The Budd–Chiari syndrome (BCS) is a rare disorder due to chronic liver disease (CLD), which is caused
by the obstruction of hepatic venous outflow that can be located at any place from the small hepatic
venules up to the entrance of the inferior vena cava (IVC) into the right atrium. Among the causes of
BCS, the rarer one is coagulation factor deficiencies. Here, we report a case of BCS associated with
deficiency of protein C resulting in thrombus in IVC. The patient was a 50-year-old male, who had been
suffering from recurrent abdominal and leg swelling for a long period of 7 years. He was evaluated
thoroughly, and other causes of liver cirrhosis were excluded.