Background: The deadly second wave of coronavirus disease-2019 (COVID-19) pandemic swept through the whole of India during the month of April–May 2021. Restrictions like lockdowns and social distancing impacted the normal functioning of life. It is in this backdrop that we need to understand the perceived stress and quality of life among people. Aim and objective: The aim and objective of this study was to evaluate and study the relationship between perceived stress and quality of life among adults living in Delhi NCR, during the second wave of the COVID-19 pandemic. Materials and methods: A 10-item perceived stress scale (PSS-10) was used to assess perceived stress among adults. The 26-item World Health Organization Quality of Life Brief Version (WHOQOL-BREF) was used to assess the quality of life. The data were collected online and analyzed using statistical methods, like independent samples t-test and Spearman's rank correlation. Results: The study found no significant difference in the perceived stress between males and females (p >0.05). There was no significant difference in various domains of quality of life, like physical health, psychological health, social relationships, and environmental health between males and females (p >0.05). Also, the overall quality of life had a significant negative correlation (p <0.01) with perceived stress. Conclusion: Better outcomes on the parameters of physical health, psychological health, social relationships, and environmental health among the participants helped them to keep perceived stress at low-to-moderate levels and achieve a better quality of life.