Introduction: Lipomas are slow-growing, lobulated, soft, mobile mass, usually found subcutaneously but can be found anywhere in the body. Case description: Our hospital presented with a case of mesenteric lipoma causing acute intestinal obstruction. Patient had a large tumor on the mesenteric border of ileum which was resected and on histopathology came out to be a mesenteric lipoma. Discussion: Mesenteric lipoma presenting as acute intestinal obstruction is a rare instance with very few cases being reported so far around the globe. Conclusion: Though mesenteric lipoma causing intestinal obstruction is rare. But from this case report we conclude that it should be considered as a differential diagnosis when patient presents with acute abdomen or intestinal obstruction.