Crouzon\'s Syndrome: A Rare Genetic Disorder

JOURNAL TITLE: International Journal of Clinical Pediatric Dentistry

Author
1. Anupriya Kaushik
2. Hindpal Bhatia
ISSN
0974-7052
DOI
10.5005/jp-journals-10005-1395
Volume
9
Issue
4
Publishing Year
2016
Pages
4
Author Affiliations
    1. Department of Pedodontics and Preventive Dentistry, MN DAV Dental College, Solan, Himachal Pradesh, India
    1. Department of Pedodontics and Preventive Dentistry, Manav Rachna Dental College, Faridabad, Haryana, India
  • Article keywords
    Crouzon\'s syndrome, Fibroblast growth factor, Premature synostosis

    Abstract

    Crouzon\'s syndrome, also known as brachial arch syndrome, is an autosomal dominant disorder with complete penetrance and variable expressivity. Described by a French neurosurgeon in 1912, it is a rare genetic disorder. Crouzon\'s syndrome is caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. Normally, the sutures in the human skull fuse after the complete growth of the brain, but if any of these sutures close early, then it may interfere with the growth of the brain. The disease is characterized by craniosynostosis, with associated dentofacial anomalies. This report describes the different clinical features in a 10-year-old male patient, with particular reference to characteristic findings of this syndrome. How to cite this article: Kaushik A, Bhatia H, Sharma N. Crouzon\'s Syndrome: A Rare Genetic Disorder. Int J Clin Pediatr Dent 2016;9(4):384-387.

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