Clozapine-resistant Schizophrenia: Strategies for the Busy Clinician

JOURNAL TITLE: Indian Journal of Private Psychiatry

Author
1. Mansi Jain
ISSN
2319-5363
DOI
10.5005/jp-journals-10067-0004
Volume
11
Issue
2
Publishing Year
2017
Pages
7
Author Affiliations
    1. Department of Psychiatry, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai, Maharashtra, India
  • Article keywords

    Abstract

    Introduction: Schizophrenia is a debilitating psychiatric illness where relapse and nonrecovery are common. Clozapine has been heralded as a management option for treatmentresistant schizophrenia (TRS). The aim of the current review is to provide a clinical overview of strategies that may be used in the management of patients that fail to show an adequate response to clozapine. The term clozapine-resistant schizophrenia and its implications are discussed along with a description of various pharmacological and nonpharmacological strategies for the management of clozapine-resistant cases or partial responders to clozapine. The evidence is discussed and the strategies are presented. There is a need for emerging strategies to augment clozapine therapy in the absence of response or in case of partial response in patients.

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