Introduction: There is an upsurge in use of complementary alternative medicines including Ayurveda among cancer patients. A systematic review of published data has shown that evidence for effectiveness of Ayurveda as add-on to conventional cancer treatment is substantial in comparison to standalone. However, there is a need for robust documentation of the cancer case management involving Ayurvedic interventions. National Cancer Institute Best Case Series program aims at systematic documentation of management using unconventional therapies for cancer for identification of novel therapies. However, a comprehensive integrated case format needs to be evolved at this juncture. Aim: To develop comprehensively integrated case record format for systematic documentation of cancer management through Ayurveda interventions. Results: Raja Ramdeo Anandilal Podar Central Ayurveda Research Institute (RRAP-CARIC) under Central Council for Research in Ayurvedic Sciences (CCRAS) has developed Cancer Case Record Format (CCRF), a comprehensive integrated format for systematic documentation including demography, definitive diagnosis, clinical examination, treatment and disease response, etc. of cancer patients after wide consultation process and pretesting on more than 500 cancer patients. Clinical significance: This may be well utilized as a tool for uniform documentation by students, scientists, researchers, and physicians.