Neuroblastoma in Late Adolescence: Case Report and Review of Literature

JOURNAL TITLE: World Journal of Endocrine Surgery

Author
1. Sasi Mouli
2. Shreyamsa Manjunath
ISSN
0975-5039
DOI
10.5005/jp-journals-10002-1239
Volume
10
Issue
3
Publishing Year
2018
Pages
6
Author Affiliations
    1. Department of Endocrine and Breast Surgery, King Georges Medical University, Lucknow, Uttar Pradesh, India
    1. Department of Endocrine and Breast Surgery, King Georges Medical University, Lucknow, Uttar Pradesh, India
  • Article keywords
    Adrenal tumor, Late adolescence, Neuroblastoma, Sympathetic nervous system tumors

    Abstract

    Neuroblastoma is an embryonal cancer of the peripheral sympathetic nervous system. It is the most common extracranial tumor of childhood and the third most common tumor overall. Neuroblastoma arises from cells of primordial neural crest. The natural history of this disease is very heterogeneous and extends from spontaneous regression to aggressive metastatic disease. Neuroblastoma in older children is extremely rare and it carries a bad prognosis. We present a case of a 15-year-old boy with unresectable neuroblastoma who was subjected to neoadjuvant chemotherapy which rendered the tumor resectable. The case highlights importance of neoadjuvant therapy in neuroblastomas, need for multimodality involvement and therapeutic challenges faced by phycisians in successfully treating aggressive neuroblastomas.

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