Background: Ministry of AYUSH deals with developing education, research, and propagation of indigenous traditional medicine systems in India, and in view of public health challenge posed by COVID-19, the ministry had issued preventive and prophylactic advisories. Results and discussion: The advisories issued by Ministry comprises interventions from different AYUSH systems of medicine for preventive health measures and also for boosting immunity during COVID-19 crisis. Further, the Ministry has undertaken study through AYUSH Sanjivani mobile app for generating data of large population with a target of 5 million people. Generation of data on effectiveness, acceptance, and usage of AYUSH advocacies and measures among the population and its impact in the prevention of COVID-19 are the core expected outcomes. Conclusion: The present short communication is related to the prophylactic advisories issued by Ministry of AYUSH and details of objectives and expected outcomes of AYUSH Sanjivani mobile application developed by AYUSH Ministry.