Lymphocytes and Melatonin Interaction in COVID-19 and Serotonin Sepsis

JOURNAL TITLE: Indian Journal of Medical Biochemistry

Author
1. Omkar K. Choudhari
2. Anita Rani
3. Sonam Spalgais
4. Umesh C Ojha
ISSN
0972-1207
DOI
10.5005/jp-journals-10054-0145
Volume
24
Issue
2
Publishing Year
2020
Pages
2
Author Affiliations
    1. Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, India
    1. Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, India
    1. Department of pulmonary Medicine ESI-PGIMSR Basaidarapur New Delhi 110015
    1. Department of Pulmonary Medicine, Employee State Insurance Post Graduate Institute of Medical Sciences and Research, Basaidarapur, New Delhi, India
  • Article keywords

    Abstract

    The pandemic of SARS-CoV-2 has affected millions of lives worldwide. Many studies have described the cytokine storm and the subsequent shock behind acute respiratory distress syndrome. Melatonin, a hormone secreted by the pineal gland has excellent anti-inflammatory and immunomodulatory functions. Its role as an adjuvant in the treatment of COVID-19 has been described by many review studies. Serotonin is the intermediate product of melatonin and deficiency of intermediate enzymes causes serotonin surge increasing capillary permeability and shock.

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