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JOURNAL TITLE: World Journal of Anemia
Twin-to-twin transfusion syndrome (TTTS) is a severe problem that affects 10–15% of monochorionic (MC) multiple pregnancies. Connecting placental vessels on chorionic plate between donor and recipient twin is accountable for inequality of blood flow. There is an indication for the superiority of fetoscopic laser ablation over serial amnioreductions regarding survival and neurological outcome for stages II–IV TTTS. However, the optimal management of stage I is still debated. In this review, we discuss the basics of twin gestation, optimal management, pathophysiology, long-term neurodevelopmental outcome, and future aspects of TTTS.
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