Background: In the present scenario, COVID-19 has become a global pandemic, creating a life threat for humans. Some studies depicted that the use of vitamin C may minimize this infection. On the contrary, few studies have denied any beneficial role of vitamin C in COVID-19. The controversies still prevail that need to attain a consensus. Therefore, through this review, we tried to find out the effects of vitamin C on COVID-19 infection. Objective: The objective of this study is to find the impact of vitamin C supplementation on COVID-19 infection and its severity. Conclusion: Vitamin C supplementation can strongly help in reducing COVID-19 and many other infectious diseases by boosting the immune system. Therefore, a regular administration of vitamin C is required to develop strong immunity against the COVID-19 pandemic.