Background: This study aimed to evaluate and compare the static frictional forces between the gold-plated and conventional stainless steel brackets following immersion in three types of mouthwashes. Materials and methods: Eighty orthodontic brackets (40 stainless steel and 40 gold-plated) were divided equally into four subgroups and dipped in 15 mL of different mouthwashes for 45 days. The mouthwashes included chlorhexidine, aloe vera, aloe vera with fluoride and distilled water as a control group. The brackets then attached to an experimental model consisted of acrylic block. Frictional resistance was measured on 0.019 × 0.025 inch stainless steel archwires using Tinius Olsen Instron universal testing machine. Independent sample t-test and one way ANOVA were used to analyze the collected data. Results: Gold-plated brackets showed high significant friction in comparison with stainless steel one in all mouthwashes. In both types of brackets, there was a statistically highly significant difference among different mouthwashes. Aloe vera mouthwash showed the highest friction with steel brackets while Chlorhexidine had a maximum effect on the frictional force with gold-plated bracket. Conclusion: During orthodontic treatment and when sliding mechanics with minimum friction is required, the orthodontist should prescribe fluoridated herbal mouth rinse with Goldplated brackets. Chlorhexidine should be excluded due to exaggerated frictional resistance that may impede or delay the intended tooth movement, from the same point of view, when using stainless steel brackets, chlorhexidine is the best mouth rinse, while herbal mouth rinse without fluoride (aloe vera mouthwash) is contraindicated. Clinical significance: Orthodontists should take care of prescribing mouth rinses to decrease their effects on the friction.