Introduction: Making up 20–30% of cases in the outpatient clinic, abnormal uterine bleeding (AUB) is a common diagnosis with considerable social and economic impact. Complaints of heavy menstrual bleeding significantly affect the quality of life resulting in time off work, thus leading to surgical intervention including hysterectomy and ultimately posing a significant impact on the health care system. Timely and appropriate management will prevent most of these problems. Materials and methods: Two hundred and forty-six women with AUB visiting outpatient Department of Obstetrics and Gynecology, AIMSR, Bathinda were included in the study after informed written consent. History and examination, ultrasonography, and serum thyroid-stimulating hormone (TSH) levels were done for all patients. The prevalence of thyroid hormone dysfunction in AUB was evaluated and the association between various menstrual patterns and thyroid profile was assessed. Results: Out of 116 cases presenting with heavy menstrual bleeding, 79 were hypothyroid, 5 were hyperthyroid, and 32 were euthyroid. Also, out of the 37 cases presenting with light menstrual bleeding, 16 were hypothyroid closely followed by 13 hyperthyroid cases. These results were statistically significant. Moreover, the most common AUB pattern in the hypothyroid group was heavy menstrual bleeding (79 cases out of 117 cases), while in the hyperthyroid group was light menstrual bleeding (in 13 cases out of 22 cases). Conclusion: The key to early diagnosis is to maintain a high index of suspicion and readily screen for the presence of abnormal thyroid function.