Removal of the mandibular single incisor is an alternative approach to treat some malocclusion. Many treatment strategies are presently used for crowded mandibular anterior dentition that include distalization of posterior teeth, slenderization, extraction of bicuspids, and extraction of mandibular incisors. This report presents the case of a boy aged 17 years with class I type III malocclusion, and the case is treated with lower single-incisor extraction due to the presence of crowding in mandibular anterior teeth, Bolton discrepancy in lower anterior by more than 4 mm, anterior cross bite, and the periodontally compromised single incisor. These all indicated the extraction of mandibular single incisor. How to cite this article Mittal K, Bohra S, Yadav S, Kakkar A. Mandibular Single-incisor Extraction: An Efficient Treatment Approach. J Mahatma Gandhi Univ Med Sci Tech 2017;2(2):97-101.