Background and objectives: The objective structured clinical examination (OSCE) is a flexible multipurpose evaluation tool that can be utilized in a clinical environment to test healthcare practitioners. This assesses competency through close examination focused on unbiased assessments. The research aimed at evaluating the attitude toward OSCE among undergraduate nursing students at a selected educational institution in Chennai. Materials and methods: A quantitative research approach is adopted with the use of descriptive design and a convenient sampling technique was used to select the samples. The study was conducted among 150 undergraduate nursing students studying in first, second, and third year, who had undergone OSCE examination. The attitude toward OSCE was assessed by using the self-administered structured questionnaire. Results: The study findings reveal that 85.51% of the nursing students had favorable attitude toward OSCE. Age (χ² = 7.940 at p = 0.05 level) and the other demographic variables had no significant association with attitude toward OSCE. Conclusion: The students felt that the OSCE was well-structured and sequential, provided opportunities to learn, and reflected real-life situation.