Ayurvedic medicines are serving the needs of ailing humanity for centuries, but there is a constant need to bring these medicines on a global platform and to give them proper scientific validity. Central council for research in ayurvedic sciences (CCRAS), Ministry of AYUSH, Government of India, since inception is dedicated in the validation of classical Ayurveda formulations through series of clinical studies, to consolidate the use of Ayurveda classical formulations, backed by proper scientific evidence. The Council has generated scientific evidence on clinical safety and efficacy of approximate 100 classical Ayurvedic formulations on 35 diseases/conditions of priority areas. The evidence on clinical efficacy and safety of Ayurvedic formulations which are vogue and available in the market are not only highly useful to practitioners and consumers for their rational use but also will strengthen integration of Ayurveda with other systems of medicine and will be helpful in convincing scientific community across the world which may also improve its market in the country and world at large.