Intolerance to dentures as a result of allergy is very rare. In such cases, the allergy is triggered not by the acrylic but mostly due to the unpolymerized precursors. Epicutaneous test reveals the allergy is due to the presence of benzoyl peroxide initiator and hydroquinone inhibitor. In contrast, the monomers methyl methacrylate (MMA) and triethylene glycol dimethacrylate are allergens that are primarily responsible and relevant for dental clinicians and technicians in their jobs. Latex and vinyl gloves are not adequate barriers for monomer and are generally unknown as clinicians still work with doughy acrylic mixtures without adequate precautions. Research papers were reviewed—many papers were studies for their cytotoxicity effects of Methyl Methacrylate. Various reports mentioned in the literature make the monomer as the main felon. Allergen-free dentures as an alternative to denture base resins and precautionary measures for dental professionals and technicians have also been mentioned.