Analysis of In Vitro Fertilization—Intracytoplasmic Sperm Injection Results from Fresh Day 2 and Day 3 Embryo Transfers at a Tertiary In Vitro Fertilization Center

JOURNAL TITLE: Journal of South Asian Federation of Obstetrics and Gynaecology

1. Jiteeka Thakkar
2. Hrishikesh Pai
3. Rohan Palshetkar
4. Nikita Lad
5. Biswanath G Dastidar
Publishing Year
Author Affiliations
    1. Fortis Hospitals—Gurugram, Delhi, Mohali, Navi Mumbai, DY Patil Hospital—Navi Mumbai, Sakra Hospital—Bengaluru, Lilavati Hospital—Mumbai; Bloom IVF Group, Mumbai, Maharashtra, India
    2. Lilavati Hospital, Mumbai, Fortis Hospital, New Delhi, Gurugram, Noida, Faridabad, DY Patil Hospital, Mumbai, Maharashtra, India
    3. Lilavati Hospital and Research Centre; Bloom IVF, Mumbai, Maharashtra, India
    4. Bloom IVF; FOGSI 2015-17; Lilavati Hospital, Mumbai, Maharashtra, India
    5. Lilavati and Bhatia Hospitals, Mumbai; DY Patil Medical College, Navi Mumbai; Fortis Hospitals, New Delhi, Gurgaon and Mohali
    6. Bloom IVF Group, Mumbai, Maharashtra, India
    7. BAUFICI Genetics, Indian SIG ASRM
    8. Bloom IVF; BAUFICI Genetics; FOGSI; IFFS; ISAR, IAGE, MOGS and MSR; Indian SIG ASRM
  • Article keywords
    Clinical pregnancy rate, Day 3, Embryo transfer, In vitro fertilization


    Embryo transfers (ET) on day 2 or day 3 following fertilization have been the standard of practice since the initial days of human in vitro fertilization (IVF). Recent advances in culture media, as well as embryo culture techniques, have prompted in a shift in strategy to day 5 blastocyst transfers following IVF. However blastocyst transfers, although resulting in slightly better pregnancy rate, are known to be associated with certain disadvantages, such as higher costs, higher cycle cancellation rates, and in vitro damage to embryos. Thus we reviewed our results with day 2 and day 3 ETs to see whether outcomes were adequate to justify a return to day 3 embryo transfer policy. Our data shows a 46% clinical pregnancy rate and 1.9% incidence of multiple pregnancy rate with cleavage transfers. Thus in our setting with a lot of poor resource patients, we feel day 2 or 3 transfer provides a good strategy for IVF cycles.

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