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JOURNAL TITLE: World Journal of Anemia
Sickle cell disease (SCD) is the most common hereditary disease globally, linked with anemia and recurrent severe pain. Pregnancy in a patient with SCD is related with high levels of maternal and fetal morbidity and mortality. Studies on potential complications during pregnancy have generated mixed data. However, it is generally accepted that women with SCD are at higher risk of adverse pregnancy outcomes and maternal mortality. Patient care has developed much over time. Nevertheless, some of the definite management issues still remain unanswered. Excellent prenatal monitoring and aggressive intervention should be established when difficulties arise for the effective management of the pregnant patient with SCD. This article discusses the etiology and the diagnosis including the clinical presentation, investigations, neonatal screening, peripheral smear, and the available management options.
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