Introduction: Langerhans cell histiocytosis (LCH) is a rare atypical cellular disorder characterized by clonal proliferation of Langerhans cells leading to myriad clinical presentations and variable outcomes. It usually occurs in children and young adults. It can be present with local and systemic manifestation involving skin, bone, mucosal tissues and internal organs. Aims and objectives: The stomatologist plays an important role in management of the disease by keeping in mind the various oral manifestations of the disease. Case report: Of a child with disseminated LCH with multiorgan involvement who presented with failure to thrive, osteolytic bony lesions and extensive cutaneous eruptions. Conclusion: Early diagnosis and awareness is necessary to treat the patients.