Peripheral and Facial Edema Associated with Olanzapine: A Case Report

JOURNAL TITLE: The Journal of Medical Sciences

Author
1. Vidhyavathi Malyam
2. Sumanth T Parameshwaraiah
3. Suha Riyaz
4. Asha C Sannappa
5. Vishnuvardhan Gopalakrishnan
ISSN
2321-354X
DOI
10.5005/jp-journals-10045-00153
Volume
6
Issue
3
Publishing Year
2020
Pages
2
  • Article keywords
    Atypical antipsychotics, Edema, Olanzapine, Side effects

    Abstract

    Olanzapine is a potent second-generation antipsychotic commonly used in the treatment of many psychiatric illnesses. It is considered more potent and has less incidence of extrapyramidal symptoms compared with first-generation antipsychotics. With sedation and weight gain being considered as the most common adverse effects, it has also been reported that peripheral edema is associated with olanzapine therapy, but only a few cases of facial edema have been reported so far. However, a definitive cause and consequence of edema are not established, as it is not commonly encountered in medical practice. As olanzapine is a commonly used atypical antipsychotic, we report a case of bilateral pitting pedal edema and facial edema in a woman with no medical comorbidities after initiating olanzapine therapy. All systemic causes of edema were ruled out, and it was completely resolved after discontinuation of olanzapine.

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