Study of Increase in Hemoglobin Concentration after Administration of Intravenous Iron Sucrose in Pregnant Women with Severe Anemia

JOURNAL TITLE: World Journal of Anemia

1. Shyama
2. Sangeeta Rai
3. Anita Kumari
Publishing Year
Author Affiliations
    1. Department of Obstetrics and Gynecology, Central Superspeciality Hospital, ECR, Patna, Bihar, India
    1. Department of Obstetrics and Gynecology, Banaras Hindu University, Varanasi, Uttar Pradesh, India
    1. Department of Medicine, All India Institute of Medical Sciences, Patna, Bihar, India
  • Article keywords
    Intravenous iron-sucrose, Pregnancy, Severe anemia


    Introduction: Iron-deficiency anemia is a great concern among obstetricians. Anemic women are at a greater risk of dying during their pregnancy. Despite the measures taken to control anemia in pregnancy in the last two decades, the severity of nutritional anemia continues to remain a public health issue of great magnitude. Oral supplement or iron has several drawbacks. Hence an idea was conceptualized to conduct a study to evaluate the efficacy of IV iron sucrose (OROFER-S) in the improvement of hemoglobin concentration in the antenatal mothers with severe anemia. Materials and methods: This progressive study was conducted in antenatal OPD of obstetrics and gynecology department of VSS Medical College, Burla, Odisha for a period of 24 months. Results: Out of 23 antenatal mothers with severe anemia, 73.91% were residing in rural area and 26.08% were residing in urban area. The cases recruited in the study were given a total of 300 mg elemental iron as iron sucrose complex diluted in 0.9% of NS per week. Hemoglobin level was estimated at the onset and again two weeks after the completion of the study. On completion of therapy, there was significant improvement in Hb level with a rise of Hb level (2.5–3) in 4.3% mothers, and (1.5–2) g/dL in 60.66% cases. No rise in Hb level was observed in 8.6% cases. Present study shows correlation between severity of anemia and gravidity with multigravida accounting for 65.21%. Most of the patients (39.13%) were just literate or had primary education (26.08%). The study groups faced only minor side effects like nausea (21.73%), shivering (13.04%), no serious anaphylactic reactions were observed. Low birth weight (47.82%) is the most common fetal complication. Further IUGR accounts for 34.78% and premature labor (13.04%). Gestational hypertension (21.73%), postpartum hemorrhage (17.39%) and preterm labor (3.90%) and the common maternal complications observed.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved