Evaluation of Salivary Antioxidant Enzymes among Smokers and Nonsmokers

JOURNAL TITLE: World Journal of Dentistry

Author
1. Tajinder Kaur Saggu
2. KMK Masthan
3. Mahesh Pundaleek Dudanakar
4. Shams UI Nisa
ISSN
0976-6006
DOI
10.5005/jp-journals-10015-1121
Volume
3
Issue
1
Publishing Year
2012
Pages
4
Author Affiliations
    1. Sree Balaji Dental College and Hospital, Chennai, Karnataka, India
    2. Sree Balaji Dental College and Hospital, Chennai, Tamil nadu, India
    1. Department of Oral Pathology and Microbiology Vasantdada Patil Dental College and Hospital, Sangli, Maharashtra India
    1. Department of Oral Medicine and Radiology Bharati Vidyapeeth Deemed University Dental College and Hospital Pune, Maharashtra, India
  • Article keywords

    Abstract

    Background

    Cigarette smoke contains various oxygen-free radicals which are considered as the main causes of damage to biomolecules when exposed to cigarette smoke. Saliva is the first biological fluid that encounters inhaled cigarette smoke (CS) and has an antioxidant defense system able to counter toxic activities of free radical species. So, the aim of this study was to compare the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in saliva of smokers and nonsmokers.

    Materials and methods

    Unstimulated saliva of 200 males (100 smokers and 100 nonsmokers) was collected. The saliva was centrifuged and the activity of salivary superoxide dismutase and glutathione peroxidase was measured according to a specific assay.

    Results

    The mean value of superoxide dismutase activity was significantly higher in the smoking group than in the nonsmoker group, while the levels of GSH-Px activity was significantly higher in the nonsmoking group than in the smoking group.

    Conclusion

    Cigarette smoke leads to an alteration in salivary antioxidant activity. Evaluating the variations in the level of antioxidant enzymes (SOD and GSH-Px) in smoker's saliva might be useful for estimating the level of oxidative stress caused by cigarette smoke. Thus, it may help in patient's education regarding the ill-effects of smoking and determining the evolution and progress of various oral diseases.

    How to cite this article

    Saggu TK, Masthan KMK, Dudanakar MP, Nisa SUI, Patil S. Evaluation of Salivary Antioxidant Enzymes among Smokers and Nonsmokers. World J Dent 2012;3(1):18-21.

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