Many thanks to JAYPEEDIGITAL platform, which has been an indispensable easy-to-use source for our...Ozlem YALCINKAYA
Jaypeedigital site offers to our students a huge number of medical publications such as textbooks...Dr Jesus Tapia Jurado
With user-friendly interface, Jaypeedigital provides extensive coverage in medicine, dentistry and...Wan Suhaimi Ariffin, MLS (Syracuse), BLS (UITM)`
Jaypeedigital platform presents an interesting and valuable collection of medical publications that...David E. García Díaz (MD)
Some of us teach in the Division of Graduate Studies and Research at the Faculty and the contents of...Arcelia Meléndez Ocamp (MD)
Subscribe to be the first to know about Best Deals and Exclusive Offers!
JOURNAL TITLE: International Journal of Infertility & Fetal Medicine
To assess the effectiveness and safety of fixed dose combination (FDC) of antioxidants in treatment of idiopathic oligoasthenozoospermia.
Placebo-controlled, Double-blind, randomized, Parallel three arm, Multicentric trial.
Fertility clinics of five centers across India.
One hundred and thirty-eight male subjects, aged between 21 and 50 years and subfertile for 1 year or more with the following baseline sperm selection criteria: Concentration <15 million/ml and total sperm motility <40%.
Eligible subjects were randomized to either of the three arms in a double-blind manner, i.e. arm 1 was given 2 tablets twice daily of FDC of antioxidants (coenzyme-Q10: 50 mg, L-carnitine: 500 mg, lycopene: 2.5 mg and zinc: 12.5 mg); arm 2 was given 1 tablet of FDC of antioxidants and one tablet of placebo twice daily and arm 3 was two tablets twice daily of matching placebo all for 180 days.
The primary outcome measures were improvement in sperm count and sperm motility, whereas pregnancy rate was the secondary efficacy outcome.
Compared to placebo, a statistically significant improvement was seen in sperm count (14.8-26.35 in arm 1 and 14.37-24.8 million/ml in arm 2, p < 0.0001), and sperm total motility (39.2-51.6% in arm 1 and 38.4-50.1% in arm 2, p < 0.0001), at 90 days, and treatment further improved these parameters at day 180. No intergroup difference was seen between arm 1 and arm 2. Mild adverse event of upper gastrointestinal discomfort by 8 subjects (three in arm 1; one in arm 2 and four subjects in arm 3) were reported. No serious adverse event was seen in the study.
Exogenous administration of fixed dose combination of antioxidants is a safe and effective therapy in improving the male subfertility.
Gopinath PM, Kalra B, Saxena A, Malik S, Kochhar K, Kalra S, Zaveri H. Fixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia: Results of a Randomized, Doubleblind, Placebo-controlled Clinical Trial. Int J Infertility Fetal Med 2013;4(1):6-13.
© 2019 Jaypee Brothers Medical Publishers (P) LTD. | All Rights Reserved