Clinical Safety of Selected Ayurvedic Formulations in Osteoarthritis

JOURNAL TITLE: Journal of Research in Ayurvedic Sciences

Author
1. Sunita
2. Shruti Khanduri
3. Bharti Gupta
4. Dinesh Baruah
5. Hemant Panigrahi
6. Tapsi Borah
7. Babita Yadav
8. Puthanveetil Kesavan Sudarsanan Nair
9. Pradeep Dua
10. Rakesh Rana
11. Uday Ravi Sekhar Namburi
12. Richa Singhal
13. Radhakrishnan
14. Veliparambil Chandran Deep
15. Maha Meda Rao
16. Shubhashree Thejasvi
17. AJV Sai Prasad
18. Pramila Devi
19. Ankush Jadhav
20. Savita Sharma
21. D Ankush
22. Sarada Ota
23. Vinod K Lavaniya
24. Narayanam Srikanth
25. Madan Mohan Padhi
26. V Rakesh Narayanan
27. Anil Mangal
28. Deepa Makhija
ISSN
2456-5601
DOI
10.5005/jras-10064-0118
Volume
4
Issue
4
Publishing Year
2020
Pages
10
Author Affiliations
    1. Central Council for Research in Ayurvedic Sciences New Delhi, India
    1. Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India
    1. Regional Ayurveda Research Institute for Lifestyle-related Disorder, Kerala, India
    1. Regional Ayurveda Research Institute, Itanagar, Arunachal Pradesh, India
    1. Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India
    1. National Ayurveda Research Institute for Panchakarma, Cheruthuruthy, Kerala, India
    1. Central Ayurveda Research Institute for Drug Development Kolkata, West Bengal, India
    1. Regional Ayurveda Research Institute for Drug Development, Gwalior, Madhya Pradesh, India
    1. Central Council for Research in Ayurvedic Sciences, New Delhi, India
    1. Central Ayurveda Research Institute for Hepatobiliary Disorders, Bhubaneswar, Odisha, India
    1. Captain Srinivasa Murthy Regional Ayurveda Research Institute for Drug Development, Chennai, Tamil Nadu, India
    1. Regional Ayurveda Research Institute for Metabolic Disorders, Bengaluru, Karnataka, India
    1. Regional Ayurveda Research Institute for Drug Development, Aamkho, Gwalior, Madhya Pradesh, India
    1. Regional Ayurveda Research Institute for Skin Disorders, Vijayawada, Andhra Pradesh, India
    1. Regional Ayurveda Research Institute for Skin Disorders Vijayawada, Andhra Pradesh, India
    1. Central Council for Research in Ayurvedic Sciences, New Delhi, India
    1. Central Council for Research in Ayurvedic Sciences, New Delhi, India
    1. Central Ayurveda Research Institute for Cardiovascular Diseases, New Delhi, India
    1. Central Council for Research in Ayurvedic Sciences, Janakpuri, New Delhi, India
  • Article keywords

    Abstract

    Background: Osteoarthritis (OA) is one of the most common forms of arthritis which is caused by the degeneration of joint cartilage. It is often associated with disability and leads to impairment of quality of life. The clinical picture is similar to the disease Sandhigatavata described in Ayurveda (one among the Vatavyadhi) and is characterized by symptoms such as Sandhi Shoola (joint pain), Sandhishopha (swelling of joint), and Prasarana-Akunchana-Ashakti (difficulty in movements of the joint). The safety of 10 Ayurvedic classical formulations most commonly used in OA was clinically evaluated and the findings are provided in this article. Aim and objective: Critical analysis of clinical safety outcomes of classical Ayurvedic formulations, viz. Vatari Guggulu, Yogaraj Guggulu, Punarnava Guggulu, Maharasnadi Kwatha, Dashmoola Ghrita, Narayan Taila, Kottamchukkadi Taila, Gandharvahasta Taila, Dhanwantara Taila, and Ksheerbala Taila in patients of OA, generated through studies at different Institutes of Central Council for Research in Ayurvedic Sciences (CCRAS). Materials and methods: Data collected from four different clinical studies completed in multiple centers of CCRAS were retrospectively evaluated to assess the safety profile of 10 formulations that are commonly used in OA. Evaluation of safety was done by analyzing liver function tests (LFT) and renal function tests (RFT) before and after the trial period. Paired sample t-test was used to compare mean change from baseline to the 84th day. A p value of <0.05 was considered significant. Conclusion: The findings in four different clinical studies reveal that all ten formulations are clinically safe in patients belonging to various age groups, gender, geographical area, and Prakriti.

    © 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved