Background: Acrylic removable partial dentures (ARPDs) are used for management of tooth loss in most developing countries. Aim: This article aims to determine prevalence of ARPDs among adult patients attending public dental clinics in Dar-es-Salaam, Tanzania. Methods: This study involved adults aged 18 years and above attending dental clinics in Dar-es-Salaam, Tanzania. Patient's hospital registration provided particulars on age and sex. Additional information sought from subjects with ARPDs included education level and denture wearing experience. Clinical assessment of ARPDs determined jaw involved and number of teeth replaced. Data were analyzed using SPSS at a p-value of less than 0.05. Results: Of the 3,225 subjects aged 18–87 years, majority were 36–87 years (n = 1,687; 52.3%) and females (n = 1,688; 52.3%). The 10.5% prevalence of patients with ARPDs showed no difference by age, sex, or location (p >0.05). Denture wearing experience of less than 2 years was statistically significantly higher among younger age-group and those with higher level of education. ARPDs in the upper jaw was statistically significantly related to young adults (n = 102; 63.8%), males (n = 86; 55.1%), and having secondary or higher level of education (n = 110; 54.5%). ARPDs replacing 1–5 teeth were statistically significantly higher among patients aged 18–35 years and those having secondary or higher level of education (p <0.05). Conclusion: The prevalence of ARPDs among attending dental patients was low (10.5%) with a denture wearing experience of less than 2 years being higher among younger adults and those with secondary or higher level of education. ARPDs in the upper jaw were related to being young, male, and having secondary or higher level of education, while replacement of 1–5 teeth was related to being young and having secondary or higher level of education. Community awareness on use of ARPDs in management of tooth loss should be emphasized. Clinical significance: Determining factors associated with wearing of dentures will assist practitioners in patient management.