Hearing Loss with Amphotericin B Therapy in Patients with Rhinocerebral Aspergillosis: Is it a Reality?

JOURNAL TITLE: Journal of Postgraduate Medicine, Education and Research

Author
1. Dharamveer Singh
2. Sandeep Mohindra
3. Karan Gupta
4. Satyawati Mohindra
5. Bhumika Gupta
ISSN
2277-8969
DOI
10.5005/jp-journals-10028-1147
Volume
49
Issue
2
Publishing Year
2015
Pages
4
Author Affiliations
    1. Department of Otolaryngology and Head and Neck Surgery, Postgraduate Institute of Medical Education and Research Chandigarh, India
    1. Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    1. Department of Otolaryngology and Head and Neck Surgery Postgraduate Institute of Medical Education and Research, Chandigarh India
    1. Department of ENT, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    1. Department of Audiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Article keywords

    Abstract

    Context

    Study carried out to investigate the relationship of amphotericin B (AmB) therapy with hearing loss developing in patients with rhinocerebral aspergillosis during prolonged AmB therapy.

    Aim

    To study the effect of prolonged AmB therapy on the hearing acuity of patients suffering from invasive fungal sinusitis. Setting and design: Nonrandomized prospective study carried in Department of Otolaryngology and Head and Neck Surgery from January, 2010 to June, 2013.

    Materials and methods

    High frequency pure tone audiometry (PTA) and cold caloric test (CCT) were done for all patients before starting of therapy with AmB. Both tests were repeated at 500 mg, 1 and 2 gm of AmB administration. Follow-up was done for all patients at 3 and 6 months after completion of therapy.

    Results

    Twenty-four patients of invasive fungal sinusitis included. On prolonged AmB therapy some patients had deterioration in hearing. But these changes were not statistically significant. The changes were mild and shift was one grade above or below. It was also seen that the hearing complaints were reported in the middle of the therapy although all these patients had baseline hearing loss.

    Conclusion

    Amphotericin B does cause some change in hearing pattern; although not statistically significant. A further study is required with more number of patients so as to say definitively that AmB causes a change in hearing. Though these patients have numerous factors which can affect hearing in many ways, a systematic study is required to go a long way in clearing the doubts attached to AmB therapy.

    Key message

    Amphotericin related hearing loss has not been reported in English literature till date. Our study focuses on the effect of AmB on hearing. Amphotericin B does cause some change in hearing pattern, although not statistically significant. All the patients complained of hearing deterioration while some showed improvement on audiogram (though not significant) showing a paradoxical feature.

    How to cite this article

    Mohindra S, Gupta B, Mohindra S, Gupta K, Singh D. Hearing Loss with Amphotericin B Therapy in Patients with Rhinocerebral Aspergillosis: Is it a Reality? J Postgrad Med Edu Res 2015;49(2):66-69.

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