Aim: To explore the medicinal plants from Shahjahanpur forest divisions of Uttar Pradesh. Materials and methods: Exploration of the Shahjahanpur forest division has been carried out during the month of June 2017. Data were collected during the medicoethno-botanical survey from Shahjahanpur forest divisions of Uttar Pradesh. Results: During exploration, records of commonly occurring medicinal plants and traditional practices with their global positioning system and potential in the field have been recorded. The important medicinal plants like Aegle marmelos (L.) Correa, Celastrus paniculatus Willd., Centella asiatica (L.) Urb., Desmodium gangeticum (L.) DC., Helicteres isora L., Holarrhena pubescens Wall. ex G. Don, Oroxylum indicum (L.) Kurz, Premna mollissima Roth, Solanum nigrum L., Terminalia tomentosa Wight and Arn. Tribulus terrestris L., etc., were recorded, which can be undertaken for pharmaceutical use through systemic conservation and cultivation. Very little knowledge is available for traditional use of medicinal plants in the area. There is a need of developing awareness among the local people of the areas. Conclusion: The study area is widely occupied by plants of Holarrhena pubescens Wall. ex G. Don and Celastrus paniculatus Willd., Oroxylum indicum (L.) Kurz, etc., for conservation in the habitat.