Time is Prolonged
Functional Platelet Defects
■ COAGULATION TIME
■ COAGULANT FACTOR DEFECTS
Haemophilia A
Haemophilia B
Von Willebrand's Disease
■ PACKED CELL VOLUME (PCV)
■ MEAN CORPUSCULAR HAEMOGLOBIN (MCH)
■ MEAN CORPUSCULAR HAEMOGLOBULIN CONCENTRATION (MCHC)
■ MEAN CORPUSCULAR VOLUME (MCV)
■ COLOUR INDEX (CI)
■ HAEMATOLOGICAL DIAGNOSIS OF LEUKEMIA
Cytochemical Characteristics
Acute myeloblastic leukaemia
Acute monoblastic leukaemia
ALL
Hairy cell leukaemia
Acute megakaryoblastic leukaemia
Leukemoid Reaction
■ HAEMOGLOBIN ELECTROPHORESIS
Haemoglobin A2
Increase
Decrease
Haemoglobin-F
Increase
■ IMMUNOGLOBULIN ESTIMATION
IgA deficiency
IgM deficiency
CHAPTER 57:
Blood Biochemistry
■ SERUM MAGNESIUM
■ SERUM PHOSPHORUS: INORGANIC
■ SERUM TRIGLYCERIDES
SERUM BILIRUBIN
Rise of Indirect Serum Bilirubin
Rise of Total Serum Bilirubin
■ SERUM CALCIUM
■ CHLORIDES
■ SODIUM
■ SERUM CHOLESTEROL
■ PLASMA PROTEINS
■ SERUM ALBUMIN
■ SERUM GLOBULIN
■ SERUM FIBRINOGEN
■ NITROGEN COMPOUNDS
■ UREA/CREATININE RATIO
■ SERUM URIC ACID
■ SERUM CREATINE
■ SERUM ALKALINE PHOSPHATASE
■ ACID PHOSPHATASE
■ SERUM AMYLASE
■ SERUM LIPASE
■ SERUM POTASSIUM
■ SERUM IRON
■ IODINE
■ SERUM FERRITIN
■ RHEUMATOID FACTOR
Positive Rheumatoid Factor
■ CHEMICAL CONSTITUENTS OF BLOOD
REFERENCE VALUES FOR URINE
CHAPTER 58:
Cerebrospinal Fluid
■ PRESSURE
Sitting Position
Increased Tension
Decreased Tension
■ APPEARANCE
Clear Fluid
Turbidity
Fine Spider Web Clot
Massive Coagulation
Blood Stained
Xanthochromia (Yellow/Colouration)
■ PROTEIN
■ GLUCOSE
Remains Normal in
Increased
Decreased
■ CHLORIDES
No Change in Level
Increased
Decreased (below 620 mg%)
■ CALCIUM
■ ACID–BASE EQUILIBRIUM
Remains Unaltered
Acidosis
■ CYTOLOGICAL LEUCOCYTE COUNT
Between 13 to 100 cell/cu.mm.
Polymorphonuclear Leucocytosis
Malignant Cells
Eosinophils
Plasma Cells
■ BACTERIA AND PARASITES
■ SEROLOGICAL
CHAPTER 59:
Glucose Tolerance Test
■ OTHER CAUSES OF LOWERED GLUCOSE TOLERANCE
■ INTRAVENOUS GLUCOSE TOLERANCE TEST
Indications
Normal
Diabetes
■ CORTISONE GLUCOSE TOLERANCE TEST
CHAPTER 60:
Bone Marrow Aspiration
■ BONE MARROW EXAMINATION
■ BONE MARROW BIOPSY
■ ACTIVITY OF ERYTHROPOIESIS
Normoblastic
Micronormoblastic
Megaloblastic
■ MYELOID/ERYTHROID RATIO
■ OTHER ABNORMALITIES
Aleukaemic Leukaemia
Multiple Myeloma
Secondary Carcinoma
Gaucher's Disease
Malaria
Kala Azar
Aplastic Anaemia
Agranulocytosis
CHAPTER 61:
Renal Function Tests
■ CONCENTRATION TEST (SPECIFIC GRAVITY TEST)
UREA CLEARANCE TEST
UREA/CREATININE RATIO
CHAPTER 62:
Liver Function Test
■ BILIRUBIN METABOLISM
Direct Van Den Bergh Reaction
Immediate
Delayed
Biphasic
Indirect Reaction
■ DIFFERENTIAL DIAGNOSIS OF JAUNDICE
■ CAUSES OF PREDOMINANTLY UNCONJUGATED HYPERBILIRUBINEMIA
After Drugs
■ CAUSES OF PREDOMINANTLY CONJUGATED HYPERBILIRUBINEMIA
■ URINE UROBILINOGEN
■ FAECAL STERCOBILINOGEN
■ CARBOHYDRATE METABOLIC TEST
Galactose Tolerance Test
Positive
Negative
■ GLUCOSE TOLERANCE TEST
■ EPINEPHRINE TOLERANCE TEST
Subnormal Response
■ PLASMA PROTEINS
■ SERUM GAMMA GLOBULIN
■ ALPHA GLOBULIN
■ BETA GLOBULIN
■ ALBUMIN/GLOBULIN RATIO
■ SERUM ENZYMES
Alkaline Phosphatase
Slight to Moderate Increase
Striking Increase
TRANSAMINASES
Other Causes
Increased
■ LACTIC DEHYDROGENASE
■ 5-NUCLEOTIDASE
■ SERUM AMMONIA
■ SERUM CHOLESTEROL
Esterified Cholesterol
Increased
■ SERUM IRON
■ TURBIDITY AND FLOCCULATION TEST
Positive Test
Positive Test
■ SERUM ALDOLASE
Elevated
SERUM BICARBONATE
Elevated
Metabolic Alkalosis
Respiratory Acidosis
Decreased
Metabolic Acidosis
Respiratory Alkalosis
■ CERULOPLASMIN AND COPPER
Ceruloplasmin
Copper
Elevated
Decreased
Creatine-Phosphokinase (CPK)
CHAPTER 63:
Fundus Examination
■ OPTIC DISC
Blurred Margin
Colour
Pale/Greyish White
Hyperemic with Swollen Disc
Deep Pink
■ PHYSIOLOGICAL CUP
■ RETINAL BLOOD VESSELS
■ MACULAR MARGIN
■ GLAUCOMA
■ PAPILLOEDEMA
■ OPTIC NEURITIS
■ OPTIC ATROPHY
■ RETINAL ARTERIOSCLEROSIS
■ HYPERTENSIVE RETINOPATHY
Grade I
Grade II
Grade III
Grade IV
■ DIABETIC RETINOPATHY
■ SEVERE ANAEMIA
■ POLYCYTHEMIA
■ LEUKAEMIA
■ OCCLUSION OF CENTRAL ARTERY OF RETINA
■ OCCLUSION OF CENTRAL VEIN
■ CHOROIDITIS
■ TOXAEMIA OF PREGNANCY
CHAPTER 64:
Laboratory Findings in Different Diseases
■ ACQUIRED IMMUNODEFICIENCY SYNDROME
■ ACUTE ADRENAL INSUFFICIENCY
■ ACUTE PANCREATITIS
■ ACUTE ALCOHOL POISONING
ACUTE LEAD POISONING
■ AFRICAN TRYPANOSOMIASIS (SLEEPING SICKNESS)
■ ANGINA PECTORIS
■ ANCYLOSTOMIASIS
■ ANKYLOSING SPONDYLITIS
■ AMPHETAMINE POISONING
■ ASCARIASIS
■ ASPIRIN POISONING
■ ATROPINE POISONING
■ BARBITURATE POISONING
■ BARTONELLOSIS
■ BERYLLOSIS
■ BILIARY CIRRHOSIS
■ CARCINOID SYNDROME
■ CARCINOMA OF OESOPHAGUS
■ CHANCROID
■ CHRONIC ALCOHOLISM
■ CHRONIC COR PULMONALE
■ CELIAC DISEASE
■ CROHN'S DISEASE
■ CRYPTOCOCCOSIS (TOLUROSIS)
■ CHRONIC GLOMERULONEPHRITIS
■ DIPHTHERIA
■ DISSEMINATED SCLEROSIS (Multiple Sclerosis)
■ ENTEROBIASIS
■ FARMERS LUNG
■ FASCIOLIASIS
■ FILARIASIS
■ GIANT CELL ARTERITIS (TEMPORAL ARTERITIS, CRANIAL ARTERITIS)
■ GIANT CELL ARTERITIS (Temporal Arteritis)
■ GONORRHOEA
■ GOUT
■ GRANULOMA INGUINALE
■ HAEMOPHILIA
■ HEAT EXHAUSTION AND SALT- DEPLETION
■ HEPATIC COMA (Hepatic Encephalopathy)
■ HEREDITARY SPHEROCYTOSIS
■ HODGKIN'S LYMPHOMA
■ HYDATID INFECTION
■ IDIOPATHIC THROMBOCYTOPENIC PURPURA
■ INFLUENZA
■ INTRACRANIAL ABSCESS
■ JUVENILE MYXOEDEMA
■ KINNER WILSON'S DISEASE (HEPATOLENTICULAR DEGENERATION)
■ KLINEFELTER'S SYNDROME
■ LEISHMANIASIS
■ LEPROSY
■ LEPTOSPIROSIS (Weil's disease)
■ LIVER FLUKE
■ LYMPHOGRANULOMA VENEREUM
■ MALARIA
■ MEASLES
■ MENINGOCOCCAL INFECTIONS
■ MUMPS
■ MYCETOMA (MADURA FOOT)
■ MYELOMATOSIS (Multiple Myeloma)
■ MYASTHENIA GRAVIS
■ OSTEOARTHROSIS
■ PARATYPHOID FEVER
■ PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA
■ PEMPHIGUS
■ PEPTIC ULCER
■ PHENYLKETONURIA
■ PLAGUE
■ POLYCYTHAEMIA VERA
■ POLYARTERITIS NODOSA
■ PRIMARY CARCINOMA LIVER
■ PULMONARY TUBERCULOSIS
■ PYLORIC OBSTRUCTION
■ RABIES
■ RHEUMATIC FEVER
■ RHEUMATOID ARTHRITIS
■ SCABIES
■ SCHISTOSOMA HAEMATOBIUM INFECTION
■ SCLERODERMA (SYSTEMIC SCLEROSIS)
■ SILICOSIS
■ STAPHYLOCOCCAL FOOD POISONING
■ SUBACUTE BACTERIAL ENDOCARDITIS
■ SARCOIDOSIS
Radiology
■ SYPHILIS
■ TAENIA SOLIUM
■ TETANUS
■ TRICHOMONIASIS
■ TROPICAL EOSINOPHILIA
■ TUBERCULAR PLEURAL EFFUSION
■ TUBERCULOUS PERITONITIS
■ TYPHOID FEVER
■ ULCERATIVE COLITIS
■ VIRAL HEPATITIS (ACUTE TYPE ‘A’)
■ VITAMIN A DEFICIENCY
■ YAWS
■ YELLOW FEVER
■ ZOLLINGER-ELLISON SYNDROME
APPENDIX:
Food and Nutrition
INDEX
TOC
Index
×
Chapter Notes
Save
Clear