Inappropriate deposition of fat leads to different forms of diseases, causing morbidity and mortality. The person looks thin despite taking adequate lipid that leads to deposition disorder called lipodystrophy syndrome (LDS). This condition abnormally distributes the fat, where it is not supposed to be deposited. Hence, the patient looks thin and the fats are not in the subcutaneous layer of the skin. It is an autoimmune disease and caused by repeated injection of fat to a particular site. It is classified into two types: generalized and localized lipodystrophy syndrome. Treatment for this syndrome is meterleptin hormone replacement therapy and circulating the site of injection. The prognosis will vary based on the severity of the syndrome.