Noninvasive ventilation (NIV) therapy has become the standard of care for home therapy of patients suffering from sleep apnea and chronic Type 2 respiratory failure. We did a retrospective study of a patient admitted with the exacerbation of these disease despite of being advised home NIV therapy. The study was performed in a tertiary care institute in the past 2 years. A total of 186 patient of chronic respiratory failure were studied who were prescribed NIV, out of which 96 patients who adhered to NIV were followed, and reasons of readmission and practical issues were studied. All the patient admitted to respiratory and general intensive care unit (ICU) were included, who needed a stay of more than 5 days. Out of 96 patients, 30 patients are of severe sleep apnea, and 25 patients are of severe chronic obstructive pulmonary disease (COPD). The most common cause of such patients going into respiratory failure after use of NIV being recurrent infection and poor willingness to continue with NIV due to psychological and medical reasons. Commonly seen medical reasons were ulcer over the bridge of the nose; inability to sleep with a mask on and feeling of suffocation with the mask. Psychological reasons include depression symptoms and a feeling of loneliness. We recorded that patient with regular follow up; the active role played by younger family members and patient on nasal mask had better outcome results as compared to their medical counterparts.