Background: Esthetics of fluorosis affected compromised maxillary incisors may influence the psychological well-being of an emotionally and physically developing child. Aim and objective: To evaluate the oral health-related quality of life (OHRQoL), esthetic perceptions and concerns of children due to fluorosis affected permanent maxillary central incisors. Design: A convenient sample of 65 children, 8–12 years were included in the study. The clinical records of the child's fluorosis perception were collected by Social Impact of Dental Disease Questionnaire and Dental Impact on Daily performance (DIDP) questionnaire that are OHRQoL indicators and examined for fluorosis using the WHO, 2013 Criteria and were scored. Overall OHRQoL scores were calculated by summing all the responses in the questionnaire. Results: Mild fluorosis and a more acceptable appearance with satisfied OHRQoL were significant factors for children's perception of good oral health. The difference in child perception was significant in the group with fluorosis experience. Conclusion: Esthetic consideration is vital in fluorosed maxillary incisors in early mixed dentition.