Many thanks to JAYPEEDIGITAL platform, which has been an indispensable easy-to-use source for our...Ozlem YALCINKAYA
Jaypeedigital site offers to our students a huge number of medical publications such as textbooks...Dr Jesus Tapia Jurado
With user-friendly interface, Jaypeedigital provides extensive coverage in medicine, dentistry and...Wan Suhaimi Ariffin, MLS (Syracuse), BLS (UITM)`
Subscribe to be the first to know about Best Deals and Exclusive Offers!
The polycystic ovary syndrome (PCOS) is the most common condition associated with chronic anovulation affecting 4 to 6% of reproductive age women.
To compare the effectiveness of laparoscopic ovarian drilling (LOD) for ovulation induction with gonadotropins in clomiphene-resistant PCOS in terms of ovulation, pregnancy, live birth, abortion, multiple pregnancies, and complication like ovarian hyperstimulation syndrome (OHSS).
A prospective hospital-based randomized trial.
It was a prospective study, which was carried out from January 2012 to May 2015. Totally, 89 women were evaluated in the study, out of which 44 women were in gonadotropin group and 45 were in LOD group.
Standard statistical analysis was done and significance of difference in results was tested by chi-square test.
Ovulation rate in gonadotropin group was 75.0% at 6 months, whereas in LOD group, it was 20% at 3 months and was increased up to 66.66% after addition of clomiphene citrate and gonadotropin. The primary outcome in terms of pregnancy in gonadotropin group was 45.45% after 6 cycles and in LOD group was 11.11% after 3 cycles and 40.00% after 6 cycles with supplementation of clomiphene citrate and gonadotropin.
The ongoing pregnancy rate from ovulation induction with LOD alone was significantly less but if supplemented by clomiphene citrate and gonadotropin, it seems equivalent to ovulation induction with gonadotropin, but the former procedure carries a lower risk of multiple pregnancies.
Yadav P, Singh S, Singh R, Jain M, Awasthi S, Raj P. To Study the Effect on Fertility Outcome by Gonadotropins
© 2019 Jaypee Brothers Medical Publishers (P) LTD. | All Rights Reserved