A study to evaluate the effectiveness of natural honey application on oral mucositis among patients undergoing radiation therapy with or without chemotherapy in selected hospital, Kanyakumari district. Out of 60 samples, 30 samples were in study group and 30 samples were in the control group. The WHO Oral Mucositis Grading Scale was used to screen the oral mucositis in the study and control group. Pre assessment was done on first day and post assessment was done on seventh day. The researcher concluded as per the study that, oral mucositis can be reduced by natural honey application. This study findings statistically proved the natural honey application is effective on oral mucositis among patient undergoing radiation therapy with or without chemotherapy.