Paget's disease of the breast is an uncommon type of cancer of nipple-areola complex and it is frequently associated with an underlying in situ or invasive carcinoma. If there is persistent eczematous involvement of the nipple, which does not respond to the local treatment, then suspicion for Paget's disease must be considered. It constitutes 1–4.3% all breast cancer cases and is frequently associated with an underlying malignancy. Paget's disease of the nipple is a rare disease that requires high suspicion and a good knowledge of symptomatology for quick diagnosis. The present study is based on four cases of Paget's disease which were evaluated further to identify the underlying cause.