Transient Neonatal Cholestasis Secondary to Coagulase-negative Staphylococci Septicemia: A Case Report

JOURNAL TITLE: Pediatric Infectious Disease

Author
1. Chitgupikar Sudharshan Raj
2. Singamala Rufus Rajkumar
3. Preethi Subramanian
4. Suneel K Kommineni
ISSN
DOI
10.5005/jp-journals-10081-1329
Volume
4
Issue
3
Publishing Year
2022
Pages
3
Author Affiliations
    1. Department of Paediatrics, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Paediatrics, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Paediatrics, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India
    1. Department of Paediatrics, MediCiti Institute of Medical Sciences, Hyderabad, Telangana, India
  • Article keywords
    Sepsis, Transient neonatal cholestasis, Ursodeoxycholic acid

    Abstract

    Transient neonatal cholestasis (NC) is characterized by early-onset cholestasis and normalization of clinical and biochemical parameters at follow-up. The causes are multifactorial and include immature bile secretion (as in the case of prematurity) and other perinatal causes. Sepsis is responsible for 20% of cases of NC. It is mandatory to rule out other causes of NC before labeling the neonate as having transient NC. The use of ursodeoxycholic acid in cholestasis has been advocated to bring a faster decline in direct bilirubin levels in neonates. Neonates have to be evaluated early considering associated risk factors so that early intervention could prevent complications and yield better outcomes.

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